CN1093901A - 烟霉醇衍生物的稳定药物组合物 - Google Patents
烟霉醇衍生物的稳定药物组合物 Download PDFInfo
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- CN1093901A CN1093901A CN93120125A CN93120125A CN1093901A CN 1093901 A CN1093901 A CN 1093901A CN 93120125 A CN93120125 A CN 93120125A CN 93120125 A CN93120125 A CN 93120125A CN 1093901 A CN1093901 A CN 1093901A
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- fatty acid
- pharmaceutical composition
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- acid ester
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- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 73
- 239000000194 fatty acid Substances 0.000 claims abstract description 73
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- 239000000203 mixture Substances 0.000 claims abstract description 31
- 230000033115 angiogenesis Effects 0.000 claims abstract description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 42
- 150000004665 fatty acids Chemical class 0.000 claims description 36
- 229910052757 nitrogen Inorganic materials 0.000 claims description 27
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- 238000000034 method Methods 0.000 claims description 18
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- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 229910052717 sulfur Inorganic materials 0.000 claims description 17
- 239000011593 sulfur Substances 0.000 claims description 17
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- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 6
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- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 5
- 125000003282 alkyl amino group Chemical group 0.000 description 5
- 239000004037 angiogenesis inhibitor Substances 0.000 description 5
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- 125000003435 aroyl group Chemical group 0.000 description 5
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- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP335828/92 | 1992-12-16 | ||
| JP33582892 | 1992-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1093901A true CN1093901A (zh) | 1994-10-26 |
Family
ID=18292862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93120125A Pending CN1093901A (zh) | 1992-12-16 | 1993-12-16 | 烟霉醇衍生物的稳定药物组合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5422363A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0602586B1 (cg-RX-API-DMAC7.html) |
| KR (1) | KR940013499A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1093901A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE153854T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2111560A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69311278T2 (cg-RX-API-DMAC7.html) |
| PH (1) | PH30120A (cg-RX-API-DMAC7.html) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5566069A (en) * | 1994-03-07 | 1996-10-15 | Monsanto Company | Computer network for collecting and analyzing agronomic data |
| US5699244A (en) * | 1994-03-07 | 1997-12-16 | Monsanto Company | Hand-held GUI PDA with GPS/DGPS receiver for collecting agronomic and GPS position data |
| EP0799616A1 (en) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Oral composition comprising a fumagillol derivative |
| US20010025046A1 (en) * | 1999-06-24 | 2001-09-27 | Rong(Ron) Liu | Self-emulsifying systems containing anticancer medicament |
| DE60034770T2 (de) | 1999-02-26 | 2008-04-30 | Sanofi-Aventis | Stabile fumagillin-formulierung |
| US6673843B2 (en) * | 1999-06-30 | 2004-01-06 | Emory University | Curcumin and curcuminoid inhibition of angiogenesis |
| AU2002239479B2 (en) * | 2000-11-01 | 2006-11-09 | Praecis Pharmaceuticals Incorporated | Peptides as Met-AP2 inhibitors |
| US6548477B1 (en) * | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| US6919307B2 (en) * | 2000-11-01 | 2005-07-19 | Praecis Pharmaceuticals, Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| US7105482B2 (en) | 2000-11-01 | 2006-09-12 | Praecis Pharmaceuticals, Inc. | Methionine aminopeptidase-2 inhibitors and methods of use thereof |
| US7001603B2 (en) * | 2001-02-28 | 2006-02-21 | Color Access, Inc. | Gelled two phase cosmetic compositions |
| KR100451485B1 (ko) * | 2002-03-28 | 2004-10-06 | 주식회사종근당 | 푸마질롤 유도체 또는 그 염의 포접 화합물, 및 이를포함하는 약제학적 조성물 |
| US20050239878A1 (en) * | 2003-12-29 | 2005-10-27 | Praecis Pharmaceuticals, Inc. | Inhibitors of methionine aminopeptidase-2 and uses thereof |
| AU2008331516B2 (en) * | 2007-11-28 | 2014-01-09 | Mersana Therapeutics, Inc. | Biocompatible biodegradable fumagillin analog conjugates |
| CN102123586A (zh) | 2008-07-18 | 2011-07-13 | 法弗根股份有限公司 | 治疗超重或肥胖受试者的方法 |
| US8642650B2 (en) | 2008-12-04 | 2014-02-04 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
| WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| KR20120083905A (ko) | 2009-10-09 | 2012-07-26 | 자프겐 코포레이션 | 비만의 치료에 사용하기 위한 설폰 화합물 |
| US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
| CN102791699B (zh) | 2010-01-08 | 2016-04-06 | 扎夫根公司 | 烟曲霉醇型化合物和其制造和使用方法 |
| US20130023513A1 (en) | 2010-01-12 | 2013-01-24 | Hughes Thomas E | Methods and Compositions for Treating Cardiovascular Disorders |
