CN109452654A - A kind of formula food and preparation method thereof for treating diabetes - Google Patents

A kind of formula food and preparation method thereof for treating diabetes Download PDF

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Publication number
CN109452654A
CN109452654A CN201811503382.4A CN201811503382A CN109452654A CN 109452654 A CN109452654 A CN 109452654A CN 201811503382 A CN201811503382 A CN 201811503382A CN 109452654 A CN109452654 A CN 109452654A
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parts
peptide
sea cucumber
formula food
oligopeptide
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郇玉芝
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Shandong Guo Htang Pharmaceutical Co Ltd
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Shandong Guo Htang Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to food technology fields, in particular a kind of formula food and preparation method thereof for treating diabetes, raw material including following parts by weight: 10-15 parts of wheat oligopeptide, 10-15 parts of maize oligopeptide, 8-12 parts of casein phosphopeptide, 4-6 parts of collagen peptide, 4-6 parts of small molecule sea cucumber peptide, 4-6 parts of Blackfungus polyhexose, spread out 4-6 parts of leaf polyose, 4-6 parts of Charantin, 4-6 parts of ginseng, 4-6 parts of Radix Astragali, 4-6 parts of Chinese yam rhizome, 4-6 parts of Semen Cuscutae, 4-6 parts of Poria cocos, 4-6 parts of the coptis, 4-6 parts of rhizoma polygonati, 4-6 parts of winter folium mori, the formula food and preparation method thereof of the treatment diabetes, pass through the wheat oligopeptide of addition, maize oligopeptide, the peptide matters such as casein phosphopeptide, it can reduce blood glucose and control blood-sugar content in normal level Position can supplement a large amount of nutritional ingredient by Chinese medicines such as the ginseng of addition, Radix Astragalis, by the plants food materials such as the Semen Cuscutae of addition and winter folium mori, convenient for promoting whole plant fiber, convenient for the absorption of medicinal material nutrition.

Description

A kind of formula food and preparation method thereof for treating diabetes
Technical field
The present invention relates to food technology field, specially a kind of formula food and preparation method thereof for treating diabetes.
Background technique
Diabetes are one group of metabolic diseases characterized by hyperglycemia.Hyperglycemia be then due to defect of insulin secretion or Its biological effect is impaired, or both have concurrently and cause.Long-standing hyperglycemia when diabetes, cause various tissues, especially eye, Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.
In clinic, drug is relied solely on to the quality of diabetes or food materials are built up one's health by taking tonic, but there is medicine in general Effect is weaker, and nutrient composition content is few and nutrition is difficult to the problem of absorbing.In consideration of it, it is proposed that a kind of formula for treating diabetes Food and preparation method thereof.
Summary of the invention
The purpose of the present invention is to provide a kind of formula foods and preparation method thereof for treating diabetes, to solve above-mentioned back The drug effect proposed in scape technology is weaker, and nutrient composition content is few and nutrition is difficult to the problem of absorbing.
To achieve the above object, on the one hand, the present invention provides a kind of formula food for treating diabetes, including following weight The raw material of number: 10-15 parts of wheat oligopeptide, 10-15 parts of maize oligopeptide, 8-12 parts of casein phosphopeptide, collagen peptide 4-6 parts, 4-6 parts of small molecule sea cucumber peptide, 4-6 parts of Blackfungus polyhexose, spread out 4-6 parts of leaf polyose, 4-6 parts of Charantin, ginseng 4-6 Part, 4-6 parts of Radix Astragali, 4-6 parts of Chinese yam rhizome, 4-6 parts of Semen Cuscutae, 4-6 parts of Poria cocos, 4-6 parts of the coptis, 4-6 parts of rhizoma polygonati, winter folium mori 4-6 Part.
Preferably, it is raw material that the wheat oligopeptide, which selects wheat gluten flour, sized mixing, protease hydrolyzed, separation, mistake It is made after filter, spray drying process.
Preferably, the maize oligopeptide using corn protein powder as raw material, is carried out pre- by continuous flow upstream ultrasonic technique Uranidin is extracted in processing, and the raw material handled well is digested using enzyme mebrane reactor, collects the peptide fragment of suitable molecular weight, passes through It is made after crossing concentration technology and the dry preparation of belt vacuum.
