CN109374845B - Efficient medicine dissolves out appearance - Google Patents
Efficient medicine dissolves out appearance Download PDFInfo
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- CN109374845B CN109374845B CN201811305368.3A CN201811305368A CN109374845B CN 109374845 B CN109374845 B CN 109374845B CN 201811305368 A CN201811305368 A CN 201811305368A CN 109374845 B CN109374845 B CN 109374845B
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- cup
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- dissolution
- crimping
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- 239000003814 drug Substances 0.000 title claims abstract description 34
- 230000001360 synchronised effect Effects 0.000 claims abstract description 107
- 238000004090 dissolution Methods 0.000 claims abstract description 96
- 230000007246 mechanism Effects 0.000 claims abstract description 51
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 48
- 230000001105 regulatory effect Effects 0.000 claims abstract description 25
- 239000011159 matrix material Substances 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 238000003825 pressing Methods 0.000 claims description 71
- 238000003756 stirring Methods 0.000 claims description 53
- 238000002788 crimping Methods 0.000 claims description 45
- 230000006835 compression Effects 0.000 claims description 39
- 238000007906 compression Methods 0.000 claims description 39
- 210000004907 gland Anatomy 0.000 claims description 14
- 238000007731 hot pressing Methods 0.000 claims description 6
- 238000000429 assembly Methods 0.000 claims description 5
- 230000000712 assembly Effects 0.000 claims description 5
- 230000000149 penetrating effect Effects 0.000 claims description 4
- 238000002474 experimental method Methods 0.000 abstract description 3
- 238000001647 drug administration Methods 0.000 abstract description 2
- 229920001971 elastomer Polymers 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 229940079593 drug Drugs 0.000 description 7
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- 238000009434 installation Methods 0.000 description 3
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 229960001680 ibuprofen Drugs 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The invention provides a high-efficiency medicine dissolution instrument which comprises a machine head and a machine base, wherein the machine head is fixed above a unit in a lifting manner through a hydraulic cylinder, a water bath box is arranged in the machine base, and dissolution cups are arranged in the water bath box in a matrix manner; the machine head is also provided with two area synchronous speed regulating mechanisms, each of the two area synchronous speed regulating mechanisms comprises an upper supporting plate arranged in the machine head, and the upper supporting plate is provided with two synchronous speed regulating components; every synchronous speed regulation subassembly all includes six rabbling mechanism, and every rabbling mechanism corresponds a dissolution cup setting, and every rabbling mechanism all includes the fixing base, and male setting (mixing) shaft is equipped with the synchronizing shaft on the fixing base, is equipped with first synchronous band pulley on the synchronizing shaft. The invention can respectively determine the rotation speed in different areas, and the rotation speed of each area can be set independently, thereby improving the working efficiency and reducing the experimental error; meanwhile, the drug administration mechanism is improved, and the accuracy of the experiment is further improved.
Description
Technical Field
The invention relates to a dissolution instrument, in particular to a high-efficiency medicine dissolution instrument.
Background
The medicine dissolution instrument is an instrument for carrying out medicine dissolution experiment, which is an electromechanical integrated test device controlled by a microcomputer, and the components are controlled in a centralized way by a precise control system. The drug dissolution test is a method for detecting dissolution rate and dissolution rate of solid drug preparations such as tablets, capsules, particles and the like under certain conditions, namely a method for simulating disintegration and dissolution in intestines and stomach through an instrument, is used for evaluating bioequivalence and bioavailability of drugs, and is also an important index for evaluating the quality of the drugs before clinical use.
Patent 201720601696.2 discloses a drug dissolution apparatus for ibuprofen soft capsules. The medicine dissolving-out instrument for the ibuprofen soft capsule comprises a machine head and a machine seat; a control system is arranged in the machine head; the machine base is provided with a water bath box, and a sensor and a dissolving cup are arranged in the box body of the water bath box; the opening of the dissolving cup is provided with an anti-evaporation cover; a rotary basket is arranged in the dissolving cup; the device also comprises a sampling system; the bottom end of the evaporation preventing cover is conical; the rotary basket comprises a cylindrical basket body frame and a rectangular basket net matched with the periphery of the basket body frame, and snap fasteners matched with each other are arranged on the short sides of the two sides of the rectangular basket net.
The stirring member of the dissolution apparatus has a single rotation speed control mode, and experimental errors are liable to occur.
Disclosure of Invention
Aiming at the problems, the invention provides a high-efficiency medicine dissolution instrument, which can be used for respectively determining the rotating speed in different areas, wherein the rotating speed of each area can be independently set, the working efficiency is improved, and the experimental error is reduced; meanwhile, the drug administration mechanism is improved, and the accuracy of the experiment is further improved.
