CN104431341A - Functional glycoconjugate for improving reproductive performance of female animals and application thereof - Google Patents
Functional glycoconjugate for improving reproductive performance of female animals and application thereof Download PDFInfo
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- CN104431341A CN104431341A CN201310419196.3A CN201310419196A CN104431341A CN 104431341 A CN104431341 A CN 104431341A CN 201310419196 A CN201310419196 A CN 201310419196A CN 104431341 A CN104431341 A CN 104431341A
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Abstract
The invention discloses a functional glycoconjugate for improving the reproductive performance of female animals. The glycoconjugate disclosed by the invention comprises the following components of 1-500mg of chitosan oligosaccharide, 1-500mg of fructo-oligosaccharide and 1-500mg of zymosan in every 1kg of feed. The functional glycoconjugate for improving the reproductive performance of the female animals, disclosed by the invention, improves the immunocompetence and the disease resistance and increase the litter size of the animals. The glycoconjugate has the advantages of zero toxicity, zero side effects, zero residuals, small additive amount, zero pollution, good repeatability and zero adverse influence on environment.
Description
Technical field
The present invention relates to a kind of functional sugar compound improving jenny reproductive performance, specifically, be a kind of animal functional sugar feed addictive containing oligosaccharides, polysaccharide, belong to agro-ecology product technique field.
Background technology
Since reform and opening-up, the animal husbandry of China maintains the growth rate of about 9%, and the output value of animal husbandry account for 1/3rd of the general production value of agriculture.For pig-breeding, China is a big country of raising pigs, in world's pig industry, occupy critical role, but we are not poweies of raising pigs.Compared with producing more than 20 fertilities of delivering sow for sale per year with the developed country sow such as America and Europe, China plants and never obtains basic solution by the problem that the fertility of sow is low.The sow ratio being mainly manifested in low Farrowing Traits is high, and sow mortality is high, and estrus time extremely again of weaning is long, causes failing to be significantly improved on total yield coefficient and the reproductive performances such as litter size of living always.And number born of sow lowly can increase the production cost on pig farm, comprising the costs such as manpower, factory building and feed can improve.
The genetic force of animal litter size is very low, and easily by the impact of environmental factor, the reproductive performance thus by selecting feed addictive to regulate and control sow is possible.At present, improving the multiple because have of sow reproductive performance, comprising the aspects such as heredity, nutrition and management.According to statistics through the seed selection of 20 years, sow year litter size only improve 1.04.Along with the improvement of boar hereditary quality, the improvement of feeding environment and management development, to continue the reproductive performance improving sow, need the trophic level improving sow to improve the reproductive performance of sow.At present, L-arginine is generally adopted to improve the litter size of the animals such as pig in the world.Result of study shows that L-arginine can improve the litter size alive of sow, but can not improve the total yield coefficient of sow.In addition, Tan Congling etc. (2010) find in in-pig daily ration, add the number of live birth 1 that FOS (FOS) can improve sow, and this has important reference significance to the research improving sow reproductive performance.
Functional sugar is that a class has the oligosaccharides of special physiological effect and the general name of glycan.Functional sugar content in feed addictive is atomic, but the physiological action that it plays in animal body is very large, have and promote beneficial bacterium growth, suppress harmful intestinal tract bacteria growing, simultaneously it has the multinomial physiological function such as reducing blood lipid, anti-oxidant, immunity moderation, penetration enhancement, energy regulating intestinal canal is healthy, and aggregate level improves the general level of the health of animal.In recent years, functional oligosaccharide becomes the focus in Animal nutrition research, has played good effect in feed industry.But the research of external regards functionality oligosaccharides to animal reproduction performance regulation and control such as sows has no report.
Chitosan oligosaccharide: improve animal immunizing power; Improve wean pig growth performance; Anticancer; Adjusting blood lipid; Regulate microbial population of animal intestinal tract.
FOS: there is Oilgosaccharkdes and strengthen effect; Balance intestinal microbial environment, promotes intestinal bifidobacteria and lactobacillus growth; There is the effect relaxed bowel.
Zymosan: the harm reducing aflatoxins, zearalenone in feed; Have alleviate radiation injury, antiviral, excite and promote the physiological actions such as immunologic function.
