CN109498500A - A kind of anti-inflammatory remediation composition of active peptide and its Essence and preparation method - Google Patents
A kind of anti-inflammatory remediation composition of active peptide and its Essence and preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention belongs to cosmetic technical fields, and in particular to a kind of anti-inflammatory remediation composition of active peptide and its Essence and preparation method.The anti-inflammatory remediation composition of active peptide includes carboxymethyl chitosan, -1 copper of tripeptides, repairs peptide and palmityl tetrapeptide -7.The Essence includes the ingredient of following mass fraction: the anti-inflammatory remediation composition 3~10% of active peptide of the present invention, the rough gentian anti-irritant factor 1~4%, thickener 0.1~0.4%, preservative 0.3~0.7%, triethanolamine 0.05~0.3% and water 87~95%.Essence of the present invention has effects that significant anti-inflammatory and repairs damaged skin to no skin irritation, and can prevent bacterium infection, avoids skin and secondary damage occurs and further deteriorate.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of anti-inflammatory remediation composition of active peptide and its Essence and
Preparation method.
Background technique
Skin is the outermost layer structure of human body, is both the perceptron and effector of nervous system, many environmental stimulis are all
The reflexive variation for causing skin of meeting.In the state of normal, human skin is maintain due to the protective effect of skin barrier
Health status, skin barrier are mainly made of cortex film and cuticula, play keep moisture of skin, prevent internal water evaporation,
It resists in external foreign matter intrusive body and a degree of anti-inflammatory effect.With the growth and life stress at modern age
Increase, for example inappropriate skin care habit of many undesirable elements, outside contamination, the excessive, ultraviolet light of operating pressure etc. can all lead to skin
Skin is different degrees of to be damaged, and phenomena such as wrinkle, color spot, skin relaxation is occurred, is accelerated skin aging.It is more serious, if too late
Shi Xiufu impaired skin, may result in skin condition and more deteriorates, or even different degrees of inflammation occurs, so as to cause tight
The skin problem of weight.
Active peptide refers to biologically active polypeptide, the main growth for controlling human body, development, immunological regulation and new old generation
It thanks.At present active peptide because not injured to human body, effect is obvious and mechanism of action is clear, therefore all added in many cosmetics
Add, in future development, application of the active peptide in cosmetics will also become a trend of cosmetics development.Rough gentian anti-irritant because
Son is using propylene glycol, water and Radix Gentianae extract as main component, and water solubility is good, can be made in any cosmetic formulations
With.Modern research shows that the rough gentian anti-irritant factor has the effect of significant anti-inflammatory, antipruritic, analgesia and detumescence.
Chinese patent application CN106236695A discloses a kind of polypeptide anti-acne and repairs Essence and preparation method thereof, this is repaired
Multiple Essence is rich in component polypeptides, mainly using hexapeptide -9, tetrapeptide -30, antibacterial peptide and penetrating peptide as main component, and adds
Natural plant extracts, which has apparent therapeutic effect for small pox, and skin can be made to become light
It is sliding and fine and smooth.Chinese patent application CN107982133A discloses a kind of anti-inflammatory reparation essence, and the anti-inflammatory reparation essence is with Radix Curcumae
Volatile oil, angelica extract, Radix Gentianae extract, Salvia root P.E and pueraria lobata brass are main active, are equipped with other auxiliary materials
Such as glycerol, butanediol, Sodium Hyaluronate, glucose and Phenoxyethanol, each component synergistic effect, effectively improve micro- follow
Ring promotes Transdermal absorption nutrition, has anti-oxidant and anti-inflammatory effect.Inflammation caused by treatment is damaged due to skin barrier at present
The method of disease mainly passes through oral anti-allergy, anti-inflammatory drug etc., is penetrated using EGF growth factor, LED light treatment or laser
Frequency carries out skin condition and recovery, but drug is mostly there is the danger of drug dependence, and some other method costs compared with
Height also has skin care item much with anti-inflammatory reparation on the market, but declares that effect is many as the product of attraction to exaggerate, practical
Upper anti-inflammatory and reparation effect is unobvious, and the infection for being highly susceptible to environmental stimuli such as ultraviolet light, bacterium and virus leads to skin
There is secondary damage in skin, further to deteriorate, and is not able to satisfy consumer demand.
