CN109568180A - A kind of preparation method and application of essential oil and the compound shell-core structure nanoparticle of PLGA - Google Patents
A kind of preparation method and application of essential oil and the compound shell-core structure nanoparticle of PLGA Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The present invention provides a kind of preparation methods of the compound shell-core structure nanoparticle of essential oil and PLGA, the following steps are included: PLGA and composite essential oil are dissolved in acetone soln, and the oil is added to be sufficiently mixed in TPGS aqueous solution after emulsify, surplus solution is precipitated by high speed centrifugation after removing acetone, the shell-core structure nanoparticle compound to get essential oil and PLGA is lyophilized in washing；Wherein, the parts by weight ratio of composite essential oil and PLGA are 1:1-1:3；Its application in hand cleanser is additionally provided simultaneously.Essential oil is encapsulated in " PLGA Nano capsule " in-core by nanoprecipitation method by the present invention, the nanoparticle of preparation has high encapsulation rate and good slow release effect, effectively avoid essential oil be oxidized caused by go bad, the term of validity containing essential oil product is extended, application field of the essential oil as addition type modifying agent is expanded；Essential oil and PLGA composite nanoparticle are applied in hand cleanser, it can not only effective cleaning hand skin, moreover it is possible to moisturizing, the effect of enhancing skin elasticity.
Description
Technical field
The present invention relates to articles for washing technical fields, and in particular to a kind of essential oil and the compound core-shell structure nanometer of PLGA
The preparation method and application of particle.
Background technique
Hand cleanser is the skin care cleaning solution based on a kind of cleaning hand, has and storage is facilitated to measure, beautiful, low stimulation and nothing
The advantages that secondary pollution.With the improvement of people ' s living standards and to beautiful higher cognition and requirement, need to carry out to both hands
Nursing and beauty are carried out while cleaning, currently, naturalization, moist type skin care hand cleaning liquid have been increasingly becoming and China led to wash
Wash the trend in market.With the raising of environmental consciousness and sense of self-protection, current consumer to the formula components of hand cleanser and
Also the moment carries out concern to interior quality.
Essential oil is also referred to as " aromatic oil ", by steam distillation, is squeezed in the flower from plant, leaf, stem, root or fruit
Method, cold-maceration or solvent extraction method refine the mixture of the volatile flavor of extraction.Essential oil mainly has terpene hydrocarbons, virtue
Fragrant hydro carbons, aldehydes, esters, alcohols and phenols etc., wherein most commonly seen with terpenoid and its derivative.Terpenoid
Referring to has (C5H8)nGeneral formula and its oxygen-containing and degree of unsaturation derivative, can regard as by isoprene or isopentane
A kind of native compound to link in various ways.
Essential oil molecular weight is minimum, is 500 a ten thousandths of human body cell, this permeates them easily in skin, and
It is mixed into human body by with fatty fiber.General plants essential oil can penetrate into skin in about 3-5 seconds by affinity interaction
The skin corium and subcutaneous tissue of skin enter human recycle system, to play its due effect, and about after 3-5 minutes
It can excrete within 4-12 hours.Essential oil is applied to hand cleanser, people, just can be abundant while cleaning hand skin
The effect of playing essential oil, is intimately combined to form layer protecting film, makes the more soft exquisiteness of skin, moisten smooth with skin surface.
The shelf-life of real 100% pure folk prescription essential oil is often long, but the folk prescription essential oil of high concentration is volatile
And have the characteristics that corrosivity, skin cannot be directly acted on, so being generally used in compounding with base oil.And base oil is guaranteed the quality
Phase is usually shorter, this makes the composite essential oil reconciled be easy to be oxidized and go bad in use, seriously affects
Product quality, the application field which greatly limits essential oil as addition type modifying agent.So being badly in need of a kind of preparation method to keep away
Exempt from essential oil be oxidized caused by go bad, extend the term of validity containing essential oil product, expand essential oil as addition type modifying agent
Application field.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation method of the compound shell-core structure nanoparticle of essential oil and PLGA and
Its application in hand cleanser preparation.
To achieve the above object, the present invention provides a kind of systems of the compound shell-core structure nanoparticle of essential oil and PLGA
Preparation Method, comprising the following steps: PLGA and composite essential oil are dissolved in acetone soln, and it is water-soluble that the oil is added to TPGS
It emulsifies after being sufficiently mixed in liquid, is precipitated surplus solution by high speed centrifugation after removing acetone, washing freeze-drying is to get essence
Oil and PLGA compound shell-core structure nanoparticle；Wherein, the parts by weight ratio of composite essential oil and PLGA are 1:1-1:3.
Further, mode/means of the emulsification include: by mixed solution under the revolving speed of 10000-12000rpm,
1-5min, then the ultrasonic emulsification 20-40min under condition of ice bath are emulsified with high speed homogenizer.
Further, the ultracentrifugal revolving speed is 15000-20000rpm, and the time of centrifugation is 10-30 min.
Further, the composite essential oil includes folk prescription essential oil and base oil；The folk prescription essential oil includes Rosa Damascana,
Sandalwood essential oil, chamomile essential oil, one of flores aurantii essential oil or a variety of；The base oil is SIMMONDSIA CHINENSIS SEED OIL, Sweet Almond Oil and Portugal
One of grape seed oil is a variety of；The folk prescription essential oil: the weight ratio of base oil is 1:4-1:9.
Further, the composite essential oil preparation method/means include: by appropriate folk prescription essential oil and base oil in temperature
10-20min is stirred with 80-120rpm under conditions of being 20-30 DEG C, is uniformly mixed and obtains composite essential oil.
This essential oil and the compound shell-core structure nanoparticle of PLGA can be applied in hand cleanser preparation.
Further, the hand cleanser preparation method/means include:
(1) following parts by weight material is taken: 10-20 parts of surfactant, 0.5-1 parts of emulsifier, 2-5 parts of moisturizer, anti-corrosion
0.5-1 parts of agent, 40-50 parts of deionized water, 10-20min is stirred with 400-600rpm under conditions of temperature is 45-55 DEG C, is made
Its mixing and emulsifying is uniform；
(2) compound shell-core structure nanoparticle addition step (1) of 10-20 parts of essential oils and PLGA is prepared mixed
It closes in liquid, and 3-37 parts of deionized waters is added, 10-20min is stirred with 150-300rpm under conditions of temperature is 25-30 DEG C,
Keep its mixing and emulsifying uniform；
(3) under conditions of temperature is 22-28 DEG C, 0.5-2 part is slowly added in the mixed liquor that obtains to step (2) and is increased
Thick dose, side stirring and emulsifying frontier inspection observing and controlling viscosity adds pH adjusting agent, measures system with pH adjusting agent when emulsifying uniform
The pH value of pH value, control system is 5-6, obtains the essential oil containing the compound shell-core structure nanoparticle of essential oil and PLGA and washes one's hands
Liquid.
Further, the surfactant includes following parts by weight material: 5-10 parts of alkyl glucoside, coconut oleoyl amine
1-5 parts and 1-5 parts of laureth sodium sulfovinate of propyl betaine.
Further, the preservative is answering for Phenoxyethanol that parts by weight ratio is 1:1-9:1 and ethyl diethyldithiocarbamate glycerol
Close preservative.
Further, the emulsifier includes Cremophor RH40 and/or glycol distearate；The guarantor
Humectant includes glycerol and/or butanediol；The thickener is sodium chloride；The pH adjusting agent is citric acid and sodium citrate.
The present invention has the advantages that
1, poly lactide-glycolide acid (PLGA) is polymerized at random by two kinds of monomer, that is, lactic acid and hydroxyacetic acid,
A kind of degradable functional polymer organic compound, have good biocompatibility, nontoxic, good encystation and at
The performance of film is widely used in pharmacy, medical engineering material and modernization industry field.The present invention is hydrophobic using essential oil
Essential oil is encapsulated in " PLGA Nano capsule " in-core by nanoprecipitation method and prepares essential oil and the compound core-shell structure of PLGA by property
Nanoparticle, the method prepare nanoparticle with high encapsulation rate and good slow release effect, are made an addition to the daily use chemicals such as hand cleanser
In product, it is possible to prevente effectively from causing product to go bad since essential oil is oxidized rotten in use containing essential oil product
Adverse consequences significantly extends the term of validity containing essential oil product, expands application neck of the essential oil as addition type modifying agent
Domain；
2, the present invention provides the preparation methods of the compound shell-core structure nanoparticle of this essential oil and PLGA in hand cleanser
In application, the compound shell-core structure nanoparticle of essential oil and PLGA is made an addition to the essential oil hand cleanser prepared in hand cleanser, no
Only can effective cleaning hand skin, while the effect of essential oil can also be given full play to, moisturizing, enhancing skin elasticity etc.；
In addition, this essential oil hand cleanser without any artificial synthetic essence, distributes fresh and clean essential oil fragrance, when use, makes us spiritual pleased
It is happy.
