CN109431882A - 复方中药提取物在制备口腔护理保健品中的应用 - Google Patents
复方中药提取物在制备口腔护理保健品中的应用 Download PDFInfo
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- CN109431882A CN109431882A CN201811368661.4A CN201811368661A CN109431882A CN 109431882 A CN109431882 A CN 109431882A CN 201811368661 A CN201811368661 A CN 201811368661A CN 109431882 A CN109431882 A CN 109431882A
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Abstract
本发明公开了复方中药提取物在制备口腔护理保健品中的应用,涉及口腔护理技术领域,即在制备口腔护理品的工艺中将复方中药提取物作为抗炎、镇痛和止血作用的唯一活性成分加入口腔护理保健品中,所述复方中药提取物为金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物,所述金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物的质量比为1:1:1:1:20:10,与现有技术相比,本发明的口腔护理产品制备过程中加入了上述中药组合物作为活性成分的原料,不仅使用安全,而且同时具有明显的抗炎、镇痛和止血作用。
Description
技术领域
本发明涉及口腔护理技术领域,尤其是一种具有防治龋齿的口腔护理保健品。
背景技术
牙龈出血是口腔科常见症状之一,是指牙龈自发性的或由于轻微刺激引起的少量流血。轻者表现为仅在吮吸、刷牙、咀嚼较硬食物时唾液中带有血丝,重者在牙龈受到轻微刺激时即出血较多甚至自发性出血。一般而言,牙龈的慢性炎症是牙龈出血的常见原因,故牙龈出血多见于牙周炎和牙龈炎患者。目前市面上出售的止血类口腔护理保健品多是添加西药止血,刺激大,易耐药。对于牙龈出血问题,也有很多添加了中草药的口腔护理保健品,副作用小,不产生依赖,可以直接作用于患处,但止血效果并不是很理想。
牙痛,是口腔科牙齿疾病最常见的症状之一,其表现为牙龈红肿、遇冷热刺激痛、面颊部肿胀等。牙痛大多由牙龈炎、牙周炎、蛀牙或折裂牙而导致牙髓(牙神经)感染所引起的。牙痛属于牙齿毛病的外在反应,有可能是龋齿、牙髓或犬齿周围的牙龈被感染,前臼齿出现裂痕也会引起牙痛,有时候仅是菜屑卡在牙缝而引起不适。很多人常用甲硝唑、芬必得西药等止疼,这类西药治标不治本,而且长期使用有副作用。
牙龈是牙周组织如牙龈、牙周膜、牙槽骨、牙骨质之一,直接暴露于口腔中,直视可见,它是由角化上皮和结缔组织组成,覆盖着牙槽骨和牙根。牙龈病是局限于牙龈组织的病变,其中最为常见的是慢性龈缘炎,又称边缘性龈炎、单纯性龈炎,属于“仅与牙菌斑有关的牙龈炎”,是菌斑性牙龈炎中最常见的疾病。3~5岁的儿童即可发生,患病率和严重程度随年龄增长而逐步增加。治疗方法用洁治术清除牙石,控制菌斑,牙龈内炎症较重时可配合局部用药:1%的过氧化氢溶液和0.12%~0.2%氯己定以及碘制剂。西药治疗对牙龈刺激性较大,长期使用易产生耐药性。
中草药由于毒性低、副作用少、取材方便等特点,受到人们的普遍认可。研究发现,有的中草药提取物可抑制致龋菌,用于龋齿的防治;有的中草药提取物具有很好的镇痛效果,有的中草药提取物具有很好止血效果,但是有些口腔护理品中的有效成分配比并不合适,起到的实际功效十分有限,并不能真正改善口腔问题。
发明内容
本发明解决的问题是提供复方中药提取物在制备口腔护理保健品中的应用方案,这种口腔护理保健品具有明显的抗炎、镇痛和止血作用。
本发明的复方中药提取物在制备口腔护理保健品中的应用方案就是在制备口腔护理保健品的工艺中将复方中药提取物作为抗炎、镇痛和止血作用的唯一活性成分加入口腔护理保健品中,所述复方中药提取物为金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物,所述金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物的质量比为1:1:1:1:20:10。
上述技术方案中,更具体的方案还可以是:所述复方中药提取物在制备牙膏工艺中作为抗炎、镇痛和止血作用的唯一活性成分,所述复方中药提取物在牙膏的总膏体中的重量百分比为3%-7%。
上述方案中,所述复方中药提取物在制备漱口水工艺中作为抗炎、镇痛和止血作用的唯一活性成分,所述复方中药提取物在漱口水工艺中的重量百分比为4%~10%。
上述方案中,所述复方中药提取物在制备牙粉工艺中作为抗炎、镇痛和止血作用的唯一活性成分,所述复方中药提取物在牙粉工艺中的重量百分比为4%~10%。
上述方案中,所述复方中药提取物在制备口香糖工艺中作为抗炎、镇痛和止血作用的唯一活性成分,所述复方中药提取物在口香糖工艺中的重量百分比为4%~10%。
上述方案中,所述复方中药提取物在制备润喉片工艺中作为抗炎、镇痛和止血作用的唯一活性成分,所述复方中药提取物在润喉片工艺中的重量百分比为4%~10%。
本发明所述的金花茶,属于山茶科山茶属,与茶、山茶、南山茶、油茶、茶梅等为孪生姐妹。《药用植物辞典》记载:广西特有药用植物。叶:清热生津、止痢。花:用于便血、月经过多。
本发明所述的罗汉果,为萌芦科植物罗汉果Siraitia grosvenorii (Swingle)C.Jeffrey ex A. M. Lu etZ.Y.Zhang的干燥果实。性味甘,凉。归肺、大肠经。主要功能是清热润肺,利咽开音,滑肠通便。
本发明所述的银杏叶,为银杏科植物银杏Ginkgo biloba L .的干燥叶。性味甘、苦、淫,平。归心、肺经。活血化瘀,通络止痛,敛肺平喘,化浊降脂。用于瘀血阻络,胸痹心痛,中风偏瘫,肺虚咳喘,高脂血症。
本发明所述的玉竹,本品为百合科植物玉竹Polygonatum odoratum (MilL )Druce的干燥根茎。性味甘,微寒。归肺、胃经。养阴润燥,生津止渴。用于肺胃阴伤,燥热咳嗽,咽干口渴,内热消渴。
本发明所述的板蓝根,为十字花科植物蒋蓝Isatis indigotica Fort.的干燥根。性味苦,寒。归心、胃经。清热解毒,凉血利咽。用于温疫时毒,发热咽痛,温毒发斑,痄腮,烂喉丹痧,大头瘟疫,丹毒,痈肿。
本发明所述的甘草,本品为豆科植物甘草Glycyrrhiza uralensis Fisch.、 胀果甘草 G lycyrrhiza inflata Bat.或光果甘草Glycyrrhizaglabra L.的干燥根和根茎。性味甘,平。归心、肺、脾、胃经。补脾益气,淸热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
本发明中药的提取方法为:将金花茶、罗汉果、玉竹、银杏叶、板蓝根和甘草按质量比为1:1:1:1:20:10的比例切碎,用4倍量的乙醇加热回流提取3小时,每批药材提取3次,然后将3次提取液合并减压浓缩成生药:提取物=1:1的提取液。
上述中药的提取方法并不局限于上述方法,也可采用其他方法进行提取,如超临界萃取、超声波萃取等。
本发明的口腔护理产品制备过程中加入了上述中药组合物作为活性成分的原料,不仅使用安全,而且具有明显的抗炎、镇痛和止血作用。
具体实施方式
下面结合实施例,对本发明做进一步说明,下列各实施例中,所涉及的百分比除非另有说明,均是以重量百分比计算。
实施例1至实施例5中的牙膏组成原料及重量百分比含量如表1:
下列各实施例中,中药抗炎、镇痛和止血作用活性成分中,各中药提取物为金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物,实施例1~3中,各中药提取物的比例按上述顺序为:1:1:1:1:20:10;实施例4中,各中药提取物的比例按上述顺序为:0:1:1:1:20:10;实施例5中,各中药提取物的比例按上述顺序为:1:1:1:0:0:10;
实施例1中牙膏的制备方法:
牙膏膏体可采用常规药物牙膏的一步法制膏生产工艺制成:在暂存缸中投入计量好的纯净水、山梨醇、复方中药提取物等液料;在预分散釜中投入计量好的方解石粉、糖精钠、羧基纤维素钠、十二烷基硫酸钠、尼泊金混酯钠等粉料,进行预分散、混合;开制膏釜真空泵吸入上述液料;然后开刮刀,进上述粉料,开搅拌器和胶体磨, 50分钟后投入香精,10分钟后依次关闭胶体磨、搅拌器、刮刀,破真空,停真空泵,取样检测合格后制成。
实施例6至实施例10的漱口水组成原料及重量百分比含量如表2:
下列各实施例中,中药抗炎、镇痛和止血作用活性成分中,各中药提取物为金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物,实施例6~8中,各中药提取物的比例按上述顺序为:1:1:1:1:20:10;实施例9中,各中药提取物的比例按上述顺序为:0:1:1:1:20:10;实施例10中,各中药提取物的比例按上述顺序为:1:1:1:0:0:10;
实施例6中漱口水的制备方法:
先将一种抗炎复方中药提取物、尼泊金混合酯钠加入食用乙醇中搅拌溶解放在暂存锅中,将山梨醇、去离子、氢化蓖麻油-40加入搅拌锅中搅拌10分钟,将暂存锅中的乙醇溶液加入搅拌锅中搅拌10分钟,最后加入香精搅拌5分钟,停止搅拌,取样检测合格后制成。
实施例7至实施例10的生产工艺参照实施例6。
实施例11至实施例15的牙粉组成原料及重量百分比含量如表3:
下列各实施例中,中药抗炎、镇痛和止血作用活性成分中,各中药提取物为金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物,实施例11~13中,各中药提取物的比例按上述顺序为:1:1:1:1:20:10;实施例14中,各中药提取物的比例按上述顺序为:0:1:1:1:20:10;实施例15中,各中药提取物的比例按上述顺序为:1:1:1:0:0:10;
实施例11、12和15中牙粉的制备方法:
将天然碳酸钙、羧甲基纤维素钠、十二烷基硫酸钠、糖精钠按配方用量称好后加入混合搅拌器中搅拌20分钟后加入一种抗炎复方中药提取物搅拌10分钟,最后加入香精、山梨醇搅拌20分钟后停机,取样检测合格后制成。
实施例13和14中牙粉的制备方法:
将二水合磷酸氢钙、二氧化硅、羧甲基纤维素钠、糖精钠、十二烷基硫酸钠、尼泊金混合酯钠按配方用量称好后加入混合搅拌器中搅拌20分钟后,加入一种抗炎复方中药提取物搅拌10分钟,最后加入香精、山梨醇搅拌20分钟后停机,取样检测合格后制成。
实施例16至实施例20的润喉片组成原料及重量百分比含量如表4:
下列各实施例中,中药抗炎、镇痛和止血作用活性成分中,各中药提取物为金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物,实施例16~18中,各中药提取物的比例按上述顺序为:1:1:1:1:20:10;实施例19中,各中药提取物的比例按上述顺序为:0:1:1:1:20:10;实施例20中,各中药提取物的比例按上述顺序为:1:1:1:0:0:10;
实施例16至实施例20的制备工艺采用现有润喉片生产工艺。
实施例21至实施例25的口香糖组成原料及重量百分比含量如表5:
下列各实施例中,中药抗炎、镇痛和止血作用活性成分中,各中药提取物为金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物,实施例21~23中,各中药提取物的比例按上述顺序为:1:1:1:1:20:10;实施例24中,各中药提取物的比例按上述顺序为:0:1:1:1:20:10;实施例25中,各中药提取物的比例按上述顺序为:1:1:1:0:0:10;