Preferably, the casein phosphoric acid uses proteolytic enzymes hydrolize bovine casein, pass through calcium-ethanol precipitation Casein phosphopeptide is extracted from hydrolysate with ion-exchange.
Preferably, the peptide of the collagen the preparation method is as follows:
(1), the ratio that fish-skin and water are 1: 6 in mass ratio is mixed, extracts 1-3 hours, is extracted at 92-98 DEG C Liquid, and pH is adjusted to 7;
(2) trypsase and enzyme live keeping agent being added in 48-72 DEG C of extracting solution and is hydrolyzed 1.5-4.5 hours, enzyme deactivation is living, Obtain enzymolysis liquid;
(3) enzymolysis liquid is subjected to deodorant, decoloration with active carbon, filtering obtains destainer;
It (4) is in mass ratio to be uniformly mixed obtain mixed liquor at 100: 0.5 with antioxidant by destainer;
(5) by mixed liquor ultrafiltration, freeze-drying.
Preferably, the small molecule sea cucumber peptide the preparation method is as follows:
(1) pretreatment of raw material: first cleaning up dried sea-cucumber, then puts into steeping tank, and the 22 of 5 times of dried sea-cucumber volume are added DEG C deionized water, impregnate 9 hours after, cleaned twice with deionized water, water and impurity exhausted;
(2) it extracts: the sea cucumber after cleaning being smashed into defibrination, 9 times of sea cucumber weight after being equivalent to cleaning of deionized water is added, 115 DEG C are then heated to, removal insoluble sludge is filtered after keeping the temperature 40min, obtains sea cucumber extract;
(3) it digests: alkali protease is added in above-mentioned sea cucumber extract and carries out first time enzymatic hydrolysis, the use of alkali protease Amount is the 1.0-1.5% of sea cucumber extract weight, and then keeping temperature is 45-55 DEG C, adjusts pH to 7.8-8.5, and pancreas egg is added White enzyme carries out second and digests, and the usage amount of trypsase is the 0.8-1.2% of sea cucumber extract weight, and finally holding temperature is 45-55 DEG C, pH to 3.0-4.0 is adjusted, pepsin is added and carries out third time enzymatic hydrolysis, the usage amount of pepsin is sea cucumber extraction The 0.8-1.2% of liquid is warming up to 92-98 DEG C of enzyme deactivation 10-15min, obtains enzymolysis liquid;
(4) it is concentrated: the enzymolysis liquid sea in step (2) is evaporated concentration through evaporator, temperature control when evaporation and concentration For system at 55 DEG C, the control of concentration pressure is concentrated into the concentrate that solid content is 25% in -0.4MPa;
(5) dry: the concentrate in step (3) to be spray-dried by drying tower, the inlet temperature of spray drying It is 180 DEG C, outlet temperature is 85 DEG C, after drying to obtain the final product.
On the other hand, it the present invention also provides a kind of preparation method of formula food for treating diabetes, is used to prepare above-mentioned The formula food of the treatment diabetes of any one, and the preparation method is as follows:
S1: choosing wheat oligopeptide, maize oligopeptide, casein phosphopeptide, collagen peptide and small molecule sea cucumber peptide, and Ultramicro-grinder is added in 5: 5: 4: 2: 2 ratio to refine 2-5 minutes, it is powdered less than 0.5mm to form particle diameter;
S2: by Blackfungus polyhexose, spreading out leaf polyose and Charantin, and powder described in step S1 is added in 1: 1: 1 ratio In shape, when addition, is blended into a small amount of clear water, and is sufficiently stirred by stirring rod, and mixing time was controlled at 5-10 minutes, is mixed Object is closed, it is spare;
S3: take ginseng, Radix Astragali, Chinese yam rhizome, the coptis and Poria cocos respectively clean dry after, be placed in kibbling mill and roughly grind 1 minute, The impurity filtered off again with filter bag filters rank≤5 μm, obtains medicinal powder;
S4: after taking the coptis, rhizoma polygonati and winter folium mori to clean and cutting, and refines 2 minutes by ultramicro-grinder, obtains granularity ≤ 10 μm, fruit seed magma solid content >=10wt% decoction;
S5: disinfection by ultraviolet light is carried out to the decoction in step S4,28-30 DEG C of sterilisation temp, operating pressure >=20MPA is purple Outside line intensity >=90 μ W/cm2, flow velocity≤500kg/h form sterile decoction;
S6: sterile decoction obtained in step S5 is placed in vacuum boiling processing environment, it is desirable that boiling temperature 55-60 DEG C, water content is no more than 93% after boiling concentration, and the ebuillition of heated time is 10 minutes, forms decoction concentrate;
S7: the mixture in step S2, the medicinal powder in step S3 and the decoction concentrate in step S6 are sufficiently stirred, Raw-food material is formed, and adaptability processing is carried out to it, obtains food.
