CN109374845A - A kind of efficient medicament dissolution instrument - Google Patents
A kind of efficient medicament dissolution instrument Download PDFInfo
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- CN109374845A CN109374845A CN201811305368.3A CN201811305368A CN109374845A CN 109374845 A CN109374845 A CN 109374845A CN 201811305368 A CN201811305368 A CN 201811305368A CN 109374845 A CN109374845 A CN 109374845A
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- stripping rotor
- molten cup
- cup ring
- synchronous
- crimp
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- 239000003814 drug Substances 0.000 title claims abstract description 33
- 238000004090 dissolution Methods 0.000 title claims abstract description 24
- 230000001360 synchronised effect Effects 0.000 claims abstract description 73
- 230000007246 mechanism Effects 0.000 claims abstract description 52
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000011159 matrix material Substances 0.000 claims abstract description 7
- 210000004907 gland Anatomy 0.000 claims description 27
- 238000000429 assembly Methods 0.000 claims description 19
- 230000000712 assembly Effects 0.000 claims description 19
- 238000003825 pressing Methods 0.000 claims description 13
- 238000002788 crimping Methods 0.000 claims description 9
- 238000007731 hot pressing Methods 0.000 claims description 6
- 238000003780 insertion Methods 0.000 claims description 5
- 230000037431 insertion Effects 0.000 claims description 5
- 230000007704 transition Effects 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 238000002474 experimental method Methods 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 description 11
- 229920001971 elastomer Polymers 0.000 description 11
- 238000000034 method Methods 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 238000009434 installation Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 238000009834 vaporization Methods 0.000 description 2
- 230000008016 vaporization Effects 0.000 description 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- -1 piece Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The invention proposes a kind of efficient medicament dissolution instrument, including head and base, head is fixed on above unit by the way that hydraulic cylinder is liftable, and water bath is equipped in base, and matrix form is equipped with stripping rotor in water bath；It is additionally provided with two region synchronous variable-speed mechanisms on head, two region synchronous variable-speed mechanisms set that there are two synchronous variable-speed components including the upper backup pad being arranged in head on upper backup pad；Each synchronous variable-speed component includes six rabbling mechanisms, the corresponding stripping rotor setting of each rabbling mechanism, each rabbling mechanism includes fixing seat, plug-type setting agitating shaft in fixing seat, the top of fixing seat is equipped with synchronizing shaft, and synchronizing shaft is equipped with the first synchronous pulley.Separated regions of the present invention determines revolving speed respectively, and the revolving speed in each region can independently be set, and improves working efficiency, reduces experimental error；Dispensing mechanism is improved simultaneously, further improves the accuracy of experiment.
Description
Technical field
The present invention relates to a kind of digestion instrument, in particular to a kind of efficient medicament dissolution instrument.
Background technique
Medicament dissolution instrument is the instrument for carrying out drug dissolution experiment, is set by the test of micro-processor controlled electromechanical integration
It is standby, centralized control is carried out to each component by precise control system.Drug dissolution experiment is to the solids medicine such as piece, capsule, particle
The detection method of object preparation dissolution rate and dissolution rate under certain condition, it may also be said to be disintegrated in stomach by instrument simulation
With the method for dissolution, for evaluate drug bioequivalence and bioavilability and clinical use before evaluate drug quality
An important indicator.
Patent 201720601696.2 discloses a kind of medicament dissolution instrument for brufen soft capsule.This kind is used for cloth Lip river
The medicament dissolution instrument of fragrant soft capsule, including head and base；Control system built in head；Water bath is mounted on base, the water
Sensor and stripping rotor are installed in the cabinet of bath cabinet；The rim of a cup of stripping rotor is equipped with vaporization prevention lid；It is set in stripping rotor and turns basket；Also wrap
Include sampling system；The bottom end of vaporization prevention lid is cone；Turn basket include columned basket body frame and with phase outside basket body frame
The two sides short side of the rectangle net of cooperation, the rectangle net is equipped with mutually matched snap-fastener.
The revolving speed control mode of the mixing component of above-mentioned digestion instrument is single, is easy to produce experimental error.
Summary of the invention
The present invention proposes a kind of efficient medicament dissolution instrument regarding to the issue above, and separated regions determines revolving speed respectively, each
The revolving speed in region all can independently be set, and improve working efficiency, reduce experimental error；Dispensing mechanism is improved simultaneously, further
Improve the accuracy of experiment.