The specific technical scheme is as follows:
the high-efficiency medicine dissolving-out instrument comprises a machine head and a machine base, wherein the machine head is fixed above a unit in a lifting manner through a hydraulic cylinder, a water bath box is arranged in the machine base, dissolving-out cups are arranged in the water bath box in a matrix manner, the number of the dissolving-out cups is 12, and the dissolving-out cups are distributed in a 2*6 mode;
the machine head is also provided with two area synchronous speed regulating mechanisms, each of the two area synchronous speed regulating mechanisms comprises an upper supporting plate arranged in the machine head, and the upper supporting plate is provided with two synchronous speed regulating components;
each synchronous speed regulation assembly comprises six stirring mechanisms, each stirring mechanism is arranged corresponding to one dissolution cup, each stirring mechanism comprises a fixed seat, a stirring shaft is arranged on the fixed seat in a plug-in manner, the top of the fixed seat is provided with a synchronous shaft, and the synchronous shaft is provided with a first synchronous belt wheel;
six stirring mechanisms in each group of synchronous speed regulating assemblies are arranged in a matrix, a fixing seat is locked and fixed below an upper supporting plate through bolts and nuts, a synchronous shaft penetrates through the upper supporting plate and is positioned above the upper supporting plate, a first synchronous belt is tensioned and fixed among six first synchronous belt wheels to realize linkage, a second synchronous belt wheel is arranged below the first synchronous belt wheel of one synchronous shaft, the second synchronous belt wheel is connected with a third synchronous belt wheel fixed on a stepping motor through the second synchronous belt, and the stepping motor is fixed on the upper supporting plate;
the stepping motor rotates to drive six stirring mechanisms of the corresponding synchronous speed regulating assembly to rotate at the same speed;
the stirring shaft can be inserted into or removed from the corresponding dissolution cup along with the lifting of the machine head;
the dissolving cup is fixed on the top plate of the water bath box; the dissolution cup is in a cylindrical structure and is in a hollow structure, the bottom end of the dissolution cup is in an arc shape, the top edge of the dissolution cup is turned outwards in the circumferential direction to form a dissolution cup flanging, the dissolution cup flanging is in a circular ring shape, and the dissolution cup flanging are integrally formed through hot pressing to form an integral structure; scales are arranged on the surface of the outer side wall of the dissolution cup; the dissolving cup ring is in a cylindrical structure with a wide upper part and a narrow lower part, and the inner diameter of the dissolving cup ring is matched with the outer diameter of the dissolving cup; the upper end of the dissolving cup ring is turned outwards in the circumferential direction to form a dissolving cup ring flanging, the dissolving cup ring flanging is circular, the dissolving cup ring and the dissolving cup ring flanging are integrally formed through hot pressing, and the dissolving cup ring flanging is of an integral structure and is matched with the dissolving cup flanging in size; the dissolution cup passes through the dissolution cup ring from top to bottom to be fixedly connected with the dissolution cup ring, the dissolution cup ring is arranged at the top end of the outer side wall of the dissolution cup, and the upper surface of the flanging of the dissolution cup ring is attached to the lower surface of the flanging of the dissolution cup; the water bath tank top plate is of a plate-shaped structure, the water bath tank top plate is provided with a water tank hole, the outer diameter of the dissolving cup ring is matched with the inner diameter of the water tank hole, the dissolving cup penetrates through the water tank hole from top to bottom, and the dissolving cup is fixedly connected with the water bath tank through the matching of the dissolving cup ring and the water tank hole; the setting angle alpha=100° of the solution cup ring and the flanging of the solution cup ring.
Further, a gland is arranged below the machine head, the gland can be arranged above the water bath box in a pressing mode, and the stirring shaft penetrates through the gland;
the pressure cover is provided with a plurality of coverage areas, a dissolution cup is corresponding to the lower part of each coverage area, and each coverage area is provided with a feed opening;
the gland is provided with a medicine feeding component;
the administration assembly comprises a plurality of administration bars, the administration bars are arranged in parallel, each administration bar is respectively covered on a row or a column of feeding openings of the coverage area, and one end of each administration bar is vertically fixed with a pull plate;
a plurality of dosing openings are formed in the pull rod and correspond to the feeding openings, a guide channel is formed between two adjacent dosing openings, the fixed terminal penetrates through the guide channel to fix the dosing rod on the pressing cover, and the dosing rod can reciprocate along the guide channel to enable the dosing opening to cover the feeding openings or leave the feeding openings;
the other ends of the administration rods penetrate through the pressing plate and are fixedly connected with a pushing plate, two guide rods are arranged on the pushing plate and are respectively arranged on two sides of the administration rods, the guide rods penetrate through the pressing plate and are fixedly connected with a limiting plate, springs are sleeved on the guide rods, and the springs are compressed between the pushing plate and the pressing plate;
the fixed terminal comprises a crimping column and a fastening bolt, the crimping column sequentially comprises a first crimping column, a second crimping column and a third crimping column from top to bottom, the first crimping column and the third crimping column are of cylindrical structures, the outer diameter of the first crimping column is larger than that of the third crimping column, the second crimping column is connected with the first crimping column and the third crimping column and is of a truncated cone-shaped structure with a large upper part and a small lower part, the crimping column penetrates through the guide channel, the third crimping column is pressed on the pressing cover, and the fastening bolt penetrates through the crimping column to be locked and fixed on the pressing cover; the second compression joint column is arranged at the top of the guide channel in a compression mode;
the feed opening has an inner diameter that is larger than the inner diameter of the administration opening.
Further, the synchronous speed regulation assembly further comprises at least one tensioning wheel, the tensioning wheel is arranged between two adjacent stirring mechanisms, the tensioning wheel is connected with the first synchronous belt and is in linkage with the first synchronous belt wheel, and the tensioning wheel is used for adjusting tightness of the first synchronous belt.
Further, in the stirring mechanism, a fixed seat and a mutually communicated inserting passage are formed in the synchronous shaft, the stirring shaft is inserted into the inserting passage in a transition fit manner, the top of the synchronous shaft is exposed out of the upper extension of the stirring shaft, and a locking mechanism is arranged at the top of the synchronous shaft;
the locking mechanism comprises a locking sleeve, a locking groove is formed in the locking sleeve, a synchronous shaft is inserted into the locking groove, an adjusting channel of the stirring shaft penetrating through the top of the locking sleeve is arranged outside, a first locking rod and a second locking rod are arranged on the side wall of the locking sleeve, the first locking rod and the second locking rod are arranged on the locking sleeve in a threaded fit manner, the first locking rod is rotated to be pressed on the stirring shaft, and the second locking rod is rotated to be pressed on the synchronous shaft;
the bottom of grafting passageway is equipped with first crimping subassembly, and the top of grafting passageway is equipped with the second crimping subassembly, and first crimping subassembly and second crimping subassembly interference fit's pressure is established on the (mixing) shaft.
Further, the synchronous shaft is inserted into the locking groove in an interference fit or transition fit.
Further, the first compression joint assembly and the second compression joint assembly both comprise rubber rings with annular structures, and four compression joint structures are uniformly arranged in the rubber rings;
the crimping structure is arranged in a crimping groove on the rubber ring;
the compression joint structure comprises an outer pressing block with a circular arc-shaped cross section, a pushing block with a rectangular cross section is arranged on the outer pressing block, and an inner pressing block with an isosceles trapezoid cross section is arranged on the pushing block;
the pressing groove sequentially comprises a first pressing groove, a second pressing groove and a third pressing groove from inside to outside, an inner pressing block is arranged in the third pressing groove, a pushing block penetrates through the second pressing groove, and an outer pressing block is arranged in the first pressing groove;
the thickness of the outer pressing block is greater than the depth of the first pressing groove, the height of the pushing block is greater than the depth of the second pressing groove, the height of the inner pressing block is less than the depth of the third pressing groove, and a cushion block with a spherical segment structure is arranged in the third pressing groove.
Further, the thickness of the outer pressing block is 0.05-0.5mm more than the depth of the first pressing groove.
Further, the outer pressing block is made of rubber or stainless steel, and the pushing block and the inner pressing block are made of stainless steel.
Further, the cushion block is a rubber cushion block.
The installation method of the two-region synchronous speed regulating mechanism comprises the following steps:
(1) The stirring shaft is inserted into the fixed seat, and is locked and fixed through the locking mechanism after the length is adjusted;
(2) The stirring mechanism and the stepping motor are fixed on the upper supporting plate, the first synchronous belt and the second synchronous belt are sleeved, and the tensioning wheel is used for adjusting the tightness of the first synchronous belt.
The application method of the administration component of the invention is as follows:
in the initial state, the spring is in a free state, and the administration opening is not covered on the feeding opening;
when the medicine is needed to be administrated, the medicines are sequentially put into the administration opening;
after the medicine is placed, the pulling plate is pulled to enable the medicine dispensing opening to be simultaneously moved to cover the feeding opening, so that the medicine simultaneously falls into the dissolving cup;
after the medicine is dispensed, the medicine dispensing rod is reset under the action of the spring.
