CN101450028A - Efficient moisture-retention sodium hyaluronic acid raw-liquor - Google Patents
Efficient moisture-retention sodium hyaluronic acid raw-liquor Download PDFInfo
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- CN101450028A CN101450028A CNA2008101637793A CN200810163779A CN101450028A CN 101450028 A CN101450028 A CN 101450028A CN A2008101637793 A CNA2008101637793 A CN A2008101637793A CN 200810163779 A CN200810163779 A CN 200810163779A CN 101450028 A CN101450028 A CN 101450028A
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Abstract
The invention discloses a high-effective moisture-keeping sodium hyaluronate stock solution comprising a sodium hyaluronate, characterized in that the solution is composed of high molecular weight sodium hyaluronate with average molecular weight more than 2. 6 million Dalton and low molecular weight sodium hyaluronate with average molecular weight lower than 10 thousand Dalton which are mixed by proportion, wherein, the high molecular weight sodium hyaluronate with average molecular weight more than 2. 6 million Dalton is of 0. 1 to 0. 5 parts by weight, the low molecular weight sodium hyaluronate with average molecular weight lower than 10 thousand Dalton is of 0. 5 to 1. 0 parts by weight, the rest is 100 parts of distilled water, the distilled water. especially can be chose for double distilled waters. The high-effective moisture-keeping sodium hyaluronate stock solution provided by the invention can effectively permeate into a corium layer to promote blood microcirculation, be beneficial to nutrient substance absorption of the skin, with beautification anti-wrinkle health care action; the high-effective moisture-keeping sodium hyaluronate stock solution provided by the invention has strong flexibility and wetting property, can be coated on the skin surface to form a layer of moisture-keeping ventilated membrane for keeping the skin nourishing, moistening and glossy.
Description
Technical field
The present invention relates to the sodium hyaluronic acid raw-liquor of a kind of wetting agent, particularly a kind of efficient moisture-retention.
Background technology
Hyaluronate sodium is as a kind of efficient moisture-retention agent, and moistening effect has its distinctive feature, except that preserving moisture, also have and lubricate, repair the effect of skin, hyaluronate sodium is compared with traditional wetting agent, except that having better moistening effect, shortcomings such as no greasy feeling and obstruction skin pore.But the wetting agent of existing hyaluronate sodium be that the auxiliary agent mixed preparing with polymer hyaluronic acid sodium and other various effects forms, but effect is not ideal enough aspect the skin nursing maintenance.
Summary of the invention
The objective of the invention is provides in a kind of porous skin for the deficiency that solves above-mentioned technology, and the sodium hyaluronic acid raw-liquor of the efficient moisture-retention of excellent repairing skin.
In order to achieve the above object, the sodium hyaluronic acid raw-liquor of the efficient moisture-retention that the present invention is designed, by mean molecule quantity at above high molecular weight sodium hyaluronate of 2,600,000 dalton and molecular weight the nanoscale low molecular weight sodium hyaluronate proportioning below 10,000 dalton form, wherein the above high-molecular weight hyaluronate sodium of 2,600,000 dalton is 0.1 to 0.5 part of weight portion, the following nanoscale low molecular weight sodium hyaluronate of 10,000 dalton is 0.5 to 1.0, all the other are 100 parts distilled water, and described distilled water can be selected DDW for use especially.The marque that can also add weight ratio in addition and be 0.1 part is the husky G-Plusl antiseptic of U.S. dragon.
The production technology of inventing the sodium hyaluronic acid raw-liquor of designed efficient moisture-retention is: weigh up raw material by above-mentioned prescription in clean room, the DDW of getting above-mentioned prescription slowly adds the high-molecular weight hyaluronate sodium that weighs up under stirring at room, add antiseptic, stirred 2 hours, after treating that high molecular weight sodium hyaluronate all dissolves, stir the low-molecular-weight hyaluronate sodium that adding down weighs up, stirred 1 hour, all promptly be made into sodium hyaluronic acid raw-liquor after the dissolving.