Specific technical solution is as follows:
A kind of efficient medicament dissolution instrument, including head and base, head are fixed on above unit by the way that hydraulic cylinder is liftable,
Water bath is equipped in base, matrix form is equipped with stripping rotor in water bath, and the quantity of stripping rotor is 12, stripping rotor is with 2*6's
Form is distributed；
Two region synchronous variable-speed mechanisms, two region synchronous variable-speed mechanisms, including the upper branch being arranged in head are additionally provided on head
Fagging, sets that there are two synchronous variable-speed components on upper backup pad；
Each synchronous variable-speed component includes six rabbling mechanisms, and the corresponding stripping rotor setting of each rabbling mechanism is each stirred
Mixing mechanism includes fixing seat, plug-type setting agitating shaft in fixing seat, and the top of fixing seat is equipped with synchronizing shaft, on synchronizing shaft
Equipped with the first synchronous pulley；
Six rabbling mechanisms in every group of synchronous variable-speed component are arranged at matrix form, and fixing seat is locked solid by screw bolt and nut
It is scheduled on the lower section of upper backup pad, synchronizing shaft passes through the top that upper backup pad is located at upper backup pad, between six the first synchronous pulleys
Tensioning fixes first synchronous belt and realizes linkage, and the lower section of the first synchronous pulley of one of synchronizing shaft is equipped with one second
Synchronous pulley, the second synchronous pulley are connected by the second synchronous belt with the third synchronous pulley being fixed on stepper motor, are walked
It is fixed on upper backup pad into motor；
Stepper motor rotation drives six rabbling mechanisms of respective synchronization regulating module to rotate at the same speed；
Agitating shaft can be inserted into or remove corresponding stripping rotor with the lifting of head；
Stripping rotor is fixed on the top plate of water bath；The cylindrical structure of stripping rotor, is hollow structure, and dissolution cup bottom is in circular arc
Shape, stripping rotor top margin peripherally and outwardly turn down, and form stripping rotor flange, stripping rotor flange is annular in shape, and stripping rotor is turned over stripping rotor
While being integrally formed through hot pressing, it is an integral structure；Stripping rotor outer side wall surface is equipped with scale；Molten cup ring is in annulus column wide at the top and narrow at the bottom
Structure, molten cup ring internal diameter and stripping rotor outer diameter are adapted；Molten cup ring upper end peripherally and outwardly turns down, and forms molten cup ring flange, molten cup
Ring flange is annular in shape, and molten cup ring is integrally formed with molten cup ring flange through hot pressing, is an integral structure, molten cup ring flange and molten cup
Flange size is adapted；Stripping rotor passes through molten cup ring realization from top to bottom and is fixedly connected with molten cup ring, and molten cup ring is set to dissolution
Cup lateral wall top, molten cup ring flange upper surface fit in the setting of molten cup flange lower surface；The plate-like structure of water-bath roof box, water
Bath cabinet top plate is equipped with tank hole, and molten cup ring outer diameter and tank hole internal diameter are adapted, and stripping rotor passes through tank hole from top to bottom, leads to
It crosses molten cup ring and cooperates realization stripping rotor to be fixedly connected with water bath with tank hole；The setting angle [alpha] of molten cup ring and molten cup ring flange=
100°。
Further, gland is equipped with below head, gland can be pressed on above water bath, and agitating shaft passes through gland；
Gland is equipped with multiple overlay areas, and a corresponding stripping rotor below each overlay area, each overlay area is equipped with
One feed openings；
Gland is equipped with dispensing component；
Component of offeing medicine includes multiple dispensing bars, and dispensing bar is arranged in parallel, and each dispensing bar is respectively overlay in a row or a column
In the feed openings of overlay area, wherein one end of multiple dispensing bars it is vertical fix a pulling plate；
It is corresponding with feed openings on pull rod to be equipped with multiple dispensings opening, a guiding is equipped between adjacent two dispensings opening
Channel, fixing terminal pass through guide channel and dispensing bar are fixed on gland, and dispensing bar can move back and forth along guide channel,
Dispensing opening is set to be covered in feed openings or leave feed openings；
It is multiple dispensing bars the other end pass through pressing plate be fixedly connected with a push plate, set in push plate there are two guide rod, guide rod
The two sides of dispensing bar are separately positioned on, guide rod passes through pressing plate and is fixedly connected with a limit plate, sheathed spring on guide rod, bullet
Spring is compressed between push plate and pressing plate；
Fixing terminal includes crimp column and fastening bolt, and crimp column successively includes the first crimp column, the second crimp column from top to bottom
With third crimp column, the first crimp column and third crimp column are cylindrical structure, and the outer diameter of the first crimp column is crimped greater than third
The outer diameter of column, the second crimp column connect the first crimp column and third crimp column, for up big and down small truncated cone-shaped structure, and crimp column is worn
It crosses guide channel, be pressed on third crimp column on gland, fastening bolt passes through crimp column and is locked on gland；Second pressure
Connect the top that column is pressed on guide channel；
The internal diameter of feed openings is greater than the internal diameter of dispensing opening.
