CN108403666A - A kind of preparation method of novel astaxanthin capsule of nano - Google Patents
A kind of preparation method of novel astaxanthin capsule of nano Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Abstract
The present invention provides a kind of preparation methods of novel astaxanthin capsule of nano, it will be dissolved with the acetone soln of astaxanthin and PLGA, it is added in the aqueous solution containing emulsifier TPGS, mix high-speed stirred, thick emulsion is obtained through broken instrument, using high pressure microjet nanometer homogenizer, the nanoemulsion with O/W is formed by super-voltage micro jet, interior phase organic solvent is removed by rotary evaporation, PLGA and astaxanthin deposition form nanoparticle after drying.Compared with prior art, the present invention has the advantage that：(1) material of the invention can effectively increase the effect that astaxanthin is sustained in vivo；Uniform particle sizes, embedding rate are high.(2) in the scale of expanding production, the super-voltage micro jet that can be automatically mixed by large-scale two-phase carries out the present invention, at low cost and environmentally safe.
Description
[technical field]
The present invention relates to microalgae products to reprocess field, is specifically related to a kind of preparation of novel astaxanthin capsule of nano
Method.
[background technology]
Astaxanthin, belongs to keto-acid carotenoid, i.e., 3,3 '-dihydroxy -4, and 4 '-diketo-β, β '-carrotene are terpene
Ethylenically unsaturated compounds, tool is fat-soluble, not soluble in water, and it is most of organic molten to be soluble in chloroform, acetone, benzene etc..And astaxanthin
Long long conjugation unsaturated double-bond structure is highly unstable, easy light, heat, oxide destruction and lose activity, astaxanthin oxygen
Become astacin after change.
Astaxanthin can protect the skin from light injury；Prevention of arterial hardens and relevant disease, active anticancer, enhances siberian crabapple
System function, safeguards the health of eyes and central nervous system, anti-infection activity, due to the above-mentioned various biological function of astaxanthin
, to allow it as health products, drug and feed addictive etc. in fields such as food, medicine, Cosmetic Manufacture and aquacultures
There is good application value.
Currently, global astaxanthin product mainly has white Jane Austen, McPherson, knob Cui that external famous brand, type can be waited to have piece
Agent, solid soft capsule (i.e. microencapsulation) and oral solution etc..
Wherein, microencapsulation is a kind of method being embedded in the substances such as solid, liquid, gas body in small closed capsule.The party
Method not only can effective protection and isolated substance, reduce oxidation reaction, be passivated light sensitivity and thermal sensitivity, moreover it is possible to effectively shield core
The bad smell of material controls the rate of release of core material, changes the physicochemical property (such as dispersibility, color, shape, density) of core material,
Improve core material bin stability.Due to the characteristic of astaxanthin itself, traditional processing method embedding rate is low, slow release effect is poor, rule
Mould production cost is high.Therefore, it is badly in need of a kind of preparation method of novel astaxanthin capsule of nano.
[invention content]
The invention reside in a kind of preparation method of good astaxanthin is provided, this method can effectively be directed to existing astaxanthin
The problem that product embedding rate is low, slow release effect is poor, large-scale production is of high cost.
Specific technical solution is as follows：
A kind of preparation method of novel astaxanthin capsule of nano, the method includes the steps of：
Step 1, a certain amount of astaxanthin and PLGA (Poly(D,L-lactide-co-glycolide) are weighed, suitable acetone is dissolved in
Middle composition organic phase；It weighs a certain amount of emulsifier TPGS (TPGS 1000) and is dissolved in water composition water phase；
Step 2, according to step 1 gained water phase, organic phase under blender mixing, obtain colostrum；
Step 3, the pre- homogeneous of Ultrasonic Cell Disruptor is passed through according to step 2 gained colostrum；
Step 4, according to step 3 to gained colostrum addition protective agent EDTA (ethylenediamine tetra-acetic acid), through super-voltage micro jet
Nanometer homogeneous；
Step 5, organic solvent is removed by Rotary Evaporators according to step 4, obtains astaxanthin capsule of nano lotion；
Step 6, gained astaxanthin capsule of nano lotion is placed in by freeze drier freeze-drying according to step 5, obtained
Astaxanthin capsule of nano powder.
As preferred：The content astaxanthin is 1-2mg/ml；The emulsifier is 0.02%-0.1%；Institute
The wall material PLGA dosages stated are 10-20mg/ml；Water phase/the oil phase is 2：1-15：1；The super-voltage micro jet homogeneous
Number 2-4 times, homogeneous pressure 12000psi-18000psi.
Compared with prior art, the present invention has the advantage that：
(1) material of the invention can effectively increase the effect that astaxanthin is sustained in vivo；Uniform particle sizes, embedding rate
It is high.
