CN105380816B - Purposes of the biologically active peptide in cosmetics preparation - Google Patents
Purposes of the biologically active peptide in cosmetics preparation Download PDFInfo
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- CN105380816B CN105380816B CN201510919356.XA CN201510919356A CN105380816B CN 105380816 B CN105380816 B CN 105380816B CN 201510919356 A CN201510919356 A CN 201510919356A CN 105380816 B CN105380816 B CN 105380816B
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- Prior art keywords
- biologically active
- active peptide
- skin
- cosmetics
- present
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 43
- 239000002537 cosmetic Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000006071 cream Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 6
- 235000021438 curry Nutrition 0.000 claims description 4
- 244000063299 Bacillus subtilis Species 0.000 claims description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 abstract description 6
- 239000000284 extract Substances 0.000 abstract description 6
- 230000036737 immune function Effects 0.000 abstract description 5
- 241000193830 Bacillus <bacterium> Species 0.000 abstract description 4
- 230000003647 oxidation Effects 0.000 abstract description 4
- 238000007254 oxidation reaction Methods 0.000 abstract description 4
- 230000037303 wrinkles Effects 0.000 abstract description 4
- 240000008067 Cucumis sativus Species 0.000 abstract description 3
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 abstract description 3
- 125000000539 amino acid group Chemical group 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 239000000287 crude extract Substances 0.000 abstract description 3
- 238000000855 fermentation Methods 0.000 abstract description 3
- 230000004151 fermentation Effects 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 239000002552 dosage form Substances 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 238000007348 radical reaction Methods 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 18
- 239000000686 essence Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 230000003712 anti-aging effect Effects 0.000 description 9
- 238000003756 stirring Methods 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000007599 discharging Methods 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000009758 senescence Effects 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000036572 transepidermal water loss Effects 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The present invention relates to a kind of new application of biologically active peptide in cosmetics preparation.Biologically active peptide of the present invention is the crude extract or extract from fermentation of bacillus product, contain 37~39 amino acid residues, it has the advantages that 1) biologically active peptide of the present invention is added in cosmetics with the dosage of additive amount 0.01%~50%, there is moisturizing water lock, enhancing skin immune function controlling；There is very strong oxidation resistance simultaneously, can inhibit radical reaction, damaged caused by reducing due to skin vigorous oxidation；Long-time service can obviously inhibit thinning of skin and elasticity to reduce, and can effectively reduce the rough degree of skin, dispel microgroove, and slow down the formation of all kinds of wrinkles of skin, Cucumber Extract keeps skin younger.2) biologically active peptide of the present invention has a wide range of application, can be good with most of cosmetic material compatibilities；It can be applied in the major dosage form of cosmetics, add simple and convenient.3) this product is safe and reliable, non-stimulated.
Description
Technical field
The invention belongs to field of biotechnology, it is related to a kind of new application of biologically active peptide in cosmetics preparation, specifically
It is related to a kind of application of the biologically active peptide from fermentation of bacillus product in preparation moisturizing anti-aging cosmetics.
Background technique
As Chinese society gradually steps into aging, moisturizing anti-aging beauty-care skin care is increasingly valued by people.Root
Show that women is most concerned about moisture-keeping crease-shedding, referral rate at present according to the survey data that Chinese essence scenting cosmetics Industry Association is issued
It is 72.2%.Therefore, it delays senescence by cosmetics, crease-resistant tender skin also becomes one of research direction of each cosmetic field.
With the continuous progress of science and technology, more and more functional components are applied into cosmetics preparation, such as: protein,
Amino acid, marine polysaccharide, plant extracts, vitamin etc..Peptides product is also more and more extensive in recent years to be applied in cosmetics,
Its purposes is concentrated mainly on anti-corrosion, antibacterial reparation, anti-oxidant and other effects, has some small-molecular peptides to have moisturizing, crease-resistant function.This
Biologically active peptide involved in inventing derives from bacillus subtilis (Ehrenberg) Cohn fermented product, contains 37~39 amino acid residues, research
It was found that such biologically active peptide has apparent growth inhibition effect to gram-positive bacteria, but it up to the present yet there are no document
Report whether the biologically active peptide has the function of moisturizing, crease-resistant, anti-aging, enhancing skin immune function controlling.Therefore, of the invention
If achievement can be market-oriented, market prospects will be very wide.