The using method of the dissolving cup comprises the following steps:
the dissolution cup penetrates through the dissolution cup ring, the inner wall of the dissolution cup ring is attached to the outer side wall of the dissolution cup, the dissolution cup ring is provided with a cup opening at the top end of the dissolution cup, the upper surface of the flanging of the dissolution cup ring is attached to the lower surface of the flanging of the dissolution cup, and the dissolution cup is fixed with the dissolution cup ring; then the dissolving cup is placed in the water tank hole, the outer side wall of the dissolving cup ring clamps the inner side wall of the water tank hole, and the dissolving cup ring has a little anti-skid fixing capacity, so that the purpose of fixing the dissolving cup ring and the top plate of the water bath box is achieved. In the experimental process, when the inside of the dissolution cup rotates through the blade, the dissolution cup is fixed through the dissolution cup ring, and the dissolution cup is kept static.
The beneficial effects of the invention are as follows:
(1) The invention can respectively determine the rotation speed in different areas, and the rotation speed of each area can be set independently, thereby improving the working efficiency and reducing the experimental error;
(2) The stirring shaft is fixed on the fixed seat through the locking mechanism, so that the stirring shaft has good stability and is not easy to fall down to damage equipment;
(3) The first compression joint assembly and the second compression joint assembly are arranged, so that the installation is convenient, the connection firmness is further improved, and the safety and the reliability are improved;
(4) The dissolving cup ring is arranged outside the dissolving cup, and is clamped into the water tank hole, so that the problem that the size of the dissolving cup is different from that of the water tank hole is solved, the dissolving cup with different sizes can be used, the dissolving cup can be completely sealed with the water tank, the using stability of the dissolving cup is improved, and the experimental accuracy is improved;
(5) The administration component is additionally arranged on the gland, so that tablets are ensured to fall into each dissolution cup at the same time, and the time difference of dropping the tablets into the dissolution cups is eliminated, thereby ensuring the consistency of experimental results;
(6) In summary, when the invention is used, the medicine is put into the dissolution cup and stirred by the stirring mechanism, and the stirring speed is regulated by the two-region synchronous speed regulating mechanism, so that the working efficiency is greatly improved.
Drawings
Fig. 1 is a cross-sectional view of the present invention.
Fig. 2 is a top view of a two-zone synchronous speed governor.
Fig. 3 is a side view of a set of synchronous speed regulation assemblies.
Fig. 4 is a cross-sectional view of the stirring mechanism.
Fig. 5 is a radial cross-sectional view of the first crimp assembly or the second crimp assembly.
Fig. 6 is an enlarged view of a portion a in fig. 5.
Fig. 7 is a top view of the present invention in an undeployed state.
Fig. 8 is a plan view showing a state of administration according to the present invention.
Fig. 9 is a top view of the cover plate.
Fig. 10 is an enlarged view of part C of fig. 6.
Fig. 11 is an enlarged view of part B of fig. 6.
Fig. 12 is a sectional view of a fixed terminal in a fixed state.
Fig. 13 is a combined cross-sectional view of a feed opening and a dispensing opening.
Fig. 14 is a side view of a platen.
Fig. 15 is a schematic view of the structure of the dissolution cup.
FIG. 16 is a schematic view of the structure of a solution cup ring.
FIG. 17 is a cross-sectional view of the solution cup ring.
Detailed Description
In order to make the technical scheme of the invention clearer and more definite, the invention is further described below with reference to the accompanying drawings, and any scheme obtained by carrying out equivalent substitution and conventional reasoning on the technical characteristics of the technical scheme of the invention falls into the protection scope of the invention.
Description of the reference numerals
The machine head 1, the machine base 2, the hydraulic cylinder 3, the water bath tank 4 and the dissolution cup 5;
the upper supporting plate 21, the synchronous speed regulating assembly 22, the stirring mechanism 23, the fixed seat 24, the stirring shaft 25, the synchronous shaft 26, the first synchronous belt 27, the first synchronous belt 28, the second synchronous belt 29, the second synchronous belt 210, the stepping motor 211, the third synchronous belt 212, the tensioning wheel 213, the inserting channel 214, the locking sleeve 215, the locking groove 216, the first locking rod 217, the second locking rod 218, the first crimping assembly 219, the second crimping assembly 220, the rubber ring 221, the crimping structure 222, the outer pressing block 223, the pushing block 224, the inner pressing block 225, the first pressing groove 226, the second pressing groove 227, the third pressing groove 228 and the cushion block 229;
gland 31, cover area 32, feed opening 33, administration rod 34, pull plate 35, administration opening 36, guide channel 37, fixed terminal 38, platen 39, push plate 310, guide rod 311, spring 312, fastening bolt 313, first crimp post 314, second crimp post 315, third crimp post 316, chute 317, first groove 318, brush 319, administration cover 320, limiting plate 321, guide slide 322;
a solution cup flange 42, a solution cup ring 43, a solution cup ring flange 44, scales 45, a water tank top plate 46 and a water tank hole 47.