The sodium hyaluronic acid raw-liquor of efficient moisture-retention provided by the invention, adopt molecular weight the hyaluronate sodium of the following small-molecular weight of 10,000 dalton and more than 2,600,000 dalton high-molecular weight hyaluronate sodium combine, can infiltrate through skin corium effectively, promote blood microcirculation, help the absorption of skin, play the crease-resistant health-care effect of beauty treatment nutrient substance; Stronger viscoelasticity and lubricity are arranged again, be applied to skin surface and can form one deck ventilated membrane of preserving moisture, keep skin moisturizing glossy.
The sodium hyaluronic acid raw-liquor of efficient moisture-retention provided by the invention can directly come skin protection to use as cosmetics, and moistening effect easy to use is obvious.And can in epidermis, remove the reactive oxygen free radical that ultraviolet radiation produced in the sunlight, protection skin is avoided its evil, plays anti-sunlight function.Effect is more aspect the skin nursing maintenance to make it.
The specific embodiment
The invention will be further described in conjunction with the accompanying drawings below by embodiment.
Embodiment 1
The sodium hyaluronic acid raw-liquor of a kind of efficient moisture-retention that present embodiment is described, by mean molecule quantity at above high molecular weight sodium hyaluronate of 2,600,000 dalton and molecular weight the nanoscale low molecular weight sodium hyaluronate proportioning below 10,000 dalton form, wherein the above high-molecular weight hyaluronate sodium of 2,600,000 dalton is 0.5 part of weight portion, the following nanoscale low molecular weight sodium hyaluronate of 10,000 dalton is 1.0 parts, all the other are 100 parts distilled water, its production technology is: weigh up raw material by above-mentioned prescription in clean room, the distilled water of getting above-mentioned prescription slowly adds the high-molecular weight hyaluronate sodium that weighs up under stirring at room, stirred 2 hours, after treating that high molecular weight sodium hyaluronate all dissolves, stir and add the low-molecular-weight hyaluronate sodium that weighs up down, stirred 1 hour, and all promptly be made into sodium hyaluronic acid raw-liquor after the dissolving.
Embodiment 2:
The sodium hyaluronic acid raw-liquor of a kind of efficient moisture-retention that present embodiment is described, by mean molecule quantity is being that 4,000,000 daltonian high molecular weight sodium hyaluronates and mean molecule quantity are that nanoscale low molecular weight sodium hyaluronate proportioning below 8,000 ten thousand dalton is formed, wherein 4,000,000 daltonian high-molecular weight hyaluronate sodiums are 0.1 part of weight portion, the following nanoscale low molecular weight sodium hyaluronate of 10,000 dalton is the DDW of 0.5 part and 100 parts, and the marque of allocating weight ratio into and be 0.1 part is the husky G-Plusl antiseptic of U.S. dragon, specifically is to get 100 kilograms of DDWs, 0.1 kilogram of mean molecule quantity 4,000,000 daltonian high molecular weight sodium hyaluronate, 0.1 kilogram of antiseptic G-Plusl (L), mean molecule quantity is 0.5 kilogram of 8,000 ten thousand a daltonian low-molecular-weight hyaluronate sodium.
Its production technology is: prepare in clean room, get 100 kilograms of DDWs and under stirring at room, slowly add 0.1 kilogram of high-molecular weight hyaluronate sodium, add antiseptic G-Plusl (L) 0.1 kilogram, stirred following 2 hours, after treating that high molecular weight sodium hyaluronate all dissolves, stir 0.5 kilogram of low-molecular-weight hyaluronate sodium of adding down, stirred 1 hour, all promptly be made into sodium hyaluronic acid raw-liquor after the dissolving.Described distilled water can be selected DDW for use especially.
Claims (3)
1, a kind of sodium hyaluronic acid raw-liquor of efficient moisture-retention, it comprises the employing hyaluronate sodium, it is characterized in that by mean molecule quantity at above high molecular weight sodium hyaluronate of 2,600,000 dalton and molecular weight the nanoscale low molecular weight sodium hyaluronate proportioning below 10,000 dalton form, wherein the above high-molecular weight hyaluronate sodium of 2,600,000 dalton is 0.1 to 0.5 part of weight portion, the following nanoscale low molecular weight sodium hyaluronate of 10,000 dalton is 0.5 to 1.0, and all the other are 100 parts distilled water.