Summary of the invention
The research of the invention finds that there is significant protect from the biologically active peptide of bacillus using biotechnology discovery
The effects of wet, crease-resistant, enhancing skin immune function controlling, anti-aging.It is an object of the invention to combine traditional technology and biological skill
The biologically active peptide obtained using biotechnology is applied in traditional cosmetics preparation, is mentioned for cosmetics developer by art
For a kind of new way for solving the skin care of moisturizing anti-aging beauty-care or provide a kind of widely selection.
To achieve the goals above, the technical solution adopted in the present invention is as follows:
The present invention provides a kind of biologically active peptide, purposes of the biologically active peptide in cosmetics preparation is special
Sign is that the purposes, which has, to be included but do not limit to one of following situations or a variety of: moisturizing water lock, enhances cutaneous immunisation
Function, crease-resistant, tender skin delay senescence.
Purposes of the biologically active peptide in cosmetics preparation, which is characterized in that used cosmetics range are as follows: liquid
Body class, type of latex type, cream kind, thermophilic curry class, powder class or powder compacting class.
Purposes of the biologically active peptide in cosmetics preparation, which is characterized in that the biologically active peptide is being made up
Usage amount in product is the 0.01~50% of the cosmetics total weight.
The biologically active peptide, which is characterized in that the biologically active peptide is from fermentation of bacillus product
Crude extract or extract.
Purposes of the biologically active peptide in cosmetics preparation, which is characterized in that the biologically active peptide is at 50 DEG C
It is added in cosmetics when following.
The biologically active peptide, which is characterized in that the biologically active peptide uses aqueous solution or freeze-dried powder.
Biologically active peptide according to the present invention contains 37~39 amino acid residues, has the advantages that
1) extract of biologically active peptide of the present invention or crude extract are with being added to of dosage of additive amount 0.01%~50%
In cosmetic, there is moisturizing water lock, enhancing skin immune function controlling and very strong oxidation resistance, can inhibit radical reaction, reduce
It is damaged caused by due to skin vigorous oxidation；Long-time service can obviously inhibit thinning of skin and elasticity to reduce, and can effectively reduce skin
The rough degree of skin, dispels microgroove, and slows down the formation of all kinds of wrinkles of skin, and Cucumber Extract keeps skin younger.
2) biologically active peptide of the present invention has a wide range of application, can be good with most of cosmetic material compatibilities；Can be applied to
In the major dosage form of cosmetic, add simple and convenient.
3) this product is safe and reliable, non-stimulated.
Specific embodiment
Embodiment 1
Embodiment 1 is that biologically active peptide is preparing the application in moisturizing essence.
1 moisturizing essence formula of table
It is respectively formulated in table 1 and is prepared respectively by following technique:
1. each component mixing in A phase is heated to 80~85 DEG C of dissolutions completely, after insulated and stirred 30min, slowly drop
Temperature.
2. B, C phase are added when A phase temperature is down to 45 DEG C, it is dispersed with stirring uniformly.
3. when temperature is down to 35 DEG C, discharging.
Embodiment 2
Embodiment 2 is application of the biologically active peptide in emulsification system.
2 moisturizing of table anti-aging frost formula
It is respectively formulated in table 2 and is prepared respectively by following technique:
1. it is complete that each component in A phase is heated with stirring to 80~85 DEG C of dissolutions；Each component mixing in B phase is heated to
90~85 DEG C of dissolutions are complete.
2. A is added in B phase, after high speed homogenization emulsifies 5min, in 80~85 DEG C of insulated and stirred 30min.
3. D, C phase are added when emulsification system temperature is slowly dropped to 45 DEG C, stir evenly.
4. when temperature is down to 35 DEG C, discharging.
Embodiment 3
Embodiment 3 is application of the biologically active peptide in the preparation thermophilic curry of anti-aging.
