CN109381521A - A kind of Chinese materia medica preparation and preparation method thereof for health care - Google Patents

A kind of Chinese materia medica preparation and preparation method thereof for health care Download PDF

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CN109381521A
CN109381521A CN201811616686.1A CN201811616686A CN109381521A CN 109381521 A CN109381521 A CN 109381521A CN 201811616686 A CN201811616686 A CN 201811616686A CN 109381521 A CN109381521 A CN 109381521A
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孙熙瑜
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638Ligustrum, e.g. Chinese privet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Insects & Arthropods (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to a kind of Chinese materia medica preparations for health care, including Radix Notoginseng 10-20%, American Ginseng 10-20%, Radix Salviae Miltiorrhizae 15-25%, borneol 5-15%, royal jelly freeze-dried powder 15-25% and fruit of glossy privet 15-25%, preparation method are successively to be uniformly mixed American Ginseng, Radix Salviae Miltiorrhizae, borneol, royal jelly freeze-dried powder and the fruit of glossy privet in proportion and be crushed to 100 mesh, and granular capsule is made.The Chinese materia medica preparation that the present invention is made using Radix Notoginseng, American Ginseng, Radix Salviae Miltiorrhizae, borneol, royal jelly and the fruit of glossy privet as raw material, with multiple efficacies, synergistic effect between each ingredient makes each effect mutually promote, the whole curative effect for enhancing said preparation, is a kind of Chinese materia medica preparation of the health care of multiple-effect.

Description

A kind of Chinese materia medica preparation and preparation method thereof for health care
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of for the Chinese materia medica preparation of health care and its preparation side Method.
Background technique
Currently, as the pressure of life and work increases and the growth at age, spirit, diet, nutrition, endocrine, medicine in addition The effects of object, many people gradually feel that various discomforts occurs in body, tired mind such as occur, and Light-headedness is had a pain in the back, property There are many reason of symptom of many senility of humanbody such as hypofunction, senility of humanbody, but theory of traditional Chinese medical science thinks, basic reason be by Caused by the long-term consumption consumptive loss of people's human body, qi-blood deficiency and Heat Diabetes.Modern medicine there is no special effect medicine therapeutic and guarantor Strong, mostly with sex hormone, drugs for nervous or multivitamin health care and treatment, but people are generally to hormone and neuromodulation medicine The side effect of object is dread, is ready using natural Chinese traditional medicines health care and treatment.But currently used strengthening vital QI to eliminate pathogenic factors, enhancing are exempted from The Chinese materia medica preparation production of epidemic disease power is complicated, and process is complex, and therapeutic effect is single and not significant enough.Therefore, it is more to prepare one kind It weighs effect and significant effect, health-preserving health-care Chinese medicine preparation applied widely, at low cost has important economy, society and reality Meaning.
Summary of the invention
The object of the invention is that solve the above-mentioned problems and to provide a kind of structure simple, design a kind of reasonable use In the Chinese materia medica preparation of health care.
The present invention through the following technical solutions to achieve the above objectives:
A kind of Chinese materia medica preparation for health care, by weight percentage, the Chinese materia medica preparation ingredient include: Radix Notoginseng 10- 20%, American Ginseng 10-20%, Radix Salviae Miltiorrhizae 15-25%, borneol 5-15%, royal jelly freeze-dried powder 15-25% and fruit of glossy privet 15-25%.
As a further optimization solution of the present invention, by weight percentage, which includes: Radix Notoginseng 15%, American Ginseng 15%, Radix Salviae Miltiorrhizae 20%, borneol 10%, royal jelly freeze-dried powder 20% and the fruit of glossy privet 20%.
As a further optimization solution of the present invention, which is mouth made of routine techniques Formulation.