Summary of the invention
The present invention is directed to overcome the deficiencies of the prior art and provide a kind of anti-inflammatory remediation composition of active peptide and its Essence and
Preparation method, which has effects that significant anti-inflammatory and repairs damaged skin, and can prevent bacterium infection, avoids
There is secondary damage and further deteriorates in skin.
To achieve the goals above, technical scheme is as follows:
A kind of anti-inflammatory remediation composition of active peptide, including carboxymethyl chitosan, -1 copper of tripeptides, reparation peptide and palmityl four
Peptide -7.
Further, the carboxymethyl chitosan, -1 copper of tripeptides, the mass ratio for repairing peptide and palmityl tetrapeptide -7 be (1~
3): (0.01~0.05): (1~3): (1~3).
Further, the mass ratio of the carboxymethyl chitosan, -1 copper of tripeptides, reparation peptide and palmityl tetrapeptide -7 is
1.22:0.02:2:2.
Further, the reparation peptide is in hexapeptide -9, Matrixyl -4, palmityl tripeptides -1 and palmityl tripeptides -5
At least one.
A kind of anti-inflammatory reparation Essence of active peptide, the ingredient including following mass fraction: the anti-inflammatory reparation of active peptide of the present invention
Composition 3~10%, the rough gentian anti-irritant factor 1~4%, thickener 0.1~0.4%, preservative 0.3~0.7%, triethanolamine
0.05~0.3% and water 87~95%.
Further, the anti-inflammatory reparation Essence of the active peptide, the ingredient including following mass fraction: active peptide of the present invention
Anti-inflammatory remediation composition 5.24%, the rough gentian anti-irritant factor 2%, thickener 0.2%, preservative 0.5%, triethanolamine 0.16%
With water 91.9%.
Further, the thickener is Carbopol.
Further, the preservative is parahydroxyacet-ophenone.
The anti-inflammatory preparation method for repairing Essence of above-mentioned active peptide, comprising the following steps:
S1, according to formula ratio, thickener and preservative is soluble in water, impregnate 5-9h, stir and be warming up under 30-40rpm
80-90 DEG C, homogeneous is stirred to being uniformly dispersed, and mixed liquor A is made；
S2, the mixed liquor A is cooled to 45-55 DEG C, triethanolamine is added according to formula ratio, stir under 30-50rpm to
It is uniformly dispersed, mixed liquid B is made；
S3, the mixed liquid B is cooled to 30-40 DEG C, the anti-inflammatory remediation composition of active peptide and dragon is added according to formula ratio
The gallbladder anti-irritant factor stirs under 30-50rpm to being uniformly dispersed, the anti-inflammatory reparation Essence of active peptide is made；
S4, by the anti-inflammatory reparation Essence sample detection of the active peptide, discharge after detection is qualified, filling, finished product detection enters
Library.
Further, the mixing speed that homogeneous stirs in the step S1 is 30rpm.
It is good through having of being chemically modified to obtain that carboxymethyl chitosan is the chitin polysaccharide that extracts from marine organisms
Good water-soluble chitosan derivative has a wide range of applications and Recent study at cosmetics, fresh-keeping and medical aspect
One of more chitosan derivatives, with excellent moisture absorption, moisturizing, conditioning and bacteria resistance function.The rough gentian anti-irritant factor
It is water-soluble good using propylene glycol, water and Radix Gentianae extract as main component, there is significant anti-inflammatory, antipruritic, analgesia and detumescence
Effect, in the inventive solutions, carboxymethyl chitosan in the anti-inflammatory remediation composition of active peptide and rough gentian anti-irritant because
Son synergistic effect, reduces the irritation of formula, and played significant antibiotic effect, avoids skin and secondary damage occur
Deteriorate with further.
On the other hand, inventor find the anti-inflammatory remediation composition of active peptide in carboxymethyl chitosan and other active peptides at
Distribution closes and produces good synergistic function, can be good at treating the scytitis as caused by environmental stimuli etc., this
It may be the component units Glucosamine and human epidermal adipose membrane layer important component ceramide due to carboxymethyl chitosan
Structure is much like, interacts with the active group of the natural anti-inflammatory reparative factor such as active peptide, forms one layer and excellent natural imitates
Raw sterile film, is attached to skin surface, can effectively resist extraneous stimulation, skin is protected, to play significant skin
Skin reparation and antiphlogistic effects.