It further, further include at least one tensioning wheel in synchronous variable-speed component, tensioning wheel is arranged in adjacent two and stirs
Mix between mechanism, tensioning wheel band connection synchronous with first, realize with the linkage of the first synchronous pulley, tensioning wheel is for adjusting first
Synchronous belt it is elastic.
Further, in rabbling mechanism, the grafting channel being interconnected in fixing seat and synchronizing shaft, agitating shaft transition is matched
In the insertion grafting channel of conjunction, the top for the exposing synchronizing shaft that agitating shaft upwardly extends, the top of synchronizing shaft is equipped with retaining mechanism；
Retaining mechanism includes lock sleeve, and lock sleeve is equipped with locking slot, and synchronizing shaft is inserted into locking slot, and agitating shaft passes through lock sleeve
Outside, the side wall of lock sleeve is equipped with the first check lock lever and the second check lock lever for the adjusting channel setting at top, the first check lock lever and
The setting that second check lock lever is threadedly engaged is on lock sleeve, and the first check lock lever of rotation is pressed on it on agitating shaft, rotation second
Check lock lever is pressed on it on synchronizing shaft；
The bottom in grafting channel is equipped with the first crimp assemblies, and the top in grafting channel is equipped with the second crimp assemblies, the first crimping group
What part and the second crimp assemblies were interference fitted is pressed on agitating shaft.
Further, in the insertion locking slot of synchronizing shaft interference fit or transition fit.
Further, the first crimp assemblies and the second crimp assemblies include the rubber ring of cirque structure, rubber ring
Inside is uniformly provided with four crimping structures；
Crimping structure is arranged in the indent on rubber ring；
Crimping structure includes the outer briquetting that section is arc-shaped structure, and outer briquetting is equipped with the pushing block of rectangular cross-section structure, pushes away
Block is equipped with the interior briquetting that section is isosceles trapezoidal structure；
Indent successively includes the first indent, the second indent and third indent from inside to outside, and interior briquetting is arranged in third indent, pushes away
Block passes through the second indent, and outer briquetting is arranged in the first indent；
The thickness of outer briquetting is greater than the depth of the first indent, and the height of pushing block is greater than the depth of the second indent, the height of interior briquetting
Less than the depth of third indent, the cushion block of segment structure is equipped in third indent.
Further, the thickness of outer briquetting than the first indent depth more than 0.05-0.5mm.
Further, outer briquetting is made using rubber or stainless steel by material, and pushing block and interior briquetting are using stainless steel as material system
At.
Further, cushion block is rubber cushion blocks.
The installation method of two region synchronous variable-speed mechanisms of the invention is as follows:
(1) agitating shaft is inserted into fixing seat, after having adjusted length, is locked by retaining mechanism；
(2) rabbling mechanism, stepper motor are fixed on upper backup pad, are arranged the first synchronous belt and the second synchronous belt, tensioning wheel
For adjusting the elastic of the first synchronous belt.
The application method of dispensing component of the invention is as follows:
When original state, spring is in free state, and dispensing opening is not covered in feed openings；
When needing to offer medicine, drug is sequentially placed into dispensing opening；
After the completion of drug is placed, pulling plate is pulled, so that dispensing is open while is moved to and is covered in feed openings, make drug while falling
Enter in stripping rotor；
After the completion of dispensing, dispensing bar resets under the action of the spring.
