CN106580735A - Skin care product containing sodium hyaluronate gel and preparing method thereof - Google Patents
Skin care product containing sodium hyaluronate gel and preparing method thereof Download PDFInfo
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- CN106580735A CN106580735A CN201610944474.0A CN201610944474A CN106580735A CN 106580735 A CN106580735 A CN 106580735A CN 201610944474 A CN201610944474 A CN 201610944474A CN 106580735 A CN106580735 A CN 106580735A
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- Prior art keywords
- hyaluronic acid
- acid sodium
- skin care
- sodium gel
- care item
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a skin care product containing sodium hyaluronate gel and a preparing method thereof. The preparing method comprises the steps of uniformly mixing the sodium hyaluronate gel, 1,3-Butanediol, glycerinum, polyethylene glycol-400, preservative and water to form a mixture M; conducting still standing, degassing and filling on the mixture M to obtain the skin care product containing the sodium hyaluronate gel. According to the skin care product containing sodium hyaluronate gel and the preparing method thereof, problems that skin care products containing sodium hyaluronate have insufficiency in water replenishing and moisture maintaining, skin feel of the products are sticky and greasy, and the production cost is high are solved.
Description
Technical field
The present invention relates to skin care item, in particular it relates to contain skin care item and its preparation of hyaluronic acid sodium gel.
Background technology
Hyaluronic acid acid sodium as Medicines, has been widely used in always ophthalmologic operation, surgery handss since the listing
In art, gynecilogical operation and arthritis treatment.Hyaluronate sodium is frequently utilized for cosmetics life also because of its excellent replenishing water and preserving moisture effect
Produce.Generally cosmetics need to use the collocation of " high, normal, basic " molecular weight to use hyaluronate sodium, and to reaching replenishing water and preserving moisture, skin sense is pure and fresh
Effect.High molecular weight sodium hyaluronate acts primarily as moistening effect, and low molecular weight sodium hyaluronate acts primarily as moisturizing effects, but
Its skin sense of the higher hyaluronate sodium of molecular weight is more glutinous greasy, if wanting to improve skin sense, reaching fresh and clean effect then needs to improve
The amount of middle-molecular-weihydroxyethyl and oligomerization hyaluronate sodium, but so can inevitably increase production cost.
The content of the invention
It is an object of the invention to provide a kind of skin care item containing hyaluronic acid sodium gel and its preparation, solve hyaluronic acid
Sodium skin care item replenishing water and preserving moisture is not enough, skin sense sticks the higher problem of greasy and production cost.
To achieve these goals, the invention provides a kind of skin care item containing hyaluronic acid sodium gel, wherein, the shield
The component of skin product includes：Hyaluronic acid sodium gel, 1,3 butylene glycol, glycerol, PEG-4000, preservative and water.
Present invention also offers a kind of preparation method of the skin care item containing hyaluronic acid sodium gel, wherein, the preparation side
Method includes：
(1) by hyaluronic acid sodium gel, 1,3 butylene glycol, glycerol, PEG-4000, preservative and water mix homogeneously,
Form mixture M；
(2) mixture M is stood into degassing, fill, obtains the skin care item containing hyaluronic acid sodium gel, wherein,
The mass percent of the hyaluronic acid sodium gel is 45-55%, and the mass percent of the 1,3 butylene glycol is
2-4%, the mass percent of the glycerol is 0.5-1%, and the mass percent of the PEG-4000 is 0.3-0.7%,
The volume ratio of the preservative be 0.5-1%, excess water.
By above-mentioned technical proposal, the present invention by hyaluronic acid sodium gel, 1,3 butylene glycol, glycerol, PEG-4000,
Preservative and water mix homogeneously, form mixture M；The mixture M is stood into degassing, fill, obtains described containing hyaluronic acid
The skin care item of sodium gel, by the synergism between each component raw material so that the skin care item moisturizing effect prepared is obvious, skin
Sense is glutinous greasy, meanwhile, the method for preparing the skin care item is simple, and raw material is easy to get.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Specific embodiment
The specific embodiment of the present invention is described in detail below.It should be appreciated that described herein concrete
Embodiment is merely to illustrate and explains the present invention, is not limited to the present invention.