| US20130266578A1 (en) | 2010-04-07 | 2013-10-10 | Thomas E. Hughes | Methods of treating an overweight subject |
| CN103249735B (zh) | 2010-07-22 | 2016-04-06 | 扎夫根股份有限公司 | 三环化合物及其制备和使用方法 |
| PH12013500934A1 (en) | 2010-11-09 | 2022-10-24 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
| US20140073691A1 (en) | 2010-11-10 | 2014-03-13 | Zafgen, Inc. | Methods and composition for Treating Thyroid Hormone Related Disorders |
| WO2012074968A1 (en) | 2010-11-29 | 2012-06-07 | Zafgen Corporation | Methods of reducing risk of hepatobiliary dysfunction during rapid weight loss with metap-2 inhibitors |
| BR112013013411A2 (pt) | 2010-11-29 | 2016-09-13 | Zafgen Inc | tratamento de obesidade usando administração não diária de 6-0-(4-dimetilaminoetxi) cinamoil fumagilol |
| US9189078B2 (en) | 2010-12-20 | 2015-11-17 | Apple Inc. | Enhancing keycap legend visibility with optical components |
| EP2668169B1 (en) | 2011-01-26 | 2017-11-15 | Zafgen, Inc. | Tetrazole compounds and methods of making and using same |
| MX342257B (es) | 2011-03-08 | 2016-09-21 | Zafgen Inc | Derivados y análogos de oxaspiro [2.5] octano. |
| BR112013028534A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos |
| AU2012253759B2 (en) | 2011-05-06 | 2016-01-21 | Zafgen Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| US9242997B2 (en) | 2011-05-06 | 2016-01-26 | Zafgen, Inc. | Tricyclic pyrazole sulphonamide compunds and methods of making and using same |
| EP2763671A2 (en) | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Methods of treating age related disorders |
| CA2861390A1 (en) | 2012-01-18 | 2013-07-25 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| JP2015509102A (ja) | 2012-01-18 | 2015-03-26 | ザフゲン，インコーポレイテッド | 三環式スルホン化合物並びにその作製および使用方法 |
| KR20150016303A (ko) | 2012-05-07 | 2015-02-11 | 자프겐 인크. | 6-o-(4-디메틸아미노에톡시) 신나모일 푸마지롤의 옥살레이트 염의 다형체 염 및 이의 제조 및 사용 방법 |
| BR112014028041A2 (pt) | 2012-05-08 | 2017-06-27 | Zafgen Inc | tratamento de obesidade hipotalâmica com inibidores de metap2 |
| EP2850079B1 (en) | 2012-05-09 | 2018-05-02 | Zafgen, Inc. | Fumigillol type compounds and methods of making and using same |
| BR112015010225A2 (pt) | 2012-11-05 | 2017-07-11 | Zafgen Inc | compostos tricíclicos e seus métodos de produção e utilização |
| JP6169716B2 (ja) | 2012-11-05 | 2017-07-26 | ザフゲン，インコーポレイテッド | 肝疾患を治療する方法 |
| BR112015010223A2 (pt) | 2012-11-05 | 2017-07-11 | Zafgen Inc | compostos tricíclicos para o uso no tratamento e/ou controle de obesidade |
| EP2968250B1 (en) | 2013-03-14 | 2019-06-19 | Zafgen, Inc. | Methods of treating renal disease and other disorders |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
| CN110769814B (zh) | 2017-03-15 | 2022-10-18 | 睿升公司 | 具有高载药量的中链甘油三酯的药物组合物及其相关方法 |
| BE1027390B1 (nl) * | 2019-06-21 | 2021-02-02 | Nutrition Sciences Nv | Mfca-samenstelling voor gebruik in de aquacultuur van schaaldieren |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0784462B2 (ja) * | 1986-07-25 | 1995-09-13 | 日清製粉株式会社 | ベンゾイミダゾ−ル誘導体 |
| CA1333363C (en) * | 1988-01-19 | 1994-12-06 | Judah Folkman | Angiogenesis inhibitor comprising fumagillin |
| PH26256A (en) * | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
| US4954496A (en) * | 1988-08-12 | 1990-09-04 | Fujisawa Pharmaceutical Company, Ltd. | Cyclohexane derivatives and pharmaceutical compositions |
| EP0359036B1 (en) * | 1988-09-01 | 1997-03-26 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives |
| ATE106726T1 (de) * | 1988-09-01 | 1994-06-15 | Takeda Chemical Industries Ltd | Angiogenese hemmendes mittel. |
| EP0386667B1 (en) * | 1989-03-06 | 1993-11-18 | Takeda Chemical Industries, Ltd. | 6-Amino-6-desoxyfumagillols, production and use thereof |
| EP0387650B1 (en) * | 1989-03-06 | 1993-03-31 | Takeda Chemical Industries, Ltd. | 6-epifumagillols, production and use thereof |
| EP0415294A3 (en) * | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
| TW282399B (cg-RX-API-DMAC7.html) * | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
| DE69114782T2 (de) * | 1990-08-08 | 1996-04-18 | Takeda Chemical Industries Ltd | Intravaskulär embolisierendes Mittel mit Gehalt an einem die Angiogenesis hemmenden Stoff. |
-
1993
- 1993-12-14 AT AT93120104T patent/ATE153854T1/de not_active IP Right Cessation
- 1993-12-14 EP EP93120104A patent/EP0602586B1/en not_active Expired - Lifetime
- 1993-12-14 DE DE69311278T patent/DE69311278T2/de not_active Expired - Fee Related
- 1993-12-15 CA CA002111560A patent/CA2111560A1/en not_active Abandoned
- 1993-12-15 PH PH47449A patent/PH30120A/en unknown
- 1993-12-15 US US08/167,479 patent/US5422363A/en not_active Expired - Lifetime
- 1993-12-16 CN CN93120125A patent/CN1093901A/zh active Pending
- 1993-12-16 KR KR1019930028037A patent/KR940013499A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE69311278T2 (de) | 1997-10-30 |
| ATE153854T1 (de) | 1997-06-15 |
| EP0602586A3 (cg-RX-API-DMAC7.html) | 1994-08-31 |
| EP0602586A2 (en) | 1994-06-22 |
| US5422363A (en) | 1995-06-06 |
| EP0602586B1 (en) | 1997-06-04 |
| PH30120A (en) | 1996-12-27 |
| DE69311278D1 (de) | 1997-07-10 |
| KR940013499A (ko) | 1994-07-15 |
| CA2111560A1 (en) | 1994-06-17 |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |