CN109561680B - 泛酸激酶的小分子调节剂 - Google Patents

泛酸激酶的小分子调节剂 Download PDF

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CN109561680B
CN109561680B CN201780043423.3A CN201780043423A CN109561680B CN 109561680 B CN109561680 B CN 109561680B CN 201780043423 A CN201780043423 A CN 201780043423A CN 109561680 B CN109561680 B CN 109561680B
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CN109561680A (zh
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L·K·夏尔马
R·E·李
C·O·罗克
S·贾可斯基
M·K·云
C·苏布兰马尼安
J·刘
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201780043423.3A 2016-06-23 2017-06-23 泛酸激酶的小分子调节剂 Active CN109561680B (zh)

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US201662354012P 2016-06-23 2016-06-23
US62/354,012 2016-06-23
PCT/US2017/039037 WO2017223474A1 (en) 2016-06-23 2017-06-23 Small molecule modulators of pantothenate kinases

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CN (1) CN109561680B (https=)
AU (1) AU2017281907B2 (https=)
DO (1) DOP2018000293A (https=)
IL (1) IL263649B (https=)
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017281907B2 (en) 2016-06-23 2021-10-21 St. Jude Children's Research Hospital, Inc. Small molecule modulators of pantothenate kinases
EP3731859B1 (en) * 2017-12-27 2025-08-20 St. Jude Children's Research Hospital, Inc. Pyridazine compounds for use to treat disorders associated with castor
KR102728619B1 (ko) 2017-12-27 2024-11-08 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 판토테네이트 키나제의 소분자 조절제
CA3106470A1 (en) * 2018-07-17 2020-01-23 Nippon Chemiphar Co., Ltd. T-type calcium channel blocker
CA3135011A1 (en) * 2019-03-27 2020-10-01 St. Jude Children's Research Hospital Small molecule modulators of pank
JPWO2020203609A1 (https=) * 2019-03-29 2020-10-08
JP2022081710A (ja) * 2019-03-29 2022-06-01 ユーティアイ リミテッド パートナーシップ 関節リウマチを治療するためのｔ型カルシウムチャネル阻害剤の使用
IL326597A (en) 2019-10-07 2026-04-01 Contineum Therapeutics Inc Muscarinic M1 acetylcholine receptor antagonists
US11752149B2 (en) 2019-12-02 2023-09-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine M1 receptor antagonists
US20240115566A1 (en) * 2020-12-16 2024-04-11 St. Jude Children's Research Hospital, Inc. Methods of treating disorders associated with castor
EP4568951A1 (en) * 2022-08-08 2025-06-18 Ajax Therapeutics, Inc. Heterocyclic amide and urea compounds as jak2 inhibitors
WO2026012398A1 (zh) * 2024-07-09 2026-01-15 长春金赛药业有限责任公司 泛酸激酶pank小分子调节剂、药物组合物及其用途
CN119745886B (zh) * 2025-01-20 2026-04-14 中国药科大学 4-异丙苯基乙酰哌嗪在制备抗阿尔茨海默病药物中的应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1474810A (zh) * 2000-09-14 2004-02-11 ���鹫˾ 取代脲,神经肽yy5受体拮抗剂
CN1753890A (zh) * 2002-12-24 2006-03-29 欧洲凯尔特公司 具有mglur1－和mglur5－拮抗活性的苯并唑类哌嗪衍生物
CN1835751A (zh) * 2003-06-12 2006-09-20 欧洲凯尔蒂克公司 用于治疗疼痛的治疗剂
CN102143958A (zh) * 2008-07-18 2011-08-03 诺瓦提斯公司 作为smo抑制剂的哒嗪衍生物
US8975398B2 (en) * 2012-05-11 2015-03-10 Abbvie Inc. NAMPT inhibitors
CN105228995A (zh) * 2013-03-13 2016-01-06 詹森药业有限公司 取代的哌啶化合物以及它们作为食欲素受体调节剂的用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216212A (en) 1978-06-08 1980-08-05 The Procter & Gamble Company Pyrazolidine anti-inflammatory composition and methods of use
EP0910565A1 (en) 1997-02-14 1999-04-28 Bayer Corporation Amide derivatives as selective neuropeptide y receptor antagonists
US6894063B2 (en) * 2000-09-14 2005-05-17 Schering Corporation Substituted urea neuropeptide Y Y5 Receptor antagonists
US20050256130A1 (en) 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
DK1531822T3 (da) 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
US7262194B2 (en) 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
CN101712653A (zh) * 2003-07-30 2010-05-26 泽农医药公司 哒嗪衍生物和它们作为治疗剂的用途
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
CA2567343A1 (en) 2004-05-20 2005-12-01 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
US7754724B2 (en) 2005-06-30 2010-07-13 Dow Agrosciences Llc N-substituted piperazines
CA2668811A1 (en) 2006-11-07 2008-06-05 Lexicon Pharmaceuticals, Inc. Methods of treating cognitive impairment and dementia
US8153633B2 (en) 2007-06-25 2012-04-10 Amgen Inc. Phthalazine compounds, compositions and methods of use
CN103396409B (zh) 2007-07-05 2015-03-11 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
DE102007035333A1 (de) * 2007-07-27 2009-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
US8431608B2 (en) 2007-08-17 2013-04-30 Icagen Inc. Heterocycles as potassium channel modulators
AU2010232533A1 (en) 2009-04-02 2011-10-13 University Of Florida Research Foundation, Inc. Engineering the pathway for succinate production
CA2772695A1 (en) 2009-09-01 2011-03-10 Novozymes, Inc. Methods for improving malic acid production in filamentous fungi
US9187772B2 (en) 2010-09-01 2015-11-17 University Of Florida Research Foundation, Inc. L-malate production by metabolically engineered escherichia coli
CA2812750C (en) 2010-09-27 2020-10-06 Exelixis, Inc. Dual inhibitors of met and vegf for the treatment of castration-resistant prostate cancer and osteoblastic bone metastases
EP2726470B1 (en) 2011-07-01 2015-04-29 reMynd NV 1,2,4-thiadiazol-5-ylpiperazine derivatives useful in the treatment of neurodegenerative diseases
AU2016249021A1 (en) 2015-04-17 2017-10-19 Assembly Biosciences, Inc. Hepatitis B viral assembly effectors
AU2017281907B2 (en) 2016-06-23 2021-10-21 St. Jude Children's Research Hospital, Inc. Small molecule modulators of pantothenate kinases
EP3731859B1 (en) 2017-12-27 2025-08-20 St. Jude Children's Research Hospital, Inc. Pyridazine compounds for use to treat disorders associated with castor
KR102728619B1 (ko) 2017-12-27 2024-11-08 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 판토테네이트 키나제의 소분자 조절제
WO2019133634A1 (en) 2017-12-27 2019-07-04 St. Jude Children's Research Hospital Small molecule modulators of pantothenate kinases
CA3106470A1 (en) 2018-07-17 2020-01-23 Nippon Chemiphar Co., Ltd. T-type calcium channel blocker
US20240115566A1 (en) 2020-12-16 2024-04-11 St. Jude Children's Research Hospital, Inc. Methods of treating disorders associated with castor

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1474810A (zh) * 2000-09-14 2004-02-11 ���鹫˾ 取代脲,神经肽yy5受体拮抗剂
CN1753890A (zh) * 2002-12-24 2006-03-29 欧洲凯尔特公司 具有mglur1－和mglur5－拮抗活性的苯并唑类哌嗪衍生物
CN1835751A (zh) * 2003-06-12 2006-09-20 欧洲凯尔蒂克公司 用于治疗疼痛的治疗剂
CN102143958A (zh) * 2008-07-18 2011-08-03 诺瓦提斯公司 作为smo抑制剂的哒嗪衍生物
US8975398B2 (en) * 2012-05-11 2015-03-10 Abbvie Inc. NAMPT inhibitors
CN105228995A (zh) * 2013-03-13 2016-01-06 詹森药业有限公司 取代的哌啶化合物以及它们作为食欲素受体调节剂的用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists";Laykea Tafesse 等;《Bioorganic & Medicinal Chemistry Letters》;20041115;第14卷(第22期);第5514-5515页、表1 *

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US10899734B2 (en) 2021-01-26
RU2019101613A (ru) 2020-07-23
AU2017281907B2 (en) 2021-10-21
CA3025260A1 (en) 2017-12-28
KR102459256B1 (ko) 2022-10-25
WO2017223474A1 (en) 2017-12-28
EP3474667A1 (en) 2019-05-01
IL263649B (en) 2022-04-01
US20210246113A1 (en) 2021-08-12
AU2017281907A1 (en) 2019-01-03
JP2019518764A (ja) 2019-07-04
CN109561680A (zh) 2019-04-02
DOP2018000293A (es) 2019-04-15
JP7078555B2 (ja) 2022-05-31
IL263649A (en) 2019-01-31
EP3474667A4 (en) 2019-11-27
ZA201808099B (en) 2019-07-31
US12552765B2 (en) 2026-02-17
RU2019101613A3 (https=) 2020-12-03
SA518400696B1 (ar) 2023-01-09
US20190300499A1 (en) 2019-10-03
MX2018015170A (es) 2019-07-04
MX383697B (es) 2025-03-14
NZ749147A (en) 2024-04-26
BR112018076441A2 (pt) 2019-04-09
SG11201811023UA (en) 2019-01-30

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