CN109453217A - Secret conditioning liquid - Google Patents
Secret conditioning liquid Download PDFInfo
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- CN109453217A CN109453217A CN201811417061.2A CN201811417061A CN109453217A CN 109453217 A CN109453217 A CN 109453217A CN 201811417061 A CN201811417061 A CN 201811417061A CN 109453217 A CN109453217 A CN 109453217A
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- conditioning liquid
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- citric acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
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Abstract
The present invention relates to secret conditioning liquids, belong to external medical product technical field, conditioning liquid includes the component of following parts by weight: 3-7 parts of hexamethylene, 2-4 parts of plant extracts, 1-2 parts of food-grade Citric Acid Mono, 5-6 parts of aid antibacteria agent, 900-1100 parts of purified water, and prepared through following method: first by aid antibacteria agent and purified water mixed dissolution and being heated, food-grade Citric Acid Mono is dropped evenly when stirring, after natural cooling, plant extracts is added, continue to stir, hexamethylene is added while stirring, adjust pH, it is uniformly mixed to obtain conditioning liquid finished product.
Description
Technical field
The present invention relates to secret conditioning liquids, belong to external medical product technical field.
Background technique
Skin covers whole body surface, is one of maximum organ of human body.The thickness of whole body skin everywhere is different, back, item
Portion, palm and vola etc. are most thick, and armpit and face are most thin, and average thickness is 0.5-4.0 millimeters.The skin of different places is held
Carry on a shoulder pole different degrees of metaboilic level and level of protection.Skin carries the secretion of daily sweat and sebum, is that human body faces
" pioneer " of surroundings, this will face various foreign matters directly, including the dust, bacterium, true in air and personal clothing
Bacterium etc. can impact skin.And privates secretion is more, is in closed environment for a long time, it is easier to bacterium is bred, if
Do not pay attention to privates cleaning sterilization usually, various inflammation may be caused, gently then itch shouting pain, secretion is abnormal, heavy then possible shadow
Ring fertility.How to keep privates healthy, is particularly important in nursing usually.
Summary of the invention
In view of the above problems, the present invention provides effective, convenient and fast daily nursing and solves germ inflammation
The secret conditioning liquid that problem uses.
To achieve the goals above, the invention adopts the following technical scheme:
Secret conditioning liquid, the conditioning liquid include the component of following parts by weight: hexamethylene 3-7
Part, 2-4 parts of plant extracts, 1-2 parts of food-grade Citric Acid Mono, 5-6 parts of aid antibacteria agent, 900-1100 parts of purified water.
The problems such as itch of private parts, peculiar smell, abnormal secretion, should be infused caused by bacterium, fungal infection mostly
The cleaning prevention for anticipating daily also will fundamentally sterilize to solve the problems, such as, and conventional conditioning liquid is to reach cleaning purpose, then can
It is added the alkaline components such as soap base, but commonly using private portion's slightly acidic environment can be destroyed, it is subsequent to be easier to be infected by germ；And drug class
Conditioning liquid bactericidal effect it is preferable, but chemical component is more, and irritation is strong, commonly using dependence is also easy to produce, leads to some diseases
Shape recurrent exerbation, toxic side effect are larger；And the privates conditioning liquid that pure plant is extracted, it can only achieve antibacterial level mostly, be not achieved
Sterilizing rank can not be solved the problems, such as thoroughly, be easy to cause problem worse, have certain defect in a word and using limitation
Property, safety and validity cannot be satisfactory to both parties.And the present invention starts with from safety and validity, mainly with cosmocil stearate
Hydrochlorate+plant extracts complex method belongs to the macromolecular raw material of environmental protection, is not easy to be absorbed by the body, and from sterilizing
It solves the problems, such as in form at all, special physical sterilization principle, long-time service does not have bacterium and generates drug resistance, i.e. this hair to it
Bright formula does not stimulate mildly, is different from traditional chemical sterilization principle, and sterilization while can stimulate skin.And the present invention matches
Side and its safety belong to practical nontoxic rank, and pregnant and lying-in women also can be used, and pleasing to the eye entrance is nontoxic.
Preferably, the plant extracts is feverfew flower extract.
Feverfew, composite family, herbaceos perennial and are waved flavone compound, chrysanthemum glucoside, terpene substances in extract
Volatile material is inhibited to microorganisms such as staphylococcus aureus, Escherichia coli, salmonellas.
Preferably, the fungicide is bis- (N1- rubigan-N5- biguanides base) the hexane digluconates of 1,6-.
Further preferably, bis- (N1- rubigan-N5- biguanides base) the hexane digluconates of 1, the 6- account for conditioning liquid
The 0.45-0.55% of total amount.
1,6- bis- (N1- rubigan-N5- biguanides base) hexane digluconates belong to cationic compound, to thin
Bacterium has apparent affinity, can destroy bacterial cell membrane, inhibits bacterial metabolism enzymatic activity, to generate killing effect to bacterium.
The present invention additionally provides another technical solution while reasonable selection raw material proportioning:
The preparation method of secret conditioning liquid, includes the following steps:
Raw material is weighed by above-mentioned component, first by aid antibacteria agent and purified water mixed dissolution and is heated, when stirring uniformly drips
Add food-grade Citric Acid Mono, after natural cooling, plant extracts is added, continues to stir, polyhexamethylene is added while stirring
Biguanide hydrochloride adjusts pH, is uniformly mixed to obtain conditioning liquid finished product.
Preferably, the temperature of heating is 40-60 DEG C, 5-7min is kept the temperature.
Preferably, the adjusting pH is 3-5.
The application method of secret conditioning liquid includes the following steps: that secret conditioning liquid is uniformly directly sprayed onto privates, naturally dry
It is dry.
Compared with prior art, the present invention has the advantage that
(1) secret conditioning liquid formula material of the present invention is environment-friendly type macromolecular substances, is not easy to be absorbed by organisms, safety foot
Enough height, pleasing to the eye entrance is nontoxic, allows more the trusting of consumer.
(2) secret conditioning liquid faintly acid formula of the present invention maintains private portion faintly acid pH, colorless and odorless milder.
(3) secret conditioning liquid wide application of the crowd of the present invention, safety is sufficiently high, and pregnant and lying-in women can use.
(4) secret conditioning liquid of the present invention uses physical sterilization principle, does not stimulate mildly, and protection beneficial bacterium kills harmful bacteria,
Private portion microecological balance is maintained, resistance is generated to it using not having bacterium for a long time, is suitble to daily nursing long-time service.
(5) spray of secret conditioning liquid one of the present invention can be easy to use without cleaning.
Specific embodiment
The following is specific embodiments of the present invention, and technical scheme of the present invention will be further described, but the present invention is simultaneously
It is not limited to these embodiments.
Embodiment 1
Ingredient: raw material is weighed by above-mentioned secret conditioning liquid ingredient, including 5 parts of hexamethylene, plant mention
3 parts of object, 1.5 parts of food-grade Citric Acid Mono, 5.5 parts of aid antibacteria agent, 1000 parts of purified water are taken, wherein plant extracts is white
Chrysanthemum extract, aid antibacteria agent are bis- (N1- rubigan-N5- biguanides base) hexanes of 1,6- for accounting for conditioning liquid total amount 0.49%
Digluconate；
Preparation: first by aid antibacteria agent and purified water mixed dissolution and being heated to 50 DEG C, keeps the temperature 6min, and when stirring uniformly drips
Add food-grade Citric Acid Mono, after natural cooling, plant extracts is added, continues to stir, polyhexamethylene is added while stirring
Biguanide hydrochloride, adjusting pH is 4, until being uniformly mixed to obtain conditioning liquid finished product.
Embodiment 2
Ingredient: raw material is weighed by above-mentioned secret conditioning liquid ingredient, including 3 parts of hexamethylene, plant mention
2 parts of object, 1 part of food-grade Citric Acid Mono, 5 parts of aid antibacteria agent, 900 parts of purified water are taken, wherein plant extracts is feverfew
Extract, aid antibacteria agent are bis- two Portugals of (N1- rubigan-N5- biguanides base) hexane 1,6- for accounting for conditioning liquid total amount 0.55%
Grape sugar lime；
Preparation: first by aid antibacteria agent and purified water mixed dissolution and being heated to 50 DEG C, keeps the temperature 6min, and when stirring uniformly drips
Adding food-grade Citric Acid Mono, after natural cooling, adjusts pH, control pH is 4, plant extracts is added, continues to stir, side stirring
Hexamethylene is added in side, until being uniformly mixed to obtain conditioning liquid finished product.
Embodiment 3
Ingredient: raw material is weighed by above-mentioned secret conditioning liquid ingredient, including 7 parts of hexamethylene, plant mention
4 parts of object, 2 parts of food-grade Citric Acid Mono, 6 parts of aid antibacteria agent, 1100 parts of purified water are taken, wherein plant extracts is feverfew
Extract, aid antibacteria agent are bis- two Portugals of (N1- rubigan-N5- biguanides base) hexane 1,6- for accounting for conditioning liquid total amount 0.54%
Grape sugar lime；
Preparation: first by aid antibacteria agent and purified water mixed dissolution and being heated to 50 DEG C, keeps the temperature 6min, and when stirring uniformly drips
Adding food-grade Citric Acid Mono, after natural cooling, adjusts pH, control pH is 4, plant extracts is added, continues to stir, side stirring
Hexamethylene is added in side, until being uniformly mixed to obtain conditioning liquid finished product.