By the compound use of three kinds of functional sugars, Long term Animal location can be improved and raise the sub-health state caused, increase the litter size of animal, extend the service life of animal.
Summary of the invention
The present invention seeks to the compound use by three kinds of functional sugars, adjustment animal intestinal is healthy, reduce the toxic action of forage poisoning element, strengthen animal immunizing power, improve latter half of gestation fetus and placenta nutrition supply ability, and then systematically regulate the physiological function of animal from integral level, improve the sub-health state of animal, improve the reproductive performance of animal, increase the service life of animal.This method not only efficiency is high, and reproducible.
For achieving the above object, the technical solution used in the present invention is:
The present invention is a kind of functional sugar compound improving jenny reproductive performance, containing following composition in its every 1kg feed: chitosan oligosaccharide 1 ~ 500mg, FOS 1 ~ 500mg and zymosan 1 ~ 500mg.
The described chitosan oligosaccharide degree of polymerization is between 2 ~ 8, and deacetylation is more than 95%, and molecular weight is between 300 ~ 2000Da.
The described FOS degree of polymerization is between 2 ~ 10, and mean molecule quantity is between 300 ~ 2000Da.
Described zymosan is yeast cell wall extract.
Described complex components comprises: chitosan oligosaccharide: 10 ~ 200 weight portions, FOS: 10 ~ 200 weight portions, zymosan: 10 ~ 200 weight portions.
Described functional sugar compound can as the feed addictive improving jenny reproductive performance active ingredient.
The addition of described functional sugar compound in every kilogram of feed is:
Chitosan oligosaccharide: 1 ~ 500mg, FOS: 1 ~ 500mg, zymosan: 1 ~ 500mg.
Described functional sugar compound also can improve the farrowing quantity of jenny second parity or the above parity of the 3rd parity by feeding animals continuously.
Described functional sugar compound is applied to jenny, and jenny of feeding continuously in weaning period, the gestational period and lactation.
Described functional sugar compound needs to add in the perfect compound feed of jenny.
This functional sugar compound needs to mix with perfect compound feed according to described ratio before use, or is made into feed addictive use.
The present invention need weaning period, the gestational period and lactation Long-term Feeding jenny, and Long-term Feeding is to reach optimum efficiency.
The present invention improves on jenny first parity nest litter size basis at functional sugar compound, and this functional sugar compound feed that continues to feed can continue to improve the nest litter size of jenny second parity.
Advantage of the present invention has: three kinds of functional sugar conbined usage, can improve the reproductive performance of jenny well, especially shows in nest litter size index.The present invention is simple to operate, efficiency is high, pollution-free, reproducible, be applicable to large-scale production.
Compare with L-arginine, there is successful, reproducible, the advantages such as suckling animals feed intake can be increased, especially continue result of use better.
Detailed description of the invention
The process for extracting that the present invention's zymosan used adopts with reference to Hou Ranran (2007).Take used yeast slurry as raw material, under different temperatures, different time, different PH condition, adopt citrate buffer solution method to extract glucomannans, the Thick many candies extracted is adopted Fehling reagent, Cetyltrimethyl Ammonium Bromide method and Sevage method carry out de-albumen process simultaneously.
The present invention is further illustrated below in conjunction with embodiment.
Case study on implementation 1 functional sugar affects mouse first parity litter size
(1) animal used as test: female and male mouse of kunming, cleaning grade animal, 3 ~ 4 week age, 12 ± 3g, thered is provided by Dalian Medical Univ's Experimental Animal Center, approval number is SCXK(the Liao Dynasty) 2008-0002, cleaning grade Animal House is raised, temperature 20 ± 1 DEG C, humidity 40% ~ 50%, illumination 12h, pellet is fed, and freely drinks water.Feed containing functional sugar mouse perfect compound feed more than 6 weeks, Mouse Weight can reach 26 ± 3g, can be used for mating test.
(2) experimental technique: choose build similar, the wean female mice that energy enlivens is divided into 3 groups at random.First group is blank group, feeds not containing the perfect compound feed (see table 1) of functional sugar; Second group is chitosan oligosaccharide group, feeds containing the perfect compound feed of 300mg/kg chitosan oligosaccharide; 3rd group is functional sugar complex group, feeds containing 100mg/kg chitosan oligosaccharide, 100mg/kg FOS, the perfect compound feed of 100mg/kg zymosan.Meanwhile, male mice is fed not containing the perfect compound feed of functional sugar.Feed containing the perfect compound feed more than 6 weeks of functional sugar compound, until mouse reaches sexual maturing period.Select female mouse vigorous and male mouse, according to female: male=1:1 carries out mating, continue to mouse and to become pregnant and till farrowing.