实施例21至实施例25的制备工艺采用现有口香糖生产工艺。
药效试验部分
1、抗炎药理学实验
采用对二甲苯致小白鼠耳廓急性炎症肿胀抗炎模型,以本发明实施例1-5的牙膏样品和实施例11-15的牙粉样品,进行抗炎作用的药理实验:选取体重18-22g健康昆明种♂小白鼠140只,随机分成14组,每组10只。牙膏空白基质组、牙粉空白基质组、只用生理盐的水空白对照、阳性药醋酸氟轻松乳膏,实施例1-5制得的牙膏样品和实施例11-15制得的牙粉样品。实验时各组每只动物右耳廓内外两面均匀涂抹二甲苯0.1ml/只致炎,左耳不加处理作自身空白对照。涂抹二甲苯30min后,各组每只动物右耳廓内外两面分别均匀涂抹各组受试物样品0.1g/只。给予受试物1h后,小白鼠颈椎脱臼处死,剪下两耳廓,用生理盐水洗去右耳廓受试物样品,干棉球擦净,重叠两耳廓,用内径8mm的打孔器在同一部位凿取两圆耳片,分别在FA1004型电子分析天平称重,右耳片重量减去左耳片重量为肿胀值,数据记录并进行统计学t检验,结果见表6。
表6 实施例样品对二甲苯致小白鼠耳廓急性炎症肿胀抗炎症肿胀的影响(±S,n=10)
注:与空白对照组比较:#P<0.005,##P<0.01,###P<0.001,▲,P>0.05。
与牙膏/石粉空白基质组比较:*P<0.05,**P<0.001,***P<0.001。
实验结果表明,实施例1-3牙膏样品组、实施例11-13牙粉样品组和醋酸氟轻松乳膏组均能使小白鼠急性炎症肿胀耳廓重量明显减轻,明显抑制二甲苯致小白鼠耳廓急性炎症肿胀,随着复方中药提取物的比例加大,抗炎作用越明显;表明含有六种中药提取物的实施例对急性炎症具有明显的抗炎作用。实施例4、实施例5和实施例14、实施例15在取用相同百分比的复方中药提取物,但每种中药提取物均少了其中的一二味中药提取物,抗炎作用并不明显。
2、镇痛药理学实验
采用本发明的牙膏样品和牙粉样品对小白鼠的镇痛作用(热板法);选取体重18~22g健康昆明种♀小白鼠,用GJ—8402型热板测痛仪,调节控制温度在55±0.5℃,将小白鼠放在热板上测定每鼠的痛阈值(小白鼠接触热板至舔后足的时间),凡舔后足时间小于5秒或大于30秒及跳跃者弃之不用,挑选合格小白鼠140只,随机均分14组,每组10只。空白对照组、牙膏空白基质组、牙粉空白基质组、阳性药双氯芬酸二乙胺乳胶剂组、实施例1-5制得的牙膏样品组和实施例11-15制得的牙粉样品组。各组小白鼠按同法重复2次测定小白鼠的正常痛阈值,每次间隔15min,取两次正常痛阈值平均值,做为该组小白鼠给药前的痛阈值。分别于各组动物每鼠4个足跖涂予相应受试物0.2g/只,空白对照组涂予生理盐水0.2ml/只,涂予受试物后15min、30min、45min按同法分别测定小白鼠的痛阈值,如小白鼠60秒(S)仍无反应,将小白鼠取出,以免烫伤,其痛阈值以60秒(s)计算,记录各组小白鼠痛阈值,数据进行统计学t检验,结果见表7。
表7 实施例样品对小白鼠的镇痛作用(热板法)(±S,n=10)
注:与给药前比较: *P<0.05, **P<0.01, △P>0.05;
与空白对照组比较: #P<0.05, ##P<0.01, ▲P>0.05;
与牙膏/石粉空白基质组比较:b P<0.05
实验结果表明:实施例1-3牙膏样品组、实施例11-13牙粉样品组和双氯芬酸二乙胺乳胶剂组与给药前及空白对照组比较,均能显著提高小白鼠痛阈值;实施例1-3的牙膏样品组与牙膏空白基质组比较,能显著提高小白鼠痛阈值;实施例11-13的牙粉样品组与牙粉空白基质组比较,能显著提高小白鼠痛阈值,表明含有六种合适比例的中药提取能的牙膏样品组和牙粉样品组具有明显的镇痛作用。实施例4-5的牙膏样品组与牙膏空白基质组比较,对小白鼠痛阈值的提高并不显著;实施例11-13的牙粉样品组与牙粉空白基质组比较,对小白鼠痛阈值的提高并不显著,表明复方中药提取物少了其中的一二味中药提取物,镇痛作用不明显。