The high-efficiency medicine dissolving-out instrument comprises a machine head 1 and a machine base 2, wherein the machine head is fixed above a unit in a lifting manner through a hydraulic cylinder 3, a water bath box 4 is arranged in the machine base, dissolving-out cups 5 are arranged in a matrix form in the water bath box, the number of the dissolving-out cups is 12, and the dissolving-out cups are distributed in a 2*6 mode;
the machine head is also provided with two area synchronous speed regulating mechanisms, each of the two area synchronous speed regulating mechanisms comprises an upper supporting plate 21 arranged in the machine head, and two synchronous speed regulating assemblies 22 are arranged on the upper supporting plate;
each synchronous speed regulation assembly comprises six stirring mechanisms 23, each stirring mechanism is arranged corresponding to one dissolution cup, each stirring mechanism comprises a fixed seat 24, a stirring shaft 25 is arranged on the fixed seat in a plug-in manner, a synchronous shaft 26 is arranged at the top of the fixed seat, and a first synchronous belt wheel 27 is arranged on the synchronous shaft;
six stirring mechanisms in each group of synchronous speed regulating assemblies are arranged in a matrix, a fixing seat is locked and fixed below an upper supporting plate through bolts and nuts, a synchronous shaft penetrates through the upper supporting plate and is positioned above the upper supporting plate, a first synchronous belt 28 is tensioned and fixed among six first synchronous belt wheels to realize linkage, a second synchronous belt wheel 29 is arranged below the first synchronous belt wheel of one synchronous shaft, the second synchronous belt wheel is connected with a third synchronous belt wheel 212 fixed on a stepping motor 211 through a second synchronous belt 210, and the stepping motor is fixed on the upper supporting plate;
the stepping motor rotates to drive six stirring mechanisms of the corresponding synchronous speed regulating assembly to rotate at the same speed;
the synchronous speed regulation assembly further comprises at least one tensioning wheel 213, the tensioning wheel is arranged between two adjacent stirring mechanisms, the tensioning wheel is connected with the first synchronous belt to realize linkage with the first synchronous belt wheel, and the tensioning wheel is used for regulating tightness of the first synchronous belt;
in the stirring mechanism, a fixed seat and a plug-in passage 214 which are mutually communicated on a synchronous shaft are inserted into the plug-in passage in a transition fit manner, the top of the synchronous shaft is exposed out from the upper extension of the stirring shaft, and a locking mechanism is arranged at the top of the synchronous shaft;
the locking mechanism comprises a locking sleeve 215, a locking groove 216 is formed in the locking sleeve, a synchronous shaft is inserted into the locking groove, an adjusting channel of the stirring shaft penetrating through the top of the locking sleeve is arranged outside, a first locking rod 217 and a second locking rod 218 are arranged on the side wall of the locking sleeve, the first locking rod and the second locking rod are arranged on the locking sleeve in a threaded fit manner, the first locking rod is rotated to be pressed on the stirring shaft, the second locking rod is rotated to be pressed on the synchronous shaft, and therefore double locking fixation of the stirring shaft and the synchronous shaft is achieved;
the bottom of the plugging channel is provided with a first compression joint component 219, the top of the plugging channel is provided with a second compression joint component 220, and the first compression joint component and the second compression joint component are in interference fit and are arranged on the stirring shaft in a compression manner;
the synchronous shaft is inserted into the locking groove in interference fit or transition fit;
the first compression joint assembly and the second compression joint assembly comprise a rubber ring 221 with a circular ring structure, and four compression joint structures 222 are uniformly arranged in the rubber ring;
the crimping structure is arranged in a crimping groove on the rubber ring;
the compression joint structure comprises an outer pressing block 223 with a circular arc-shaped cross section, a pushing block 224 with a rectangular cross section is arranged on the outer pressing block, and an inner pressing block 225 with an isosceles trapezoid cross section is arranged on the pushing block;
the pressing groove sequentially comprises a first pressing groove 226, a second pressing groove 227 and a third pressing groove 228 from inside to outside, an inner pressing block is arranged in the third pressing groove, a pushing block penetrates through the second pressing groove, and an outer pressing block is arranged in the first pressing groove;
the thickness of the outer pressing block is larger than the depth of the first pressing groove, the height of the pushing block is larger than the depth of the second pressing groove, the height of the inner pressing block is smaller than the depth of the third pressing groove, and a cushion block 229 with a spherical segment structure is arranged in the third pressing groove;
the thickness of the outer pressing block is 0.05-0.5mm more than the depth of the first pressing groove; the outer pressing block is made of rubber or stainless steel, and the pushing block and the inner pressing block are made of stainless steel; the cushion block is a rubber cushion block;
a gland 31 is arranged below the machine head, the gland can be arranged above the water bath box in a pressing way, and the stirring shaft passes through the gland and can be inserted into or removed from a corresponding dissolution cup along with the lifting of the machine head;
the pressure cover is provided with a plurality of coverage areas 32, one dissolution cup is arranged below each coverage area, and each coverage area is provided with a feed opening 33;