The thermophilic curry formula of 3 anti-aging of table
It is respectively formulated in table 3 and is prepared respectively by following technique:
1. each component in A phase is heated with stirring to 80~85 DEG C of dissolutions completely, and cool down after insulated and stirred 30min.
2. B is dispersed with stirring uniformly to middle each component.
3. B, C phase are added when A phase temperature is down to 45 DEG C, it is dispersed with stirring uniformly.
4. when temperature is down to 35 DEG C, discharging.
Below by way of gelatine/biological activity peptide for specific test example cosmetics purposes
Test example 1
This test example has studied the moistening effect for Essence prepared by the embodiment of the present invention 1.
Test method: choosing the Chinese women of skin health totally 36 people, and subject tests first 2 days, and skin care is stopped using to produce
Product, are randomly divided into 4 groups, and every group of 9 people crank arm inside with subject as test point；Blank group does not smear any cosmetics, and control group applies
Comparative formula Essence is smeared, 1 group of smearing is tested and is formulated 2 Essences, 2 groups of smearings is tested and is formulated 1 Essence.Respectively in 0h,
1h, 2h and 4h skin moisture content and transepidermal water loss amount.As a result as shown in table 4, table 5.
The change rate of 4 each group test section moisture content of skin MMV of table
The change rate of 5 each group test section skin dehydration TEWL value of table
By table 4 as it can be seen that in test period 4h, after subject uses Essence, the hydration rate of 2 groups of 1 group of test and test
Extremely significant (p < 0.01) higher than blank group, the hydration rate of control group are significantly higher than (the p < 0.05) of blank group, test 1 group
It is significantly higher than (the p < 0.05) of control group with 2 groups of hydration rate of test；This illustrates that comparative formula, formula 1,2 Essences of formula are equal
With moisturizing effect, and significant effect；Compared with comparative formula Essence, the moisturizing effect of 2 Essences of formula 1 and formula is more aobvious
It writes (p < 0.05).It can be seen that biologically active peptide is added in Essence, have significant moisturizing effect (p < 0.05).By table 5
As it can be seen that after subject uses Essence, skin dehydration TWEWL value is in decreasing trend, and always below sky in test period 4h
White group；The percentage of water loss of each group is negative value in 1h, 2h and 4h, and always below blank group, illustrates that test sample has
The effect of skin water loss is reduced, and the effect for testing 1 group and 2 groups of test is extremely significant (p < 0.01), the effect of control group is aobvious
It writes (p < 0.05)；It can be seen that biologically active peptide, which is added in Essence, can significantly reduce transepidermal water loss rate, water can be effectively lockked
Divide (p < 0.05).In general, biologically active peptide is added into Essence, moisture content of skin (p < can be significantly increased
0.05), and percutaneous loss moisture (p < 0.05) is reduced, there is significant moisturizing, water lock effect (p < 0.05), moistening effect is aobvious
It writes (p < 0.05).
Test example 2
This test example has studied to be exempted from for the crease-resistant of face cream prepared by the embodiment of the present invention 2, anti-aging, enhancing skin
Epidemic disease power effect.
Test method: choosing Health China women 30 of 30~55 years old, early daily, evening wash one's face after by the eye on everyone left side
Comparative formula face cream in embodiment 2 is smeared at angle and cheek, is smeared in embodiment 2 at the right canthus and cheek and is formulated 1 face cream；It holds
It is continuous to use 30 days.The results show that have the function of to adjust cutaneous immunisation power after 1 face cream using being formulated compared with comparative formula face cream,
Crease-resistant moistening effect is significant (p < 0.05), has preferable eliminating wrinkle ability, while having both moistening effect；For a long time adhere to using
It can obviously inhibit thinning of skin and elasticity to reduce, can effectively reduce the degree of roughness of skin, dispel microgroove, slow down all kinds of skin wrinkles
The formation of line, Cucumber Extract, skin is moist, delay skin aging, more aobvious youth.This illustrates that biologically active peptide has moisturizing
Crease-resistant, enhancing skin immune function controlling, delay skin aging function.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (5)
1. purposes of the biologically active peptide in cosmetics preparation, which is characterized in that the purposes is moisturizing water lock；
The biologically active peptide derives from bacillus subtilis (Ehrenberg) Cohn fermented product from biologically active peptide, contains 37~39 ammonia
Base acid.
