CN109527176A - A kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine - Google Patents

A kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine Download PDF

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Publication number
CN109527176A
CN109527176A CN201811540062.6A CN201811540062A CN109527176A CN 109527176 A CN109527176 A CN 109527176A CN 201811540062 A CN201811540062 A CN 201811540062A CN 109527176 A CN109527176 A CN 109527176A
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parts
trioxypurine
free radical
extract
hypoglycemic
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金晓飞
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Hunan Zemai Biotechnology Co Ltd
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Hunan Zemai Biotechnology Co Ltd
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Priority to CN201811540062.6A priority Critical patent/CN109527176A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/48Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/04Sulfur, selenium or tellurium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/748Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998Hordeum (barley)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

The invention discloses a kind of hypoglycemic antitumor pressed candies of effect and preparation method thereof of removing free radical anti-trioxypurine, and pressed candy of the invention includes the raw material of following weight percent: 5 parts -50 parts of blackcurrant extract, 10 parts -40 parts of plant extract rich in selenium, 5 parts -30 parts of sorghum extract, 5 parts -40 parts of grape seed extract, 3 parts -30 parts of grape boisiana extract, 10 parts -30 parts of filler, 0.5 part -2 parts of lubricant.The tabletting after uniformly mixing, pelletizing of the above raw material, obtain with remove free radical, anti-trioxypurine, hypoglycemic, antitumor effect pressed candy.Pressed candy provided by the invention has obvious removing free radical, anti-trioxypurine, hypoglycemic, antitumor effect, can be used for preparing the application for removing free radical, anti-trioxypurine, hypoglycemic, antitumor food or health food.