A kind of preparation method of the Chinese materia medica preparation for health care as described above, comprising the following steps:
S1: it takes Radix Notoginseng, American Ginseng, Radix Salviae Miltiorrhizae and the fruit of glossy privet dry by weight percentage and collects;
S2: the Radix Notoginseng of the step S1 drying collected, western health, Radix Salviae Miltiorrhizae and the fruit of glossy privet are mixed by weight percentage with borneol It uniformly and crushes, is sieved, obtains evengranular powder;
S3: being added royal jelly freeze-dried powder in the powder obtained in step s 2, stir evenly, that is, obtains the Chinese materia medica preparation.
It as a further optimization solution of the present invention, further include step S4, concrete operations after the step S3 are as follows: by step The canned capsule that granulates of Chinese materia medica preparation that S3 is obtained, and bottle.
As a further optimization solution of the present invention, size of being sieved in the step S2 is 100 mesh.
As a further optimization solution of the present invention, Chinese materia medica preparation content is about in the granular capsule of the step S4 preparation 500mg/, the bottling quantity is 50~60/bottle.
The principle of the present invention are as follows:
Radix Notoginseng is the dry root and rhizome of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen, tool There is a dissipating stasis and stanching bleeding, the effect of detumescence ding-tong is spitted blood for spitting blood, bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, and chest and abdomen shouting pain is fallen and flutterred Swelling and pain.
American Ginseng, Chinese medicine name are the root of Panax quinquefolium L. of araliaceae, choose the root of growth 3~6 years, dig and adopt in autumn, Branch, palpus tail are removed, is dried, water spray is wet, crust is hit, then smoke it with Sulfur, after drying, white powder person of color, referred to as powder Light American Ginseng.I.e. gross weight dries or drying person after having dug, and is American ginseng;Its major function are as follows: beneficial lung yin, the clear fire of deficiency type are raw Saliva quenches the thirst.It controls the deficiency syndrome of the lung to cough long, blood loss, dry throat and mouth, abnormal heat is tired of tired;Tonifying lung fall fire, born fluid, relieving restlessness is tired, empty and have fiery person's phase Preferably;Tonifying yin is brought down a fever, ginger QI invigorating, centralizing qi;It is prosperous to control lung-fire, coughing with a lot of sputum, the deficiency of vital energy breathes out to breathe heavily, blood loss, internal lesion caused by overexertion, and controlling nocturnal emission with astringent drugs is calmed the nerves, raw Produce all void;Clearing lung-heat kidney, cool heart spleen are relieved summer heat, are relieved the effect of alcohol with fall fire;Gas point can be subsidized, and can help blood system.
Radix Salviae Miltiorrhizae is the dry root and rhizome of Lamiaceae plant Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge., spring, Qiu Erji Excavation removes silt, dry.National most area is all distributed, and has promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness, cool blood The effect of carbuncle that disappears;For chest impediment and cardialgia, stomach duct and abdomen hypochondriac pain, a lump in the abdomen causing distension and pain, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhea warp It closes, sore swell and ache curative.
Borneol also known as piece brain, orange slices, L-Borneol, kapur, MEIHUA BINGPIAN, Dipterocarpus pilosus, plum blossom brain, borneol brain, Mei Bing Deng, it is through steam distillation and to be recrystallized and obtained by composite family Blumea balsamifera cauline leaf or lauraceae plant borneol camphor tree branches and leaves, also useful turpentine Oil is obtained through a series of chemical method techniques, can be used for closing card coma, for red eye, swell pain, sore throat aphtha swells for sore Bitterly, it is not held back after bursting.
Royal jelly also known as bee milk, honeybee royal cream, queen bee cream, royal jelly, are the young worker bee pharynxes that larva is cultivated in honeycomb The secretion of gland, is supplied with the food that will become the larva of queen bee and the lifelong food of queen bee, and so-called royal jelly is exactly green Prime of life honeybee eats a kind of milk secreted after pollen, milk and great nutritive value of this milk just as mammal And immune function.Its major function are as follows: assisting in reducing blood sugar, this effect is mainly because its Insulin-Like peptides reasoning contained obtains Come, Insulin-Like peptides be treat diabetes specific medicament, it is demonstrated experimentally that daily 10 grams of royal jelly shared with Lin Zhongling it is edible Play the role for the treatment of diabetes and insomnia;Anti-oxidation efficacy, it has very strong effect to the reparation and regeneration of cell, wherein Superoxide dismutase (SOD) be oxidation resistant main component;Reduce blood lipid, balanced fatty metabolism and glycometabolism;Control blood Enlargement of pipe reduces blood pressure;Liver is protected, hepatitis virus is killed, and virus can be inhibited to replicate in liver cell;Antibacterial disappears Inflammation, anti-aging effects, and strengthen sexual function effect, while also anti-radiation, enhance the effect of memory.