Compared with prior art, the present invention has the following beneficial effects:
(1) the natural anti-inflammatory reparation such as the carboxymethyl chitosan in the anti-inflammatory remediation composition of active peptide of the present invention and active peptide because
The active group interaction of son, forms one layer of excellent natural bionical sterile film, is attached to skin surface, the reparation essence of preparation
Magnificent liquid can effectively resist extraneous stimulation, protect skin, played significant skin repair and anti-inflammatory effect.
(2) carboxymethyl chitosan in the anti-inflammatory remediation composition of active peptide of the present invention cooperates with work with the rough gentian anti-irritant factor
With formula rationally, reduces the irritation of formula, the reparation Essence of preparation has played significant antibacterial action, avoided skin
There is secondary damage and further deterioration in skin.
Specific embodiment
The present invention is further described below by way of specific embodiment, the present invention is not limited only to following embodiment.In this hair
In bright range or the contents of the present invention are not being departed from, in spirit and scope, the change that carries out to the present invention is combined or replaced
It changes, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Carbopol of the present invention repairs peptide purchased from Shenzhen and ties up fine jade biotechnology purchased from the weighing apparatus Industrial Co., Ltd. of Shanghai million
Co., Ltd, the rough gentian anti-irritant factor are purchased from Guangdong Di Mei new material Science and Technology Ltd..
Embodiment 1, the anti-inflammatory remediation composition of active peptide of the present invention
The anti-inflammatory remediation composition of 1 active peptide of the embodiment of the present invention, including carboxymethyl chitosan, -1 copper of tripeptides, repair peptide and
Palmityl tetrapeptide -7.
The carboxymethyl chitosan, -1 copper of tripeptides repair the mass ratio of peptide and palmityl tetrapeptide -7 as 1:0.01:1:1.
The reparation peptide be hexapeptide -9, Matrixyl -4, palmityl tripeptides -1 and palmityl tripeptides -5, mass ratio 1:
1:1:1.
Embodiment 2, the anti-inflammatory remediation composition of active peptide of the present invention
The anti-inflammatory remediation composition of 2 active peptide of the embodiment of the present invention, including carboxymethyl chitosan, -1 copper of tripeptides, repair peptide and
Palmityl tetrapeptide -7.
The carboxymethyl chitosan, -1 copper of tripeptides repair the mass ratio of peptide and palmityl tetrapeptide -7 as 1.22:0.02:2:
2。
The reparation peptide be hexapeptide -9, Matrixyl -4, palmityl tripeptides -1 and palmityl tripeptides -5, mass ratio 1:
1:1:1.
Embodiment 3, the anti-inflammatory remediation composition of active peptide of the present invention
The anti-inflammatory remediation composition of 3 active peptide of the embodiment of the present invention, including carboxymethyl chitosan, -1 copper of tripeptides, repair peptide and
Palmityl tetrapeptide -7.
The carboxymethyl chitosan, -1 copper of tripeptides repair the mass ratio of peptide and palmityl tetrapeptide -7 as 3:0.05:4:4.
The reparation peptide be hexapeptide -9, Matrixyl -4, palmityl tripeptides -1 and palmityl tripeptides -5, mass ratio 1:
1:1:1.
Anti-inflammatory reparation Essence of embodiment 4, active peptide of the present invention and preparation method thereof
4 active peptide of the embodiment of the present invention anti-inflammatory reparation Essence, by following quality at being grouped as: 1 active peptide of embodiment
Anti-inflammatory remediation composition 8.52kg, rough gentian anti-irritant factor 3.5kg, Carbopol 0.2kg, parahydroxyacet-ophenone 0.4kg, three
Ethanol amine 0.18kg and water 87.2kg.
The anti-inflammatory preparation method for repairing Essence of above-mentioned active peptide, comprising the following steps:
S1, according to formula ratio, thickener and preservative is soluble in water, impregnate 5-9h, stir and be warming up under 30-40rpm
80-90 DEG C, homogeneous is stirred to being uniformly dispersed under 30rpm, and mixed liquor A is made；
S2, the mixed liquor A is cooled to 45-55 DEG C, triethanolamine is added according to formula ratio, stir under 30-50rpm to
It is uniformly dispersed, mixed liquid B is made；
S3, the mixed liquid B is cooled to 30-40 DEG C, the anti-inflammatory remediation composition of active peptide and dragon is added according to formula ratio
The gallbladder anti-irritant factor stirs under 30-50rpm to being uniformly dispersed, the anti-inflammatory reparation Essence of active peptide is made；
S4, by the anti-inflammatory reparation Essence sample detection of the active peptide, discharge after detection is qualified, filling, finished product detection enters
Library.
