CN109381406A - A kind of preparation method and applications of the cosmetic composition with anti-aging effects - Google Patents
A kind of preparation method and applications of the cosmetic composition with anti-aging effects Download PDFInfo
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- CN109381406A CN109381406A CN201811079119.7A CN201811079119A CN109381406A CN 109381406 A CN109381406 A CN 109381406A CN 201811079119 A CN201811079119 A CN 201811079119A CN 109381406 A CN109381406 A CN 109381406A
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- extract
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- siberian cocklebur
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 34
- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims description 11
- 239000000284 extract Substances 0.000 claims abstract description 82
- 241001251949 Xanthium sibiricum Species 0.000 claims abstract description 35
- 241000222336 Ganoderma Species 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims abstract description 25
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims abstract description 25
- 235000021014 blueberries Nutrition 0.000 claims abstract description 25
- 238000000605 extraction Methods 0.000 claims abstract description 19
- 240000000851 Vaccinium corymbosum Species 0.000 claims abstract description 18
- 239000002904 solvent Substances 0.000 claims abstract description 17
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 14
- 241001233914 Chelidonium majus Species 0.000 claims abstract description 12
- 235000021028 berry Nutrition 0.000 claims abstract description 12
- 229940106154 cocklebur extract Drugs 0.000 claims abstract description 6
- 238000004090 dissolution Methods 0.000 claims abstract description 6
- 230000002255 enzymatic effect Effects 0.000 claims abstract description 6
- 238000002955 isolation Methods 0.000 claims abstract description 6
- 238000001291 vacuum drying Methods 0.000 claims abstract description 6
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- 238000000034 method Methods 0.000 claims description 12
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- PXTQQOLKZBLYDY-UHFFFAOYSA-N bis(2-ethylhexyl) carbonate Chemical compound CCCCC(CC)COC(=O)OCC(CC)CCCC PXTQQOLKZBLYDY-UHFFFAOYSA-N 0.000 description 1
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- 231100000283 hepatitis Toxicity 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
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- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 1
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- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
A kind of cosmetic composition with anti-aging effects, count by weight percentage, formula includes component: Black Ganoderma extract 5%-10%, blueberry berry extract 0.5%-2%, Siberian cocklebur extract 0.5%-2%, Radix Cynanchi Paniculati extract 2%-4%, Rhizoma Polygonati Odorati extract 5%-10%, surplus is cosmetic base, step: preparing Black Ganoderma extract, and Tian Chi Lake of Mountain Baitou water, microwave abstracting is added, extracting solution filters, filter vacuum is concentrated into medicinal extract, vacuum drying, weighing, solvent dissolution, constant volume, it is spare, obtain Black Ganoderma extracting solution；Enzymatic isolation method extracts blueberry berry extract, and Tian Chi Lake of Mountain Baitou water is added, obtains blueberry fruit extracting solution；It leaches and extracts Siberian cocklebur, solvent is added, impregnate, filter to obtain Siberian cocklebur extracting solution；Using ultrasonic wave extraction Radix Cynanchi Paniculati extract, Tian Chi Lake of Mountain Baitou water is added；Radix Cynanchi Paniculati extract is extracted, paniculate swallowwort extracting solution is obtained；Ultrasonic wave extraction Rhizoma Polygonati Odorati extract is added Tian Chi Lake of Mountain Baitou water, obtains radix polygonati officinalis extracting solution.With anti-aging, antiviral, anticancer, remove free radical excessive in vivo, antioxidation.
Description
Technical field
The present invention relates to chemical field, the preparation method of specifically a kind of cosmetic composition with anti-aging effects and
It is applied.
Background technique
Due to factors such as age, ultraviolet radiation, diet, environment, the skin of people gradually tends to aging.Research is thought at present
Skin aging mainly includes two class of natural aging and light aging.About its origin cause of formation, there are many theories, such as theory Of heredity, immunology
It says, free radical theory etc., wherein free radical theory increasingly obtains the approval of people.Free radical theory is thought with age
Generated change of skin is as caused by the side effect of free radical.Under normal circumstances, the generation of machine interior free yl with disappear
It loses and is in dynamic balance state, and when body aging, there is acute or chronic decrease, mistake in the ability that free radical is removed in body
To histiocytic large biological molecule chemical structure is constituted breaking reaction will occur for surplus free radical, to damage normal group
Knit the integrality of form and function.