The invention provides a kind of skin care item containing hyaluronic acid sodium gel, wherein, the component of the skin care item includes：Thoroughly
Bright matter acid sodium gel, 1,3 butylene glycol, glycerol, PEG-4000, preservative and water, it is preferred that the hyaluronate sodium coagulates
The mass percent of glue is 45-55%, and the mass percent of the 1,3 butylene glycol is 2-4%, the quality percentage of the glycerol
It is 0.3-0.7% than the mass percent for 0.5-1%, the PEG-4000, the volume ratio of the preservative is 0.5-
1%, excess water.The skin care item prepared have the advantages that replenishing water and preserving moisture, skin sense are fine and smooth.
In order that skin care item possess it is more permanent guarantee the quality, prevent it from going bad, the preservative is double (methylol) miaows
One or more in oxazolidinyl urea, methyl hydroxybenzoate and iodine propilolic alcohol butyl mephenesin Carbamate, can suppress microorganism in skin care item
Grow, prevent skin care item from being polluted by antibacterial.
In order that obtained skin care item possess more excellent moistening effect, the hyaluronic acid sodium gel is by graininess
Hyaluronic acid sodium gel and non-particulate hyaluronic acid sodium gel are mixed to get, and the graininess hyaluronic acid sodium gel and non-
The mass ratio of graininess hyaluronic acid sodium gel is 1:1-1.2.
Present invention also offers a kind of preparation method of the skin care item containing hyaluronic acid sodium gel, wherein, the preparation side
Method includes：By hyaluronic acid sodium gel, 1,3 butylene glycol, glycerol, PEG-4000, preservative and water mix homogeneously, formed
Mixture M；The mixture M is stood into degassing, fill, the skin care item containing hyaluronic acid sodium gel are obtained, wherein, it is described
The mass percent of hyaluronic acid sodium gel is 45-55%, and the mass percent of the 1,3 butylene glycol is 2-4%, described sweet
The mass percent of oil is 0.5-1%, and the mass percent of the PEG-4000 is 0.3-0.7%, the preservative
Volume ratio is 0.5-1%, excess water.
In order that skin care item possess it is more permanent guarantee the quality, prevent it from going bad, the preservative is double (methylol) miaows
One or more in oxazolidinyl urea, methyl hydroxybenzoate and iodine propilolic alcohol butyl mephenesin Carbamate, can suppress microorganism in skin care item
Grow, prevent skin care item from being polluted by antibacterial.
In order that obtained skin care item possess more excellent moistening effect, the hyaluronic acid sodium gel is by graininess
Hyaluronic acid sodium gel and non-particulate hyaluronic acid sodium gel are mixed to get, and the graininess hyaluronic acid sodium gel and non-
The mass ratio of graininess hyaluronic acid sodium gel is 1:1-1.2.
Hereinafter will be described the present invention by embodiment.
Embodiment 1
By 45g hyaluronic acid sodium gels, 2g1,3- butanediols, 0.5g glycerol, 0.3g PEG-4000s, 0.5g preservative
With 51.7g water mix homogeneously, mixture M is formed；The mixture M is stood into degassing, fill, obtains described containing hyaluronate sodium
The skin care item A1 of gel.
Embodiment 2
By 55g hyaluronic acid sodium gels, 4g1,3- butanediols, 1g glycerol, 0.7g PEG-4000s, 1g preservative and
38.3g water mix homogeneously, forms mixture M；The mixture M is stood into degassing, fill, obtains described solidifying containing hyaluronate sodium
The skin care item A2 of glue.
Embodiment 3
By 50g hyaluronic acid sodium gels, 3g1,3- butanediols, 0.5g glycerol, 0.5g PEG-4000s, 0.7g preservative
With 45.3g water mix homogeneously, mixture M is formed；The mixture M is stood into degassing, fill, obtains described containing hyaluronate sodium
The skin care item A3 of gel.
Comparative example 1
By 35g hyaluronic acid sodium gels, 1g1,3- butanediols, 0.2g glycerol, 0.2g PEG-4000s, 0.2g preservative
With 63.4g water mix homogeneously, mixture M is formed；The mixture M is stood into degassing, fill, obtains described containing hyaluronate sodium
The skin care item D1 of gel.
Comparative example 2
By 65g hyaluronic acid sodium gels, 6g1,3- butanediols, 2g glycerol, 1g PEG-4000s, 2g preservative and 24g
Water mix homogeneously, forms mixture M；The mixture M is stood into degassing, fill, obtains described containing hyaluronic acid sodium gel
Skin care item D2.