Anti-inflammatory reparation Essence of embodiment 5, active peptide of the present invention and preparation method thereof
5 active peptide of the embodiment of the present invention anti-inflammatory reparation Essence, by following quality at being grouped as: 2 active peptide of embodiment
Anti-inflammatory remediation composition 5.24kg, rough gentian anti-irritant factor 2kg, Carbopol 0.2kg, parahydroxyacet-ophenone 0.5kg, three second
Hydramine 0.16kg and water 91.9kg.
The anti-inflammatory preparation method for repairing Essence of above-mentioned active peptide, comprising the following steps:
S1, according to formula ratio, thickener and preservative is soluble in water, impregnate 5-9h, stir and be warming up under 30-40rpm
80-90 DEG C, homogeneous is stirred to being uniformly dispersed under 30rpm, and mixed liquor A is made；
S2, the mixed liquor A is cooled to 45-55 DEG C, triethanolamine is added according to formula ratio, stir under 30-50rpm to
It is uniformly dispersed, mixed liquid B is made；
S3, the mixed liquid B is cooled to 30-40 DEG C, the anti-inflammatory remediation composition of active peptide and dragon is added according to formula ratio
The gallbladder anti-irritant factor stirs under 30-50rpm to being uniformly dispersed, the anti-inflammatory reparation Essence of active peptide is made；
S4, by the anti-inflammatory reparation Essence sample detection of the active peptide, discharge after detection is qualified, filling, finished product detection enters
Library.
Anti-inflammatory reparation Essence of embodiment 6, active peptide of the present invention and preparation method thereof
6 active peptide of the embodiment of the present invention anti-inflammatory reparation Essence, by following quality at being grouped as: 3 active peptide of embodiment
Anti-inflammatory remediation composition 3.02kg, rough gentian anti-irritant factor 1kg, Carbopol 0.3kg, parahydroxyacet-ophenone 0.4kg, three second
Hydramine 0.28kg and water 95kg.
The anti-inflammatory preparation method for repairing Essence of above-mentioned active peptide, comprising the following steps:
S1, according to formula ratio, thickener and preservative is soluble in water, impregnate 5-9h, stir and be warming up under 30-40rpm
80-90 DEG C, homogeneous is stirred to being uniformly dispersed under 30rpm, and mixed liquor A is made；
S2, the mixed liquor A is cooled to 45-55 DEG C, triethanolamine is added according to formula ratio, stir under 30-50rpm to
It is uniformly dispersed, mixed liquid B is made；
S3, the mixed liquid B is cooled to 30-40 DEG C, the anti-inflammatory remediation composition of active peptide and dragon is added according to formula ratio
The gallbladder anti-irritant factor stirs under 30-50rpm to being uniformly dispersed, the anti-inflammatory reparation Essence of active peptide is made；
S4, by the anti-inflammatory reparation Essence sample detection of the active peptide, discharge after detection is qualified, filling, finished product detection enters
Library.
Comparative example 1
Compared with Example 5, the difference of this comparative example is only that: the anti-inflammatory remediation composition of active peptide is tripeptides -1
Copper repairs peptide and palmityl tetrapeptide -7, does not add carboxymethyl chitosan.
Comparative example 2
Compared with Example 5, the difference of this comparative example is only that: not adding the rough gentian anti-irritant factor.
Comparative example 3
Compared with Example 5, the difference of this comparative example is only that: carboxymethyl shell in the anti-inflammatory remediation composition of active peptide
Glycan, -1 copper of tripeptides repair the mass ratio of peptide and palmityl tetrapeptide -7 as 4:0.02:2:2.
The anti-inflammatory reparation Essence of test example one, active peptide of the present invention measures skin irritation
According to " cosmetics safety technical specification " (version in 2015) skin irritation/corrosion test to 4~6 He of embodiment
The anti-inflammatory reparation Essence of active peptide prepared by comparative example 1~2 carries out dermoreaction scoring, and concrete operations are as follows:
1, experimental animal: healthy white rabbit 20, female, 1.8~2.2kg, skin zero damage are divided into 5 groups, every group 4
Only.