The application method of stripping rotor are as follows:
Stripping rotor is passed through into molten cup ring, molten cup ring inner wall is fitted in into molten cup lateral wall, and stripping rotor top is arranged in molten cup ring
Rim of a cup, molten cup ring flange upper surface fit in stripping rotor flange lower surface, stripping rotor and molten cup ring are fixed；Then by stripping rotor
It is put into tank hole, molten cup ring lateral wall blocks tank hole inner sidewall, and molten cup ring has the anti-skidding crystallized ability of a bit, reaches molten
The purpose that cup ring and water-bath roof box are fixed.In experimentation, when rotating in stripping rotor through blade, stripping rotor is fixed through molten cup ring
Effect, stripping rotor are remain stationary.
The invention has the benefit that
(1) separated regions of the present invention determines revolving speed respectively, and the revolving speed in each region can independently be set, and improves working efficiency, reduces
Experimental error；
(2) agitating shaft is fixed in fixing seat by retaining mechanism, and stability is good, is not easy to fall damage equipment；
The setting of (3) first crimp assemblies and the second crimp assemblies, it is easy for installation, the fastness of connection is further improved,
It is more safe and reliable；
(4) by adding molten cup ring outside stripping rotor, molten cup ring is caught in tank hole, solves stripping rotor size and water tank pore size
The stripping rotor of different size size can be used in different problem, and stripping rotor can be completely closely sealed with water bath, improves stripping rotor
The stability used, experiment accuracy improve；
(5) dispensing component is added on gland, guarantees that tablet is fallen into each stripping rotor simultaneously, is eliminated tablet and is lost in stripping rotor
Time difference, to guarantee the consistency of experimental result；
(6) in conclusion the present invention is stirred, mixing speed in use, by drug investment stripping rotor by rabbling mechanism
It is adjusted by two region synchronous variable-speed mechanisms, working efficiency greatly improved.
Detailed description of the invention
Fig. 1 is cross-sectional view of the present invention.
Fig. 2 is two region synchronous variable-speed mechanism top views.
Fig. 3 is the side view of one group of synchronous variable-speed component.
Fig. 4 is the cross-sectional view of rabbling mechanism.
Fig. 5 is the radial cross-section of the first crimp assemblies or the second crimp assemblies.
Fig. 6 is part A enlarged drawing in Fig. 5.
Fig. 7 is state top view of the invention of not offeing medicine.
Fig. 8 is dispensing state top view of the present invention.
Fig. 9 is cover board top view.
Figure 10 is C portion enlarged drawing in Fig. 6.
Figure 11 is part B enlarged drawing in Fig. 6.
Figure 12 is fixing terminal stationary state cross-sectional view.
Figure 13 is feed openings and dispensing opening combinations cross-sectional view.
Figure 14 is pressing plate side view.
Figure 15 is stripping rotor structural schematic diagram.
Figure 16 is the structural schematic diagram of molten cup ring.
Figure 17 is the cross-sectional view of molten cup ring.
Specific embodiment
Clear to be more clear technical solution of the present invention, the present invention is described further with reference to the accompanying drawing,
The technical characteristic of any pair of technical solution of the present invention carries out the scheme that equivalencing is obtained with conventional reasoning and each falls within guarantor of the present invention
Protect range.
Description of symbols
Head 1, base 2, hydraulic cylinder 3, water bath 4, stripping rotor 5；
Upper backup pad 21, synchronous variable-speed component 22, rabbling mechanism 23, fixing seat 24, agitating shaft 25, synchronizing shaft 26, first are synchronous
Belt wheel 27, the first synchronous belt 28, the second synchronous pulley 29, the second synchronous belt 210, stepper motor 211, third synchronous pulley 212,
Tensioning wheel 213, grafting channel 214, lock sleeve 215, locking slot 216, the first check lock lever 217, the second check lock lever 218, first pressure
Connected components 219, the second crimp assemblies 220, rubber ring 221, crimping structure 222, outer briquetting 223, pushing block 224, interior briquetting 225,
First indent 226, the second indent 227, third indent 228, cushion block 229；
Gland 31, overlay area 32, feed openings 33, dispensing bar 34, pulling plate 35, dispensing opening 36, guide channel 37, fixing end
Sub 38, pressing plate 39, push plate 310, guide rod 311, spring 312, fastening bolt 313, the first crimp column 314, the second crimp column
315, third crimp column 316, sliding slot 317, the first groove 318, hairbrush 319, dispensing lid 320, limit plate 321, guide runner
322；
Molten cup flange 42, molten cup ring 43, molten cup ring flange 44, scale 45, water tank top plate 46, tank hole 47.
