CN109432323A - A kind of natto composite preparation and its application - Google Patents
A kind of natto composite preparation and its application Download PDFInfo
- Publication number
- CN109432323A CN109432323A CN201811603564.9A CN201811603564A CN109432323A CN 109432323 A CN109432323 A CN 109432323A CN 201811603564 A CN201811603564 A CN 201811603564A CN 109432323 A CN109432323 A CN 109432323A
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- natto
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Links
- 235000013557 nattō Nutrition 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims description 12
- 239000002131 composite material Substances 0.000 title claims description 3
- 239000000203 mixture Substances 0.000 claims abstract description 48
- 229940026314 red yeast rice Drugs 0.000 claims abstract description 25
- 244000197580 Poria cocos Species 0.000 claims abstract description 24
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 24
- 244000194101 Ginkgo biloba Species 0.000 claims abstract description 17
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 17
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 13
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 13
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 13
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 13
- 230000002537 thrombolytic effect Effects 0.000 claims abstract description 8
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 7
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 5
- 240000000171 Crataegus monogyna Species 0.000 claims abstract 3
- 239000000284 extract Substances 0.000 claims description 26
- 235000020717 hawthorn extract Nutrition 0.000 claims description 15
- 235000002723 Dioscorea alata Nutrition 0.000 claims description 11
- 235000005362 Dioscorea floribunda Nutrition 0.000 claims description 11
- 235000004868 Dioscorea macrostachya Nutrition 0.000 claims description 11
- 235000005361 Dioscorea nummularia Nutrition 0.000 claims description 11
- 235000005360 Dioscorea spiculiflora Nutrition 0.000 claims description 11
- 235000004879 dioscorea Nutrition 0.000 claims description 11
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 8
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 8
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 8
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 8
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 8
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 8
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 8
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 8
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 8
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 6
- 235000013305 food Nutrition 0.000 claims description 6
- 208000007536 Thrombosis Diseases 0.000 claims description 5
- 201000001320 Atherosclerosis Diseases 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 3
- 235000009508 confectionery Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 235000013402 health food Nutrition 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- 206010008092 Cerebral artery thrombosis Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 239000001962 taste-modifying agent Substances 0.000 claims 1
- 235000008440 Crataegus cuneata Nutrition 0.000 abstract 1
- 235000014283 Crataegus pinnatifida var major Nutrition 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 18
- 235000001188 Peltandra virginica Nutrition 0.000 description 13
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 108010007622 LDL Lipoproteins Proteins 0.000 description 9
- 102000007330 LDL Lipoproteins Human genes 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 235000012000 cholesterol Nutrition 0.000 description 8
- 208000024172 Cardiovascular disease Diseases 0.000 description 6
- 241001092040 Crataegus Species 0.000 description 6
- 208000032928 Dyslipidaemia Diseases 0.000 description 6
- 208000017170 Lipid metabolism disease Diseases 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 244000144993 groups of animals Species 0.000 description 4
- 230000003908 liver function Effects 0.000 description 4
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
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- 208000026106 cerebrovascular disease Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 235000007056 Dioscorea composita Nutrition 0.000 description 1
- 235000009723 Dioscorea convolvulacea Nutrition 0.000 description 1
- 108010010234 HDL Lipoproteins Proteins 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 235000006350 Ipomoea batatas var. batatas Nutrition 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 241001251949 Xanthium sibiricum Species 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 108010022197 lipoprotein cholesterol Proteins 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
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- 238000000034 method Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
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- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The present invention relates to a kind of application of natto composition and the composition in terms of Antilpemic and thrombolytic, it further includes ginkgo leaf that the composition, which includes natto, red yeast rice, Chinese yam, hawthorn and Poria cocos,.
Description
Technical field
The present invention relates to a kind of application of natto composition and the composition in terms of Antilpemic and thrombolytic, belong to food and medicine
Field.
Background technique
Various slow diseases domestic at present are high-incidence, based on country advocates precautions, slow sick, maintaining healthy product the wound of prevention and treatment be ground into for
The hot spot of research.The cardiovascular disease death rate persistently increases in nearly 20 years, has become the big killer of China human mortality service life first.I
State's Patients with Cardiovascular/Cerebrovascular Diseases dies of nearly 3,000,000 people of cardiovascular and cerebrovascular disease every year, it is total every year to account for China more than 2.7 hundred million people
The 51% of Death causes.And the different degrees of disability of patient 75% to survive, 40% weight are residual.