The fruit of glossy privet is the fruit of Oleaceae plants glossy privet, and when winter fruit maturation picks, and removes branches and leaves and dries, or by fruit It after slightly smoking, dries, or sets to scald in hot water and dry later;Its function is nourishing liver and kidney, and strong waist and knee controls yin asthenia generating intrinsic heat, dizzy, mesh flower, Tinnitus, soreness and weakness of waist and knees, poliosis is nourishing liver and kidney, improving eyesight black hair, is used for dizziness and tinnitus, soreness and weakness of waist and knees, poliosis, mesh are dark It is unknown.
The Chinese materia medica preparation that the present invention is made using Radix Notoginseng, American Ginseng, Radix Salviae Miltiorrhizae, borneol, royal jelly and the fruit of glossy privet as raw material, tool There are many functions, and wherein Radix Notoginseng is mutually promoted with Radix Salviae Miltiorrhizae, enhances the effect of the invigorating circulation of blood to dissipate blood stasis and reducing swelling and relieving pain of the medicament, in addition, bee Royal jelly be combined with each other with the fruit of glossy privet, plays the role of hypoglycemic, blood lipid, anti-aging and tonifying Qi kidney tonifying, the collaboration between each ingredient Effect, makes each effect mutually promote, enhances the whole curative effect of said preparation, be a kind of Chinese materia medica preparation of the health care of multiple-effect.
The beneficial effects of the present invention are:
1) present invention is using pure plant as raw material, and production method is simple, and capsule-type particle can convenient for taking It is taken as daily health products;
2) principle of the invention according to many years Chinese medicine pharmacy, by Radix Notoginseng, American Ginseng, Radix Salviae Miltiorrhizae, borneol and royal jelly freeze-dried powder The granular capsule of mixed grinding rear support is taken in proportion, by the mutual synergistic effect between each component, has strengthening vital QI to eliminate pathogenic factors, peace The vital organs of the human body increase the generation of osteocyte and erythrocyte;Help is developed, qi-blood tonifying, anti-heart failure;It activates blood circulation and disperses blood clots, cleaning is certainly By base, anti-aging, the effect of promoting longevity;
3) adaptation population's range of the present invention is wide, hormone-free, has no toxic side effect, at low cost, has health care function.
Specific embodiment
The application is described in further detail below, it is necessary to which indicated herein to be, following specific embodiments are only used It is further detailed in the application, should not be understood as the limitation to the application protection scope, person skilled in art Some nonessential modifications and adaptations can be made to the application according to above-mentioned application content.
Embodiment 1
A kind of Chinese materia medica preparation for health care, by weight percentage, which includes: Radix Notoginseng 10%, American Ginseng 20%, Radix Salviae Miltiorrhizae 15%, borneol 15%, royal jelly freeze-dried powder 15% and the fruit of glossy privet 25%.
The Chinese materia medica preparation for health care is that system is taken orally made of routine techniques, and preparation method includes following step It is rapid:
S1: it takes Radix Notoginseng, American Ginseng, Radix Salviae Miltiorrhizae and the fruit of glossy privet dry by weight percentage and collects;
S2: the Radix Notoginseng of the step S1 drying collected, western health, Radix Salviae Miltiorrhizae and the fruit of glossy privet are mixed by weight percentage with borneol It uniformly and crushes, sieves with 100 mesh sieve, obtain evengranular powder;
S3: being added royal jelly freeze-dried powder in the powder obtained in step s 2, stir evenly, that is, obtains the Chinese materia medica preparation;
S4: the step S3 Chinese materia medica preparation obtained is made to 500mg/ capsules, and 50 are packed into one bottle.
