CN109394568A - Ampulla hyaluronic acid stoste and preparation method thereof - Google Patents
Ampulla hyaluronic acid stoste and preparation method thereof Download PDFInfo
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- CN109394568A CN109394568A CN201811299275.4A CN201811299275A CN109394568A CN 109394568 A CN109394568 A CN 109394568A CN 201811299275 A CN201811299275 A CN 201811299275A CN 109394568 A CN109394568 A CN 109394568A
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- hyaluronic acid
- parts
- ampulla
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- sodium hyaluronate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of ampulla hyaluronic acid stostes and preparation method thereof, belong to cosmetic field.In order to solve the problems, such as that hyaluronic acid stoste performance of keeping humidity is not strong and need to add preservative in the prior art, a kind of ampulla hyaluronic acid stoste and preparation method thereof is proposed.The ampulla hyaluronic acid stoste includes following component according to parts by weight: including 80-90 parts of deionized water, 2-5 parts of butanediol, 5-10 parts of glycerol, 2.5-5 parts of 1,2- pentanediol, 0.1-2 parts of Sodium Hyaluronate, 0.1-2 parts of digestion oligomerization Sodium Hyaluronate.The present invention provides a kind of hyaluronic acid stoste formulas, can form the hyaluronic acid stoste of efficient moisture-retention, and without any pigment, additive, when use will not damage skin；And the present invention uses ampulla as the container of hyaluronic acid stoste, is not required to addition preservative, corkage is used, so that stoste is not by extraneous germ contamination.
Description
Technical field
The present invention relates to a kind of hyaluronic acid stostes and preparation method thereof, and in particular to a kind of ampulla hyaluronic acid stoste and
Preparation method.
Background technique
Sodium Hyaluronate has unique moistening effect as a kind of efficient moisture-retention agent, in addition to moisturizing, there are also lubricating, repairs
The effect of multiple skin, Sodium Hyaluronate is compared with traditional moisturizer, in addition to better moistening effect, no greasy feeling and blocking
The disadvantages of skin pore.But the moisturizer of existing Sodium Hyaluronate is with polymer hyaluronic acid sodium and various other effects
Auxiliary agent mixed preparing forms.Hyaluronic acid stoste has that moistening effect and health performance are bad at present, and protects
It deposits and needs to add preservative and be also easy to improve conserving time limit, when taking by extraneous germ contamination.
Publication date is on June 10th, 2009, in the Chinese patent of Publication No. CN101450028, disclose it is a kind of efficiently
The sodium hyaluronic acid raw-liquor of moisturizing, the invention are polymer hyaluronic acid sodium and low-numerator sodium hyaluronate group according to a certain ratio
At moistening effect is general and joined G-Plusl preservative, may cause allergy.
Summary of the invention
It is an object of the invention to overcome the above deficiencies in the existing technologies, and provide that a kind of moistening effect is good, skin
Skin absorbs the fast and not ampulla hyaluronic acid stoste and preparation method thereof of adding preservative agent.
Technical solution used by the present invention solves the above problems is: the ampulla hyaluronic acid stoste includes in parts by weight
The following component of meter: including 80-90 part of deionized water, 2-5 parts of butanediol, 5-10 parts of glycerol, 2.5-5 parts of 1,2- pentanediol, saturating
0.1-1 parts of bright matter acid sodium, 0.1-1 parts of digestion oligomerization Sodium Hyaluronate.
Preferably, heretofore described ampulla hyaluronic acid stoste includes following component according to parts by weight: including
85 parts of deionized water, 3.5 parts of butanediol, 7.5 parts of glycerol, 3.5 parts of 1,2- pentanediol, 0.5 part of Sodium Hyaluronate, digestion oligomerization are saturating
Bright 0.5 part of matter acid sodium.
A kind of preparation method of ampulla hyaluronic acid stoste, includes the following steps:
Weighed deionized water: being first added in emulsion pot by S1, adds load weighted 1,2- pentanediol, is warming up to 80
DEG C, stirring is to being completely dissolved；
S2: cooling after dissolution completely, pot temperature to be emulsified is down to 65 DEG C -75 DEG C, sequentially add load weighted glycerol, butanediol,
Sodium Hyaluronate and digestion oligomerization Sodium Hyaluronate, stirring is to being completely dissolved；
S3: preparation pH adjusting agent；Emulsion pot continues to be cooled to 30 DEG C -35 DEG C simultaneously, and pH adjusting agent is added dropwise after cooling until pH value
For 5-6, hyaluronic acid stoste is obtained；
S4: ampulla hyaluronic acid stoste obtained by S3 is filling into ampulla, and moist heat sterilization is to get arriving sterile ampulla hyaluronic acid
Stoste.