2, test method: according to " cosmetics safety technical specification " (version in 2015) skin irritation/corrosion test pair
The anti-inflammatory reparation Essence of active peptide prepared by embodiment 4~6 and comparative example 1~2 carries out dermoreaction scoring, and test procedure is such as
Under:
Experiment white rabbit back backbone diamond wool is cut for 24 hours before S1, test, does not damage epidermis, unhairing range or so is respectively
3cm × 3cm, application area are 2.5cm × 2.5cm；
S2, tested material (i.e. the anti-inflammatory reparation Essence of active peptide of embodiment 4~6 and the preparation of comparative example 1~2) 0.5mL is taken
It is applied on the skin of side, other side skin is as control.It smears 1 time daily, continuously smears 14d.Since second day, every time
Cropping before smearing removes residual tested material with water.After 1 hour observation as a result, by table 1 carry out dermoreaction scoring, check plot and
Trial zone is equally handled；
S3, evaluation of result: being calculated according to the following formula daily every animal average integral, determines skin irritatin intensity by table 2.
The scoring of 1 skin wound repair of table
2 skin irritatin strength grading of table
| Integral mean value | Intensity |
| 0~0.5 | It is nonirritant |
| 0.5~2.0 | Subexcite |
| 2.0~6.0 | Moderate stimulation |
| 6.0~8.0 | Strong and stimulating |
3,3 test result: be see the table below according to Tables 1 and 2 statistical result.
The anti-inflammatory reparation Essence irritation test result of the active peptide of the present invention of table 3
It can be obtained by upper table 3, the anti-inflammatory reparation Essence of 4~6 active peptide of the embodiment of the present invention is to no skin irritation, comparison
Example 1 does not add carboxymethyl chitosan, and comparative example 2 does not add the rough gentian anti-irritant factor, i.e., generates subexcite to skin, illustrates this
Invention carboxymethyl chitosan can interact with the rough gentian anti-irritant factor, form a kind of natural sterile film, formula rate
Rationally, there is protective effect for skin, reduces the irritation of formula.
The anti-inflammatory reparation Essence anti-inflammatory efficacy measurement of test example two, active peptide of the present invention
1, trial target: the anti-inflammatory reparation Essence of active peptide prepared by embodiment 4~6 and comparative example 1~3；
2, tested crowd: acne female patient 300 (PillshuryI grades), the age 23~32 years old, all patients were
Receive to inform and signs informed consent form；
3, be grouped: being divided into five groups, every group of 50 people, every group average age 26 ± 2 years old；
4, test method: after every group of subject cleans face, after identical skin nursing, embodiment 4 is used respectively
~6 and comparative example 1~3 prepare active peptide repair Essence, be used continuously 4 weeks, test assessment result it is as shown in table 4.
Active peptide prepared by 4 embodiment 4~6 of table and comparative example 1~3 repairs (4 weeks) the feedback conclusive tables on probation of Essence
From upper table 4:
(1) the anti-inflammatory reparation Essence of active peptide prepared by the embodiment of the present invention 4~6 has significant antiphlogistic effects, tested
After person is using repairing Essence 4 weeks, face acne, papule, useless fellow and the tubercle of most subjects disappear substantially, while tested
There are the bad phenomenons such as allergy, red swelling of the skin in non-someone in the questionnaire of person.
(2) compared with Example 5, comparative example 1 does not add carboxymethyl chitosan, comparative example 2 do not add rough gentian anti-irritant because
Son, antiphlogistic effects are decreased obviously, and illustrate to interact between the anti-inflammatory reparation Essence each component of active peptide of the present invention, are played
Significant antiphlogistic effects；Still further aspect, comparative example 3 change the ratio of each component in the anti-inflammatory remediation composition of active peptide, resist
Scorching effect is declined, and illustrates that carboxymethyl chitosan of the present invention and other active peptide component ratios are reasonable, has been played significant anti-
Scorching effect.
The anti-inflammatory reparation Essence antibacterial functions measurement of test example three, active peptide of the present invention
1, test material: the anti-inflammatory reparation Essence of active peptide prepared by embodiment 4~6 and comparative example 1~3, acne propionic acid
Bacillus ATCC11827 and staphylococcus aureus ATCC6538 are all from Guangdong Microbes Inst；
2, experimental method: weighing the anti-inflammatory reparation Essence of active peptide prepared by embodiment 4~6 and comparative example 1~3 respectively,
The detection of antibacterial functions is carried out referring to GB/T20844.3-2008 succusion, experimental result is as shown in table 5~10.