Embodiment 2
A kind of Chinese materia medica preparation for health care, by weight percentage, which includes: Radix Notoginseng 15%, American Ginseng 15%, Radix Salviae Miltiorrhizae 20%, borneol 10%, royal jelly freeze-dried powder 20% and the fruit of glossy privet 20%.
The Chinese materia medica preparation for health care is that system is taken orally made of routine techniques, and preparation method includes following step It is rapid:
S1: it takes Radix Notoginseng, American Ginseng, Radix Salviae Miltiorrhizae and the fruit of glossy privet dry by weight percentage and collects;
S2: the Radix Notoginseng of the step S1 drying collected, western health, Radix Salviae Miltiorrhizae and the fruit of glossy privet are mixed by weight percentage with borneol It uniformly and crushes, sieves with 100 mesh sieve, obtain evengranular powder;
S3: being added royal jelly freeze-dried powder in the powder obtained in step s 2, stir evenly, that is, obtains the Chinese materia medica preparation;
S4: the step S3 Chinese materia medica preparation obtained is made to 500mg/ capsules, and 55 are packed into one bottle.
Embodiment 3
A kind of Chinese materia medica preparation for health care, by weight percentage, which includes: Radix Notoginseng 20%, American Ginseng 10%, Radix Salviae Miltiorrhizae 25%, borneol 5%, royal jelly freeze-dried powder 25% and the fruit of glossy privet 15%.
The Chinese materia medica preparation for health care is that system is taken orally made of routine techniques, and preparation method includes following step It is rapid:
S1: it takes Radix Notoginseng, American Ginseng, Radix Salviae Miltiorrhizae and the fruit of glossy privet dry by weight percentage and collects;
S2: the Radix Notoginseng of the step S1 drying collected, western health, Radix Salviae Miltiorrhizae and the fruit of glossy privet are mixed by weight percentage with borneol It uniformly and crushes, sieves with 100 mesh sieve, obtain evengranular powder;
S3: being added royal jelly freeze-dried powder in the powder obtained in step s 2, stir evenly, that is, obtains the Chinese materia medica preparation;
S4: the step S3 Chinese materia medica preparation obtained is made to 500mg/ capsules, and 60 are packed into one bottle.
Effect detection is carried out to the Chinese materia medica preparation for being used for health care prepared by above-described embodiment 1-3, is detected in advance Under the premise of having no toxic side effect, the crowd for being 12-80 years old to age bracket carries out effect monitoring, as a result as follows:
Mr. Ji, male, 47 years old, physical symptom showed as malaise, deficiency of the kidney;Take the Chinese materia medica preparation glue of the acquisition of embodiment 2 Capsule once a grain, adheres to the physical condition for taking and implementing monitoring Mr. Ji, as a result are as follows: take the Chinese materia medica preparation one week once a day Afterwards, Mr. Ji indicate breathes hard situation have slight improvement, but be not it is particularly evident, win state slightly improve;Take the Chinese medicine After preparation one month, Mr. Ji indicates that body & mind state is clearly better, and the love life time extends.
Certain is made pottery, female, 44 years old, physical symptom showed themselves in that diarrhea before dawn, bed-wetting, urine collapse, and the big loose stool of getting up early is thin, can not go out.Clothes 2 times a day once two grains, and Mrs Tao is measured in real time with the Chinese materia medica preparation, as a result shows themselves in that and take after a week, pottery Defecation situation slightly improves from Ms indicates morning, and after taking one month, defecation is normal, and to twice, urine situation slightly has within one day one Improve, defecation frequency is reduced, and waist-leg is energetically, can carry out outdoor activities.