(2) super-voltage micro jet of the invention in the scale of expanding production, can automatically being mixed by large-scale two-phase
It carries out, it is at low cost and environmentally safe.
[description of the drawings]
Fig. 1 is the preparation method flow diagram of astaxanthin capsule of nano of the present invention.
Fig. 2 is astaxanthin particle diameter distribution of the present invention.
Fig. 3 is the astaxanthin capsule of nano under transmission electron microscope.
Fig. 4 is the astaxanthin heat resistance after thermogravimetric analysis display embedding.
[specific implementation mode]
In order to keep the technological means that the present invention realizes clear, below by embodiment, the present invention is further explained.
It is further described the present invention with reference to specific embodiment.
A kind of preparation method flow chart of novel astaxanthin capsule of nano as shown in Figure 1, will dissolved with astaxanthin and
The acetone soln of PLGA is added in the aqueous solution containing emulsifier TPGS, mixes high-speed stirred, is slightly emulsified through broken instrument
Liquid is formed the nanoemulsion with O/W by super-voltage micro jet, is steamed by rotation using high pressure microjet nanometer homogenizer
Hair removes interior phase organic solvent, and PLGA and astaxanthin deposition form nanoparticle after drying.
Embodiment 1
1) astaxanthin 4mg, PLGA 60mg are weighed, is dissolved in 4ml acetone and constitutes organic phase；Weigh 20mg emulsifiers TPGS
It is dissolved in 40ml water and constitutes water phase；
2) water phase and mixing 1min are poured slowly at blender 2000r/min according to step 1 gained organic phase, is obtained just
Breast；
3) the pre- homogeneous of Ultrasonic Cell Disruptor is passed through according to step 2 gained colostrum；
4) protective agent EDTA 15mg are added to gained colostrum according to step 3, it is equal at 15000psi through super-voltage micro jet
Matter 2 times；
5) astaxanthin capsule of nano lotion is obtained by removing organic solvent at 45 DEG C of Rotary Evaporators according to step 4；
6) gained astaxanthin capsule of nano lotion is placed in for 24 hours by freeze drier freeze-drying according to step 5, obtains shrimp
Green element capsule of nano powder.
Embodiment 2
1) astaxanthin 6mg, PLGA 80mg are weighed, is dissolved in 4ml acetone and constitutes organic phase；Weigh 32mg emulsifiers TPGS
It is dissolved in 40ml water and constitutes water phase；
2) water phase and mixing 1min are poured slowly at blender 2000r/min according to step 1 gained organic phase, is obtained just
Breast；
3) the pre- homogeneous of Ultrasonic Cell Disruptor is passed through according to step 2 gained colostrum；
4) protective agent EDTA 20mg are added to gained colostrum according to step 3, it is equal at 16000psi through super-voltage micro jet
Matter 3 times；
5) astaxanthin capsule of nano lotion is obtained by removing organic solvent at 45 DEG C of Rotary Evaporators according to step 4；
6) gained astaxanthin capsule of nano lotion is placed in for 24 hours by freeze drier freeze-drying according to step 5, obtains shrimp
Green element capsule of nano powder.
The present invention carries out nanometer embedding treatment by super-voltage micro jet technology to astaxanthin, passes through super-voltage micro jet skill
Art can be by astaxanthin capsule of nano large-scale production, and macromolecule wall material emulsifier used, the capsule of nano prepared are slow
It releases performance to greatly enhance, stability of material is good, is not easily decomposed under normality, is easy to preserve, and the term of validity is long, and Fig. 4 is aobvious for thermogravimetric analysis
Show that the astaxanthin heat resistance after embedding improves.
One of mode the above is only the implementation of the present invention, protection scope of the present invention are not limited in above-mentioned embodiment party
Formula, every technical solution for belonging to the principle of the invention all belong to the scope of protection of the present invention.For those skilled in the art
Speech, several improvement carried out without departing from the principles of the present invention, these improvement also should be regarded as the protection model of the present invention
It encloses.
Claims (6)
1. a kind of preparation method of novel astaxanthin capsule of nano, which is characterized in that the method includes the steps of：
Step 1, a certain amount of astaxanthin and PLGA are weighed, is dissolved in suitable acetone and constitutes organic phase；Weigh a certain amount of emulsification
Agent TPGS is dissolved in water and constitutes water phase；
Step 2, according to step 1 gained water phase, organic phase under blender mixing, obtain colostrum；
Step 3, the pre- homogeneous of Ultrasonic Cell Disruptor is passed through according to step 2 gained colostrum；
Step 4, protective agent EDTA is added to gained colostrum according to step 3, through super-voltage micro jet nanometer homogeneous；
Step 5, organic solvent is removed by Rotary Evaporators according to step 4, obtains astaxanthin capsule of nano lotion；
Step 6, gained astaxanthin capsule of nano lotion is placed in by freeze drier freeze-drying according to step 5, obtains shrimp blueness
Plain capsule of nano powder.