the gland is provided with a medicine feeding component;
the administration assembly comprises a plurality of administration bars 34 arranged in parallel with each other, each of which covers a row or column of feed openings in the coverage area, one of the ends of the plurality of administration bars being vertically fixed with a pull plate 35;
a plurality of dosing openings 36 are formed in the pull rod corresponding to the feeding openings, a guide channel 37 is formed between two adjacent dosing openings, the fixed terminal 38 penetrates through the guide channel to fix the dosing rod on the pressing cover, and the dosing rod can reciprocate along the guide channel to enable the dosing opening to cover the feeding openings or leave the feeding openings;
the other ends of the administration rods penetrate through the pressing plate 39 and are fixedly connected with a pushing plate 310, two guide rods 311 are arranged on the pushing plate and are respectively arranged on two sides of the administration rods, the guide rods penetrate through the pressing plate and are fixedly connected with a limiting plate 321, springs 312 are sleeved on the guide rods, and the springs are compressed between the pushing plate and the pressing plate;
the fixed terminal comprises a compression joint column and a fastening bolt 313, wherein the compression joint column sequentially comprises a first compression joint column 314, a second compression joint column 315 and a third compression joint column 316 from top to bottom, the first compression joint column and the third compression joint column are of cylindrical structures, the outer diameter of the first compression joint column is larger than that of the third compression joint column, the second compression joint column is connected with the first compression joint column and the third compression joint column and is of a truncated cone-shaped structure with a large upper part and a small lower part, the compression joint column penetrates through the guide channel, the third compression joint column is arranged on the compression cover in a compression joint manner, and the fastening bolt penetrates through the compression joint column to be locked and fixed on the compression cover; the second compression joint column is arranged at the top of the guide channel in a compression mode;
the inner diameter of the feeding opening is larger than that of the dosing opening;
the pressing plate is fixed on the pressing cover through a screw, a chute 317 for penetrating the administration rod is arranged on the pressing plate, a guide sliding block 322 is arranged on the side wall of the chute, and the guide sliding block is inserted into the guide chute positioned at two sides of the administration rod; a circle of first grooves 318 are formed in the inner wall of the dosing opening in an inward concave manner, the bottoms of the first grooves are open, and the first grooves are internally provided with brushes 319, and the lengths of the brushes are smaller than the heights of the first grooves; a dispensing cap 320 is removably disposed over the dispensing opening.
The dissolution cup is in a cylindrical structure and is in a hollow structure, the bottom end of the dissolution cup is in an arc shape, the top edge of the dissolution cup is turned outwards in the circumferential direction to form a dissolution cup flanging 42, the dissolution cup flanging 42 is in a circular ring shape, and the dissolution cup flanging 42 are integrally formed through hot pressing to form an integral structure; the outer side wall surface of the dissolving cup is provided with scales 45; the dissolving cup ring 43 is in a circular column structure with a wide upper part and a narrow lower part, and the inner diameter of the dissolving cup ring 43 is matched with the outer diameter of the dissolving cup; the upper end of the dissolving cup ring 43 is turned outwards in the circumferential direction to form a dissolving cup ring flanging 44, the dissolving cup ring flanging 44 is circular, the dissolving cup ring 43 and the dissolving cup ring flanging 44 are integrally formed through hot pressing to form an integral structure, and the dissolving cup ring flanging 44 is matched with the dissolving cup flanging 42 in size; the dissolution cup passes through the dissolution cup ring 43 from top to bottom to be fixedly connected with the dissolution cup ring 43, the dissolution cup ring 43 is arranged at the top end of the outer side wall of the dissolution cup, and the upper surface of the flanging 44 of the dissolution cup ring is attached to the lower surface of the flanging 42 of the dissolution cup; the water bath tank top plate 46 is of a plate-shaped structure, the water bath tank top plate 46 is provided with a water tank hole 47, the outer diameter 43 of the dissolving cup ring is matched with the inner diameter of the water tank hole 47, the dissolving cup penetrates through the water tank hole 47 from top to bottom, and the dissolving cup ring 43 is matched with the water tank hole 47 to realize the fixed connection of the dissolving cup and the water bath tank 46; the material of the dissolving cup ring 43 and the flange 44 of the dissolving cup ring is silicon rubber; the thickness of the solution cup ring 43 is consistent with that of the solution cup ring flanging 44; the setting angle α=100° of the solution cup ring 43 and the solution cup ring flange 44
The installation method of the two-region synchronous speed regulating mechanism comprises the following steps:
(1) The stirring shaft is inserted into the fixed seat, and is locked and fixed through the locking mechanism after the length is adjusted;
(2) The stirring mechanism and the stepping motor are fixed on the upper supporting plate, the first synchronous belt and the second synchronous belt are sleeved, and the tensioning wheel is used for adjusting the tightness of the first synchronous belt.