Compared with prior art, beneficial effects of the present invention:
1, the formula food and preparation method thereof of the treatment diabetes, by the wheat oligopeptide of addition, maize oligopeptide, The peptide matters such as casein phosphopeptide can reduce blood glucose and by blood-sugar content control in normal horizontal position, reduce and the heart occur The risk factor of vascular diseases.
2, the formula food and preparation method thereof of the treatment diabetes can by Chinese medicines such as the ginseng of addition, Radix Astragalis A large amount of nutritional ingredient is supplemented, the nutrient content of food is promoted.
3, the formula food and preparation method thereof of the treatment diabetes is eaten by plants such as the Semen Cuscutae of addition and winter folium moris Material, convenient for promoting whole plant fiber, convenient for the absorption of medicinal material nutrition.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described, Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all Belong to the scope of protection of the invention.
Embodiment 1
On the one hand, the present invention provides a kind of formula food for treating diabetes, the raw material including following parts by weight: wheat 10 parts of oligopeptide, 10 parts of maize oligopeptide, 8 parts of casein phosphopeptide, 4 parts of collagen peptide, 4 parts of small molecule sea cucumber peptide, black wood 4 parts of fungus polysaccharides spread out 4 parts of leaf polyose, 4 parts of Charantin, 4 parts of ginseng, 4 parts of Radix Astragali, 4 parts of Chinese yam rhizome, 4 parts of Semen Cuscutae, Poria cocos 4 Part, 4 parts of the coptis, 4 parts of rhizoma polygonati, 4 parts of winter folium mori, it is raw material that wheat oligopeptide, which selects wheat gluten flour, is sized mixing, protease enzyme It is made after solution, separation, filtering, spray drying process, maize oligopeptide passes through continuous flow upstream ultrasound using corn protein powder as raw material Technology is pre-processed, and uranidin is extracted, and the raw material handled well is digested using enzyme mebrane reactor, collects suitable molecular weight Peptide fragment is made after concentration technology and the dry preparation of belt vacuum, and casein phosphoric acid uses proteolytic enzymes hydrolize cow's milk Casein extracts casein phosphopeptide by calcium-ethanol precipitation and ion-exchange from hydrolysate.
In the present embodiment, the peptide of collagen the preparation method is as follows:
(1), the ratio that fish-skin and water are 1: 6 in mass ratio is mixed, extracts 1-3 hours, is extracted at 92-98 DEG C Liquid, and pH is adjusted to 7;
(2) trypsase and enzyme live keeping agent being added in 48-72 DEG C of extracting solution and is hydrolyzed 1.5-4.5 hours, enzyme deactivation is living, Obtain enzymolysis liquid;
(3) enzymolysis liquid is subjected to deodorant, decoloration with active carbon, filtering obtains destainer;
It (4) is in mass ratio to be uniformly mixed obtain mixed liquor at 100: 0.5 with antioxidant by destainer;
(5) by mixed liquor ultrafiltration, freeze-drying.
Further, small molecule sea cucumber peptide the preparation method is as follows:
(1) pretreatment of raw material: first cleaning up dried sea-cucumber, then puts into steeping tank, and the 22 of 5 times of dried sea-cucumber volume are added DEG C deionized water, impregnate 9 hours after, cleaned twice with deionized water, water and impurity exhausted;
(2) it extracts: the sea cucumber after cleaning being smashed into defibrination, 9 times of sea cucumber weight after being equivalent to cleaning of deionized water is added, 115 DEG C are then heated to, removal insoluble sludge is filtered after keeping the temperature 40min, obtains sea cucumber extract;
(3) it digests: alkali protease is added in above-mentioned sea cucumber extract and carries out first time enzymatic hydrolysis, the use of alkali protease Amount is the 1.0-1.5% of sea cucumber extract weight, and then keeping temperature is 45-55 DEG C, adjusts pH to 7.8-8.5, and pancreas egg is added White enzyme carries out second and digests, and the usage amount of trypsase is the 0.8-1.2% of sea cucumber extract weight, and finally holding temperature is 45-55 DEG C, pH to 3.0-4.0 is adjusted, pepsin is added and carries out third time enzymatic hydrolysis, the usage amount of pepsin is sea cucumber extraction The 0.8-1.2% of liquid is warming up to 92-98 DEG C of enzyme deactivation 10-15min, obtains enzymolysis liquid;
(4) it is concentrated: the enzymolysis liquid sea in step (2) is evaporated concentration through evaporator, temperature control when evaporation and concentration For system at 55 DEG C, the control of concentration pressure is concentrated into the concentrate that solid content is 25% in -0.4MPa;
(5) dry: the concentrate in step (3) to be spray-dried by drying tower, the inlet temperature of spray drying It is 180 DEG C, outlet temperature is 85 DEG C, after drying to obtain the final product.
Further, the protease hydrolyzed of wheat oligopeptide is that microbial protease is selected from alkali protease, acidic protein One of enzyme and neutral proteinase are a variety of.
Embodiment 2
A kind of formula food for treating diabetes, the raw material including following parts by weight: 12 parts of wheat oligopeptide, corn are low 12 parts of poly- peptide, 5 parts of collagen peptide, 5 parts of small molecule sea cucumber peptide, 5 parts of Blackfungus polyhexose, spreads out leaf at 10 parts of casein phosphopeptide 5 parts of polysaccharide, 5 parts of Charantin, 5 parts of ginseng, 5 parts of Radix Astragali, 5 parts of Chinese yam rhizome, 5 parts of Semen Cuscutae, 5 parts of Poria cocos, 5 parts of the coptis, rhizoma polygonati 5 Part, 5 parts of winter folium mori, it is raw material that wheat oligopeptide, which selects wheat gluten flour, is sized mixing, protease hydrolyzed, separation, filtering, is sprayed It is made after drying process, maize oligopeptide is pre-processed by continuous flow upstream ultrasonic technique, mentioned using corn protein powder as raw material Extracting yellow element, the raw material handled well are digested using enzyme mebrane reactor, collect the peptide fragment of suitable molecular weight, by work is concentrated It is made after skill and the dry preparation of belt vacuum, casein phosphoric acid uses proteolytic enzymes hydrolize bovine casein, passes through calcium-ethyl alcohol The precipitation method and ion-exchange extract casein phosphopeptide from hydrolysate.
In the present embodiment, the concentration technology of maize oligopeptide is using heating condensing mode, in vacuum boiling processing environment, It is required that boiling temperature is 60-80 DEG C, water content is no more than 12% after boiling concentration, and the ebuillition of heated time is 20 minutes.
Further, the model that the dry preparation of belt vacuum is produced using Changzhou sage Wanda's drying equipment Co., Ltd The vacuum bag drying machine of ZLG, support circuit can also be provided by the producer, in addition to this, the present invention in be related to circuit and Electronic component and module are the prior art, and those skilled in the art may be implemented completely, are not necessarily to superfluous words, and the present invention protects The content of shield is not related to the improvement for software and method yet.
