CN109641864B - 抗感染药剂 - Google Patents

抗感染药剂 Download PDF

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Publication number
CN109641864B
CN109641864B CN201780050757.3A CN201780050757A CN109641864B CN 109641864 B CN109641864 B CN 109641864B CN 201780050757 A CN201780050757 A CN 201780050757A CN 109641864 B CN109641864 B CN 109641864B
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China
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group
optionally
alkyl
halogen
substituted
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CN201780050757.3A
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English (en)
Chinese (zh)
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CN109641864A (zh
Inventor
芭芭拉·福特
尼尔·诺克罗斯
驰慕德·詹森
比阿特丽斯·布拉干纳
伊恩·吉伯特
劳拉·克莱格霍恩
苏珊·戴维斯
克里斯多夫·沃波尔
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University of Dundee
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University of Dundee
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201780050757.3A 2016-06-20 2017-06-20 抗感染药剂 Active CN109641864B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1610724.5A GB201610724D0 (en) 2016-06-20 2016-06-20 Anti-infective agents
GB1610724.5 2016-06-20
PCT/GB2017/051809 WO2017221002A1 (en) 2016-06-20 2017-06-20 Anti-infective agents

Publications (2)

Publication Number Publication Date
CN109641864A CN109641864A (zh) 2019-04-16
CN109641864B true CN109641864B (zh) 2023-04-04

Family

ID=56895232

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780050757.3A Active CN109641864B (zh) 2016-06-20 2017-06-20 抗感染药剂

Country Status (7)

Country Link
US (2) US20190225592A1 (enExample)
EP (1) EP3472141B1 (enExample)
JP (1) JP7041129B2 (enExample)
CN (1) CN109641864B (enExample)
ES (1) ES2936482T3 (enExample)
GB (1) GB201610724D0 (enExample)
WO (1) WO2017221002A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112839714A (zh) * 2018-10-19 2021-05-25 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒疾病的色烯-4-酮衍生物
BR112022011689A2 (pt) 2019-12-19 2022-09-06 Oxford Drug Design Ltd Compostos de 2-amino-n-(amino-oxo-arila-lambda6-sulfanilideno) acetamida e seu uso terapêutico
GB202206076D0 (en) 2022-04-26 2022-06-08 Univ Of Dunee Novel anti-infective agents
CN116196465B (zh) * 2022-12-29 2025-04-18 深圳市迈捷生命科学有限公司 一种用于皮肤损伤修复的胶原蛋白组合物及其生产方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE964055C (de) * 1954-08-26 1957-05-16 Chemiewerk Homburg Ag Verfahren zur Herstellung von am Stickstoff substituierten Chromon-2-carbonsaeureamiden
DE970224C (de) * 1954-03-26 1958-08-28 Chemiewerk Homburg Ag Verfahren zur Herstellung von am Stickstoff substituierten Chromon-2-carbonsaeureamiden
CN1035827A (zh) * 1988-02-29 1989-09-27 株式会社三和化学研究所 旋光性的4-氧代-1-苯并吡喃-2-羧酸衍生物及其中间体的制备方法
WO2006094601A1 (de) * 2005-03-10 2006-09-14 Merck Patent Gmbh Chromen-4-on-derivate

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2078719B (en) 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds
ZA813354B (en) * 1980-06-02 1982-05-26 Ici Ltd Heterocyclic compounds
JPH0637498B2 (ja) * 1986-06-25 1994-05-18 武田薬品工業株式会社 抗生物質ｔａｎ−８７６およびその製造法
US5171865A (en) * 1988-02-29 1992-12-15 Sanwa Kagaku Kenkyusho Co., Ltd. Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
JP4561245B2 (ja) * 2004-08-31 2010-10-13 住友化学株式会社 クロモン化合物及びその用途
PH12013501057A1 (en) 2010-11-22 2013-09-09 Mitsui Mining & Smelting Co Ltd Surface-treated copper foil
GB201206280D0 (en) * 2012-04-10 2012-05-23 Univ Dundee Anti-malarial agents
GB2511470B (en) 2012-04-25 2020-07-15 Univ Sussex Treatment of fungal infections using alternative oxidase inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE970224C (de) * 1954-03-26 1958-08-28 Chemiewerk Homburg Ag Verfahren zur Herstellung von am Stickstoff substituierten Chromon-2-carbonsaeureamiden
DE964055C (de) * 1954-08-26 1957-05-16 Chemiewerk Homburg Ag Verfahren zur Herstellung von am Stickstoff substituierten Chromon-2-carbonsaeureamiden
CN1035827A (zh) * 1988-02-29 1989-09-27 株式会社三和化学研究所 旋光性的4-氧代-1-苯并吡喃-2-羧酸衍生物及其中间体的制备方法
WO2006094601A1 (de) * 2005-03-10 2006-09-14 Merck Patent Gmbh Chromen-4-on-derivate

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Benzopyrones. 7. synthesis anticallergic activity of some 2-(5-tetrazolyl) chromones;ELLIS G P等;《journal of medicinal chemistry》;19781130;第21卷(第11期);1120-1126 *
Chromone Studies. Part 4." Structural Analysis of Chromone-derived 2-Amino-3-(2-hydroxy benzoyl) acrylamides;Deborah N. Davidson等;《J.CHEM.SOC.PERKIN TRANS》;19910831(第8期);1181 *
Chromone Studies. Part 5." Kinetics and Mechanism of the Reaction of 4-0x0-4H-chromene-2-carboxamides with Dimethylamine;Deborah N. Davidson;《J.CHEM. SOC.PERKIN TRANS》;19911031(第10期);1509 *
Malonic Acid Receptors With Decarboxylative Activity;Cesar Raposo等;《MEDICINAL CHEMISTRY RESEARCH》;20160808;第22卷(第11期);2547-2556 *

Also Published As

Publication number Publication date
US11485720B2 (en) 2022-11-01
US20190225592A1 (en) 2019-07-25
JP2019522048A (ja) 2019-08-08
WO2017221002A1 (en) 2017-12-28
ES2936482T3 (es) 2023-03-17
EP3472141A1 (en) 2019-04-24
US20210101877A1 (en) 2021-04-08
EP3472141B1 (en) 2022-10-05
CN109641864A (zh) 2019-04-16
JP7041129B2 (ja) 2022-03-23
GB201610724D0 (en) 2016-08-03

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