2. the preparation method according to claim, which is characterized in that the content astaxanthin is 1-2mg/ml.
3. the preparation method according to claim, which is characterized in that the emulsifier is 0.02%-0.1%.
4. the preparation method according to claim, which is characterized in that the wall material PLGA dosages are 10-20mg/ml.
5. the preparation method according to claim, which is characterized in that the water phase/oil phase is 2:1-15:1.
6. the preparation method according to claim, which is characterized in that super-voltage micro jet homogenization cycles 2-4 times,
Homogeneous pressure 12000psi-18000psi.
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| CN201810218389.5A CN108403666A (en) | 2018-03-16 | 2018-03-16 | A kind of preparation method of novel astaxanthin capsule of nano |
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| CN201810218389.5A CN108403666A (en) | 2018-03-16 | 2018-03-16 | A kind of preparation method of novel astaxanthin capsule of nano |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109123573A (en) * | 2018-09-26 | 2019-01-04 | 济南彦盛彦企业管理咨询有限责任公司 | Giving off a strong fragrance chafing dish bottom flavorings preparation method |
| CN109363168A (en) * | 2018-12-12 | 2019-02-22 | 深圳职业技术学院 | A kind of preparation method of astaxanthin microcapsules |
| CN109568180A (en) * | 2018-11-27 | 2019-04-05 | 常州良福朗清生物科技有限公司 | A kind of preparation method and application of essential oil and the compound shell-core structure nanoparticle of PLGA |
| CN109893513A (en) * | 2019-03-29 | 2019-06-18 | 广东现代汉方科技有限公司 | Compound Astaxanthin In Haematococcus Pluvialis self-emulsifying soft capsule and the preparation method and application thereof |
| CN111296729A (en) * | 2020-02-17 | 2020-06-19 | 广西大学 | Water-soluble astaxanthin product and preparation method thereof |
| CN112402404A (en) * | 2020-12-17 | 2021-02-26 | 日照职业技术学院 | Preparation method of astaxanthin ester nano composite particles |
| CN112998270A (en) * | 2021-04-12 | 2021-06-22 | 海南三元星生物科技股份有限公司 | Preparation method of astaxanthin microcapsules |
| WO2022021612A1 (en) | 2020-07-27 | 2022-02-03 | 中国海洋大学 | Method for preparing water-soluble astaxanthin, and astaxanthin aqueous solution prepared using said method |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109123573A (en) * | 2018-09-26 | 2019-01-04 | 济南彦盛彦企业管理咨询有限责任公司 | Giving off a strong fragrance chafing dish bottom flavorings preparation method |
| CN109568180A (en) * | 2018-11-27 | 2019-04-05 | 常州良福朗清生物科技有限公司 | A kind of preparation method and application of essential oil and the compound shell-core structure nanoparticle of PLGA |
| CN109363168A (en) * | 2018-12-12 | 2019-02-22 | 深圳职业技术学院 | A kind of preparation method of astaxanthin microcapsules |
| CN109893513A (en) * | 2019-03-29 | 2019-06-18 | 广东现代汉方科技有限公司 | Compound Astaxanthin In Haematococcus Pluvialis self-emulsifying soft capsule and the preparation method and application thereof |
| CN109893513B (en) * | 2019-03-29 | 2021-08-10 | 广东现代汉方科技有限公司 | Composite haematococcus pluvialis astaxanthin self-emulsifying soft capsule and preparation method and application thereof |
| CN111296729A (en) * | 2020-02-17 | 2020-06-19 | 广西大学 | Water-soluble astaxanthin product and preparation method thereof |
| CN111296729B (en) * | 2020-02-17 | 2023-10-03 | 广西大学 | Water-soluble astaxanthin product and preparation method thereof |
| WO2022021612A1 (en) | 2020-07-27 | 2022-02-03 | 中国海洋大学 | Method for preparing water-soluble astaxanthin, and astaxanthin aqueous solution prepared using said method |
| CN112402404A (en) * | 2020-12-17 | 2021-02-26 | 日照职业技术学院 | Preparation method of astaxanthin ester nano composite particles |
| CN112998270A (en) * | 2021-04-12 | 2021-06-22 | 海南三元星生物科技股份有限公司 | Preparation method of astaxanthin microcapsules |
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Application publication date: 20180817 |