CN109430758A - A kind of oral solution and preparation method thereof with auxiliary hyperglycemic function - Google Patents
A kind of oral solution and preparation method thereof with auxiliary hyperglycemic function Download PDFInfo
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- CN109430758A CN109430758A CN201811037811.3A CN201811037811A CN109430758A CN 109430758 A CN109430758 A CN 109430758A CN 201811037811 A CN201811037811 A CN 201811037811A CN 109430758 A CN109430758 A CN 109430758A
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- juice
- oral solution
- purple
- auxiliary hyperglycemic
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- 229940100688 oral solution Drugs 0.000 title claims abstract description 25
- 230000003345 hyperglycaemic effect Effects 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 14
- 238000000855 fermentation Methods 0.000 claims abstract description 13
- 230000004151 fermentation Effects 0.000 claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 13
- 244000276331 Citrus maxima Species 0.000 claims abstract description 12
- 235000001759 Citrus maxima Nutrition 0.000 claims abstract description 12
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 claims abstract description 12
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims abstract description 11
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 10
- 235000008078 Arctium minus Nutrition 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 229940026314 red yeast rice Drugs 0.000 claims abstract description 10
- 244000113306 Monascus purpureus Species 0.000 claims abstract description 9
- 235000002322 Monascus purpureus Nutrition 0.000 claims abstract description 9
- 229940057059 monascus purpureus Drugs 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 239000006071 cream Substances 0.000 claims abstract description 7
- 235000015201 grapefruit juice Nutrition 0.000 claims abstract description 7
- 235000016709 nutrition Nutrition 0.000 claims abstract description 7
- 230000035764 nutrition Effects 0.000 claims abstract description 7
- 239000002002 slurry Substances 0.000 claims abstract description 7
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 4
- 244000068988 Glycine max Species 0.000 claims abstract description 4
- 239000000084 colloidal system Substances 0.000 claims abstract description 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 3
- 240000005528 Arctium lappa Species 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000015097 nutrients Nutrition 0.000 claims 1
- 230000035622 drinking Effects 0.000 abstract description 3
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- 244000166550 Strophanthus gratus Species 0.000 abstract description 2
- 235000009508 confectionery Nutrition 0.000 abstract description 2
- 235000013402 health food Nutrition 0.000 abstract description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 17
- 239000008103 glucose Substances 0.000 description 16
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 229940127003 anti-diabetic drug Drugs 0.000 description 8
- 239000003472 antidiabetic agent Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 241000208843 Arctium Species 0.000 description 7
- 230000002218 hypoglycaemic effect Effects 0.000 description 7
- 235000021152 breakfast Nutrition 0.000 description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 4
- 230000000291 postprandial effect Effects 0.000 description 4
- BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229960000346 gliclazide Drugs 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 229960004329 metformin hydrochloride Drugs 0.000 description 3
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 3
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- 230000002641 glycemic effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000007939 sustained release tablet Substances 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- QWCKQJZIFLGMSD-UHFFFAOYSA-N 2-Aminobutanoic acid Natural products CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000017925 CHRM3 Human genes 0.000 description 1
- 101150060249 CHRM3 gene Proteins 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- QWCKQJZIFLGMSD-GSVOUGTGSA-N D-alpha-aminobutyric acid Chemical compound CC[C@@H](N)C(O)=O QWCKQJZIFLGMSD-GSVOUGTGSA-N 0.000 description 1
- 102000051325 Glucagon Human genes 0.000 description 1
- 108060003199 Glucagon Proteins 0.000 description 1
- 102100024295 Maltase-glucoamylase Human genes 0.000 description 1
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000002164 acetylcholinergic effect Effects 0.000 description 1
- 108010028144 alpha-Glucosidases Proteins 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 241000385540 bacterium 10 Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 102000006995 beta-Glucosidase Human genes 0.000 description 1
- 108010047754 beta-Glucosidase Proteins 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- YLRFCQOZQXIBAB-RBZZARIASA-N fluoxymesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)C[C@@H]2O YLRFCQOZQXIBAB-RBZZARIASA-N 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
- 229960004666 glucagon Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 235000020795 whole food diet Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of oral solution and preparation method thereof with auxiliary hyperglycemic function, belongs to health food processing technique field.Weigh the burdock powder of certain mass, clear water is added to stir evenly, obtain fructus arctii cream within sterilizing 10-15 minutes, shaddock is removed the peel, it squeezes the juice to obtain grapefruit juice, fructus arctii cream and grapefruit juice are uniformly mixed to obtain mixed juice, the soy bean hydrolyzed protein powder in mixed juice, it stirs evenly, pH is adjusted to 6.8-7.0, it sterilizes 10 minutes under the conditions of 90-95 DEG C, cool to 32-35 DEG C, purple red yeast rice strain is accessed from inclined-plane, obtain purple Monas cuspurpureus Went fermentation liquid within culture 4-5 days, purple Monas cuspurpureus Went fermentation liquid obtains nutrition slurries through mycelium colloid mill defibrination, nutrition slurries are using filter, allotment, concentration, it is filling, sealing, sterilizing is got product.Oral solution of the invention is not only in good taste, the smell of fruits is very sweet, safe for drinking, but also has the function of auxiliary hyperglycemic.