Specific embodiment
The present invention will be further described With reference to embodiment, following embodiment be intended to illustrate invention and
It is not limitation of the invention further.
Raw material of the present invention can synthesize commercially or according to the prior art.
Embodiment 1
A kind of preparation method of essential oil and the compound shell-core structure nanoparticle of PLGA, comprising the following steps:
(1) by folk prescription essential oil Rosa Damascana 0.5g, sandalwood essential oil 0.5g, chamomile essential oil 0.5g, flores aurantii essential oil 0.5g with
Base oil SIMMONDSIA CHINENSIS SEED OIL 10g is placed in 250ml three-necked flask, is stirred under conditions of temperature is 25 DEG C of condition with 100rpm
10min is uniformly mixed it spare；
(2) the composite essential oil 15mg that precision weighs in 30mg PLGA and step (1) is dissolved in 10ml acetone soln, and
The oil is added to equipped with being sufficiently mixed in the three-necked flask that 30ml mass fraction is 0.5%TPGS aqueous solution, in 11000rpm
Revolving speed under, emulsify 2min, then the ultrasonic emulsification 30min under condition of ice bath with high speed homogenizer, remove third with Rotary Evaporators
Ketone is precipitated surplus solution by high speed centrifugation, and ultracentrifugal revolving speed is 18000rpm, and the time of centrifugation is
The shell-core structure nanoparticle compound to get essential oil and PLGA is lyophilized after washing 3 times in 20min.
This composite nanoparticle is used to prepare in hand cleanser, preparation step includes:
(1) alkyl glucoside 10g, Cocoamidopropyl betaine 5g, laureth sodium sulfovinate 5g are weighed respectively,
0.5g Cremophor RH40 and 0.5g glycol distearate；5g glycerol；0.9g Phenoxyethanol and 0.1g ethyl second
Base glycerol；40g deionized water is placed in 250ml beaker, is stirred 20min under conditions of temperature is 50 DEG C with 500rpm, is made it
Mixing and emulsifying is uniform；
(2) compound shell-core structure nanoparticle addition step (1) of essential oil made from 15g and PLGA is prepared
In mixed liquor, and 18g deionized water is added, 10min is stirred with 200rpm in the condition that temperature is 30 DEG C, makes its mixing and emulsifying
Uniformly.
(3) 0.5g thickening is slowly added in the mixed liquor obtained under conditions of temperature is 25 DEG C of condition to step (2)
Agent sodium chloride, side stirring and emulsifying frontier inspection observing and controlling viscosity add pH adjusting agent citric acid and sodium citrate, and side emulsification is uniform
While measuring system pH in time with pH adjusting agent, the pH value of control system is 6, obtains the shell core compound containing essential oil and PLGA
The essential oil hand cleanser of structure nano particle.
Embodiment 2:
A kind of preparation method of essential oil and the compound shell-core structure nanoparticle of PLGA, comprising the following steps:
(1) folk prescription essential oil Rosa Damascana 1g, sandalwood essential oil 1g and base oil SIMMONDSIA CHINENSIS SEED OIL 10g are placed in tri- mouthfuls of 250ml burnings
In bottle, 15min is stirred with 100rpm under conditions of 25 DEG C, is uniformly mixed it spare.
(2) the composite essential oil 15mg that precision weighs in 30mg PLGA and step (1) is dissolved in 10ml acetone soln, and
The oil is added to equipped with abundant in the three-necked flask that 30ml mass fraction is 0.5%TPGS (water-soluble VE) aqueous solution
Mixing emulsifies 2min, then the ultrasonic emulsification 30min under condition of ice bath with high speed homogenizer, uses under the revolving speed of 11000rpm
Rotary Evaporators remove acetone, and surplus solution is precipitated by high speed centrifugation, and ultracentrifugal revolving speed is 18000rpm,
The time of centrifugation is 20min, and the shell-core structure nanoparticle compound to get essential oil and PLGA is lyophilized after washing 3 times.