Embodiment 3
A kind of formula food for treating diabetes, the raw material including following parts by weight: 15 parts of wheat oligopeptide, corn are low 15 parts of poly- peptide, 6 parts of collagen peptide, 6 parts of small molecule sea cucumber peptide, 6 parts of Blackfungus polyhexose, spreads out leaf at 12 parts of casein phosphopeptide 6 parts of polysaccharide, 6 parts of Charantin, 6 parts of ginseng, 6 parts of Radix Astragali, 6 parts of Chinese yam rhizome, 6 parts of Semen Cuscutae, 6 parts of Poria cocos, 6 parts of the coptis, rhizoma polygonati 6 Part, 6 parts of winter folium mori, it is raw material that wheat oligopeptide, which selects wheat gluten flour, is sized mixing, protease hydrolyzed, separation, filtering, is sprayed It is made after drying process, maize oligopeptide is pre-processed by continuous flow upstream ultrasonic technique, mentioned using corn protein powder as raw material Extracting yellow element, the raw material handled well are digested using enzyme mebrane reactor, collect the peptide fragment of suitable molecular weight, by work is concentrated It is made after skill and the dry preparation of belt vacuum, casein phosphoric acid uses proteolytic enzymes hydrolize bovine casein, passes through calcium-ethyl alcohol The precipitation method and ion-exchange extract casein phosphopeptide from hydrolysate.
Comparative example 1
It is compared with embodiment 1, difference in this case is that, collagen peptide is substituted for albumen peptide former, as one kind Comparative example, a kind of formula food for treating diabetes, the raw material including following parts by weight: 15 parts of wheat oligopeptide, corn are low 15 parts of poly- peptide, 12 parts of casein phosphopeptide, 6 parts of albumen peptide former, 6 parts of small molecule sea cucumber peptide, 6 parts of Blackfungus polyhexose, to spread out leaf more Sugar 6 parts, 6 parts of Charantin, 6 parts of ginseng, 6 parts of Radix Astragali, 6 parts of Chinese yam rhizome, 6 parts of Semen Cuscutae, 6 parts of Poria cocos, 6 parts of the coptis, 6 parts of rhizoma polygonati, 6 parts of winter folium mori, it is raw material that wheat oligopeptide, which selects wheat gluten flour, is sized mixing, protease hydrolyzed, separation, filtering, spray drying It is made after process, maize oligopeptide is pre-processed using corn protein powder as raw material by continuous flow upstream ultrasonic technique, is extracted yellow Pigment, the raw material handled well are digested using enzyme mebrane reactor, and the peptide fragment of suitable molecular weight is collected, by concentration technology and It is made after the dry preparation of belt vacuum, casein phosphoric acid uses proteolytic enzymes hydrolize bovine casein, passes through calcium-ethanol precipitation Method and ion-exchange extract casein phosphopeptide from hydrolysate.
Comparative example 2
It is compared with embodiment 1, difference in this case is that, ginseng is substituted for American ginseng, it is a kind of as a kind of comparative example The formula food for treating diabetes, the raw material including following parts by weight: 15 parts of wheat oligopeptide, 15 parts of maize oligopeptide, junket 12 parts of protein phosphatase polypeptide, 6 parts of small molecule sea cucumber peptide, 6 parts of Blackfungus polyhexose, spreads out 6 parts of leaf polyose, balsam pear at 6 parts of collagen peptide Plain 6 parts, 6 parts of American ginseng, 6 parts of Radix Astragali, 6 parts of Chinese yam rhizome, 6 parts of Semen Cuscutae, 6 parts of Poria cocos, 6 parts of the coptis, 6 parts of rhizoma polygonati, 6 parts of winter folium mori, It is raw material that wheat oligopeptide, which selects wheat gluten flour, is sized mixing, protease hydrolyzed, separation, filtering, is made after spray drying process At maize oligopeptide is pre-processed using corn protein powder as raw material by continuous flow upstream ultrasonic technique, and uranidin, place are extracted The raw material managed is digested using enzyme mebrane reactor, collects the peptide fragment of suitable molecular weight, true by concentration technology and belt Be made after the dry preparation of sky, casein phosphoric acid uses proteolytic enzymes hydrolize bovine casein, by calcium-ethanol precipitation and from Sub- exchange process extracts casein phosphopeptide from hydrolysate.