The anti-inflammatory anti-microbial property for repairing Essence of the active peptide of 5 embodiment 4 of table preparation
The anti-inflammatory anti-microbial property for repairing Essence of the active peptide of 6 embodiment 5 of table preparation
The anti-inflammatory anti-microbial property for repairing Essence of the active peptide of 7 embodiment 6 of table preparation
The anti-inflammatory anti-microbial property for repairing Essence of the active peptide of 8 comparative example 1 of table preparation
The anti-inflammatory anti-microbial property for repairing Essence of the active peptide of 9 comparative example 2 of table preparation
The anti-inflammatory anti-microbial property for repairing Essence of the active peptide of 10 comparative example 3 of table preparation
(1) by table 5~7 it is found that the anti-inflammatory reparation Essence of active peptide of the preparation of the embodiment of the present invention 4~6 is for acne third
Acidfast bacilli and staphylococcus aureus have significant inhibiting effect, wherein it is best with the antibacterial effect of embodiment 5, for the present invention
Most preferred embodiment；
It (2), can not be anti-with rough gentian by table 8~10 it is found that compared with Example 5, comparative example 1 does not add carboxymethyl chitosan
Stimulating factor synergistic effect, causes antibacterial effect to be declined；Comparative example 2 does not add the rough gentian anti-irritant factor, can not be with carboxylic first
Base enclosure glycan synergistic effect, causes antibacterial effect to be greatly reduced；Comparative example 3 changes each group in the anti-inflammatory remediation composition of active peptide
The ratio divided, antibacterial effect are declined, and illustrate that carboxymethyl chitosan of the present invention is cooperateed with active peptide and the rough gentian anti-irritant factor
Effect, formula rate is reasonable, has played significant antibacterial effect.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (10)
1. a kind of anti-inflammatory remediation composition of active peptide, which is characterized in that including carboxymethyl chitosan, -1 copper of tripeptides, repair peptide and
Palmityl tetrapeptide -7.
2. the anti-inflammatory remediation composition of active peptide as described in claim 1, which is characterized in that the carboxymethyl chitosan, tripeptides -1
Copper repairs the mass ratio of peptide and palmityl tetrapeptide -7 as (1~3): (0.01~0.05): (1~3): (1~3).
3. the anti-inflammatory remediation composition of active peptide as claimed in claim 2, which is characterized in that the carboxymethyl chitosan, tripeptides -1
Copper repairs the mass ratio of peptide and palmityl tetrapeptide -7 as 1.22:0.02:2:2.
4. the anti-inflammatory remediation composition of active peptide as described in claim 1, which is characterized in that the reparation peptide is hexapeptide -9, palm
At least one of acyl pentapeptide -4, palmityl tripeptides -1 and palmityl tripeptides -5.
5. the anti-inflammatory remediation composition of the active peptide as described in Claims 1 to 4 is any is in preparing the anti-inflammatory reparation Essence of active peptide
Application.
6. a kind of anti-inflammatory reparation Essence of active peptide, which is characterized in that the ingredient including following mass fraction: such as claim 1
The anti-inflammatory remediation composition 3~10% of the active peptide, the rough gentian anti-irritant factor 1~4%, thickener 0.1~0.4%, anti-corrosion
Agent 0.3~0.7%, triethanolamine 0.05~0.3% and water 87~95%.
7. the anti-inflammatory reparation Essence of active peptide as claimed in claim 6, which is characterized in that the thickener is Carbopol.
8. the anti-inflammatory reparation Essence of active peptide as claimed in claim 6, which is characterized in that the preservative is para hydroxybenzene second
Ketone.
9. a kind of anti-inflammatory preparation method for repairing Essence of active peptide as described in claim 6~8 is any, which is characterized in that packet
Include following steps:
S1, according to formula ratio, thickener and preservative is soluble in water, impregnate 5-9h, stirring is warming up to 80-90 under 30-40rpm
DEG C, homogeneous is stirred to being uniformly dispersed, and mixed liquor A is made；
S2, the mixed liquor A is cooled to 45-55 DEG C, triethanolamine is added according to formula ratio, stirring extremely disperses under 30-50rpm
Uniformly, mixed liquid B is made；
S3, the mixed liquid B is cooled to 30-40 DEG C, the anti-inflammatory remediation composition of active peptide is added according to formula ratio and rough gentian is anti-
Stimulating factor stirs under 30-50rpm to being uniformly dispersed, the anti-inflammatory reparation Essence of active peptide is made；
S4, by the anti-inflammatory reparation Essence sample detection of the active peptide, discharge after detection is qualified, filling, finished product detection, storage.