A kind of efficient medicament dissolution instrument as shown in the figure, including head 1 and base 2, head are liftable by hydraulic cylinder 3
It is fixed on above unit, water bath 4 is equipped in base, matrix form is equipped with stripping rotor 5 in water bath, and the quantity of stripping rotor is 12
A, stripping rotor is distributed in the form of 2*6；
Two region synchronous variable-speed mechanisms are additionally provided on head, two region synchronous variable-speed mechanisms include the upper support being arranged in head
Plate 21, sets that there are two synchronous variable-speed components 22 on upper backup pad；
Each synchronous variable-speed component includes six rabbling mechanisms 23, the corresponding stripping rotor setting of each rabbling mechanism, each
Rabbling mechanism includes fixing seat 24, and the top of plug-type setting agitating shaft 25 in fixing seat, fixing seat is equipped with synchronizing shaft 26,
Synchronizing shaft is equipped with the first synchronous pulley 27；
Six rabbling mechanisms in every group of synchronous variable-speed component are arranged at matrix form, and fixing seat is locked solid by screw bolt and nut
It is scheduled on the lower section of upper backup pad, synchronizing shaft passes through the top that upper backup pad is located at upper backup pad, between six the first synchronous pulleys
Tensioning fixes first synchronous belt 28 and realizes linkage, and the lower section of the first synchronous pulley of one of synchronizing shaft is equipped with one the
Two synchronous pulleys 29, the third synchronous pulley that the second synchronous pulley synchronous belt 210 and be fixed on stepper motor 211 by second
212 are connected, and stepper motor is fixed on upper backup pad；
Stepper motor rotation drives six rabbling mechanisms of respective synchronization regulating module to rotate at the same speed；
It further include at least one tensioning wheel 213 in synchronous variable-speed component, tensioning wheel is arranged between two adjacent rabbling mechanisms,
Tensioning wheel band connection synchronous with first is realized and is used to adjust the pine of the first synchronous belt with the linkage of the first synchronous pulley, tensioning wheel
Tightly；
In rabbling mechanism, the insertion in the grafting channel 214 being interconnected in fixing seat and synchronizing shaft, agitating shaft transition fit is inserted
It connects in road, the top for the exposing synchronizing shaft that agitating shaft upwardly extends, the top of synchronizing shaft is equipped with retaining mechanism；
Retaining mechanism includes lock sleeve 215, and lock sleeve is equipped with locking slot 216, and synchronizing shaft is inserted into locking slot, and agitating shaft passes through
Outside, the side wall of lock sleeve is equipped with the first check lock lever 217 and the second check lock lever 218 for adjusting channel setting at the top of lock sleeve,
On lock sleeve, the first check lock lever of rotation makes it be pressed on agitating shaft for the setting that first check lock lever and the second check lock lever are threadedly engaged
On, the second check lock lever of rotation is pressed on it on synchronizing shaft, so that the double locking for realizing agitating shaft and synchronizing shaft is fixed；
The bottom in grafting channel is equipped with the first crimp assemblies 219, and the top in grafting channel is equipped with the second crimp assemblies 220, and first
What crimp assemblies and the second crimp assemblies were interference fitted is pressed on agitating shaft；
In the insertion locking slot of synchronizing shaft interference fit or transition fit；
First crimp assemblies and the second crimp assemblies include the rubber ring 221 of cirque structure, and the inside of rubber ring is uniformly set
There are four crimping structures 222；
Crimping structure is arranged in the indent on rubber ring；
Crimping structure includes the outer briquetting 223 that section is arc-shaped structure, and outer briquetting is equipped with the pushing block of rectangular cross-section structure
224, pushing block is equipped with the interior briquetting 225 that section is isosceles trapezoidal structure；
Indent successively includes the first indent 226, the second indent 227 and third indent 228 from inside to outside, and interior briquetting is arranged in third
In indent, pushing block passes through the second indent, and outer briquetting is arranged in the first indent；
The thickness of outer briquetting is greater than the depth of the first indent, and the height of pushing block is greater than the depth of the second indent, the height of interior briquetting
Less than the depth of third indent, the cushion block 229 of segment structure is equipped in third indent；
The thickness of outer briquetting than the first indent depth more than 0.05-0.5mm；Outer briquetting is made using rubber or stainless steel by material,
Pushing block and interior briquetting are made using stainless steel of material；Cushion block is rubber cushion blocks；
Gland 31 is equipped with below head, gland can be pressed on above water bath, and agitating shaft passes through gland and can be with the lifting of head