This composite nanoparticle is used to prepare in hand cleanser, preparation step includes:
(1) alkyl glucoside 10g, Cocoamidopropyl betaine 5g, laureth sodium sulfovinate 5g are weighed respectively,
0.5g Cremophor RH40 and 0.5g glycol distearate；5g glycerol；0.9g Phenoxyethanol and 0.1g ethyl second
Base glycerol；40g deionized water is placed in 250ml beaker, stirs 20min under conditions of 50 DEG C with 500rpm, makes its mixing cream
Change uniform；
(2) compound shell-core structure nanoparticle addition step (1) of essential oil made from 20g and PLGA is prepared
In mixed liquor, and 13g deionized water is added, 10min is stirred with 200rpm under conditions of temperature is 30 DEG C, makes its mixing cream
Change uniform.
(3) 0.5g thickening is slowly added in the mixed liquor obtained under conditions of temperature is 25 DEG C of condition to step (2)
Agent sodium chloride, side stirring and emulsifying frontier inspection observing and controlling viscosity add pH adjusting agent citric acid and sodium citrate, and side emulsification is uniform
While measuring system pH in time with pH adjusting agent, the pH value of control system is 5, obtains the shell core compound containing essential oil and PLGA
The essential oil hand cleanser of structure nano particle.
Embodiment 3
A kind of preparation method of essential oil and the compound shell-core structure nanoparticle of PLGA, comprising the following steps:
(1) by folk prescription essential oil Rosa Damascana 0.5g, sandalwood essential oil 0.5g, chamomile essential oil 0.5g, flores aurantii essential oil 0.5g with
Base oil SIMMONDSIA CHINENSIS SEED OIL 10g is placed in 250ml three-necked flask, stirs 20min under conditions of temperature is 25 DEG C with 100rpm,
It is uniformly mixed it spare.
(2) the composite essential oil 30mg that precision weighs in 30mg PLGA and step (1) is dissolved in 10ml acetone soln, and
The oil is added to equipped with being sufficiently mixed in the three-necked flask that 30ml mass fraction is 0.5%TPGS aqueous solution, in 11000rpm
Revolving speed under, emulsify 2min, then the ultrasonic emulsification 30min under condition of ice bath with high speed homogenizer, remove third with Rotary Evaporators
Ketone is precipitated surplus solution by high speed centrifugation, and ultracentrifugal revolving speed is 18000rpm, and the time of centrifugation is
The shell-core structure nanoparticle compound to get essential oil and PLGA is lyophilized after washing 3 times in 20min.
This composite nanoparticle is used to prepare in hand cleanser, preparation step includes:
(1) alkyl glucoside 10g, Cocoamidopropyl betaine 5g, laureth sodium sulfovinate 5g are weighed respectively,
0.5g Cremophor RH40 and 0.5g glycol distearate；5g glycerol；0.9g Phenoxyethanol and 0.1g ethyl second
Base glycerol；40g deionized water is placed in 250ml beaker, stirs 20min under conditions of 50 DEG C with 500rpm, makes its mixing cream
Change uniform；
(2) compound shell-core structure nanoparticle addition step (1) of essential oil made from 15g and PLGA is prepared
In mixed liquor, and 18g deionized water is added, 10min is stirred with 200rpm under conditions of temperature is 30 DEG C, makes its mixing cream
Change uniform；
(3) 0.5g thickening is slowly added in the mixed liquor obtained under conditions of temperature is 25 DEG C of condition to step (2)
Agent sodium chloride, side stirring and emulsifying frontier inspection observing and controlling viscosity add pH adjusting agent citric acid and sodium citrate, and side emulsification is uniform
While measuring system pH in time with pH adjusting agent, the pH value of control system is 5, obtains the shell core compound containing essential oil and PLGA
The essential oil hand cleanser of structure nano particle.
Embodiment 4
A kind of preparation method of essential oil and the compound shell-core structure nanoparticle of PLGA, comprising the following steps:
(1) by folk prescription essential oil Rosa Damascana 0.5g, sandalwood essential oil 0.5g, chamomile essential oil 0.5g, flores aurantii essential oil 0.5g with
Base oil Sweet Almond Oil 10g is placed in 250ml three-necked flask, is stirred 10min under conditions of temperature is 20 DEG C with 80rpm, is made
It is uniformly mixed spare；
(2) the composite essential oil 15mg that precision weighs in 30mg PLGA and step (1) is dissolved in 10ml acetone soln, and
The oil is added to equipped with being sufficiently mixed in the three-necked flask that 30ml mass fraction is 0.5%TPGS aqueous solution, in 10000rpm
Revolving speed under, emulsify 1min, then the ultrasonic emulsification 20min under condition of ice bath with high speed homogenizer, remove third with Rotary Evaporators
Ketone is precipitated surplus solution by high speed centrifugation, and ultracentrifugal revolving speed is 15000rpm, and the time of centrifugation is
The shell-core structure nanoparticle compound to get essential oil and PLGA is lyophilized after washing 2 times in 10min.
This composite nanoparticle is used to prepare in hand cleanser, preparation step includes:
(1) alkyl glucoside 12g, Cocoamidopropyl betaine 3g, laureth sodium sulfovinate 5g are weighed respectively,
0.4g Cremophor RH40 and 0.5g glycol distearate；2g glycerol；0.9g Phenoxyethanol, 0.1g ethyl diethyldithiocarbamate
Glycerol and 40g deionized water are placed in 250ml beaker, are stirred 10min in the condition that temperature is 50 DEG C with 400rpm, are kept it mixed
It is uniform to close emulsification；
(2) compound shell-core structure nanoparticle addition step (1) of essential oil made from 15g and PLGA is prepared
In mixed liquor, and 21.1g deionized water is added, 10min is stirred with 150rpm in the condition that temperature is 25 DEG C, makes its mixing cream
Change uniform.
(3) 0.5g thickening is slowly added in the mixed liquor obtained under conditions of temperature is 22 DEG C of condition to step (2)
Agent sodium chloride, side stirring and emulsifying frontier inspection observing and controlling viscosity add pH adjusting agent citric acid and sodium citrate, and side emulsification is uniform
While measuring system pH in time with pH adjusting agent, the pH value of control system is 6, obtains the shell core compound containing essential oil and PLGA
The essential oil hand cleanser of structure nano particle.
Embodiment 5
A kind of preparation method of essential oil and the compound shell-core structure nanoparticle of PLGA, comprising the following steps:
(1) by folk prescription essential oil Rosa Damascana 0.4g, sandalwood essential oil 0.6g, chamomile essential oil 0.6g, flores aurantii essential oil 0.4g with
Base oil grape seed oil 10g is placed in 250ml three-necked flask, stirs 20min under conditions of temperature is 30 DEG C with 120rpm,
It is uniformly mixed it spare；
(2) the composite essential oil 15mg that precision weighs in 30mg PLGA and step (1) is dissolved in 10ml acetone soln, and
The oil is added to equipped with being sufficiently mixed in the three-necked flask that 30ml mass fraction is 0.5%TPGS aqueous solution, in 12000rpm
Revolving speed under, emulsify 5min, then the ultrasonic emulsification 40min under condition of ice bath with high speed homogenizer, remove third with Rotary Evaporators
Ketone is precipitated surplus solution by high speed centrifugation, and ultracentrifugal revolving speed is 20000rpm, and the time of centrifugation is
The shell-core structure nanoparticle compound to get essential oil and PLGA is lyophilized after washing 4 times in 30min.
This composite nanoparticle is used to prepare in hand cleanser, preparation step includes:
(1) alkyl glucoside 11g, Cocoamidopropyl betaine 3g, laureth sodium sulfovinate 6g are weighed respectively,
0.4g Cremophor RH40 and 0.4g glycol distearate；2g butanediol；0.9g Phenoxyethanol, 0.1g ethyl second
Base glycerol and 40g deionized water are placed in 250ml beaker, are stirred 20min in the condition that temperature is 50 DEG C with 600rpm, are made it
Mixing and emulsifying is uniform；
(2) mixing that the compound shell-core structure nanoparticle step (1) of essential oil made from 15g and PLGA is prepared
In liquid, and 21.2g deionized water is added, 20min is stirred with 300rpm in the condition that temperature is 30 DEG C, keeps its mixing and emulsifying equal
It is even.
(3) it is 28 DEG C of condition in temperature, is slowly added to 1g thickener sodium chloride in the mixed liquor obtained to step (2),
Side stirring and emulsifying frontier inspection observing and controlling viscosity, adds pH adjusting agent citric acid and sodium citrate, is adjusted when emulsifying uniform with pH
Agent measures system pH in time, and the pH value of control system is 6, obtains the core-shell structure nanoparticle compound containing essential oil and PLGA
The essential oil hand cleanser of son.