Embodiment 4
Ingredient: raw material is weighed by above-mentioned secret conditioning liquid ingredient, including 5 parts of hexamethylene, plant mention
3 parts of object, 1.5 parts of food-grade Citric Acid Mono, 5.5 parts of aid antibacteria agent, 1000 parts of purified water are taken, wherein plant extracts is white
Chrysanthemum extract, aid antibacteria agent are bis- (N1- rubigan-N5- biguanides base) hexanes of 1,6- for accounting for conditioning liquid total amount 0.49%
Digluconate；
Preparation: first by aid antibacteria agent and purified water mixed dissolution and being heated to 40 DEG C, keeps the temperature 5min, and when stirring uniformly drips
Add food-grade Citric Acid Mono, after natural cooling, adjust pH, control pH is 2.5, and plant extracts is added, continues to stir, while stirring
It mixes side and hexamethylene is added, until being uniformly mixed to obtain conditioning liquid finished product.
Embodiment 5
Ingredient: raw material is weighed by above-mentioned secret conditioning liquid ingredient, including 5 parts of hexamethylene, plant mention
3 parts of object, 1.5 parts of food-grade Citric Acid Mono, 5.5 parts of aid antibacteria agent, 1000 parts of purified water are taken, wherein plant extracts is white
Chrysanthemum extract, aid antibacteria agent are bis- (N1- rubigan-N5- biguanides base) hexanes of 1,6- for accounting for conditioning liquid total amount 0.49%
Digluconate；
Preparation: first by aid antibacteria agent and purified water mixed dissolution and being heated to 60 DEG C, keeps the temperature 7min, and when stirring uniformly drips
Add food-grade Citric Acid Mono, after natural cooling, adjust pH, control pH is 5.5, and plant extracts is added, continues to stir, while stirring
It mixes side and hexamethylene is added, until being uniformly mixed to obtain conditioning liquid finished product.
Embodiment 6
Difference with embodiment 1 is only that the plant extracts number of embodiment 6 is 1 part.
Embodiment 7
Difference with embodiment 1 is only that the plant extracts number of embodiment 7 is 5 parts.
Embodiment 8
Difference with embodiment 1 is only that the aid antibacteria agent of embodiment 8 is other common fungicide.
Comparative example 1
Difference with embodiment 1 is only that, hexamethylene is free of in 1 raw material of comparative example.
Comparative example 2
Difference with embodiment 1 is only that, plant extracts is free of in 2 raw material of comparative example.
Comparative example 3
Difference with embodiment 1 is only that, aid antibacteria agent is free of in 3 raw material of comparative example.
Comparative example 4
Difference with embodiment 1 is only that, food-grade Citric Acid Mono is free of in 4 raw material of comparative example.
Above-described embodiment 1-10 and comparative example the 1-4 conditioning liquid produced are tested, the results are shown in Table 1:
Wherein, application method includes the following steps: that secret conditioning liquid is uniformly directly sprayed onto privates, spontaneously dries；
Comparative example 5
Difference with the above-mentioned conditioning liquid produced is only that comparative example 5 uses commercially available conditioning liquid.
Table 1: the service condition of conditioning liquid
Illustrate: the pH range in the present invention is primarily to adaptation private parts weak acid environment, safeguards privates Tiny ecosystem
It balances and customizes, do not directly affect restraining and sterilizing bacteria effect.
Test background
For trying strain: staphylococcus aureus, Escherichia coli, Candida albicans.
The scoring of vaginal mucosa stimulate the reaction calculates: according to rabbit vagina epithelial tissue, leukocyte infiltration, the congestion of blood vessel, water
Every item rating total score that swells calculates.Stimulate the reaction scoring=test group, which averagely stimulates integral-negative control group averagely, stimulates integral.Often
Group test in triplicate, is averaged.
Sterilizing rate: refer to and terminate reaction, the sterilization logarithm tested and be calculated when conditioning liquid acts on 1min.Every group of test
In triplicate, it is averaged.And domestic thimerosal bactericidal effect most standard are as follows: staphylococcus aureus, Escherichia coli averagely kill
Logarithm of going out is 5, and it is 4 that Candida albicans, which averagely kills logarithm, so in this test just higher than the data of highest standard result
It is indicated with > 5 He > 4.