2, the sodium hyaluronic acid raw-liquor of efficient moisture-retention according to claim 1 is characterized in that described distilled water selects DDW for use.
3, the sodium hyaluronic acid raw-liquor of efficient moisture-retention according to claim 1 and 2, the marque that it is characterized in that also comprising weight ratio and be 0.1 part is the husky G-Plusl antiseptic of U.S. dragon.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101637793A CN101450028A (en) | 2008-12-31 | 2008-12-31 | Efficient moisture-retention sodium hyaluronic acid raw-liquor |
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| CNA2008101637793A CN101450028A (en) | 2008-12-31 | 2008-12-31 | Efficient moisture-retention sodium hyaluronic acid raw-liquor |
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| CN101450028A true CN101450028A (en) | 2009-06-10 |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173205A (en) * | 2013-05-21 | 2014-12-03 | 江苏天恒纳米科技有限公司 | Fat burning and warming oil |
| CN105434271A (en) * | 2015-12-23 | 2016-03-30 | 广州昕润生物科技有限公司 | Composition for moisture preservation and aging resistance and preparation method thereof |
| CN106580735A (en) * | 2016-10-26 | 2017-04-26 | 山东银河生物科技有限公司 | Skin care product containing sodium hyaluronate gel and preparing method thereof |
| US9693947B1 (en) * | 2017-02-03 | 2017-07-04 | Jan Marini Skin Research | HYLA3D hylauronic acid activating complex |
| CN107157802A (en) * | 2017-06-19 | 2017-09-15 | 严立栋 | A kind of hyaluronic acid stoste |
| CN107184539A (en) * | 2017-04-05 | 2017-09-22 | 中山卡丝生物科技有限公司 | It is a kind of containing stem cell medium can Wash-free mask liquid preparation method and applications |
| US9855206B2 (en) | 2012-10-17 | 2018-01-02 | Cosmed Pharmaceutical Co., Ltd. | Hyaluronic acid gel and manufacturing method thereof |
| CN107582424A (en) * | 2017-10-11 | 2018-01-16 | 广州青葱贸易有限公司 | A kind of Sodium Hyaluronate mixture and application thereof |
| CN107929094A (en) * | 2017-12-28 | 2018-04-20 | 娇时日化（杭州）股份有限公司 | A kind of stoste and its preparation process |
| CN108078841A (en) * | 2017-12-25 | 2018-05-29 | 陕西佰傲再生医学有限公司 | A kind of moisturiser of preservative free and preparation method thereof |
| CN109010205A (en) * | 2018-08-29 | 2018-12-18 | 广州四环康源化妆品有限公司 | A kind of sensitivity flesh remediation composition and preparation method thereof |
| CN109394568A (en) * | 2018-11-02 | 2019-03-01 | 蝶柔化妆品(浙江)有限公司 | Ampulla hyaluronic acid stoste and preparation method thereof |
| CN110721149A (en) * | 2019-11-21 | 2020-01-24 | 江苏巴帝恩生物科技有限公司 | Preparation method of split yeast fermentation product filtrate composition |
| CN110882182A (en) * | 2018-09-11 | 2020-03-17 | 铑家(北京)文化发展有限公司 | Cosmetic for enhancing skin barrier function and preparation method thereof |
| CN111374904A (en) * | 2018-12-29 | 2020-07-07 | 好维股份有限公司 | Oral care composition |
| WO2020258775A1 (en) | 2019-06-26 | 2020-12-30 | 常州百瑞吉生物医药有限公司 | Hyaluronic acid skin protection composition, and preparation method therefor and application thereof |
| CN112999106A (en) * | 2019-12-18 | 2021-06-22 | 江苏天晟药业股份有限公司 | Natural moisturizing liquid and preparation method thereof |