Finally, it should be noted that above embodiments are only to illustrate the present invention and not limit skill described in the invention
Art scheme；Those skilled in the art should understand that still can modify to the present invention or equivalent replacement；And one
The technical solution and its improvement for not departing from the spirit and scope of the present invention are cut, should all be covered in claim model of the invention
In enclosing.
Claims (10)
1. the preparation method of a kind of essential oil and the compound shell-core structure nanoparticle of PLGA, which comprises the following steps:
PLGA and composite essential oil are dissolved in acetone soln, and the oil is added to be sufficiently mixed in TPGS aqueous solution after emulsify, remove
It goes after acetone to be precipitated surplus solution by high speed centrifugation, the core-shell structure compound to get essential oil and PLGA is lyophilized in washing
Nanoparticle；Wherein, the parts by weight ratio of composite essential oil and PLGA are 1:1-1:3.
2. preparation method according to claim 1, which is characterized in that mode/means of the emulsification include: that will mix
Solution emulsifies 1-5min, then the ultrasonic emulsification 20- under condition of ice bath under the revolving speed of 10000-12000rpm, with high speed homogenizer
40min。
3. preparation method according to claim 1, which is characterized in that the ultracentrifugal revolving speed is 15000-
20000rpm, the time of centrifugation are 10-30min.
4. preparation method according to claim 1, which is characterized in that the composite essential oil includes folk prescription essential oil and basis
Oil；The folk prescription essential oil includes Rosa Damascana, sandalwood essential oil, chamomile essential oil, one of flores aurantii essential oil or a variety of；The base
Plinth oil is SIMMONDSIA CHINENSIS SEED OIL, one of Sweet Almond Oil and grape seed oil or a variety of；The folk prescription essential oil: the weight part ratio of base oil
Example is 1:4-1:9.
5. preparation method according to claim 4, which is characterized in that the composite essential oil preparation method/means include:
Appropriate folk prescription essential oil and base oil are stirred into 10-20min under conditions of temperature is 20-30 DEG C with 80-120rpm, are uniformly mixed
Obtain composite essential oil.
6. a kind of essential oil as obtained by any one of claim 1-5 method and the compound shell-core structure nanoparticle of PLGA exist
The application of hand cleanser preparation.
7. application according to claim 6, which is characterized in that the hand cleanser preparation method/means include:
(1) following parts by weight material is taken: 10-20 parts of surfactant, 0.5-1 parts of emulsifier, 2-5 parts of moisturizer, preservative
0.5-1 parts, 40-50 parts of deionized water, 10-20min is stirred with 400-600rpm under conditions of temperature is 45-55 DEG C, makes it
Mixing and emulsifying is uniform；
(2) mixed liquor that step (1) is prepared is added in the compound shell-core structure nanoparticle of 10-20 parts of essential oils and PLGA
In, and 3-37 parts of deionized waters are added, 10-20min is stirred with 150-300rpm under conditions of temperature is 25-30 DEG C, makes it
Mixing and emulsifying is uniform；
(3) under conditions of temperature is 22-28 DEG C, 0.5-2 parts of thickeners are slowly added in the mixed liquor that obtains to step (2),
Side stirring and emulsifying frontier inspection observing and controlling viscosity, adds pH adjusting agent, measures system pH, control with pH adjusting agent when emulsifying uniform
The pH value of system processed is 5-6, obtains the essential oil hand cleanser containing the compound shell-core structure nanoparticle of essential oil and PLGA.
8. preparation method according to claim 7, which is characterized in that the surfactant includes following parts by weight material
Material: 5-10 parts of alkyl glucoside, 1-5 parts and 1-5 parts of laureth sodium sulfovinate of Cocoamidopropyl betaine.
9. preparation method according to claim 7, which is characterized in that the preservative is that parts by weight ratio is 1:1-9:
1 Phenoxyethanol and the compound preservative of ethyl diethyldithiocarbamate glycerol.
10. preparation method according to claim 7, which is characterized in that the emulsifier includes PEG-40 hydrogenated castor
Oil and/or glycol distearate；The moisturizer includes glycerol and/or butanediol；The thickener is sodium chloride；It is described
PH adjusting agent is citric acid and sodium citrate.
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