It is inserted into or removes corresponding stripping rotor；
Gland is equipped with multiple overlay areas 32, and a stripping rotor is corresponded to below each overlay area, is set on each overlay area
There are a feed openings 33；
Gland is equipped with dispensing component；
Component of offeing medicine includes multiple dispensing bars 34, and dispensing bar is arranged in parallel, and each dispensing bar is respectively overlay in a row or one
In the feed openings for arranging overlay area, wherein one end of multiple dispensing bars it is vertical fix a pulling plate 35；
It is corresponding with feed openings on pull rod to be equipped with multiple dispensings opening 36, one, which is equipped with, between adjacent two dispensings opening leads
To channel 37, fixing terminal 38 passes through guide channel and dispensing bar is fixed on gland, and dispensing bar can carry out past along guide channel
Multiple movement makes dispensing opening be covered in feed openings or leave feed openings；
It is multiple dispensing bars the other end pass through pressing plate 39 be fixedly connected with a push plate 310, set in push plate there are two guide rod
311, guide rod is separately positioned on the two sides of dispensing bar, and guide rod passes through pressing plate and is fixedly connected with a limit plate 321, guide rod
Upper sheathed spring 312, spring-compressed is between push plate and pressing plate；
Fixing terminal includes crimp column and fastening bolt 313, and crimp column successively includes the first crimp column 314, second from top to bottom
Crimp column 315 and third crimp column 316, the first crimp column and third crimp column are cylindrical structure, the outer diameter of the first crimp column
Greater than the outer diameter of third crimp column, the second crimp column connects the first crimp column and third crimp column, for up big and down small truncated cone-shaped
Structure, crimp column pass through guide channel, are pressed on third crimp column on gland, and fastening bolt passes through crimp column and is locked
On gland；Second crimp column is pressed on the top of guide channel；
The internal diameter of feed openings is greater than the internal diameter of dispensing opening；
Pressing plate is fixed by screws on gland, and pressing plate is equipped with for the sliding slot 317 across dispensing bar, is set on the side wall of sliding slot
There is a guide runner 322, in the plug-type guide chute for being arranged in dispensing bar two sides of guide runner；The inner wall for opening of offeing medicine
On be recessed inwardly be equipped with first groove 318 of circle, the bottom opening of the first groove is equipped with hairbrush 319, hairbrush in the first groove
Length less than the first groove height；Dispensing opening is upper dismountable equipped with dispensing lid 320.
The cylindrical structure of stripping rotor is hollow structure, and dissolution cup bottom is in arc-shaped, and stripping rotor top margin peripherally and outwardly turns over
Folding, forms molten cup flange 42, molten cup flange 42 is annular in shape, and stripping rotor is integrally formed with molten cup flange 42 through hot pressing, is integrated
Formula structure；Stripping rotor outer side wall surface is equipped with scale 45；Molten cup ring 43 be in annulus rod structure wide at the top and narrow at the bottom, molten 43 internal diameter of cup ring with
Stripping rotor outer diameter is adapted；Molten 43 upper end of cup ring peripherally and outwardly turns down, and forms molten cup ring flange 44, and molten cup ring flange 44 is in annulus
Shape, molten cup ring 43 are integrally formed through hot pressing with molten cup ring flange 44, are an integral structure, molten cup ring flange 44 and molten cup flange 42
Size is adapted；Stripping rotor passes through the molten realization of cup ring 43 from top to bottom and is fixedly connected with molten cup ring 43, and molten cup ring 43 is set to molten
Cup lateral wall top out, molten 44 upper surface of cup ring flange fit in molten 42 lower surface of cup flange setting；Water-bath roof box 46 is in plate
Shape structure, water-bath roof box 46 are equipped with tank hole 47, and molten cup ring outer diameter 43 is adapted with 47 internal diameter of tank hole, and stripping rotor is from upper
Across tank hole 47 under and, is cooperated by molten cup ring 43 with tank hole 47 and realize that stripping rotor is fixedly connected with water bath 46；Molten cup
Ring 43, molten 44 material selection silicone rubber material of cup ring flange；Molten 43 thickness of cup ring and molten 44 consistency of thickness of cup ring flange；Molten cup ring
43 with setting angle [alpha]=100 ° of molten cup ring flange 44
The installation method of two region synchronous variable-speed mechanisms of the invention is as follows:
(1) agitating shaft is inserted into fixing seat, after having adjusted length, is locked by retaining mechanism；
(2) rabbling mechanism, stepper motor are fixed on upper backup pad, are arranged the first synchronous belt and the second synchronous belt, tensioning wheel
For adjusting the elastic of the first synchronous belt.