Bacteriostasis rate after 20min: refer to using the antibacterial efficiency after conditioning liquid 20min, measured.Every group of test in triplicate, takes
Average value.
It is skilled to this field although present invention has been described in detail and some specific embodiments have been cited
For technical staff, as long as it is obvious for can making various changes or correct without departing from the spirit and scope of the present invention.
Claims (8)
1. secret conditioning liquid, which is characterized in that the conditioning liquid includes the component of following parts by weight: cosmocil stearate
3-7 parts of hydrochlorate, 2-4 parts of plant extracts, 1-2 parts of food-grade Citric Acid Mono, 5-6 parts of aid antibacteria agent, purified water 900-
1100 parts.
2. conditioning liquid according to claim 1, which is characterized in that the plant extracts is feverfew flower extract.
3. conditioning liquid according to claim 1, which is characterized in that the aid antibacteria agent is that bis- (N1- is to chlorobenzene by 1,6-
Base-N5- biguanides base) hexane digluconate.
4. conditioning liquid according to claim 3, which is characterized in that 1, the 6- is bis- (N1- rubigan-N5- biguanides base)
Hexane digluconate accounts for the 0.45-0.55% of conditioning liquid total amount.
5. the preparation method of secret conditioning liquid, which is characterized in that the method includes the following steps:
Raw material is weighed by above-mentioned component, first by aid antibacteria agent and purified water mixed dissolution and is heated, when stirring drops evenly food
Grade Citric Acid Mono after natural cooling, is added plant extracts, continues to stir, poly hexamethylene biguanide is added while stirring
Hydrochloride adjusts pH, is uniformly mixed to obtain conditioning liquid finished product.
6. the preparation method of conditioning liquid according to claim 5, which is characterized in that the temperature of heating is 40-60 DEG C, heat preservation
5-7min。
7. the preparation method of conditioning liquid according to claim 5, which is characterized in that the adjusting pH is 3-5.
8. the application method of secret conditioning liquid, which is characterized in that described method includes following steps: directly that secret conditioning liquid is equal
It is even to be sprayed onto privates, it spontaneously dries.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811417061.2A CN109453217A (en) | 2018-11-26 | 2018-11-26 | Secret conditioning liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811417061.2A CN109453217A (en) | 2018-11-26 | 2018-11-26 | Secret conditioning liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109453217A true CN109453217A (en) | 2019-03-12 |
Family
ID=65611679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811417061.2A Pending CN109453217A (en) | 2018-11-26 | 2018-11-26 | Secret conditioning liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109453217A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109395068A (en) * | 2018-11-26 | 2019-03-01 | 浙江舒是生物科技有限公司 | A kind of refractory wound Special sterilizing liquid |
| CN110179901A (en) * | 2019-06-26 | 2019-08-30 | 江志铭 | A kind of soft net conditioning liquid of schoolgirl and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102408951A (en) * | 2011-09-23 | 2012-04-11 | 石家庄菠莉亚日用化工有限公司 | Disinfecting and deodorizing cleaning agent for refrigerator and preparation process thereof |
| RU2462258C1 (en) * | 2010-12-30 | 2012-09-27 | Государственное образовательное учреждение высшего профессионального образования "Самарский государственный медицинский Университет "Федерального агентства по здравоохранению и социальному развитию" | Method of skin and soft tissue wound and wound infection healing |
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2018
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2462258C1 (en) * | 2010-12-30 | 2012-09-27 | Государственное образовательное учреждение высшего профессионального образования "Самарский государственный медицинский Университет "Федерального агентства по здравоохранению и социальному развитию" | Method of skin and soft tissue wound and wound infection healing |
| CN102408951A (en) * | 2011-09-23 | 2012-04-11 | 石家庄菠莉亚日用化工有限公司 | Disinfecting and deodorizing cleaning agent for refrigerator and preparation process thereof |
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| 刘甜等: "《女性身体私密书》", 30 September 2014, 湖南科学技术出版社 * |
| 崔树玉等: "胍类消毒剂及其研究进展", 《中国消毒学杂志》 * |
| 张一宾: "《工业防霉剂》", 28 February 2001, 中国物资出版社 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109395068A (en) * | 2018-11-26 | 2019-03-01 | 浙江舒是生物科技有限公司 | A kind of refractory wound Special sterilizing liquid |
| CN110179901A (en) * | 2019-06-26 | 2019-08-30 | 江志铭 | A kind of soft net conditioning liquid of schoolgirl and preparation method thereof |
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Application publication date: 20190312 |