Description
Technical field
The invention discloses a kind of oral solution and preparation method thereof with auxiliary hyperglycemic function, belongs to health food and adds
Work technical field.
Background technique
In recent years, with the improvement of social and economic condition, the continuous improvement of living standards of the people, the change of dietary structure,
The attenuating of labor intensity, crowd's average life span extend, and stress situation increases and the improvement of diabetes detection means, with the world
Various countries are the same, and China's diabetes prevalence is being gradually increasing, and influence of the diabetes to the health of our people is on the rise, according in
The data that magnificent medical association's diabetology branch announces shows that there are about 1.18 hundred million diabetics now in China, accounts for about global trouble
The 27% of person, it has also become the treatment of the most country of diabetic in the world, diabetes and its complication has been given with nursing
Country causes very big economy and society to bear, and obtained diabetes and needs lifelong medication treatment, but most hypoglycemic medicines
More or less side effect will be generated, to human body in order to farthest reduce the side effect of hypoglycemic medicine, diabetic
Other than selecting to be suitble to the hypoglycemic medicine of oneself, matched should also have effects that the wholefood of auxiliary hyperglycemic,
Preferable auxiliary hyperglycemic effect not only can be obtained, the dosage of antidiabetic drug can also be reduced, reduces antidiabetic drug to body
The side effect of bring.So the hypoglycemic product of edible safety is processed into using natural edible raw material in recent years into ability
The hot spot of domain researcher research.
Summary of the invention
The object of the present invention is to provide it is a kind of it is in good taste, the smell of fruits is very sweet, safe for drinking with auxiliary hyperglycemic function
Oral solution and preparation method thereof.
The object of the present invention is achieved like this:
The burdock powder of certain mass is weighed, the clear water of 8-10 times of burdock powder quality is added, stirs evenly, goes out under the conditions of 121 DEG C
Bacterium 10-15 minutes fructus arctii cream, by shaddock peeling, grapefruit juice of squeezing the juice to obtain, according to mass ratio 2:1 ratio by fructus arctii cream and shaddock
Juice is uniformly mixed to obtain mixed juice.
1% soy bean hydrolyzed protein powder is added in mixed juice, stirs evenly, pH is adjusted to 6.8-7.0, at 90-95 DEG C
Under the conditions of sterilize 10 minutes, cool to 32-35 DEG C, from inclined-plane access purple red yeast rice strain, in 32-35 DEG C, 160-200rpm
Under conditions of shaking table culture 4-5 days purple Monas cuspurpureus Went fermentation liquid, purple Monas cuspurpureus Went fermentation liquid obtains nutrition through mycelium colloid mill defibrination
Slurries, nutrition slurries are got product using filter, allotment, concentration, filling, sealing, sterilizing.
Oral solution beneficial effect of the invention includes the following aspects:
First, the raw material of oral solution of the invention have passed through the fermentation of purple red yeast rice, contain inhibition carbon in Monas cuspurpureus Went fermentation liquid
The substance that hydrate absorbs has significant blood sugar decreasing effect, in addition, the metabolite of purple red yeast rice can also pass through increase
The acetylcholine release of nerve endings carrys out the muscarine M3 receptor (a kind of acetylcholinergic receptor) in stimulating pancreas cell, to increase
Add the release of insulin and reduces the concentration of blood glucose.
Second, raw materials used oral solution of the invention is all natural food materials, is free of drug ingedient, is made to human body without secondary
With it is safe for eating.
Third, the raw material of oral solution of the invention contain fructus arctii, oligofructose rich in fructus arctii, the oligomeric fruit of fructus arctii
Sugar has the function of good inhibition alpha-glucosidase activity, can delay absorption of the carbohydrate in enteron aisle, to reduce blood
Sugar improves interior free yl to beta Cell of islet in addition, burdock fructooligosaccharidcan can significantly reduce the oxidative stress pressure of diabetes
Damage, to play hypoglycemic effect indirectly.
4th, the raw material of oral solution of the invention contains shaddock, and shaddock contains chromium, there is the medical value for the treatment of diabetes,
It can stimulate the secretion of insulin, therefore, can reduce the blood glucose of diabetic.
5th, oral solution of the invention has strong shaddock fragrance, and for grapefruit juice after purple red koji fermentation, purple is red
Reference state aroma-producing substance in shaddock can be converted to free state aroma-producing substance by the beta-glucosidase that song metabolism generates, and be increased
The fragrance of oral solution of the present invention.
6th, the γ-aminobutyric acid that oral solution of the invention is generated rich in the metabolism of purple red yeast rice is after measured, of the invention
Alpha-aminobutyric acid content is 1.73mg/100ml in the oral solution of embodiment.γ-aminobutyric acid can promote beta Cell of islet group increasing
It is raw, and β cell is protected by the destruction of autoimmunity, not increase insulin level, Plasma Glucagon Level is reduced, while reducing blood
Sugar level and improvement blood glucose fluctuation amplitude.
7th, glucose content is extremely low in oral solution of the invention, will not have an impact to the blood glucose of diabetes patient, although
Contain more glucose in shaddock, is unfavorable for diabetes patient, but most glucose in shaddock are in purple
It is utilized in the form of carbon source by purple red yeast rice during red koji fermentation, so remaining glucose is seldom, in addition, in burdock powder
It is starch-containing, it is also unfavorable for diabetes patient, but the starch in burdock powder is during purple red koji fermentation
It is utilized in the form of carbon source by purple red yeast rice, after measured, content of starch only has 0.14% in the oral solution of the embodiment of the present invention,
Glucose content only has 0.13%, so will not have an impact to the blood glucose of diabetes patient.
Specific embodiment
The purple red yeast rice CICC5013 that the present invention uses is purchased in Chinese industrial Microbiological Culture Collection administrative center.
The burdock powder of certain mass is weighed, 9 times of burdock powder quality of clear water is added, stirs evenly, goes out under the conditions of 121 DEG C
Bacterium 10 minutes fructus arctii cream, by shaddock peeling, grapefruit juice of squeezing the juice to obtain, according to mass ratio 2:1 ratio by fructus arctii cream and grapefruit juice
It is uniformly mixed to obtain mixed juice.
1% soy bean hydrolyzed protein powder is added in mixed juice, stirs evenly, pH is adjusted to 7.0, under the conditions of 95 DEG C
Sterilizing 10 minutes, cools to 34 DEG C, and purple red yeast rice strain, the shaking table culture 5 under conditions of 34 DEG C, 160rpm are accessed from inclined-plane
It purple Monas cuspurpureus Went fermentation liquid, purple Monas cuspurpureus Went fermentation liquid obtain nutrition slurries through mycelium colloid mill defibrination, nutrition slurries using
Filter, allotment, concentration, filling, sealing, sterilizing are got product.
Oral solution implementation result test of the present invention:
The oral solution of the embodiment of the present invention is drunk through patient 22 that clinic suffers from diabetes, 3 times a day, is drunk with breakfast, lunch and dinner, every time
50ml is continuously drunk 45 days, and the antidiabetic drug that patient takes during drinking oral solution of the present invention halves.
As a result: it shares 20 hypoglycemic effects and meets or exceeds the effect for normally taking full dose antidiabetic drug originally, account for 90.9%,
There are 2 hypoglycemic effects to fail to achieve the effect that normally to take full dose antidiabetic drug originally, accounts for 9.1%, as can be seen from the above results,
Oral solution of the invention is shared with antidiabetic drug, is not only had preferable auxiliary hyperglycemic effect, can also be reduced the use of antidiabetic drug
Amount reduces antidiabetic drug to the side effect of body bring.
It is illustrated below:
Lee's ××, female 65 years old, suffer from diabetes B, serum triglyceride is higher, takes Metformin hydrochloride daily originally
(0.25g) three times, each one, fasting blood-glucose is controlled in 9.4mmol/L or so, and postprandial two hours glycemic controls exist
11.6mmol/L or so drinks oral solution of the embodiment of the present invention with breakfast, lunch and dinner daily during test, each 50ml, three times a day, together
When the Metformin hydrochloride (0.25g) taken daily halve, i.e., take Metformin hydrochloride (0.25g) daily three times, every time half
Piece, during test, fasting blood-glucose average value is down to 7.7mmol/L, and postprandial two hours blood glucose average value is down to 9.1mmol/L, and 45
Physical examination serum triglyceride restores normal after the test for it.
Shen ×, male 57 years old, suffers from diabetes B, Gliclazide sustained-release tablet (30mg) two is originally taken when daily breakfast
Piece, fasting blood-glucose are controlled in 6.5mmol/L or so, and postprandial two hours glycemic controls are daily during 8.3mmol/L or so, test
Oral solution of the embodiment of the present invention is drunk with breakfast, lunch and dinner, each 50ml three times a day, while taking Gliclazide delayed-release when daily breakfast
Piece (30mg) halves, i.e., daily breakfast when to take Gliclazide sustained-release tablet (30mg) a piece of, during test, fasting blood-glucose average value
It is down to 5.9mmol/L, postprandial two hours blood glucose average value is down to 7.6mmol/L.
Claims (2)
1. a kind of production method of the oral solution with auxiliary hyperglycemic function, it is characterized in that by the preparation of following process and
At:
(1) the burdock powder of certain mass is weighed, the clear water of 8-10 times of burdock powder quality is added, stirs evenly, under the conditions of 121 DEG C
Sterilizing 10-15 minute fructus arctii cream, by shaddock peeling, grapefruit juice of squeezing the juice to obtain, according to the ratio of mass ratio 2:1 by fructus arctii is newborn and shaddock
Sub- juice is uniformly mixed to obtain mixed juice；
(2) 1% soy bean hydrolyzed protein powder is added in mixed juice, stirs evenly, pH is adjusted to 6.8-7.0, in 90-95 DEG C of item
It sterilizes 10 minutes under part, cools to 32-35 DEG C, purple red yeast rice strain is accessed from inclined-plane, in 32-35 DEG C, 160-200rpm
Under the conditions of shaking table culture 4-5 days purple Monas cuspurpureus Went fermentation liquid, purple Monas cuspurpureus Went fermentation liquid obtains nutrient paste through mycelium colloid mill defibrination
Liquid, nutrition slurries are got product using filter, allotment, concentration, filling, sealing, sterilizing.
2. the manufacturing method according to claim 1 oral solution obtained with auxiliary hyperglycemic function.
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| CN201811037811.3A CN109430758A (en) | 2018-09-06 | 2018-09-06 | A kind of oral solution and preparation method thereof with auxiliary hyperglycemic function |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106520451A (en) * | 2016-12-26 | 2017-03-22 | 天津科技大学 | Monascus fruit wine and preparation method thereof |
| CN107333940A (en) * | 2017-05-24 | 2017-11-10 | 山东中惠生物科技股份有限公司 | Burdock functional red yeast rice health protection tea and preparation method thereof |
-
2018
- 2018-09-06 CN CN201811037811.3A patent/CN109430758A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106520451A (en) * | 2016-12-26 | 2017-03-22 | 天津科技大学 | Monascus fruit wine and preparation method thereof |
| CN107333940A (en) * | 2017-05-24 | 2017-11-10 | 山东中惠生物科技股份有限公司 | Burdock functional red yeast rice health protection tea and preparation method thereof |
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