| CN115607478A (en) * | 2021-07-13 | 2023-01-17 | 上海菲柏丽生物科技有限公司 | Micromolecular sodium hyaluronate stock solution as well as preparation method and application thereof |
-
2008
- 2008-12-31 CN CNA2008101637793A patent/CN101450028A/en active Pending
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110339087A (en) * | 2012-10-17 | 2019-10-18 | 考司美德制药株式会社 | Hyaluronic acid derivatives and preparation method thereof |
| US9855206B2 (en) | 2012-10-17 | 2018-01-02 | Cosmed Pharmaceutical Co., Ltd. | Hyaluronic acid gel and manufacturing method thereof |
| CN110384624A (en) * | 2012-10-17 | 2019-10-29 | 考司美德制药株式会社 | Hyaluronic acid derivatives and preparation method thereof |
| CN104173205A (en) * | 2013-05-21 | 2014-12-03 | 江苏天恒纳米科技有限公司 | Fat burning and warming oil |
| CN105434271A (en) * | 2015-12-23 | 2016-03-30 | 广州昕润生物科技有限公司 | Composition for moisture preservation and aging resistance and preparation method thereof |
| CN106580735A (en) * | 2016-10-26 | 2017-04-26 | 山东银河生物科技有限公司 | Skin care product containing sodium hyaluronate gel and preparing method thereof |
| US9693947B1 (en) * | 2017-02-03 | 2017-07-04 | Jan Marini Skin Research | HYLA3D hylauronic acid activating complex |
| CN107184539A (en) * | 2017-04-05 | 2017-09-22 | 中山卡丝生物科技有限公司 | It is a kind of containing stem cell medium can Wash-free mask liquid preparation method and applications |
| CN107157802A (en) * | 2017-06-19 | 2017-09-15 | 严立栋 | A kind of hyaluronic acid stoste |
| CN107582424A (en) * | 2017-10-11 | 2018-01-16 | 广州青葱贸易有限公司 | A kind of Sodium Hyaluronate mixture and application thereof |
| CN108078841A (en) * | 2017-12-25 | 2018-05-29 | 陕西佰傲再生医学有限公司 | A kind of moisturiser of preservative free and preparation method thereof |
| CN107929094A (en) * | 2017-12-28 | 2018-04-20 | 娇时日化（杭州）股份有限公司 | A kind of stoste and its preparation process |
| CN109010205A (en) * | 2018-08-29 | 2018-12-18 | 广州四环康源化妆品有限公司 | A kind of sensitivity flesh remediation composition and preparation method thereof |
| CN110882182A (en) * | 2018-09-11 | 2020-03-17 | 铑家(北京)文化发展有限公司 | Cosmetic for enhancing skin barrier function and preparation method thereof |
| CN109394568A (en) * | 2018-11-02 | 2019-03-01 | 蝶柔化妆品(浙江)有限公司 | Ampulla hyaluronic acid stoste and preparation method thereof |
| CN111374904A (en) * | 2018-12-29 | 2020-07-07 | 好维股份有限公司 | Oral care composition |
| CN111374904B (en) * | 2018-12-29 | 2023-02-28 | 好维股份有限公司 | Oral care composition |
| WO2020258775A1 (en) | 2019-06-26 | 2020-12-30 | 常州百瑞吉生物医药有限公司 | Hyaluronic acid skin protection composition, and preparation method therefor and application thereof |
| CN110721149A (en) * | 2019-11-21 | 2020-01-24 | 江苏巴帝恩生物科技有限公司 | Preparation method of split yeast fermentation product filtrate composition |
| CN112999106A (en) * | 2019-12-18 | 2021-06-22 | 江苏天晟药业股份有限公司 | Natural moisturizing liquid and preparation method thereof |
| CN115607478A (en) * | 2021-07-13 | 2023-01-17 | 上海菲柏丽生物科技有限公司 | Micromolecular sodium hyaluronate stock solution as well as preparation method and application thereof |
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Open date: 20090610 |