Preferably, pH adjusting agent described in S3 of the present invention is citric acid, sodium citrate buffer solution.
Preferably, the preparation method of pH adjusting agent described in S3 of the present invention includes the following steps:
S1: accurately weighing citric acid and sodium citrate, is prepared into the solution of 0.1mol/L respectively；
S2: citric acid and sodium citrate solution are measured respectively by the volume ratio of 8:17；
S3: the solution of measurement is mixed, and is stirred evenly to get citric acid, the sodium citrate buffer solution to pH value for 5.4.
Preferably, heretofore described deionized water is solvent；The butanediol, glycerol are moisturizer；It is described transparent
Matter acid sodium and digestion oligomerization Sodium Hyaluronate are moisturizer and skin conditioning agent；The Sodium Hyaluronate is made with good moisturizing
With skin moisturizing being kept smooth, fine and smooth tender, high resilience has wrinkle resistant, crease-resistant, beauty and health care and restores skin physiology
The effect of function, and the generation of chapped skin and wrinkle can be prevented；The digestion oligomerization Sodium Hyaluronate is very low molecular weight
Sodium Hyaluronate, molecular weight are less than 10kDa and are more easily absorbed by the skin compared to general Sodium Hyaluronate, play improvement skin
Matter, the effect of replenishing water and preserving moisture；1, the 2- pentanediol is moisturizer and has antisepsis, and 1,2- pentanediol is had excellent performance
Moisturizer, while there is antisepsis, the product of preservative free can be prepared, allergy caused by preservative is reduced, moreover it is possible to which dissolution is difficult
Molten active constituent.
Preferably, moist heat sterilization temperature described in S4 of the present invention is 110 DEG C -130 DEG C, sterilization time 10min-
15min。
Compared with prior art, the present invention having the following advantages that and effect: the present invention provides a kind of hyaluronic acid stostes
Formula, can form the hyaluronic acid stoste of efficient moisture-retention, and without any pigment, additive, when use will not cause to damage to skin
Evil, molecular weight is small, absorptions is fast, can store moisture content, increase skin volume, allows turgor, plentiful, flexible, and can improve
Cohesion between cutin internal layer makes epidermis skin restore fine and smooth, moist, glossy；It can also be discharged in skin by accelerating to be metabolized
Harmful substance, bright color restore healthy skin.The present invention uses ampulla as the container of hyaluronic acid stoste, and ampulla is one
Kind asepsis vacuum packing so saves stoste and is not required to addition preservative, and the capacity of ampulla is small, and general corkage is to use,
It can guarantee stoste not by extraneous germ contamination.
Specific embodiment
Below by embodiment, the present invention is described in further detail, following embodiment be explanation of the invention and
The invention is not limited to following embodiments.
Embodiment 1.
Ampulla hyaluronic acid stoste in the present embodiment includes following component according to parts by weight: including deionized water 85
Part, 3.5 parts of butanediol, 7.5 parts of glycerol, 3.5 parts of 1,2- pentanediol, 0.5 part of Sodium Hyaluronate, digestion oligomerization Sodium Hyaluronate
0.5 part.
The preparation method of ampulla hyaluronic acid stoste in the present embodiment, includes the following steps:
Weighed deionized water: being first added in emulsion pot by S1, adds load weighted 1,2- pentanediol, is warming up to 80
DEG C, stirring is to being completely dissolved；
S2: cooling after dissolution completely, pot temperature to be emulsified is down to 65 DEG C -75 DEG C, sequentially add load weighted glycerol, butanediol,
Sodium Hyaluronate and digestion oligomerization Sodium Hyaluronate, stirring is to being completely dissolved；
S3: preparation pH adjusting agent；Emulsion pot continues to be cooled to 30 DEG C -35 DEG C simultaneously, and pH adjusting agent is added dropwise after cooling until pH value
For 5-6, hyaluronic acid stoste is obtained；
S4: hyaluronic acid stoste obtained by S3 is filling into ampulla, and moist heat sterilization, moist heat sterilization temperature is 110 DEG C -130 DEG C, is gone out
The bacterium time be 10min-15min to get arrive sterile ampulla hyaluronic acid stoste.
PH adjusting agent described in the present embodiment S3 is citric acid, sodium citrate buffer solution.The preparation method of the pH adjusting agent
Include the following steps:
S1: accurately weighing citric acid and sodium citrate, is prepared into the solution of 0.1mol/L respectively；
S2: citric acid and sodium citrate solution are measured respectively by the volume ratio of 8:17；
S3: the solution of measurement is mixed, and is stirred evenly to get citric acid, the sodium citrate buffer solution to pH value for 5.4.This reality
Applying the deionized water in example is solvent；The butanediol, glycerol are moisturizer；The Sodium Hyaluronate and digestion oligomerization hyalomitome
Sour sodium is skin conditioning agent；The 1,2- pentanediol is moisturizer and has antisepsis.