The application method of dispensing component of the invention is as follows:
When original state, spring is in free state, and dispensing opening is not covered in feed openings；
When needing to offer medicine, drug is sequentially placed into dispensing opening；
After the completion of drug is placed, pulling plate is pulled, so that dispensing is open while is moved to and is covered in feed openings, make drug while falling
Enter in stripping rotor；
After the completion of dispensing, dispensing bar resets under the action of the spring.
The application method of stripping rotor are as follows:
Stripping rotor is passed through into molten cup ring, molten cup ring inner wall is fitted in into molten cup lateral wall, and stripping rotor top is arranged in molten cup ring
Rim of a cup, molten cup ring flange upper surface fit in stripping rotor flange lower surface, stripping rotor and molten cup ring are fixed；Then by stripping rotor
It is put into tank hole, molten cup ring lateral wall blocks tank hole inner sidewall, and molten cup ring has the anti-skidding crystallized ability of a bit, reaches molten
The purpose that cup ring and water-bath roof box are fixed.In experimentation, when rotating in stripping rotor through blade, stripping rotor is fixed through molten cup ring
Effect, stripping rotor are remain stationary.
Claims (4)
1. a kind of efficient medicament dissolution instrument, it is characterized in that, including head and base, head pass through the liftable fixation of hydraulic cylinder
Above unit, water bath is equipped in base, matrix form is equipped with stripping rotor in water bath, and the quantity of stripping rotor is 12, molten
Cup is distributed in the form of 2*6 out；
Two region synchronous variable-speed mechanisms, two region synchronous variable-speed mechanisms, including the upper branch being arranged in head are additionally provided on head
Fagging, sets that there are two synchronous variable-speed components on upper backup pad；
Each synchronous variable-speed component includes six rabbling mechanisms, and the corresponding stripping rotor setting of each rabbling mechanism is each stirred
Mixing mechanism includes fixing seat, plug-type setting agitating shaft in fixing seat, and the top of fixing seat is equipped with synchronizing shaft, on synchronizing shaft
Equipped with the first synchronous pulley；
Six rabbling mechanisms in every group of synchronous variable-speed component are arranged at matrix form, and fixing seat is locked solid by screw bolt and nut
It is scheduled on the lower section of upper backup pad, synchronizing shaft passes through the top that upper backup pad is located at upper backup pad, between six the first synchronous pulleys
Tensioning fixes first synchronous belt and realizes linkage, and the lower section of the first synchronous pulley of one of synchronizing shaft is equipped with one second
Synchronous pulley, the second synchronous pulley are connected by the second synchronous belt with the third synchronous pulley being fixed on stepper motor, are walked
It is fixed on upper backup pad into motor；
Stepper motor rotation drives six rabbling mechanisms of respective synchronization regulating module to rotate at the same speed；
Agitating shaft can be inserted into or remove corresponding stripping rotor with the lifting of head；
Stripping rotor is fixed on the top plate of water bath；The cylindrical structure of stripping rotor, is hollow structure, and dissolution cup bottom is in circular arc
Shape, stripping rotor top margin peripherally and outwardly turn down, and form stripping rotor flange, stripping rotor flange is annular in shape, and stripping rotor is turned over stripping rotor
While being integrally formed through hot pressing, it is an integral structure；Stripping rotor outer side wall surface is equipped with scale；Molten cup ring is in annulus column wide at the top and narrow at the bottom
Structure, molten cup ring internal diameter and stripping rotor outer diameter are adapted；Molten cup ring upper end peripherally and outwardly turns down, and forms molten cup ring flange, molten cup
Ring flange is annular in shape, and molten cup ring is integrally formed with molten cup ring flange through hot pressing, is an integral structure, molten cup ring flange and molten cup
Flange size is adapted；Stripping rotor passes through molten cup ring realization from top to bottom and is fixedly connected with molten cup ring, and molten cup ring is set to dissolution
Cup lateral wall top, molten cup ring flange upper surface fit in the setting of molten cup flange lower surface；The plate-like structure of water-bath roof box, water
Bath cabinet top plate is equipped with tank hole, and molten cup ring outer diameter and tank hole internal diameter are adapted, and stripping rotor passes through tank hole from top to bottom, leads to