Atherosclerosis is the pathologic basis of cardiovascular disease, and generation, development mechanism are highly complex, and influence factor is many
It is more.Dyslipidemia has prominent position as atherosclerosis important risk factor in preventing and treating cardiovascular disease.Often at present
With lipid-regulation medicine easy damaged alimentary canal, liver, muscle etc., side effect is big, and thrombolysis, anticoagulant bleeding risk be big, therapeutic effect
It is limited and can only temporarily alleviate the symptoms, it is not able to satisfy the healthy demand of patient.It is natural without side-effects to be badly in need of exploitation, safety is mild,
It can effectively improve symptom and eliminate the product of inducement to solve the pain of patient.
Summary of the invention
The present invention is to provide a kind of composition for safeguarding health, and especially this composition is naturally without side-effects, safety
Mildly, it can effectively adjust blood lipid, reduce thrombus, inducement, prevention or treatment hyperlipidemia, blood are eliminated while being effectively improved symptom
Bolt, atherosclerosis, myocardial infarction or the medium disease of ischemic cerebral apoplexy.
Object of the present invention is to what is be achieved through the following technical solutions:
A kind of composition mainly includes following components in parts by weight: natto 1-30 parts by weight, red yeast rice 1-50 parts by weight, mountain
Medicine 1-50 parts by weight, hawthorn 1-50 parts by weight, Poria cocos 1-40 parts by weight.
Preferably, above-mentioned composition further includes ginkgo leaf 1-50 parts by weight.
Preferably, above-mentioned composition includes natto 5-28 parts by weight, red yeast rice 5-35 parts by weight, Chinese yam 5-40 parts by weight, mountain
Short, bristly hair or beard 5-40 parts by weight, Poria cocos 5-35 parts by weight.
Preferably, above-mentioned composition includes natto 5-28 parts by weight, red yeast rice 5-35 parts by weight, Chinese yam 5-40 parts by weight, mountain
Short, bristly hair or beard 5-40 parts by weight, Poria cocos 5-35 parts by weight, ginkgo leaf 5-25 parts by weight.
It is furthermore preferred that above-mentioned composition includes 25 parts by weight of natto, 35 parts by weight of red yeast rice, 30 parts by weight of Chinese yam, hawthorn 30
Parts by weight, 25 parts by weight of Poria cocos；Or 10 parts by weight of natto, 20 parts by weight of red yeast rice, 40 parts by weight of Chinese yam, 30 parts by weight of hawthorn, Fu
20 parts by weight of Siberian cocklebur, 20 parts by weight of ginkgo leaf；Or 10 parts by weight of natto, 20 parts by weight of red yeast rice, 40 parts by weight of Chinese yam, 40 weight of hawthorn
Part, 30 parts by weight of Poria cocos, 10 parts by weight of ginkgo leaf.
Preferably, the component that above-mentioned composition includes further includes respective extract.
Preferably, above-mentioned composition includes natto 5-28 parts by weight, red yeast rice 5-35 parts by weight, yam extract 5-40 weight
Part, haw thorn extract 5-40 parts by weight, tuckahoe extracts 5-35 parts by weight.
Preferably, above-mentioned composition includes natto 5-28 parts by weight, red yeast rice 5-35 parts by weight, yam extract 5-40 weight
Part, haw thorn extract 5-40 parts by weight, tuckahoe extracts 5-35 parts by weight, ginkgo biloba p.e 5-25 parts by weight.
It is furthermore preferred that above-mentioned composition include 25 parts by weight of natto, 35 parts by weight of red yeast rice, 30 parts by weight of yam extract,
30 parts by weight of haw thorn extract, 25 parts by weight of tuckahoe extracts；Or 10 parts by weight of natto, 20 parts by weight of red yeast rice, yam extract
40 parts by weight, 30 parts by weight of haw thorn extract, 20 parts by weight of tuckahoe extracts, 20 parts by weight of ginkgo biloba p.e；Or natto 10
Parts by weight, 20 parts by weight of red yeast rice, 40 parts by weight of yam extract, 40 parts by weight of haw thorn extract, 30 parts by weight of tuckahoe extracts,
10 parts by weight of ginkgo biloba p.e.
The present composition is crushed or is extracted by each component, screening (or not sieving), mixing, packaging etc. are conventional in proportion
Preparation method is made.
Preparation made of the present composition preferably comprise the various auxiliary materials of addition be made drug, special medicine purposes food,
Health food, functional food, food, candy, beverage etc..
Preparation made of the present composition preferably comprises addition auxiliary material and pulvis, granule, tablet, capsule, flexible glue is made
Capsule, oral solution or candy.
Auxiliary material used in preparation made of the present composition preferably includes filler, lubricant, stabilizer, disintegrating agent, mouth
The one or more of improving agent.