With advancing age, skin starts that aging state is presented, including the collagen, elastin laminin, glutinous in skin
The blood vessel die back of skin-nourishing is supplied in the different degrees of reduction of polysaccharide equal size, and vessel wall elasticity reduces, and skin epidermis gradually becomes
Thin, protuberance, subcutaneous fat are reduced, and wrinkle, chloasma and senile plaque occur.The main reason for generating these phenomenons is free radical
Increase.Therefore, removing free radical excessive in vivo is the important channel for solving skin aging.
This research extracts Black Ganoderma, blueberry fruit, Siberian cocklebur, paniculate swallowwort, radix polygonati officinalis plant, and carries out to mixed extract
Whether senile-resistant efficacy evaluation, research this product can apply in anti-aging class cosmetics.
Ganoderma lucidum is a kind of medicinal fungi, has red ganoderma, Ganoderma Sinense, Bai Lingzhi, Ganoderma Multiplicatum, Black Ganoderma, Ganoderma Sinense by color
Point.China has long history as drug using ganoderma lucidum, and Modern medical experiment proves that ganoderma lucidum has antitumor, immune increase
The effects of strong, can be used for anti-curing oncoma, hyperlipemia, hat D disease, chronic bronchitis, neurasthenia, hepatitis, oligoleukocythemia,
Delay senescence etc..Wherein the polysaccharide in ganoderma lucidum has hypoglycemic, anti-oxidant, removing free radical, anti-aging, adjusts immune function,
It is present in the mycelium and fructification of Ganoderma fungi.
Blueberry is commonly called as red bean (or tooth pimple), is that the high and cold Area distribution such as China Daxing'an Mountainrange is more, accumulation is biggish
A kind of wild acinus.Blueberry fruit is not only full of nutrition, and medical value also with higher, wherein the anthocyanin of fruit can disappear
Except asthenopia, increase the medicinal functions such as eyesight, anti-oxidant, anti-aging, anti-inflammatory and anticancer.
Siberian cocklebur composite family Xanthium (XanthiumL) plant, there are about 25 kinds, there are 3 kinds and 1 mutation in China in the whole world.According to another report
Claim the whole world there are about 30 kinds, China there may be 4 kind of 2 mutation.The fruit of Siberian cocklebur maturation zone involucre is that parts of generic medicinal plants (is commonly called as Siberian cocklebur
Son), it records in going through an edition Chinese Pharmacopoeia, for treating anemofrigid headache, nasosinusitis runny nose, rubella itch, arthritis with fixed pain caused by dampness muscular constricture etc..Siberian cocklebur grass,
Insect (Herba Xanthii) in siberian cocklebur root and cocklebur stem is also widely used in clinic, and different parts ingredient and drug effect are not
Together.In modern medicine, Siberian cocklebur then has antibacterial, anti-oxidant, antitumor, anticoagulation, anti-inflammatory and analgesic activity, to blood, painstaking effort
Guard system and immune system all have an impact.Experiment discovery xanthium sibiricum can efficiently reduce lipid (LPO) peroxidation,
Destruction of the harmful substance to eucaryotic cell structure and function is avoided, to the trend that is improved of superoxide dismutase (SOD) activity,
Show that the achene of Siberian cocklebur can enhance the damage that body can be reduced free radical to body to the removing of free radical.
Paniculate swallowwort is Luo Mo section herbaceous plant, acrid flavour, warm-natured, returns liver, stomach meridian.With wind-dispelling dampness elimination, antalgesic-antipruritic
Effect can be used for rheumatic arthralgia, stomach expires a variety of diseases such as distending pain, toothache, pain in the loins, traumatic injury.Modern pharmacological research confirmation, Xu
The root skin of long minister in ancient times contains the ingredients such as Paeonol, there is extensive pharmacological action, can be used to ease pain, calmness, cool down, anti-inflammatory, resistance
State reaction, blood pressure lowering, anti-oxidant, prevention Ca2+ influx, alleviation myocardial ischemia, reducing blood lipid, antiatherosclerosis and antibacterial etc..
Radix polygonati officinalis is the important medicinal and edible plant of state, and dry rhizome has nourishing yin to moisten dryness, and promote the production of body fluid to quench thirst function, main to use
In treatment lung stomach-Yin wound, cough caused by dryness-heat, Heat Diabetes.It is as a kind of better than the battalion joined the enriching yin of stilbene, prevent dry cooling and driving away summer heat
Feeding invigorant is more and more welcomed by the people, and demand increases year by year.Modern chemical composition research discovery: contain in radix polygonati officinalis
There are the Multiple components such as polysaccharide, steroid saponin, Homoisoflavonoids, volatile oil, agglutinin and dipeptides.Wherein, because of radix polygonati officinalis water solubility
Polysaccharide has the different physiological roles such as anti-aging, anti-oxidant, antiviral, hypoglycemic and strengthen immunity.
The effect of because of every kind of plant, is different, so we are combined it by different proportion, thus effective anti-aging.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of cosmetic composition with anti-aging effects, using super
Sound method extracts polysaccharide, the polysaccharide in Black Ganoderma, the Paeonol in paniculate swallowwort and the anthocyanin in blueberry fruit and grey in radix polygonati officinalis
Effective component in ear, has the function that anti-aging, and these types of plant is had and removes free radical excessive in vivo, and antioxygen is turned into
A kind of cosmetic composition with anti-senescence function is prepared with combination.
To solve the above-mentioned problems, the invention discloses a kind of preparation sides of cosmetic composition with anti-aging effects
Method and its application.
The technical solution of the present invention is as follows: a kind of cosmetic composition with anti-aging effects, count by weight percentage,
Formula includes following component:
Black Ganoderma extract 5%-10%
Blueberry berry extract 0.5%-2%
Siberian cocklebur extract 0.5%-2%
Radix Cynanchi Paniculati extract 2%-4%
Rhizoma Polygonati Odorati extract 5%-10%
Surplus is cosmetic base.
A kind of preparation method of the cosmetic composition with anti-aging effects, comprising the following steps:
(1) it takes microwave extraction method to prepare Black Ganoderma extract, smashed Black Ganoderma 2.00-4.00g is accurately weighed, by solid-liquid
Tian Chi Lake of Mountain Baitou water is added than 1:20, microwave power 300-500W, the microwave abstracting 10-40min at a temperature of 35-40 DEG C are extracted
Liquid filters, and filter vacuum is concentrated into medicinal extract, and 30-40 DEG C of vacuum drying, weighing, solvent dissolution, constant volume is spare, obtains Black Ganoderma
Extracting solution；
(2) enzymatic isolation method extracts blueberry berry extract, and 30-50 DEG C of hydrolysis temperature, enzymolysis liquid initial pH value is 3.5-5.5, enzyme dosage
For 5-7mg/g, solid-to-liquid ratio is that Tian Chi Lake of Mountain Baitou water is added in 1:4, and enzymolysis time 2-4h obtains blueberry fruit extracting solution；
(3) it leaches and extracts Siberian cocklebur, weigh 1:20 Siberian cocklebur powder and solvent is added, Siberian cocklebur extraction is obtained by filtration in 60-70 DEG C of immersion 2h
Liquid；
(4) ultrasonic wave extraction Radix Cynanchi Paniculati extract is used, is 40-50 DEG C, ultrasonic time 10-40min in ultrasonic temperature, ultrasound
Power 300-500W, solid-liquid ratio are to extract Radix Cynanchi Paniculati extract under conditions of Tian Chi Lake of Mountain Baitou water is added in 1:10, obtain paniculate swallowwort
Extracting solution；
(5) ultrasonic wave extraction Rhizoma Polygonati Odorati extract is 40-50 DEG C, ultrasonic time 30-40min in ultrasonic temperature, ultrasonic power
50-100W, solid-liquid ratio are that 1:60 is added under conditions of Tian Chi Lake of Mountain Baitou water, extract Rhizoma Polygonati Odorati extract, obtain radix polygonati officinalis extracting solution.
The partial solvent being previously mentioned in step 3 is added with one of 1,3 butanediols, propylene glycol, butanediol.
A kind of application of the cosmetic composition with anti-aging effects in Essence.
Usefulness of the present invention: preparation method of the invention uses ultrasonic method to extract the polysaccharide in radix polygonati officinalis, in Black Ganoderma
Polysaccharide, the Paeonol in paniculate swallowwort and the effective component in anthocyanin and Siberian cocklebur in blueberry fruit, reach the work of anti-aging
With by these types of plant with free radical excessive in vivo is removed, antioxidation combination, which prepares one kind, has anti-aging
The cosmetic composition of function meets people and effectively requires cosmetics safety, has a extensive future.
Detailed description of the invention
Fig. 1 is that cosmetic composition of the invention removes DPPH free radical test result figure.
Specific embodiment
Below with reference to embodiment, the invention will be further described.
The cosmetic composition removes DPPH experiment:
One, reagent prepares
(1) 3.943mgDPPH is settled to 50mL with 95% ethyl alcohol
(2) 10mg or so Trolox is settled to 100mL with 95% ethyl alcohol
(3) CBS-Anti-aging fluid(cosmetic composition)
Two, experimental procedure
(1) school UV zero, 95% ethyl alcohol is as blank sample
(2) preliminary experiment (selection of DPPH concentration)
500 μ L DPPH+1000 μ L, 95% ethyl alcohol shakes 10s, stands 10min, surveys absorbance value (absorbance value at 520nm
0.45-0.55 then can be used as following experiment DPPH solution)
(3) measurement of Trolox
After DPPH or 95% ethyl alcohol is added, 10s is shaken, stands 10min, surveys absorbance value
(4) it tests
After DPPH or 95% ethyl alcohol is added, 10s is shaken, stands 10min
(5) absorbance is surveyed at 520nm respectively, makes table, mapping obtains IC50 value.
Calculation formula: inhibiting rate (%)=[1-(S-SB)/(C-CB)] * 100
As a result
The cosmetic composition removes DPPH free radical test result figure and sees attached drawing:
As a result: the cosmetic composition has the function of removing DPPH free radical.
Conclusion: i.e. the cosmetic composition has anti-aging effects.
Embodiment 1
A kind of preparation method of the cosmetic composition with anti-aging effects, comprising the following steps:
(1) it takes microwave extraction method to prepare Black Ganoderma extract, accurately weighs smashed Black Ganoderma 3.00g, by solid-to-liquid ratio 1:
20 are added Tian Chi Lake of Mountain Baitou water, microwave power 400W, the microwave abstracting 20min at a temperature of 35 DEG C, and extracting solution filters, filter vacuum
It is concentrated into medicinal extract, 40 DEG C of vacuum drying, weighing, solvent dissolution, constant volume is spare, obtains Black Ganoderma extracting solution；
(2) enzymatic isolation method extract blueberry berry extract, 50 DEG C of hydrolysis temperature, enzymolysis liquid initial pH value be 4.5, enzyme dosage 5mg/g,
Solid-to-liquid ratio is that Tian Chi Lake of Mountain Baitou water is added in 1:4, and enzymolysis time 3h obtains blueberry fruit extracting solution；
(3) it leaches and extracts Siberian cocklebur, weigh the solvent that 1:20 Siberian cocklebur powder is added 50%, Siberian cocklebur extraction is obtained by filtration in 60 DEG C of immersion 2h
Liquid；
(4) ultrasonic wave extraction Radix Cynanchi Paniculati extract is used, is 50 DEG C, ultrasonic time 20min in ultrasonic temperature, ultrasonic power
420W, solid-liquid ratio are to extract Radix Cynanchi Paniculati extract under conditions of Tian Chi Lake of Mountain Baitou water is added in 1:10, obtain paniculate swallowwort extracting solution；
(5) ultrasonic wave extraction Rhizoma Polygonati Odorati extract is 50 DEG C, ultrasonic time 35min, ultrasonic power 80W in ultrasonic temperature, feed liquid
Under conditions of Tian Chi Lake of Mountain Baitou water is added for 1:60, Rhizoma Polygonati Odorati extract is extracted, radix polygonati officinalis extracting solution is obtained.
Embodiment 2
A kind of preparation method of the cosmetic composition with anti-aging effects, comprising the following steps:
(1) it takes microwave extraction method to prepare Black Ganoderma extract, accurately weighs smashed Black Ganoderma 3.00g, by solid-to-liquid ratio 1:
20 are added Tian Chi Lake of Mountain Baitou water, microwave power 400W, the microwave abstracting 20min at a temperature of 35 DEG C, and extracting solution filters, filter vacuum
It is concentrated into medicinal extract, 40 DEG C of vacuum drying, weighing, solvent dissolution, constant volume is spare, obtains Black Ganoderma extracting solution；
(2) enzymatic isolation method extract blueberry berry extract, 50 DEG C of hydrolysis temperature, enzymolysis liquid initial pH value be 4.5, enzyme dosage 6mg/g,
Solid-to-liquid ratio is that Tian Chi Lake of Mountain Baitou water is added in 1:4, and enzymolysis time 3h obtains blueberry fruit extracting solution；
(3) it leaches and extracts Siberian cocklebur, weigh 1:20 Siberian cocklebur powder and 50% solvent is added, Siberian cocklebur extraction is obtained by filtration in 60 DEG C of immersion 2h
Liquid；
(4) ultrasonic wave extraction Radix Cynanchi Paniculati extract is used, is 50 DEG C, ultrasonic time 20min in ultrasonic temperature, ultrasonic power
420W, solid-liquid ratio are to extract Radix Cynanchi Paniculati extract under conditions of Tian Chi Lake of Mountain Baitou water is added in 1:10, obtain paniculate swallowwort extracting solution；
(5) ultrasonic wave extraction Rhizoma Polygonati Odorati extract is 50 DEG C, ultrasonic time 35min, ultrasonic power 80W in ultrasonic temperature, feed liquid
Under conditions of Tian Chi Lake of Mountain Baitou water is added for 1:60, Rhizoma Polygonati Odorati extract is extracted, radix polygonati officinalis extracting solution is obtained.
Embodiment 3
A kind of preparation method of the cosmetic composition with anti-aging effects, comprising the following steps:
(1) it takes microwave extraction method to prepare Black Ganoderma extract, accurately weighs smashed Black Ganoderma 3.00g, by solid-to-liquid ratio 1:
20 are added Tian Chi Lake of Mountain Baitou water, microwave power 400W, the microwave abstracting 20min at a temperature of 35 DEG C, and extracting solution filters, filter vacuum
It is concentrated into medicinal extract, 40 DEG C of vacuum drying, weighing, solvent dissolution, constant volume is spare, obtains Black Ganoderma extracting solution；
(2) enzymatic isolation method extract blueberry berry extract, 50 DEG C of hydrolysis temperature, enzymolysis liquid initial pH value be 4.5, enzyme dosage 7mg/g,
Solid-to-liquid ratio is that Tian Chi Lake of Mountain Baitou water is added in 1:4, and enzymolysis time 3h obtains blueberry fruit extracting solution；
(3) it leaches and extracts Siberian cocklebur, weigh 1:20 Siberian cocklebur powder and 50% solvent is added, Siberian cocklebur extraction is obtained by filtration in 60 DEG C of immersion 2h
Liquid；
(4) ultrasonic wave extraction Radix Cynanchi Paniculati extract is used, is 50 DEG C, ultrasonic time 20min in ultrasonic temperature, ultrasonic power
420W, solid-liquid ratio are to extract Radix Cynanchi Paniculati extract under conditions of Tian Chi Lake of Mountain Baitou water is added in 1:10, obtain paniculate swallowwort extracting solution；
(5) ultrasonic wave extraction Rhizoma Polygonati Odorati extract is 50 DEG C, ultrasonic time 35min, ultrasonic power 80W in ultrasonic temperature, feed liquid
Under conditions of Tian Chi Lake of Mountain Baitou water is added for 1:60, Rhizoma Polygonati Odorati extract is extracted, radix polygonati officinalis extracting solution is obtained.
The cosmetics embodiment 4-6 made of the above method is as follows:
Embodiment 4
This composition with anti-senescence function, dosage form are Essence, and count by weight percentage, formula is comprising following
Component:
Black Ganoderma extract 5%；Blueberry berry extract 0.5%；Siberian cocklebur extract 0.5%；Radix Cynanchi Paniculati extract 2%；Rhizoma Polygonati Odorati extract
5%；Solvent 30%-50%；Surplus measures each component by formula, is fitted into the bottle sterilized after mixing at normal temperature.
Embodiment 5
This composition with anti-senescence function, dosage form are essence cream, and count by weight percentage, formula is comprising following
Component:
A phase: diethyl hexylcarbonate 6%；Dimethyl silicone polymer 0.5%；Tocopherol acetate 0.5%；Acrylic acid (ester) class/the third
Acrylamide copolymer 2%；Saualane 1.5%；Glycerol 3%；Acrylic acid (esters)/C10-30 alkylol acrylamide acid esters 0.25%；
B phase: Black Ganoderma extract 5%；Blueberry berry extract 0.5%；Siberian cocklebur extract 0.5%；Radix Cynanchi Paniculati extract 2%；Radix polygonati officinalis mentions
Take object 5%；Solvent 30%-50%；Surplus is Tian Chi Lake of Mountain Baitou water.
A phase is stirred evenly, homogeneous 1min under B phase revolving speed 10800r/m is added, is fitted into the bottle sterilized.
Embodiment 6
This cosmetic composition with anti-senescence function, dosage form are moisturiser, count by weight percentage, formula packet
Containing following components:
A phase: one or three decylate 5% of tricaprylin；A sad capric acid coconut ester 5%；C16 alcohol 2%；C18 alcohol 2%；Methyl-isothiazol
Quinoline ketone 0.10%；Essence 0.15%；
B phase: Black Ganoderma extract 5%；Blueberry berry extract 0.5%；Siberian cocklebur extract 0.5%；Radix Cynanchi Paniculati extract 2%；Radix polygonati officinalis mentions
Take object 5%；Solvent 30%-50%；Surplus is cosmetic base.
A phase is stirred evenly, homogeneous 1min under B phase revolving speed 10800r/m is added, is fitted into the bottle sterilized.
By experiment case study 4-6, it is not difficult to find out that this anti-apolexis composition is effective, and either water and milk or frost is equal
This product can be added.
This feature of ultrasonic wave extraction is greatly utilized in present invention application ultrasonic extraction method radix polygonati officinalis, paniculate swallowwort, extracts
It is high-efficient, the time is short, impurity is few, at low cost, effective component leaches completely, can directly collect leachate, cooperates Black Ganoderma, blueberry
Effective component in fruit, Siberian cocklebur mixes a kind of efficient anti-apolexis composition, and this product is extracted form natural plant, is suitable for
Sensitive skin crowd meets requirement of the people to cosmetics safety validity, has a extensive future.
This feature of ultrasonic wave extraction is greatly utilized in present invention application ultrasonic extraction method radix polygonati officinalis, paniculate swallowwort, extracts
It is high-efficient, the time is short, impurity is few, at low cost, effective component leach completely, can directly collect leachate.With anti-aging, disease-resistant
Poison, anticancer remove free radical excessive in vivo, antioxidation and the Black Ganoderma antitumor, enhancing is immune, are anti-oxidant, anti-ageing
The blueberry fruit of old anticancer, antibacterial, it is anti-oxidant, antitumor, body can be enhanced free radical can be reduced to body to the removing of free radical
The Siberian cocklebur combination of damage prepare a kind of cosmetic composition with anti-senescence function, feature is suitble to responsive type skin
Crowd, and composition has anti-inflammatory, anti-oxidant and antibacterial and other effects, declines suitable for skin caused by excessive free radical in vivo
Always.
Claims (4)
1. a kind of cosmetic composition with anti-aging effects, which is characterized in that count by weight percentage, formula comprising with
Lower component:
Black Ganoderma extract 5%-10%
Blueberry berry extract 0.5%-2%
Siberian cocklebur extract 0.5%-2%
Radix Cynanchi Paniculati extract 2%-4%
Rhizoma Polygonati Odorati extract 5%-10%
Surplus is cosmetic base.
2. a kind of preparation method of cosmetic composition with anti-aging effects according to claim 1, feature exist
In, comprising the following steps:
(1) it takes microwave extraction method to prepare Black Ganoderma extract, accurately weighs smashed Black Ganoderma 2.00-4.00g, by solid
Tian Chi Lake of Mountain Baitou water is added in liquor ratio 1:20, and microwave power 300-500W, the microwave abstracting 10-40min at a temperature of 35-40 DEG C are mentioned
Liquid is taken to filter, filter vacuum is concentrated into medicinal extract, and 30-40 DEG C of vacuum drying, weighing, solvent dissolution, constant volume is spare, obtains black spirit
Sesame extracting solution；
(2) enzymatic isolation method extracts blueberry berry extract, and 30-50 DEG C of hydrolysis temperature, enzymolysis liquid initial pH value is 3.5-5.5, enzyme dosage
For 5-7mg/g, solid-to-liquid ratio is that Tian Chi Lake of Mountain Baitou water is added in 1:4, and enzymolysis time 2-4h obtains blueberry fruit extracting solution；
(3) it leaches and extracts Siberian cocklebur, weigh 1:20 Siberian cocklebur powder and solvent is added, Siberian cocklebur extraction is obtained by filtration in 60-70 DEG C of immersion 2h
Liquid；
(4) ultrasonic wave extraction Radix Cynanchi Paniculati extract is used, is 40-50 DEG C, ultrasonic time 10-40min in ultrasonic temperature, ultrasound
Power 300-500W, solid-liquid ratio are to extract Radix Cynanchi Paniculati extract under conditions of Tian Chi Lake of Mountain Baitou water is added in 1:10, obtain paniculate swallowwort
Extracting solution；
(5) ultrasonic wave extraction Rhizoma Polygonati Odorati extract is 40-50 DEG C, ultrasonic time 30-40min in ultrasonic temperature, ultrasonic power
50-100W, solid-liquid ratio are that 1:60 is added under conditions of Tian Chi Lake of Mountain Baitou water, extract Rhizoma Polygonati Odorati extract, obtain radix polygonati officinalis extracting solution.
3. a kind of preparation method of cosmetic composition with anti-aging effects according to claim 2, feature exist
In: the partial solvent being previously mentioned in step 3 is added with one of 1,3 butanediols, propylene glycol, butanediol.
4. a kind of application of cosmetic composition with anti-aging effects in Essence.
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| CN110613663A (en) * | 2019-10-25 | 2019-12-27 | 浙江兰树化妆品有限公司 | Skin repairing composition, skin care product and preparation method thereof |
| CN111840171A (en) * | 2020-08-26 | 2020-10-30 | 王鹏 | Cynanchum paniculatum essence and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110613663A (en) * | 2019-10-25 | 2019-12-27 | 浙江兰树化妆品有限公司 | Skin repairing composition, skin care product and preparation method thereof |
| CN111840171A (en) * | 2020-08-26 | 2020-10-30 | 王鹏 | Cynanchum paniculatum essence and preparation method thereof |
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