It crosses molten cup ring and cooperates realization stripping rotor to be fixedly connected with water bath with tank hole；The setting angle [alpha] of molten cup ring and molten cup ring flange=
100°。
2. a kind of efficient medicament dissolution instrument as described in claim 1, it is characterized in that, gland is equipped with below head, gland can
It is pressed on above water bath, agitating shaft passes through gland；
Gland is equipped with multiple overlay areas, and a corresponding stripping rotor below each overlay area, each overlay area is equipped with
One feed openings；
Gland is equipped with dispensing component；
Component of offeing medicine includes multiple dispensing bars, and dispensing bar is arranged in parallel, and each dispensing bar is respectively overlay in a row or a column
In the feed openings of overlay area, wherein one end of multiple dispensing bars it is vertical fix a pulling plate；
It is corresponding with feed openings on pull rod to be equipped with multiple dispensings opening, a guiding is equipped between adjacent two dispensings opening
Channel, fixing terminal pass through guide channel and dispensing bar are fixed on gland, and dispensing bar can move back and forth along guide channel,
Dispensing opening is set to be covered in feed openings or leave feed openings；
It is multiple dispensing bars the other end pass through pressing plate be fixedly connected with a push plate, set in push plate there are two guide rod, guide rod
The two sides of dispensing bar are separately positioned on, guide rod passes through pressing plate and is fixedly connected with a limit plate, sheathed spring on guide rod, bullet
Spring is compressed between push plate and pressing plate；
Fixing terminal includes crimp column and fastening bolt, and crimp column successively includes the first crimp column, the second crimp column from top to bottom
With third crimp column, the first crimp column and third crimp column are cylindrical structure, and the outer diameter of the first crimp column is crimped greater than third
The outer diameter of column, the second crimp column connect the first crimp column and third crimp column, for up big and down small truncated cone-shaped structure, and crimp column is worn
It crosses guide channel, be pressed on third crimp column on gland, fastening bolt passes through crimp column and is locked on gland；Second pressure
Connect the top that column is pressed on guide channel；
The internal diameter of feed openings is greater than the internal diameter of dispensing opening.
3. a kind of efficient medicament dissolution instrument as described in claim 1, it is characterized in that, it further include at least in synchronous variable-speed component
One tensioning wheel, tensioning wheel are arranged between two adjacent rabbling mechanisms, and tensioning wheel band connection synchronous with first is realized and the
The linkage of one synchronous pulley, tensioning wheel is for adjusting the elastic of the first synchronous belt.
4. a kind of efficient medicament dissolution instrument as described in claim 1, it is characterized in that, in rabbling mechanism, fixing seat and same
The grafting channel being interconnected on axis is walked, in the insertion grafting channel of agitating shaft transition fit, exposing that agitating shaft upwardly extends
The top at the top of synchronizing shaft, synchronizing shaft is equipped with retaining mechanism；
Retaining mechanism includes lock sleeve, and lock sleeve is equipped with locking slot, and synchronizing shaft is inserted into locking slot, and agitating shaft passes through lock sleeve
Outside, the side wall of lock sleeve is equipped with the first check lock lever and the second check lock lever for the adjusting channel setting at top, the first check lock lever and
The setting that second check lock lever is threadedly engaged is on lock sleeve, and the first check lock lever of rotation is pressed on it on agitating shaft, rotation second
Check lock lever is pressed on it on synchronizing shaft；
The bottom in grafting channel is equipped with the first crimp assemblies, and the top in grafting channel is equipped with the second crimp assemblies, the first crimping group
What part and the second crimp assemblies were interference fitted is pressed on agitating shaft.
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| CN201811305368.3A CN109374845B (en) | 2018-11-05 | 2018-11-05 | Efficient medicine dissolves out appearance |
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| Publication number | Publication date |
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| CN109374845B (en) | 2024-03-29 |
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