Comparative example 3
It is compared with embodiment 1, difference in this case is that, winter folium mori is substituted for ginkgo biloba p.e, as one kind Comparative example, a kind of formula food for treating diabetes, the raw material including following parts by weight: 15 parts of wheat oligopeptide, corn are low 15 parts of poly- peptide, 6 parts of collagen peptide, 6 parts of small molecule sea cucumber peptide, 6 parts of Blackfungus polyhexose, spreads out leaf at 12 parts of casein phosphopeptide 6 parts of polysaccharide, 6 parts of Charantin, 6 parts of ginseng, 6 parts of Radix Astragali, 6 parts of Chinese yam rhizome, 6 parts of Semen Cuscutae, 6 parts of Poria cocos, 6 parts of the coptis, rhizoma polygonati 6 Part, 6 parts of ginkgo biloba p.e, it is raw material that wheat oligopeptide, which selects wheat gluten flour, is sized mixing, protease hydrolyzed, separation, mistake It is made after filter, spray drying process, maize oligopeptide is carried out pre- using corn protein powder as raw material by continuous flow upstream ultrasonic technique Uranidin is extracted in processing, and the raw material handled well is digested using enzyme mebrane reactor, collects the peptide fragment of suitable molecular weight, passes through It is made after crossing concentration technology and the dry preparation of belt vacuum, casein phosphoric acid uses proteolytic enzymes hydrolize bovine casein, leads to It crosses calcium-ethanol precipitation and ion-exchange extracts casein phosphopeptide from hydrolysate.
Sugar is treated according to made from above-described embodiment 1, embodiment 2, embodiment 3, comparative example 1, comparative example 2 and comparative example 3 Each performance parameter of formula food of urine disease makes following table:
Nutrient component meter
Fatty acid Linolenic acid Protein Vitamin Cellulose
Embodiment 1 Content is higher Content is high Content is high Content is higher Content is high
Embodiment 2 Content is high Content is higher Content is higher Content is high Content is high
Embodiment 3 Content is high Content is high Content is high Content is high Content is high
Comparative example 1 Content is medium Content is medium Content is relatively low Content is medium Content is medium
Comparative example 2 Content is medium Content is medium Content is relatively low Content is medium Content is low
Comparative example 3 Content bottom Content is medium Content is relatively low Content is medium Content is medium
Take effect table
It can be obtained according to above table data, the formula food for the treatment of diabetes produced by the invention is needed for diabetic Common product is above in the content of nutrient, while in taste impression, assimilation effect, stabilizing blood sugar effect, mitigation blood glucose effect It is superior to existing product in fruit and prevention complication effect, takes the formula food for sending the treatment diabetes of open-birth production elsewhere for a long time, Holistic health can be improved, improve the quality of life of patient, it is particularly possible to malnutrition caused by diabetes be effectively relieved Phenomenon.
On the other hand, it the present invention also provides a kind of preparation method of formula food for treating diabetes, is used to prepare above-mentioned The formula food of the treatment diabetes of any one, and the preparation method is as follows:
S1: choosing wheat oligopeptide, maize oligopeptide, casein phosphopeptide, collagen peptide and small molecule sea cucumber peptide, and Ultramicro-grinder is added in 5: 5: 4: 2: 2 ratio to refine 2-5 minutes, it is powdered less than 0.5mm to form particle diameter;
S2: by Blackfungus polyhexose, spreading out leaf polyose and Charantin, and the powdered interior of step S1 is added in 1: 1: 1 ratio, It is blended into a small amount of clear water when addition, and is sufficiently stirred by stirring rod, mixing time was controlled at 5-10 minutes, mixture is obtained, It is spare;
S3: take ginseng, Radix Astragali, Chinese yam rhizome, the coptis and Poria cocos respectively clean dry after, be placed in kibbling mill and roughly grind 1 minute, The impurity filtered off again with filter bag filters rank≤5 μm, obtains medicinal powder;
S4: after taking the coptis, rhizoma polygonati and winter folium mori to clean and cutting, and refines 2 minutes by ultramicro-grinder, obtains granularity ≤ 10 μm, fruit seed magma solid content >=10wt% decoction;
S5: disinfection by ultraviolet light is carried out to the decoction in step S4,28-30 DEG C of sterilisation temp, operating pressure >=20MPA is purple Outside line intensity >=90 μ W/cm2, flow velocity≤500kg/h form sterile decoction;
S6: sterile decoction obtained in step S5 is placed in vacuum boiling processing environment, it is desirable that boiling temperature 55-60 DEG C, water content is no more than 93% after boiling concentration, and the ebuillition of heated time is 10 minutes, forms decoction concentrate;
S7: the mixture in step S2, the medicinal powder in step S3 and the decoction concentrate in step S6 are sufficiently stirred, Form raw-food material.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry For personnel it should be appreciated that the present invention is not limited to the above embodiments, described in the above embodiment and specification is only the present invention Preference, be not intended to limit the invention, without departing from the spirit and scope of the present invention, the present invention also has various Changes and improvements, these changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by institute Attached claims and its equivalent thereof.