3、止血药理学试验
采用兔肝脏局部创面损伤出血模型,采用本发明的实施例3牙膏样品、实施例5牙膏样品和实施例12牙粉样品、实施例14牙粉样品,进行止血作用的药理实验:取健康白色家兔20只,体重2.0~2.5kg,雌雄兼用。用3%戊巴比妥钠30mg/kg耳缘静脉缓慢注入,家兔麻醉后,仰卧固定于手术台上,腹部正中切口长约6~8cm,暴露并固定肝脏,用手术剪在肝左叶切去肝脏组织长约1cm,宽约1cm,高约1cm,创面呈喷射样出血。擦去喷出的血后,立即在创面局部敷涂待试物样品1g,纱布复盖,以200g砝码压迫1min,1min后移去砝码,观察止血效果,以不出血为止血,如仍出血,则加敷涂待试物样品后继续加压,每隔30s观察一次,记录止血时间,如超过3min仍然出血,则记为未能止血,止血时间记为>3min。每次样品测试后,用37℃生理盐水洗去残留受试物,使创面重新出血,再测试下一受试物样品。每只兔子进行四次肝脏局部创面损伤止血测试实验,各受试物样品按拉丁方程序敷药,以减少肝脏局部创面损伤切口差异和用药顺序的影响。每个受试物样品总计进行20次兔肝脏局部创面损伤出血的止血实验。止血效果按倒数计分法(10/T)记为分值F,3min以上未能止血,F无分值记为0。记录并进行统计学t检验,结果见表8。
表8 样品对兔肝脏局部创面损伤出血的止血效果(±S)
注:与淀粉组比较:### P<0.001, ▲ P>0.05。
与牙膏空白基质组比较:*** P<0.001。
实验结果表明,实施例3牙膏样品组、实施例12牙粉样品组和云南白药组均对兔肝脏局部创面损伤出血有明显的止血效果,具有明显的止血作用。表明含有六种合适比例的中药提取能的牙膏样品组和牙粉样品组具有明显的止血作用。实施例5牙膏样品组和实施例14牙粉样品组对兔肝脏局部创面损伤出血的止血效果优于空白基质组,但低于实施例3牙膏样品组、实施例12牙粉样品组的止血效果。
Claims (6)
1.复方中药提取物在制备口腔护理保健品中的应用,即在制备口腔护理品的工艺中将复方中药提取物作为抗炎、镇痛和止血作用的唯一活性成分加入口腔护理保健品中,所述复方中药提取物为金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物,所述金花茶提取物、罗汉果提取物、银杏叶提取物、玉竹提取物、板蓝根提取物和甘草提取物的质量比为1:1:1:1:20:10。
2.根据权利要求1所述的复方中药提取物在制备口腔护理保健品中的应用,其特征在于:所述复方中药提取物在制备牙膏工艺中作为抗炎、镇痛和止血作用的唯一活性成分,所述复方中药提取物在牙膏的总膏体中的重量百分比为3%-7%。
3.根据权利要求1所述的复方中药提取物在制备口腔护理保健品中的应用,其特征在于:所述复方中药提取物在制备漱口水工艺中作为抗炎、镇痛和止血作用的唯一活性成分,所述复方中药提取物在漱口水工艺中的重量百分比为4%~10%。
4.根据权利要求1所述的复方中药提取物在制备口腔护理保健品中的应用,其特征在于:所述复方中药提取物在制备牙粉工艺中作为抗炎、镇痛和止血作用的唯一活性成分,所述复方中药提取物在牙粉工艺中的重量百分比为4%~10%。
5.根据权利要求1所述的复方中药提取物在制备口腔护理保健品中的应用,其特征在于:所述复方中药提取物在制备口香糖工艺中作为抗炎、镇痛和止血作用的唯一活性成分,所述复方中药提取物在口香糖工艺中的重量百分比为4%~10%。
6.根据权利要求1所述的复方中药提取物在制备口腔护理保健品中的应用,其特征在于:所述复方中药提取物在制备润喉片工艺中作为抗炎、镇痛和止血作用的唯一活性成分,所述复方中药提取物在润喉片工艺中的重量百分比为4%~10%。
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