The application method of the administration component of the invention is as follows:
in the initial state, the spring is in a free state, and the administration opening is not covered on the feeding opening;
when the medicine is needed to be administrated, the medicines are sequentially put into the administration opening;
after the medicine is placed, the pulling plate is pulled to enable the medicine dispensing opening to be simultaneously moved to cover the feeding opening, so that the medicine simultaneously falls into the dissolving cup;
after the medicine is dispensed, the medicine dispensing rod is reset under the action of the spring.
The using method of the dissolving cup comprises the following steps:
the dissolution cup penetrates through the dissolution cup ring, the inner wall of the dissolution cup ring is attached to the outer side wall of the dissolution cup, the dissolution cup ring is provided with a cup opening at the top end of the dissolution cup, the upper surface of the flanging of the dissolution cup ring is attached to the lower surface of the flanging of the dissolution cup, and the dissolution cup is fixed with the dissolution cup ring; then the dissolving cup is placed in the water tank hole, the outer side wall of the dissolving cup ring clamps the inner side wall of the water tank hole, and the dissolving cup ring has a little anti-skid fixing capacity, so that the purpose of fixing the dissolving cup ring and the top plate of the water bath box is achieved. In the experimental process, when the inside of the dissolution cup rotates through the blade, the dissolution cup is fixed through the dissolution cup ring, and the dissolution cup is kept static.
Claims (2)
1. The efficient medicine dissolving-out instrument is characterized by comprising a machine head and a machine base, wherein the machine head is fixed above a unit in a lifting manner through a hydraulic cylinder, a water bath box is arranged in the machine base, dissolving-out cups are arranged in the water bath box in a matrix manner, the number of the dissolving-out cups is 12, and the dissolving-out cups are distributed in a 2*6 mode;
the machine head is also provided with two area synchronous speed regulating mechanisms, each of the two area synchronous speed regulating mechanisms comprises an upper supporting plate arranged in the machine head, and the upper supporting plate is provided with two synchronous speed regulating components;
each synchronous speed regulation assembly comprises six stirring mechanisms, each stirring mechanism is arranged corresponding to one dissolution cup, each stirring mechanism comprises a fixed seat, a stirring shaft is arranged on the fixed seat in a plug-in manner, the top of the fixed seat is provided with a synchronous shaft, and the synchronous shaft is provided with a first synchronous belt wheel;
six stirring mechanisms in each group of synchronous speed regulating assemblies are arranged in a matrix, a fixing seat is locked and fixed below an upper supporting plate through bolts and nuts, a synchronous shaft penetrates through the upper supporting plate and is positioned above the upper supporting plate, a first synchronous belt is tensioned and fixed among six first synchronous belt wheels to realize linkage, a second synchronous belt wheel is arranged below the first synchronous belt wheel of one synchronous shaft, the second synchronous belt wheel is connected with a third synchronous belt wheel fixed on a stepping motor through the second synchronous belt, and the stepping motor is fixed on the upper supporting plate;
the stepping motor rotates to drive six stirring mechanisms of the corresponding synchronous speed regulating assembly to rotate at the same speed;
the stirring shaft can be inserted into or removed from the corresponding dissolution cup along with the lifting of the machine head;
the dissolving cup is fixed on the top plate of the water bath box; the dissolution cup is in a cylindrical structure and is in a hollow structure, the bottom end of the dissolution cup is in an arc shape, the top edge of the dissolution cup is turned outwards in the circumferential direction to form a dissolution cup flanging, the dissolution cup flanging is in a circular ring shape, and the dissolution cup flanging are integrally formed through hot pressing to form an integral structure; scales are arranged on the surface of the outer side wall of the dissolution cup; the dissolving cup ring is in a cylindrical structure with a wide upper part and a narrow lower part, and the inner diameter of the dissolving cup ring is matched with the outer diameter of the dissolving cup; the upper end of the dissolving cup ring is turned outwards in the circumferential direction to form a dissolving cup ring flanging, the dissolving cup ring flanging is circular, the dissolving cup ring and the dissolving cup ring flanging are integrally formed through hot pressing, and the dissolving cup ring flanging is of an integral structure and is matched with the dissolving cup flanging in size; the dissolution cup passes through the dissolution cup ring from top to bottom to be fixedly connected with the dissolution cup ring, the dissolution cup ring is arranged at the top end of the outer side wall of the dissolution cup, and the upper surface of the flanging of the dissolution cup ring is attached to the lower surface of the flanging of the dissolution cup; the water bath tank top plate is of a plate-shaped structure, the water bath tank top plate is provided with a water tank hole, the outer diameter of the dissolving cup ring is matched with the inner diameter of the water tank hole, the dissolving cup penetrates through the water tank hole from top to bottom, and the dissolving cup is fixedly connected with the water bath tank through the matching of the dissolving cup ring and the water tank hole; the setting angle alpha=100° of the solution cup ring and the flanging of the solution cup ring;