Description

A kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine
Technical field
The present invention relates to technical field of health care food, the specially a kind of hypoglycemic antitumor function of removing free radical anti-trioxypurine The pressed candy of effect.
Background technique
Currently, the drug of clinical treatment diabetes is mostly chemical synthesis similar drug, such as sulfanilamide (SN);Class biguanides glucolase Inhibitor, insulin sensitizer etc., but chemical classes antidiabetic drug is long-term takes, can be larger to hepar damnification, side effect is larger, holds It is also easy to produce drug resistance, is unfavorable for taking for a long time;The effect of a large amount of pharmacology and clinical research discovery, natural drug, ingredient was with pair Act on it is small, multiple target point, action temperature and, have certain control action to complication, in order to adapt to the modern life, develop blood sugar reducing function Significantly, Small side effects, convenient to take, portable product is necessary, has great social effect and market value.
Summary of the invention
The purpose of the present invention is to provide it is a kind of remove the hypoglycemic antitumor effect of free radical anti-trioxypurine pressed candy, To solve the problems mentioned in the above background technology.
To achieve the above object, the invention provides the following technical scheme: a kind of removing free radical anti-trioxypurine is hypoglycemic anti-swollen The pressed candy of the effect of tumor, the raw material comprising following parts by weight: 5 parts -50 parts of blackcurrant extract, plant extract rich in selenium 10 parts -40 parts, 5 parts -30 parts of sorghum extract, 5 parts -40 parts of grape seed extract, 3 parts -30 parts of grape boisiana extract, filler 10 parts -30 parts, 0.5 part -2 parts of lubricant.
Further, preferred weight portion rate are as follows: 10 parts -40 parts of blackcurrant extract, 8 part -30 of plant extract rich in selenium Part, 10 parts -20 parts of sorghum extract, 15 parts -35 parts of grape seed extract, 5 parts -20 parts of grape boisiana extract, 15 parts of filler - 20 parts, 0.8 part -2 parts of lubricant.
Further, Se content is 0.5 ~ 5000mg/kg in the plant extract rich in selenium.
Further, the selenium-enriched plant is selenium-rich wheat seeding, product containing organic selenium, selenium-rich peanuts seedling, selenium-rich rice, selenium-rich Huang One of stilbene, Agaricus campestris rich in selenium, selenium-rich land for building dish are a variety of.
Further, the filler is starch, dextrin, mannitol, lactose, sucrose, microcrystalline cellulose, oligomeric wood One or more of sugar, D-sorbite;The lubricant be one of magnesium stearate, silica, superfine silica gel powder or It is several.
A kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine, preparation include walking in detail below It is rapid:
Step is 1.: the blackcurrant extract, the plant extract rich in selenium, the sorghum extract, the grape pip are mentioned After taking object, the grape boisiana extract, the filler and mix lubricant sieving, stoste is obtained;
Step is 2.: stoste is pelletized, tabletting or direct tablet compressing after granulation, obtain it is described have remove free radical, anti-trioxypurine, drop blood The pressed candy of sugared, antitumor effect.
Preferably, the passing-screen size is 50 ~ 100 mesh.
Preferably, the tabletting includes wet granule compression tablet, dry granulation tabletting or direct tablet compressing.
Preferably, pressed candy in anthocyanidin content be 0.1-500mg/ piece, Resveratrol content 0.1- 400mg/ piece, Se content are 0.1-10mg/ piece.
Preferably, the pressed candy removes free radical, anti-trioxypurine, hypoglycemic, antitumor food or guarantor in preparation In health food.
Compared with prior art, the beneficial effects of the present invention are: pressed candy provided by the invention has obvious remove certainly By base, anti-trioxypurine, hypoglycemic, antitumor effect, used raw material belongs to plant extracts, plant material side effect Small, drug resistance is low, can take for a long time, and extract is convenient for the absorption of human body, significant effect;The present invention can be used for preparing removing freely The application of base, anti-trioxypurine, hypoglycemic, antitumor food or health food.
It is solid to reduce serum gallbladder rich in vitamin and amino acid and needed by human body minerals for blackcurrant extract therein Alcohol, cerebral arteriovenous malformation;It can delay body aging, body immunity is provided;Anticancer, anti-cancer are played in the generation of energy blocking nitrosamine formation Effect;
Selenium-enriched plant selenium and vitamin E collaboration in vivo, can protect cell membrane, prevent the oxidation of unsaturated fatty acid, micro Selenium has protective effect on cancer risk and liver-protective effect;
Sorghum extract is sweet in flavor, warm-natured, puckery, enters spleen, stomach meridian;So it has stomach function regulating, disperse accumulation, middle benefit gas, puckery stomach, stops cholera Effect;The diseases such as major function water retention due to hypofunction of the spleen, indigestion and damp-heat diarrhea, difficult urination;
Grape seed extract removes free radical, anti-aging, strengthen immunity and removes free radical, prevents free radical to human body cell It destroys;Allergy gos deep into the release that cell fundamentally inhibits sensitizing factor " histamine ", improves cell to the tolerance of anaphylactogen;Clearly Except sensitization free radical, anti-inflammatory, antiallergy;Stablize skin heart tissue;Vascular protection cardiovascular and cerebrovascular is protected, cholesterol is reduced, is prevented Only artery sclerosis, prevention cerebral hemorrhage, apoplexy, hemiplegia etc.;
Grape boisiana extract is sweet, flat, effect heat-clearing, hemostasis.Control rheumatism, morbilli.Dysentery, sore swollen toxin.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described, Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all Belong to the scope of protection of the invention.
Embodiment 1
A kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine, the raw material comprising following parts by weight: 30 parts of blackcurrant extract, 20 parts of plant extract rich in selenium, 10 parts of sorghum extract, 25 parts of grape seed extract, grapevine mention Take 10 parts of object, 15 parts of filler, 0.8 part of lubricant.
Further, the selenium-enriched plant is the mixture of selenium-rich wheat seeding, product containing organic selenium.
Further, the filler is the mixture of lactose, sucrose;The lubricant is magnesium stearate.
Step is 1.: by the blackcurrant extract, the plant extract rich in selenium, the sorghum extract, the grape After seed extract, the grape boisiana extract, the filler and the mix lubricant cross 50 meshes, stoste is obtained;
Step is 2.: stoste is pelletized, tabletting or direct tablet compressing after granulation, obtain it is described have remove free radical, anti-trioxypurine, drop blood The pressed candy of sugared, antitumor effect.
Embodiment 2
A kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine, the raw material comprising following parts by weight: 40 parts of blackcurrant extract, 30 parts of plant extract rich in selenium, 20 parts of sorghum extract, 35 parts of grape seed extract, grapevine mention Take 20 parts of object, 25 parts of filler, 2 parts of lubricant.
Further, the selenium-enriched plant is the mixture of selenium-rich peanuts seedling, selenium-rich rice, selenium-rich Radix Astragali.
Further, the filler is the mixture of microcrystalline cellulose, xylo-oligosaccharide;The lubricant is dioxy SiClx.
Step is 1.: by the blackcurrant extract, the plant extract rich in selenium, the sorghum extract, the grape After seed extract, the grape boisiana extract, the filler and the mix lubricant cross 90 meshes, stoste is obtained;
Step is 2.: stoste is pelletized, tabletting or direct tablet compressing after granulation, obtain it is described have remove free radical, anti-trioxypurine, drop blood The pressed candy of sugared, antitumor effect.
Embodiment 3
A kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine, the raw material comprising following parts by weight: 20 parts of blackcurrant extract, 25 parts of plant extract rich in selenium, 25 parts of sorghum extract, 35 parts of grape seed extract, grapevine mention Take 25 parts of object, 30 parts of filler, 2 parts of lubricant.
Further, the selenium-enriched plant is selenium-rich rice, mixes in selenium-rich Radix Astragali, Agaricus campestris rich in selenium, selenium-rich land for building dish Object.
Further, the filler is the mixture of mannitol, lactose, sucrose;The lubricant is micro mist silicon Glue.
Step is 1.: by the blackcurrant extract, the plant extract rich in selenium, the sorghum extract, the grape After seed extract, the grape boisiana extract, the filler and the mix lubricant sieve with 100 mesh sieve, stoste is obtained;
Step is 2.: stoste is pelletized, tabletting or direct tablet compressing after granulation, obtain it is described have remove free radical, anti-trioxypurine, drop blood The pressed candy of sugared, antitumor effect.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (10)