10. the anti-inflammatory preparation method for repairing Essence of active peptide as claimed in claim 9, which is characterized in that the step S1
The mixing speed of middle homogeneous stirring is 30rpm.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110292539A (en) * | 2019-08-01 | 2019-10-01 | 深圳市健翔生物制药有限公司 | It is a kind of repair hormone face peptide composition and its application |
| CN116549316A (en) * | 2023-04-24 | 2023-08-08 | 广州领衔生物科技有限公司 | Composition containing blue copper peptide freeze-dried powder and application of composition in cosmetics |
| CN116869837A (en) * | 2023-09-05 | 2023-10-13 | 广州美尔生物科技有限公司 | Anti-stinging and antiallergic composition and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236665A (en) * | 2016-08-30 | 2016-12-21 | 广州科玛生物科技股份有限公司 | A kind of baby child's Flos pini is felt well body prickly-heat powder |
| CN106265120A (en) * | 2016-09-12 | 2017-01-04 | 珠海金肽生物科技有限公司 | Cytokine-like effect of a kind of nine Oligopeptide Compositions and cosmetic applications |
| CN107137261A (en) * | 2017-03-24 | 2017-09-08 | 上海伽誉生物科技有限公司 | Preparation method, purposes and the plant extract device of the rough gentian anti-irritant factor |
| CN107737053A (en) * | 2017-11-30 | 2018-02-27 | 珠海安和生化科技有限公司 | Antiallergy maintenance emulsion and preparation method thereof |
| CN107982180A (en) * | 2018-01-05 | 2018-05-04 | 广州赛美药业有限公司 | A kind of anti-inflammatory antiallergic mask and preparation method thereof |
| CN108078868A (en) * | 2018-02-01 | 2018-05-29 | 四川艾医生医疗科技有限公司 | A kind of antiallergic composition for skin care item |
-
2018
- 2018-12-04 CN CN201811475556.0A patent/CN109498500A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236665A (en) * | 2016-08-30 | 2016-12-21 | 广州科玛生物科技股份有限公司 | A kind of baby child's Flos pini is felt well body prickly-heat powder |
| CN106265120A (en) * | 2016-09-12 | 2017-01-04 | 珠海金肽生物科技有限公司 | Cytokine-like effect of a kind of nine Oligopeptide Compositions and cosmetic applications |
| CN107137261A (en) * | 2017-03-24 | 2017-09-08 | 上海伽誉生物科技有限公司 | Preparation method, purposes and the plant extract device of the rough gentian anti-irritant factor |
| CN107737053A (en) * | 2017-11-30 | 2018-02-27 | 珠海安和生化科技有限公司 | Antiallergy maintenance emulsion and preparation method thereof |
| CN107982180A (en) * | 2018-01-05 | 2018-05-04 | 广州赛美药业有限公司 | A kind of anti-inflammatory antiallergic mask and preparation method thereof |
| CN108078868A (en) * | 2018-02-01 | 2018-05-29 | 四川艾医生医疗科技有限公司 | A kind of antiallergic composition for skin care item |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110292539A (en) * | 2019-08-01 | 2019-10-01 | 深圳市健翔生物制药有限公司 | It is a kind of repair hormone face peptide composition and its application |
| CN116549316A (en) * | 2023-04-24 | 2023-08-08 | 广州领衔生物科技有限公司 | Composition containing blue copper peptide freeze-dried powder and application of composition in cosmetics |
| CN116549316B (en) * | 2023-04-24 | 2024-03-22 | 广州领衔生物科技有限公司 | Composition containing blue copper peptide freeze-dried powder and application of composition in cosmetics |
| CN116869837A (en) * | 2023-09-05 | 2023-10-13 | 广州美尔生物科技有限公司 | Anti-stinging and antiallergic composition and preparation method and application thereof |
| CN116869837B (en) * | 2023-09-05 | 2023-11-21 | 广州美尔生物科技有限公司 | Anti-stinging and antiallergic composition and preparation method and application thereof |
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