Auxiliary material used in preparation made of the present composition more preferably include microcrystalline cellulose, sodium carboxymethyl starch, starch,
One of magnesium stearate, silica, xylitol or more than one.
Compared with prior art, technical solution provided by the invention has the advantage that
Natto, red yeast rice, Chinese yam, hawthorn, Poria cocos are carried out compatibility by the present invention according to a certain percentage, are achieved unexpected
Synergistic effect.The present composition has specific compatibility relationship, and changing compatibility relationship then cannot achieve the significant effect of the prescription
Fruit.The present invention can obtain more preferably it has furthermore been found that ginkgo leaf and above-mentioned composition are carried out compatibility together according to a certain percentage
Antilpemic and thrombolytic effect.
The present composition confirms that the present composition has no any poison through acute toxicity test, feeding trial research in 30 days
Side effect.
Specific embodiment
Preparation example explanation: below with reference to embodiment, being described in further detail claim of the invention,
But any limitation of the invention is not constituted, anyone limited times done in the claims in the present invention protection scope is repaired
Change, still within the scope of the claims of the present invention.It should be noted that employed in technical solution provided by the invention
Raw material, outside non-specified otherwise, prepared by conventional means or by commercial channel purchase.
Embodiment 1
A kind of composition provided by the invention, the component including following weight number: natto 30g；Red yeast rice 50g；Hawthorn is extracted
Object 5g；Yam extract 5g；Tuckahoe extracts 5g.
Embodiment 2
A kind of composition provided by the invention, the component including following weight number: natto 5g；Red yeast rice 5g；Haw thorn extract
50g；Yam extract 50g；Tuckahoe extracts 30g.
Embodiment 3
A kind of composition provided by the invention, the component including following weight number: natto 25g；Red yeast rice 35g；Chinese yam is extracted
Object 30g；Haw thorn extract 30g；Tuckahoe extracts 25g.
Embodiment 4
A kind of composition provided by the invention, the component including following weight number: natto 25g；Red yeast rice 35g；Chinese yam is extracted
Object 30g；Haw thorn extract 30g；Tuckahoe extracts 25g；Ginkgo biloba p.e 5g.
Embodiment 5
A kind of composition provided by the invention, the component including following weight number: natto 10g, red yeast rice 20g, Chinese yam are extracted
Object 40g, haw thorn extract 30g, tuckahoe extracts 20g, ginkgo biloba p.e 20g.
Embodiment 6
A kind of composition provided by the invention, the component including following weight number: natto 10g, red yeast rice 20g, Chinese yam are extracted
Object 40g, haw thorn extract 40g, tuckahoe extracts 30g, ginkgo biloba p.e 10g.
Composition of the invention the preparation method comprises the following steps: after each component is weighed be uniformly mixed.
Embodiment explanation: the advantages of having in order to better illustrate the present invention, the composition provided by the invention is given below
The effect of test, but do not constitute any limitation of the invention.
One, Efficacy experiments comparative example
Comparative example 1
Natto 30g；Red yeast rice 50g.
Comparative example 2
Haw thorn extract 50g；Yam extract 50g；Tuckahoe extracts 30g.
Comparative example 3
Natto 30g；Red yeast rice 50g；Haw thorn extract 25g；Ginkgo biloba p.e 25g.
Comparative example 4
Haw thorn extract 50g；Yam extract 50g；Tuckahoe extracts 30g；Ginkgo biloba p.e 25g.
Comparative example 5
Certain commercially available oral preparation with Antilpemic and thrombolytic effect.
Two, Antilpemic and thrombolytic evaluation experimental
1, test sample: the composition of Example 1-6 and comparative example 1-4 preparation, addition cornstarch to 160g mix
Filling capsule after even, every 300mg.It is 3 times a day, 2 tablets each time that human body, which recommends dosage,.
2, Evaluation is tested
2.1 experimental methods: 130 SD rats are divided into 13 groups, respectively blank group, model group, embodiment 1-6 and comparison
Example 1-5 group, every group of 10 animals.In addition to blank control group is fed using normal diet, other groups of animals use high lipid food
It feeds.After 7 days, the medical fluid that corresponding 5 times of human bodies recommend dosage is given in stomach-filling respectively for embodiment 1-6 and comparative example 1-5 group animal, empty
White control group and model group give the distilled water of same volume.After 3 weeks after groups of animals chloral hydrate anesthesia, eye socket takes blood, from
The heart obtains serum.Measure total cholesterol, low-density lipoprotein white level.