(3) test item: the every only female mouse litter size of statistics.
(4) statistical method: the data acquisition SPSS Duncan's multiple rangetest collected analyzes.
(5) result:
As can be seen from table 2. result, functional sugar complex group and chitosan oligosaccharide group can significantly improve the litter size (13.40 ± 3.00/13.50 ± 1.83/11.33 ± 3.11, functional sugar complex group/chitosan oligosaccharide group/control group, P<0.05) of mouse.
Table 1. experimental basis daily ration composition and nutritional labeling
Table 2. functional sugar affects mouse first parity litter size
Case study on implementation 2 functional sugar is to mouse second parity Reproduction
(1) animal used as test: this group experiment mouse source used is tested identical with upper group.After female and male mice mating is also farrowed and terminated in embodiment 1, continue to feed containing functional sugar feed to mouse, Mouse Weight reaches 51.2 ± 0.4g.Mouse is raised at cleaning grade Animal House, temperature 20 ± 1 DEG C, humidity 40% ~ 50%, illumination 12h, and pellet is fed, and freely drinks water.
(2) experimental technique: choose build similar, the female wean mouse that energy enlivens is divided into 3 groups at random.First group is blank group, feeds not containing the perfect compound feed of functional sugar; Second group is chitosan oligosaccharide group, feeds containing the perfect compound feed of 300mg/kg chitosan oligosaccharide; 3rd group is functional sugar complex group, feeds containing the perfect compound feed of 100mg/kg chitosan oligosaccharide, 100mg/kg FOS, 100mg/kg zymosan.Meanwhile, male mice is fed not containing the perfect compound feed of functional sugar.Feed containing the perfect compound feed more than 6 weeks of functional sugar compound, until mouse reaches sexual maturing period.Select female mouse vigorous and male mouse, according to female: male=1:1 carries out mating, until mouse farrows after becoming pregnant.
(3) test item: statistics every only female mouse litter size, litter weight, individual weight.
(4) statistical method: the data acquisition SPSS Duncan's multiple rangetest collected analyzes.
(5) result:
As can be seen from table 3. result, functional sugar complex group and chitosan oligosaccharide group can improve the litter size (13.75 ± 2.45/12.56 ± 1.51/11.56 ± 2.96, functional sugar complex group/chitosan oligosaccharide group/control group) (P<0.05) of mouse second parity.
As can be seen from table 4. result, functional sugar complex group obviously can reduce neonatal mice body weight (2.73 ± 0.27/3.26 ± 0.47, functional sugar complex group/control group) (P<0.05), chitosan oligosaccharide group Mouse Weight is lower than control group, but difference not obvious (3.00 ± 0.37/3.26 ± 0.47, chitosan oligosaccharide group/control group) (P>0.05)
Table 3. functional sugar affects mouse second parity litter size
Table 4. functional sugar is to mouse second parity Reproduction
Embodiment 3 functional sugar is to mouse pregnancy later stage Reproduction
(1) animal used as test: female and male mouse of kunming, cleaning grade animal, 3 ~ 4 week age, 12 ± 3g, thered is provided by Dalian Medical Univ's Experimental Animal Center, approval number is SCXK(the Liao Dynasty) 2008-0002, cleaning grade Animal House is raised, temperature 20 ± 1 DEG C, humidity 40% ~ 50%, illumination 12h, pellet is fed, and freely drinks water.Feed containing functional sugar mouse daily ration more than 6 weeks, Mouse Weight can reach 26 ± 3g, and mouse mating is become pregnant, and from calculating the 1st day of becoming pregnant, puts to death mouse and for experiment to becoming pregnant 19 days.