Embodiment 2.
Ampulla hyaluronic acid stoste in the present embodiment includes following component according to parts by weight: including deionized water 90
Part, 5 parts of butanediol, 10 parts of glycerol, 5 parts of 1,2- pentanediol, 1 part of Sodium Hyaluronate, 1 part of digestion oligomerization Sodium Hyaluronate.
The preparation method of ampulla hyaluronic acid stoste in the present embodiment, includes the following steps:
Weighed deionized water: being first added in emulsion pot by S1, adds load weighted 1,2- pentanediol, is warming up to 80
DEG C, stirring is to being completely dissolved；
S2: cooling after dissolution completely, pot temperature to be emulsified is down to 65 DEG C -75 DEG C, sequentially add load weighted glycerol, butanediol,
Sodium Hyaluronate and digestion oligomerization Sodium Hyaluronate, stirring is to being completely dissolved；
S3: preparation pH adjusting agent；Emulsion pot continues to be cooled to 30 DEG C -35 DEG C simultaneously, and pH adjusting agent is added dropwise after cooling until pH value
For 5-6, hyaluronic acid stoste is obtained；
S4: hyaluronic acid stoste obtained by S3 is filling into ampulla, and moist heat sterilization, moist heat sterilization temperature is 110 DEG C -130 DEG C, is gone out
The bacterium time be 10min-15min to get arrive sterile ampulla hyaluronic acid stoste.
PH adjusting agent described in the present embodiment S3 is citric acid, sodium citrate buffer solution, the preparation method of the pH adjusting agent
Include the following steps:
S1: accurately weighing citric acid and sodium citrate, is prepared into the solution of 0.1mol/L respectively；
S2: citric acid and sodium citrate solution are measured respectively by the volume ratio of 8:17；
S3: the solution of measurement is mixed, and is stirred evenly to get citric acid, the sodium citrate buffer solution to pH value for 5.4.
Deionized water in the present embodiment is solvent；The butanediol, glycerol are moisturizer；The Sodium Hyaluronate and enzyme
Cutting oligomerization Sodium Hyaluronate is skin conditioning agent；The 1,2- pentanediol is moisturizer and has antisepsis.
Embodiment 3.
Ampulla hyaluronic acid stoste in the present embodiment includes following component according to parts by weight: including deionized water 80
Part, 2 parts of butanediol, 5 parts of glycerol, 2.5 parts of 1,2- pentanediol, 0.1 part of Sodium Hyaluronate, 0.1 part of digestion oligomerization Sodium Hyaluronate.
The preparation method of ampulla hyaluronic acid stoste in the present embodiment, includes the following steps:
Weighed deionized water: being first added in emulsion pot by S1, adds load weighted 1,2- pentanediol, is warming up to 80
DEG C, stirring is to being completely dissolved；
S2: cooling after dissolution completely, pot temperature to be emulsified is down to 65 DEG C -75 DEG C, sequentially add load weighted glycerol, butanediol,
Sodium Hyaluronate and digestion oligomerization Sodium Hyaluronate, stirring is to being completely dissolved；
S3: preparation pH adjusting agent；Emulsion pot continues to be cooled to 30 DEG C -35 DEG C simultaneously, and pH adjusting agent is added dropwise after cooling until pH value
For 5-6, hyaluronic acid stoste is obtained；
S4: hyaluronic acid stoste obtained by S3 is filling into ampulla, and moist heat sterilization, moist heat sterilization temperature is 110 DEG C -130 DEG C, is gone out
The bacterium time be 10min-15min to get arrive sterile ampulla hyaluronic acid stoste.
PH adjusting agent described in the present embodiment S3 is citric acid, sodium citrate buffer solution, the preparation method of the pH adjusting agent
Include the following steps:
S1: accurately weighing citric acid and sodium citrate, is prepared into the solution of 0.1mol/L respectively；
S2: citric acid and sodium citrate solution are measured respectively by the volume ratio of 8:17；
S3: the solution of measurement is mixed, and is stirred evenly to get citric acid, the sodium citrate buffer solution to pH value for 5.4.
Deionized water in the present embodiment is solvent；The butanediol, glycerol are moisturizer；The Sodium Hyaluronate and enzyme
Cutting oligomerization Sodium Hyaluronate is skin conditioning agent；The 1,2- pentanediol is moisturizer and has antisepsis.