2. purposes according to claim 1, which is characterized in that used cosmetics range are as follows: liquid type, type of latex type,
Cream kind, thermophilic curry class, powder class or powder compacting class.
3. purposes according to claim 1, which is characterized in that usage amount of the biologically active peptide in cosmetics be
The 0.01~50% of the cosmetics total weight.
4. purposes according to claim 3, which is characterized in that makeup is added at 50 DEG C or less for the biologically active peptide
In product.
5. purposes according to claim 1, which is characterized in that the biologically active peptide uses aqueous solution or freeze-dried powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510919356.XA CN105380816B (en) | 2015-12-14 | 2015-12-14 | Purposes of the biologically active peptide in cosmetics preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510919356.XA CN105380816B (en) | 2015-12-14 | 2015-12-14 | Purposes of the biologically active peptide in cosmetics preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105380816A CN105380816A (en) | 2016-03-09 |
| CN105380816B true CN105380816B (en) | 2019-04-30 |
Family
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|---|---|---|---|
| CN201510919356.XA Active CN105380816B (en) | 2015-12-14 | 2015-12-14 | Purposes of the biologically active peptide in cosmetics preparation |
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| Country | Link |
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| CN (1) | CN105380816B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902477B (en) * | 2016-04-27 | 2018-11-02 | 深圳市容大生物技术有限公司 | The comprehensive biological agent and preparation method thereof for improving eye vigor |
| CN108354851A (en) * | 2018-04-24 | 2018-08-03 | 黄宪超 | Small-molecular peptides skin care ointment |
| CN111514181B (en) * | 2020-04-01 | 2022-10-04 | 广州睿森生物科技有限公司 | Antibacterial composition, antibacterial composite nano-particles, preparation method of antibacterial composite nano-particles and targeted slow-release nano-private gel |
| CN111494277A (en) * | 2020-04-28 | 2020-08-07 | 广州欧正化妆品技术研究院有限公司 | Acne removing factor, acne removing soft mask gel and preparation method thereof |
| CN115054566B (en) * | 2022-06-29 | 2023-12-29 | 广州禾力生物科技有限公司 | Scalp aging resisting composition and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101608203A (en) * | 2008-06-19 | 2009-12-23 | 陈栋梁 | A kind of fish skin collagen peptide and preparation technology and purposes with humidity-holding effect |
| CN103421872A (en) * | 2013-03-08 | 2013-12-04 | 广州市鼍龙生物技术开发有限公司 | Preparation method and application of crocodile-skin collagen peptide |
| CN104498551A (en) * | 2014-12-23 | 2015-04-08 | 天津北洋百川生物技术有限公司 | Preparation method of macromolecule gamma-polyglutamic acid and shaving foam |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008110927A (en) * | 2006-10-30 | 2008-05-15 | Yamada Bee Farm Corp | Cosmetic containing royal jelly protein hydrolyzate |
| CN103255187B (en) * | 2012-02-21 | 2015-02-18 | 华熙福瑞达生物医药有限公司 | Low molecular hyaluronate, preparation method and purpose thereof |
| CN102793657B (en) * | 2012-08-22 | 2015-09-16 | 珀莱雅化妆品股份有限公司 | A kind of skin care item containing biological buffer |
-
2015
- 2015-12-14 CN CN201510919356.XA patent/CN105380816B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101608203A (en) * | 2008-06-19 | 2009-12-23 | 陈栋梁 | A kind of fish skin collagen peptide and preparation technology and purposes with humidity-holding effect |
| CN103421872A (en) * | 2013-03-08 | 2013-12-04 | 广州市鼍龙生物技术开发有限公司 | Preparation method and application of crocodile-skin collagen peptide |
| CN104498551A (en) * | 2014-12-23 | 2015-04-08 | 天津北洋百川生物技术有限公司 | Preparation method of macromolecule gamma-polyglutamic acid and shaving foam |
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