Lee, female, 38 years old, physical symptom showed themselves in that skin is dark yellow, and there are spots for skin surface, and it is existing that skin has relaxation As, and monthly menstrual flow is big, with severe stomachache.The Chinese materia medica preparation is taken, 3 times a day, once two grains, and Mrs Li is carried out As a result real-time detection shows themselves in that after taking 20 days that Mrs Li indicates that skin condition slightly improves, more fine and smooth and pimple It reduces, after taking 2 months, intermenstrual period blood volume clot is reduced, and feeling of pain weakens.
What certain, male, 24 years old, physical symptom show themselves in that throat it is dry itch, pain, cough from morning, take the Chinese materia medica preparation, one Day 3 times, once a grain, and certain is measured in real time to what, as a result shows themselves in that after taking 3 days, the dry symptom decrease of itching of throat, from morning Status of cough is reduced, and after taking one month, the above symptom disappears substantially.
Mr. Wang, male, 15 years old, physical symptom showed themselves in that the long acne of face, and with acne print, surface is red and swollen, takes the Chinese medicine system Agent 3 times a day once two grains, and is measured in real time Mr. Wang, as a result shows themselves in that after taking 10 days, part variola abatement, acne Print desalination, after taking three months, face's small pox is significantly reduced, and acne print is reduced, and facial redness is taken off.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention Protect range.

Claims (7)

1. a kind of Chinese materia medica preparation for health care, which is characterized in that by weight percentage, the Chinese materia medica preparation is at subpackage It includes: Radix Notoginseng 10-20%, American Ginseng 10-20%, Radix Salviae Miltiorrhizae 15-25%, borneol 5-15%, royal jelly freeze-dried powder 15-25% and glossy privet Sub- 15-25%.
2. a kind of Chinese materia medica preparation for health care according to claim 1, which is characterized in that by weight percentage Meter, which includes: Radix Notoginseng 15%, American Ginseng 15%, Radix Salviae Miltiorrhizae 20%, borneol 10%, royal jelly freeze-dried powder 20% With the fruit of glossy privet 20%.
3. a kind of Chinese materia medica preparation for health care according to claim 1, it is characterised in that: this is used for health care Chinese materia medica preparation be routine techniques made of oral preparation.
4. a kind of preparation method of the Chinese materia medica preparation for health care as described in claim 1-3, which is characterized in that including Following steps:
S1: it takes Radix Notoginseng, American Ginseng, Radix Salviae Miltiorrhizae and the fruit of glossy privet dry by weight percentage and collects;
S2: the Radix Notoginseng of the step S1 drying collected, western health, Radix Salviae Miltiorrhizae and the fruit of glossy privet are uniformly mixed by weight percentage with borneol And crush, it is sieved, obtains evengranular powder;
S3: being added royal jelly freeze-dried powder in the powder obtained in step s 2, stir evenly, that is, obtains the Chinese materia medica preparation.
5. a kind of preparation method of Chinese materia medica preparation for health care according to claim 4, which is characterized in that described It further include step S4, concrete operations after step S3 are as follows: by the canned capsule that granulates of Chinese materia medica preparation that step S3 is obtained, and bottle.
6. a kind of preparation method of Chinese materia medica preparation for health care according to claim 4, it is characterised in that: described Size of being sieved in step S2 is 100 mesh.
7. a kind of preparation method of Chinese materia medica preparation for health care according to claim 5, it is characterised in that: described Chinese materia medica preparation content is about 500mg/ in the granular capsule of step S4 preparation, and the bottling quantity is 50~60/bottle.
CN201811616686.1A 2018-12-28 2018-12-28 A kind of Chinese materia medica preparation and preparation method thereof for health care Pending CN109381521A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129469A (en) * 2007-03-05 2008-02-27 厦门金日制药有限公司 Traditional Chinese medicine composition for preventing and controlling cardiovascular disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129469A (en) * 2007-03-05 2008-02-27 厦门金日制药有限公司 Traditional Chinese medicine composition for preventing and controlling cardiovascular disease

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Application publication date: 20190226

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