In addition, it should be noted that, the specific embodiments described in this specification, the shape of parts and components are named
Title etc. can be different, and above content is only to structure of the invention example explanation described in this specification.It is all according to
According to equivalence changes or simple change that the invention patent design structure, feature and principle is done, it is included in this hair
In the protection scope of bright patent.Those skilled in the art can do described specific embodiment various
The mode that the modify or supplement or adopt of various kinds is similar substitutes, and without departing from structure of the invention or surmounts present claims
Range defined in book, is within the scope of protection of the invention.
Claims (7)
1. a kind of ampulla hyaluronic acid stoste, which is characterized in that the ampulla hyaluronic acid stoste include according to parts by weight as
Lower component: 80-90 parts of deionized water, 2-5 parts of butanediol, 5-10 parts of glycerol, 2.5-5 parts of 1,2- pentanediol, Sodium Hyaluronate
0.1-1 parts, 0.1-1 parts of digestion oligomerization Sodium Hyaluronate.
2. ampulla hyaluronic acid stoste according to claim 1, which is characterized in that the ampulla hyaluronic acid stoste includes pressing
The following component of parts by weight meter: including 85 parts of deionized water, 3.5 parts of butanediol, 7.5 parts of glycerol, 3.5 parts of 1,2- pentanediol,
0.5 part of Sodium Hyaluronate, 0.5 part of digestion oligomerization Sodium Hyaluronate.
3. a kind of preparation method of the ampulla hyaluronic acid stoste as described in claim 1-2 any claim, feature exist
In including the following steps:
Weighed deionized water: being first added in emulsion pot by S1, adds load weighted 1,2- pentanediol, is warming up to 80
DEG C, stirring is to being completely dissolved；
S2: cooling after dissolution completely, pot temperature to be emulsified is down to 65 DEG C -75 DEG C, sequentially add load weighted glycerol, butanediol,
Sodium Hyaluronate and digestion oligomerization Sodium Hyaluronate, stirring is to being completely dissolved；
S3: preparation pH adjusting agent；Emulsion pot continues to be cooled to 30 DEG C -35 DEG C simultaneously, and pH adjusting agent is added dropwise after cooling until pH value
For 5-6, hyaluronic acid stoste is obtained；
S4: hyaluronic acid stoste obtained by S3 is filling into ampulla, and moist heat sterilization is to get former to sterile ampulla hyaluronic acid
Liquid.
4. the preparation method of ampulla hyaluronic acid stoste according to claim 3, which is characterized in that pH described in S3 is adjusted
Agent is citric acid, sodium citrate buffer solution.
5. the preparation method of ampulla hyaluronic acid stoste according to claim 3, which is characterized in that pH described in S3 is adjusted
The preparation method of agent includes the following steps:
S1: accurately weighing citric acid and sodium citrate, is prepared into the solution of 0.1mol/L respectively；
S2: citric acid and sodium citrate solution are measured respectively by the volume ratio of 8:17；
S3: the solution of measurement is mixed, and is stirred evenly to get citric acid, the sodium citrate buffer solution to pH value for 5.4.
6. the preparation method of ampulla hyaluronic acid stoste according to claim 3, which is characterized in that the deionized water is
Solvent；The butanediol, glycerol are moisturizer；The Sodium Hyaluronate and digestion oligomerization Sodium Hyaluronate are moisturizer and skin
Conditioner；The 1,2- pentanediol is moisturizer and has antisepsis.
7. the preparation method of ampulla hyaluronic acid stoste according to claim 3, which is characterized in that wet described in S4
Heat sterilization temperatures are 110 DEG C -130 DEG C, sterilization time 10min-15min.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112516024A (en) * | 2020-12-11 | 2021-03-19 | 广州市拉凯尔干细胞研究所 | Hyaluronic acid skin care stock solution with blue light damage resisting effect |
| CN113398060A (en) * | 2021-07-29 | 2021-09-17 | 广州雅驰化妆品有限公司 | Apple stem cell stock solution formula |
| CN114557946A (en) * | 2022-03-22 | 2022-05-31 | 无锡知妍生物科技有限公司 | Hyaluronic acid gel and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112516024A (en) * | 2020-12-11 | 2021-03-19 | 广州市拉凯尔干细胞研究所 | Hyaluronic acid skin care stock solution with blue light damage resisting effect |
| CN113398060A (en) * | 2021-07-29 | 2021-09-17 | 广州雅驰化妆品有限公司 | Apple stem cell stock solution formula |
| CN114557946A (en) * | 2022-03-22 | 2022-05-31 | 无锡知妍生物科技有限公司 | Hyaluronic acid gel and preparation method thereof |
| CN114557946B (en) * | 2022-03-22 | 2024-02-23 | 无锡知妍生物科技有限公司 | Hyaluronic acid gel's preparation facilities |
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