Claims (7)

1. a kind of formula food for treating diabetes, it is characterised in that: the raw material including following parts by weight: wheat oligopeptide 10-15 parts, 10-15 parts of maize oligopeptide, 8-12 parts of casein phosphopeptide, 4-6 parts of collagen peptide, small molecule sea cucumber peptide 4-6 Part, spreads out 4-6 parts of leaf polyose, 4-6 parts of Charantin, 4-6 parts of ginseng, 4-6 parts of Radix Astragali, Chinese yam rhizome 4-6 at 4-6 parts of Blackfungus polyhexose Part, 4-6 parts of Semen Cuscutae, 4-6 parts of Poria cocos, 4-6 parts of the coptis, 4-6 parts of rhizoma polygonati, 4-6 parts of winter folium mori.
2. the formula food for the treatment of diabetes according to claim 1, it is characterised in that: the wheat oligopeptide is selected small Wheat Gluten is raw material, is sized mixing, protease hydrolyzed, separation, filtering, is made after spray drying process.
3. the formula food for the treatment of diabetes according to claim 1, it is characterised in that: the maize oligopeptide is with corn Albumen powder is raw material, is pre-processed by continuous flow upstream ultrasonic technique, and uranidin is extracted, and the raw material handled well is anti-using enzyme membrane It answers device to be digested, collects the peptide fragment of suitable molecular weight, be made after concentration technology and the dry preparation of belt vacuum.
4. the formula food for the treatment of diabetes according to claim 1, it is characterised in that: the casein phosphoric acid uses egg White hydrolases bovine casein extracts casein phosphorus by calcium-ethanol precipitation and ion-exchange from hydrolysate Sour peptide.
5. the formula food for the treatment of diabetes according to claim 1, it is characterised in that: prepared by the peptide of the collagen Method is as follows:
(1), the ratio that fish-skin and water are 1: 6 in mass ratio is mixed, is extracted 1-3 hours at 92-98 DEG C, obtains extracting solution, And pH is adjusted to 7;
(2) trypsase and enzyme live keeping agent are added in 48-72 DEG C of extracting solution and are hydrolyzed 1.5-4.5 hours, enzyme deactivation is living, obtains Enzymolysis liquid;
(3) enzymolysis liquid is subjected to deodorant, decoloration with active carbon, filtering obtains destainer;
It (4) is in mass ratio to be uniformly mixed obtain mixed liquor at 100: 0.5 with antioxidant by destainer;
(5) by mixed liquor ultrafiltration, freeze-drying.