(2) experimental technique: choose build similar, the wean female mice that energy enlivens is divided into 3 groups at random.First group is blank group, feeds not containing the perfect compound feed of functional sugar; Second group is chitosan oligosaccharide group, feeds containing the perfect compound feed of 300mg/kg chitosan oligosaccharide; 3rd group is functional sugar complex group, feeds containing the perfect compound feed of 100mg/kg chitosan oligosaccharide, 100mg/kg FOS, 100mg/kg zymosan.Meanwhile, male mice is fed not containing the perfect compound feed of functional sugar.Feed containing the perfect compound feed more than 6 weeks of functional sugar compound, until mouse reaches sexual maturing period.Select female mouse vigorous and male mouse, according to female: male=1:1 carries out mating, become pregnant to 19 ages in days until mouse.
(3) test item: the every only index such as the total embryo number of female mouse, live embryo number, fetus-uterus weight, nest fetus weight, nest Placental Weight, diameter of placenta, fetus weight/Placental Weight of statistics.
(4) statistical method: the data acquisition SPSS Duncan's multiple rangetest collected analyzes.
(5) result:
Table 5. functional sugar is on mouse pregnancy embryo number impact in 19 days
As can be seen from table 5. result, chitosan oligosaccharide group can significantly improve mouse live embryo sum (14.30 ± 1.06/12.82 ± 2.21) (P<0.05), and functional sugar complex group can improve live embryo sum 0.64 (13.46 ± 2.26/12.82 ± 2.21) (P>0.05).
Table 6. functional sugar is to mouse pregnancy 19 days each Reproductions
Can find out from table 6. result, chitosan oligosaccharide group can significantly improve fetus-weight/weight ratio (39.04 ± 1.64/33.50 ± 4.40, uterus, chitosan oligosaccharide group/control group) (P<0.05), functional sugar complex group and chitosan oligosaccharide group to a certain degree can improve (P>0.05) nest Placental Weight (2.13 ± 0.70/1.92 ± 0.20/1.82 ± 0.47) and nest fetus heavy (18.26 ± 3.06/19.50 ± 1.87/17.76 ± 2.98).Chitosan oligosaccharide group fetus/placenta ratio is higher than control group (10.31 ± 0.55/9.92 ± 2.21), and between these two groups, difference is not obvious.
Claims (10)
1. improve a functional sugar compound for jenny reproductive performance, it is characterized in that, described compounds constituent components comprises: chitosan oligosaccharide: 1 ~ 500 weight portion, FOS: 1 ~ 500 weight portion, zymosan: 1 ~ 500 weight portion.
2. according to functional sugar compound according to claim 1, it is characterized in that: the described chitosan oligosaccharide degree of polymerization is between 2 ~ 8, and deacetylation is more than 95%, and molecular weight is between 300 ~ 2000Da.
3. according to the functional sugar compound described in claim 1 or 2, it is characterized in that: the described FOS degree of polymerization is between 2 ~ 10, and mean molecule quantity is between 300 ~ 2000Da.
4. according to the functional sugar compound described in claim 1 or 2, it is characterized in that: described zymosan is yeast cell wall extract.
5. according to functional sugar compound according to claim 1, it is characterized in that, described complex components comprises: chitosan oligosaccharide: 10 ~ 200 weight portions, FOS: 10 ~ 200 weight portions, zymosan: 10 ~ 200 weight portions.
6. an application for the arbitrary described functional sugar compound of claim 1-5, is characterized in that: described functional sugar compound can as the feed addictive improving jenny reproductive performance active ingredient.
7. according to application according to claim 6, it is characterized in that, the addition of described functional sugar compound in every kilogram of feed is:
Chitosan oligosaccharide: 1 ~ 500mg, FOS: 1 ~ 500mg, zymosan: 1 ~ 500mg.
8. according to the application described in claim 6 or 7, it is characterized in that, described functional sugar compound also can improve the farrowing quantity of jenny second parity or the above parity of the 3rd parity by feeding animals continuously.
9. according to application according to claim 6, it is characterized in that: described functional sugar compound is applied to jenny, and jenny of feeding continuously in weaning period, the gestational period and lactation.
10. according to application according to claim 6, it is characterized in that: described functional sugar compound needs to add in the perfect compound feed of jenny.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109674813A (en) * | 2018-12-12 | 2019-04-26 | 大连海洋大学 | For improving the compound formulation of buck physiological function |
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| CN109674813A (en) * | 2018-12-12 | 2019-04-26 | 大连海洋大学 | For improving the compound formulation of buck physiological function |
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