1. a kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine, it is characterised in that: comprising following heavy Measure number raw material: 5 parts -50 parts of blackcurrant extract, 10 parts -40 parts of plant extract rich in selenium, 5 parts -30 parts of sorghum extract, 5 parts -40 parts of grape seed extract, 3 parts -30 parts of grape boisiana extract, 10 parts -30 parts of filler, 0.5 part -2 parts of lubricant.
2. a kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine according to claim 1, It is characterized in that: preferred weight portion rate are as follows: 10 parts -40 parts of blackcurrant extract, 8 parts -30 parts of plant extract rich in selenium, sorghum mention Take 10 parts -20 parts of object, 15 parts -35 parts of grape seed extract, 5 parts -20 parts of grape boisiana extract, 15 parts -20 parts of filler, lubrication 0.8 part -2 parts of agent.
3. a kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine according to claim 1, Be characterized in that: Se content is 0.5 ~ 5000mg/kg in the plant extract rich in selenium.
4. a kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine according to claim 1, Be characterized in that: the selenium-enriched plant is selenium-rich wheat seeding, product containing organic selenium, selenium-rich peanuts seedling, selenium-rich rice, selenium-rich Radix Astragali, selenium-rich One of mushroom, selenium-rich land for building dish are a variety of.
5. a kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine according to claim 1, Be characterized in that: the filler is starch, dextrin, mannitol, lactose, sucrose, microcrystalline cellulose, xylo-oligosaccharide, sorbose One or more of alcohol;The lubricant is one or more of magnesium stearate, silica, superfine silica gel powder.
6. a kind of pressed candy of the hypoglycemic antitumor effect of removing free radical anti-trioxypurine described in -5 according to claim 1, It is characterized by: its preparation comprising the following specific steps
Step is 1.: the blackcurrant extract, the plant extract rich in selenium, the sorghum extract, the grape pip are mentioned After taking object, the grape boisiana extract, the filler and mix lubricant sieving, stoste is obtained;
Step is 2.: stoste is pelletized, tabletting or direct tablet compressing after granulation, obtain it is described have remove free radical, anti-trioxypurine, drop blood The pressed candy of sugared, antitumor effect.
7. a kind of pressed candy preparation for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine according to claim 6 Method, it is characterised in that: the passing-screen size is 50 ~ 100 mesh.
8. a kind of pressed candy preparation for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine according to claim 6 Method, it is characterised in that: the tabletting includes wet granule compression tablet, dry granulation tabletting or direct tablet compressing.
9. a kind of pressed candy preparation for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine according to claim 6 Method, it is characterised in that: pressed candy in anthocyanidin content be 0.1-500mg/ piece, Resveratrol content 0.1- 400mg/ piece, Se content are 0.1-10mg/ piece.
10. a kind of pressed candy system for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine according to claim 6 Preparation Method, it is characterised in that: the pressed candy preparation remove free radical, anti-trioxypurine, hypoglycemic, antitumor food or In health food.
CN201811540062.6A 2018-12-17 2018-12-17 A kind of pressed candy for removing the hypoglycemic antitumor effect of free radical anti-trioxypurine Pending CN109527176A (en)

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Publication number Priority date Publication date Assignee Title
CN111938006A (en) * 2019-05-15 2020-11-17 无锡浦棠生物科技有限公司 Cubilose collagen peptide tablet candy

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