6. the formula food for the treatment of diabetes according to claim 1, it is characterised in that: the system of the small molecule sea cucumber peptide Preparation Method is as follows:
(1) pretreatment of raw material: first cleaning up dried sea-cucumber, then puts into steeping tank, and 22 DEG C of 5 times of dried sea-cucumber volume are added Deionized water is cleaned twice with deionized water after impregnating 9 hours, water and impurity is exhausted;
(2) it extracts: the sea cucumber after cleaning being smashed into defibrination, 9 times of sea cucumber weight after being equivalent to cleaning of deionized water is added, then 115 DEG C are warming up to, removal insoluble sludge is filtered after keeping the temperature 40min, obtains sea cucumber extract;
(3) it digests: alkali protease is added in above-mentioned sea cucumber extract and carries out first time enzymatic hydrolysis, the usage amount of alkali protease is The 1.0-1.5% of sea cucumber extract weight, then keeping temperature is 45-55 DEG C, adjusts pH to 7.8-8.5, and trypsase is added It carries out second to digest, the usage amount of trypsase is the 0.8-1.2% of sea cucumber extract weight, and finally keeping temperature is 45- 55 DEG C, pH to 3.0-4.0 is adjusted, pepsin is added and carries out third time enzymatic hydrolysis, the usage amount of pepsin is sea cucumber extract 0.8-1.2%, be warming up to 92-98 DEG C of enzyme deactivation 10-15min, obtain enzymolysis liquid;
(4) it is concentrated: the enzymolysis liquid sea in step (2) is evaporated concentration through evaporator, temperature when evaporation and concentration, which controls, to exist 55 DEG C, the control of concentration pressure is concentrated into the concentrate that solid content is 25% in -0.4MPa;
(5) dry: the concentrate in step (3) to be spray-dried by drying tower, the inlet temperature of spray drying is 180 DEG C, outlet temperature is 85 DEG C, after drying to obtain the final product.
7. a kind of preparation method for the formula food for treating diabetes, it is characterised in that: it is any one to be used to prepare claim 1-6 The formula food for the treatment of diabetes described in, and the preparation method is as follows:
S1: wheat oligopeptide, maize oligopeptide, casein phosphopeptide, collagen peptide and small molecule sea cucumber peptide are chosen, and presses 5: 5: 4: 2: 2 ratio is added ultramicro-grinder and refines 2-5 minutes, and it is powdered less than 0.5mm to form particle diameter;
S2: by Blackfungus polyhexose, spreading out leaf polyose and Charantin, powdered interior described in the ratio addition step S1 in 1: 1: 1, It is blended into a small amount of clear water when addition, and is sufficiently stirred by stirring rod, mixing time was controlled at 5-10 minutes, mixture is obtained, It is spare;
S3: take ginseng, Radix Astragali, Chinese yam rhizome, the coptis and Poria cocos respectively clean dry after, be placed in kibbling mill and roughly grind 1 minute, then use The impurity that filter bag filters off filters rank≤5 μm, obtains medicinal powder;
S4: after taking the coptis, rhizoma polygonati and winter folium mori to clean and cutting, and refines 2 minutes by ultramicro-grinder, obtains granularity≤10 μm, fruit seed magma solid content >=10wt% decoction;
S5: in step S4 decoction carry out disinfection by ultraviolet light, 28-30 DEG C of sterilisation temp, operating pressure >=20MPA, ultraviolet light Intensity >=90 μ W/cm2, flow velocity≤500kg/h form sterile decoction;
S6: sterile decoction obtained in step S5 being placed in vacuum boiling processing environment, it is desirable that boiling temperature is 55-60 DEG C, Water content is no more than 93% after boiling concentration, and the ebuillition of heated time is 10 minutes, forms decoction concentrate;
S7: the mixture in step S2, the medicinal powder in step S3 and the decoction concentrate in step S6 are sufficiently stirred, and are formed Raw-food material, and adaptability processing is carried out to it, obtain food.
CN201811503382.4A 2018-12-10 2018-12-10 A kind of formula food and preparation method thereof for treating diabetes Pending CN109452654A (en)

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CN108185441A (en) * 2018-01-17 2018-06-22 江苏优曦特斯生物制品有限公司 A kind of formula food for treating diabetes and preparation method thereof
CN108606156A (en) * 2018-03-28 2018-10-02 中国食品发酵工业研究院有限公司 A kind of wheat oligopeptide and its industrialized preparing process
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CN101948524A (en) * 2010-09-02 2011-01-19 天津大学 Multi-phosphopeptide-enriched casein hydrolyzate and preparation method thereof
CN103014108A (en) * 2012-12-08 2013-04-03 保龄宝生物股份有限公司 Preparation method of corn oligopeptide
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Application publication date: 20190312