Table 1
Table 1
| Embodiment is numbered | Moistening effect | Skin sense |
| A1 | Very well | It is fine and smooth |
| A2 | Very well | It is fine and smooth |
| A3 | Very well | It is fine and smooth |
| A4 | Very well | It is fine and smooth |
| A5 | Preferably | Relatively stick greasy |
| D1 | Difference | Stick very much greasy |
| D2 | Difference | Stick very much greasy |
According to upper table as can be seen that obtained skin care item A1-A5 within the scope of the invention, its moistening effect and skin sense all
Obtained low-numerator sodium hyaluronate D1 and D2 outer in the scope of the invention are better than, and it is obtained in currently preferred scope
Skin care item A1-A3 its various aspects of performance will be better than A4 and A5, therefore can realize the excellent performance of keeping humidity of skin care item and exquisiteness
Skin sense.
The preferred embodiment of the present invention described in detail above, but, the present invention is not limited in above-mentioned embodiment
Detail, the present invention range of the technology design in, various simple variants can be carried out to technical scheme, this
A little simple variants belong to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned specific embodiment, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The compound mode of energy is no longer separately illustrated.
Additionally, combination in any can also be carried out between a variety of embodiments of the present invention, as long as it is without prejudice to this
The thought of invention, it should equally be considered as content disclosed in this invention.
Claims (9)
1. a kind of skin care item containing hyaluronic acid sodium gel, it is characterised in that the component of the skin care item includes：Hyaluronate sodium
Gel, 1,3 butylene glycol, glycerol, PEG-4000, preservative and water.
2. skin care item according to claim 1, it is characterised in that the mass percent of the hyaluronic acid sodium gel is
45-55%, the mass percent of the 1,3 butylene glycol is 2-4%, and the mass percent of the glycerol is 0.5-1%, described
The mass percent of PEG-4000 is 0.3-0.7%, and the volume ratio of the preservative is 0.5-1%, excess water.
3. skin care item according to claim 2, it is characterised in that the preservative be Bis(hydroxymethyl)imidazolidinyl urea,
One or more in methyl hydroxybenzoate and iodine propilolic alcohol butyl mephenesin Carbamate.
4. skin care item according to claim 1, it is characterised in that the hyaluronic acid sodium gel is by graininess hyaluronic acid
Sodium gel and non-particulate hyaluronic acid sodium gel are mixed to get.
5. skin care item according to claim 4, it is characterised in that the graininess hyaluronic acid sodium gel and non-particulate
The mass ratio of hyaluronic acid sodium gel is 1:1-1.2.
6. a kind of preparation method of the skin care item containing hyaluronic acid sodium gel, it is characterised in that the preparation method includes：
(1) by hyaluronic acid sodium gel, 1,3 butylene glycol, glycerol, PEG-4000, preservative and water mix homogeneously, formed
Mixture M；
(2) mixture M is stood into degassing, fill, obtains the skin care item containing hyaluronic acid sodium gel, wherein,
The mass percent of the hyaluronic acid sodium gel is 45-55%, and the mass percent of the 1,3 butylene glycol is 2-
4%, the mass percent of the glycerol is 0.5-1%, and the mass percent of the PEG-4000 is 0.3-0.7%, institute
State preservative volume ratio be 0.5-1%, excess water.
7. preparation method according to claim 6, it is characterised in that the preservative is double (methylol) imidazolidinyls
One or more in urea, methyl hydroxybenzoate and iodine propilolic alcohol butyl mephenesin Carbamate.
8. preparation method according to claim 6, it is characterised in that the hyaluronic acid sodium gel is by graininess hyalomitome
Sour sodium gel and non-particulate hyaluronic acid sodium gel are mixed to get.
9. preparation method according to claim 6, it is characterised in that the graininess hyaluronic acid sodium gel and non-particulate
The mass ratio of shape hyaluronic acid sodium gel is 1:1-1.2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610944474.0A CN106580735A (en) | 2016-10-26 | 2016-10-26 | Skin care product containing sodium hyaluronate gel and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610944474.0A CN106580735A (en) | 2016-10-26 | 2016-10-26 | Skin care product containing sodium hyaluronate gel and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106580735A true CN106580735A (en) | 2017-04-26 |
Family
ID=58590379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610944474.0A Pending CN106580735A (en) | 2016-10-26 | 2016-10-26 | Skin care product containing sodium hyaluronate gel and preparing method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375068A (en) * | 2017-07-25 | 2017-11-24 | 广州铭心化妆品有限公司 | A kind of hormone is releived Essence and preparation method thereof |
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Application publication date: 20170426 |