2.2 experimental results: total cholesterol, low-density lipoprotein white level are as shown in table 1 after groups of animals administration.Model group with
Blank group compares, and model group rats total cholesterol and low-density lipoprotein white level significantly increase, and illustrates modeling success.Each experimental group
(P < 0.05) is decreased significantly compared with model group total cholesterol, low-density lipoprotein white level.It is the total cholesterol of embodiment 1-2, low
Density lipoprotein levels are compared with comparative example 1-5 significant difference (P < 0.05).The total cholesterol level of embodiment 3-6 is compared with embodiment
1-2 is lower and significant difference (P < 0.05), and low-density lipoprotein white level is high compared with blank group but there was no significant difference (P > 0.05).
Total cholesterol, low-density lipoprotein white level (n=10) after the administration of 1 groups of animals of table
2.3 discuss: above-mentioned the experimental results showed that there is composition representated by embodiment 1-2 significant reducing blood lipid outstanding to make
With, and its effect is considerably better than positive drug and other composition of prescription.Herein on basis, resulting embodiment 3- is advanced optimized
Composition representated by 6 achieves the more unexpected effect for improving dyslipidemia.Dyslipidemia is that the hearts such as thrombus occur
The pathologic basis of vascular diseases can effectively improve dyslipidemia, eliminates cardiovascular disease and inducement occurs, solve the pain of patient.
3, human experiment is tested
Mrs Liu, dyslipidemia and thrombus for many years, are voluntarily indicated to wish to foretaste, be foretasted using capsule made of embodiment 5
30 days laggard promoting circulation of blood rouge, liver function and color-Doppler ultrasound figure inspection, total cholesterol, triglycerides, low-density lipoprotein significantly reduce, high
Density lipoprotein increases, and blood lipid patch is obviously reduced, and liver function is without influence, during which feedback without any adverse reactions.
Mr. Ding, dyslipidemia and thrombus for many years, are voluntarily indicated to wish to foretaste, be foretasted using capsule made of embodiment 5
30 days laggard promoting circulation of blood rouge, liver function and color-Doppler ultrasound figure inspection, total cholesterol, triglycerides, low-density lipoprotein significantly reduce, blood
Rouge patch is obviously reduced, and liver function is without influence, during which feedback without any adverse reactions.
Above-mentioned experiment case study shows that this composition is naturally without side-effects, and safety is mild, can effectively adjust blood lipid, reduce blood
Bolt.
Claims (10)
1. a kind of natto composition, which is characterized in that mainly include following components in parts by weight: natto 1-30 parts by weight, red yeast rice
1-50 parts by weight, Chinese yam 1-50 parts by weight, hawthorn 1-50 parts by weight, Poria cocos 1-40 parts by weight.
2. composition as described in claim 1, which is characterized in that further include ginkgo leaf 1-50 parts by weight.
3. such as composition claimed in claims 1-2, which is characterized in that the component includes respective extract.
4. the composition as described in claim 1-3, which is characterized in that the composition includes 25 parts by weight of natto, red yeast rice 35
Parts by weight, 30 parts by weight of Chinese yam, 30 parts by weight of hawthorn, 25 parts by weight of Poria cocos；
Or 10 parts by weight of natto, 20 parts by weight of red yeast rice, 40 parts by weight of yam extract, 30 parts by weight of haw thorn extract, Poria cocos mention
Take 20 parts by weight of object, 20 parts by weight of ginkgo biloba p.e；
Or 10 parts by weight of natto, 20 parts by weight of red yeast rice, 40 parts by weight of yam extract, 40 parts by weight of haw thorn extract, Poria cocos mention
Take 30 parts by weight of object, 10 parts by weight of ginkgo biloba p.e.
5. the composition as described in claim 1-4, which is characterized in that the composition is in preparing Antilpemic and thrombolytic acting formulations
Application.
6. application as claimed in claim 5, which is characterized in that the Antilpemic and thrombolytic effect include prevent or treatment hyperlipidemia,
Thrombus, atherosclerosis, myocardial infarction or cerebral arterial thrombosis.
7. application as claimed in claim 5, which is characterized in that the composite preparation is matched comprising drug, special medicine purposes
Square food, health food or food.
8. application as claimed in claim 5, which is characterized in that pulvis, granule, piece is made in the composition addition auxiliary material
Agent, capsule, soft capsule, oral solution or candy.
9. application as claimed in claim 8, it is characterised in that the auxiliary material includes filler, lubricant, stabilizer, disintegration
Agent, taste modifying agent one or more.
10. application as claimed in claim 8, it is characterised in that the auxiliary material includes microcrystalline cellulose, sodium carboxymethyl starch, shallow lake
One of powder, magnesium stearate, silica, xylitol or more than one.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113180173A (en) * | 2021-05-08 | 2021-07-30 | 姚忠泽 | Novel solid beverage for reducing blood fat and preparation method thereof |
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