a gland is arranged below the machine head, the gland is arranged above the water bath box in a pressing way, and the stirring shaft penetrates through the gland;
the pressure cover is provided with a plurality of coverage areas, a dissolution cup is corresponding to the lower part of each coverage area, and each coverage area is provided with a feed opening;
the gland is provided with a medicine feeding component;
the administration assembly comprises a plurality of administration bars, the administration bars are arranged in parallel, each administration bar is respectively covered on a row or a column of feeding openings of the coverage area, and one end of each administration bar is vertically fixed with a pull plate;
a plurality of dosing openings are formed in the pull rod and correspond to the feeding openings, a guide channel is formed between two adjacent dosing openings, the fixed terminal penetrates through the guide channel to fix the dosing rod on the pressing cover, and the dosing rod can reciprocate along the guide channel to enable the dosing opening to cover the feeding openings or leave the feeding openings;
the other ends of the administration rods penetrate through the pressing plate and are fixedly connected with a pushing plate, two guide rods are arranged on the pushing plate and are respectively arranged on two sides of the administration rods, the guide rods penetrate through the pressing plate and are fixedly connected with a limiting plate, springs are sleeved on the guide rods, and the springs are compressed between the pushing plate and the pressing plate;
the fixed terminal comprises a crimping column and a fastening bolt, the crimping column sequentially comprises a first crimping column, a second crimping column and a third crimping column from top to bottom, the first crimping column and the third crimping column are of cylindrical structures, the outer diameter of the first crimping column is larger than that of the third crimping column, the second crimping column is connected with the first crimping column and the third crimping column and is of a truncated cone-shaped structure with a large upper part and a small lower part, the crimping column penetrates through the guide channel, the third crimping column is pressed on the pressing cover, and the fastening bolt penetrates through the crimping column to be locked and fixed on the pressing cover; the second compression joint column is arranged at the top of the guide channel in a compression mode;
the inner diameter of the feeding opening is larger than that of the dosing opening;
in the stirring mechanism, a fixed seat and a synchronous shaft are mutually communicated and inserted into the inserting passage in a transitional fit manner, the top of the synchronous shaft is exposed out from the upper extension of the stirring shaft, and a locking mechanism is arranged at the top of the synchronous shaft;
the locking mechanism comprises a locking sleeve, a locking groove is formed in the locking sleeve, a synchronous shaft is inserted into the locking groove, an adjusting channel of the stirring shaft penetrating through the top of the locking sleeve is arranged outside, a first locking rod and a second locking rod are arranged on the side wall of the locking sleeve, the first locking rod and the second locking rod are arranged on the locking sleeve in a threaded fit manner, the first locking rod is rotated to be pressed on the stirring shaft, and the second locking rod is rotated to be pressed on the synchronous shaft;
the bottom of grafting passageway is equipped with first crimping subassembly, and the top of grafting passageway is equipped with the second crimping subassembly, and first crimping subassembly and second crimping subassembly interference fit's pressure is established on the (mixing) shaft.
2. The apparatus of claim 1, wherein the synchronous speed regulation assembly further comprises at least one tensioning wheel, the tensioning wheel is disposed between two adjacent stirring mechanisms, the tensioning wheel is connected with the first synchronous belt to realize linkage with the first synchronous belt wheel, and the tensioning wheel is used for regulating tightness of the first synchronous belt.
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| CN201811305368.3A CN109374845B (en) | 2018-11-05 | 2018-11-05 | Efficient medicine dissolves out appearance |
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| CN201811305368.3A CN109374845B (en) | 2018-11-05 | 2018-11-05 | Efficient medicine dissolves out appearance |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110045070B (en) * | 2019-04-03 | 2024-08-16 | 禄根仪器(镇江)有限公司 | Automatic release rate sampling system's mechanism of uncapping of dissolving cup |
| CN111707791B (en) * | 2020-06-28 | 2022-08-05 | 青海省药品检验检测院 | Self-monitoring intelligent disintegration tester |
| CN112023700A (en) * | 2020-08-11 | 2020-12-04 | 禄根仪器(镇江)有限公司 | Full-automatic filter membrane replacing device |
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| CN109374845A (en) | 2019-02-22 |
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