CN111195308A

CN111195308A - Compound preparation for reducing blood pressure and blood fat and preparation method thereof

Info

Publication number: CN111195308A
Application number: CN202010119511.0A
Authority: CN
Inventors: 陈曦; 杨伟
Original assignee: Jiangsu Food and Pharmaceutical Science College
Current assignee: Jiangsu Food and Pharmaceutical Science College
Priority date: 2020-02-26
Filing date: 2020-02-26
Publication date: 2020-05-26

Abstract

The invention discloses a blood pressure and blood fat reducing compound preparation and a preparation method thereof, belonging to the technical field of blood pressure and blood fat reducing medicines. The preparation method comprises the steps of preparation of pharmacodynamic raw materials, raw material treatment, raw material mixing, medicament preparation and the like, wherein a fixed plate, a lifting plate, a rotating shaft and a stirring plate are arranged in an extraction tank for extracting the first auxiliary material in the raw material treatment. The compound preparation can play the effects of reducing blood pressure and blood fat in multiple targets and multiple mechanisms, can more comprehensively strengthen the vascular system of a human body, and provides powerful guarantee for the blood circulation of the human body; the extraction tank adopted in the preparation method is uniform and sufficient in extraction, and is convenient to operate.

Description

Compound preparation for reducing blood pressure and blood fat and preparation method thereof

Technical Field

The invention relates to the field of blood pressure and blood fat reducing medicines, in particular to a blood pressure and blood fat reducing compound preparation and a preparation method thereof.

Background

The three-high disease is a common disease of modern people and presents the trend of aging, the reduction of the three-high disease is the regulation of medicines except paying attention to diet and exercise, and the chemical medicines are the first choice of many people, and when the blood pressure reducing and lipid lowering medicines are taken for a long time, the side effects are gradually highlighted, and the blood potassium is reduced or is high and the blood uric acid is increased due to the diuretic antihypertensive medicines; calcium antagonists may cause tachycardia or bradycardia or sexual dysfunction; blockers can cause postural hypotension and glycolipid metabolic disorders; acting on central nervous system hypotensive drugs can cause arrhythmia, paralysis tremor, and even depression. Adverse effects of lipid-lowering statins, including myalgia, myositis, and rhabdomyolysis; liver, kidney damage; digestive tract reaction; causing an increase in blood glucose; rebound of blood fat after stopping taking medicine. The traditional Chinese medicine has the characteristics of multiple targets, multiple mechanisms, bidirectional regulation and less side effects, and has advantages in the aspect of treating metabolic diseases.

In the preparation process of the medicine containing the traditional Chinese medicine, an extraction technology is often used for processing the traditional Chinese medicine, an extraction tank is a common device for extracting the traditional Chinese medicine, at present, the existing extraction tank only realizes the stirring function through a stirring mechanism, the medicine is basically deposited at the bottom, and the extraction uniformity is poor; the medicine cannot be extruded after extraction, which is not favorable for the sufficient extraction of the medicine.

Disclosure of Invention

1. Technical problem to be solved

The technical problem to be solved by the invention is to provide a compound preparation for reducing blood pressure and blood fat and a preparation method thereof, wherein the compound preparation can play the effects of reducing blood pressure and blood fat in multiple targets and multiple mechanisms, can more comprehensively strengthen the vascular system of a human body, and provides powerful guarantee for the blood circulation of the human body; the extraction tank adopted in the preparation method is uniform and sufficient in extraction, and is convenient to operate.

2. Technical scheme

In order to solve the problems, the invention adopts the following technical scheme:

a compound preparation for reducing blood pressure and blood fat comprises the following raw materials in parts by weight:

17-20 parts of grape seeds;

20-30 parts of sophora japonica;

10-15 parts of a first auxiliary material;

20-30 parts of a second auxiliary material;

60-65 parts of starch;

8-10 parts of sucrose powder;

3-5 parts of mannitol;

wherein the first auxiliary material is at least one of angelica, salvia miltiorrhiza, safflower, red paeony root and platycodon grandiflorum; the auxiliary material II is at least any one of red dates, bananas, peaches, oranges, apples, kiwifruits and mint;

the invention also provides a preparation method of the compound preparation for reducing blood pressure and blood fat, which comprises the following steps:

s1, preparing pharmacodynamic raw materials: selecting grape seeds, flos sophorae, an auxiliary material I and an auxiliary material II, respectively cleaning and airing for later use;

s2, raw material treatment: weighing powdery starch, sucrose powder and mannitol according to the weight part ratio, and the grape seeds, the sophora flower, the first auxiliary material and the second auxiliary material which are dried in the step S1 respectively, dividing all the dried auxiliary materials into small pieces or small pieces, filling the small pieces or small pieces into a gauze bag, tying the bag opening, and putting the gauze bag into an extraction tank for extraction to obtain an extracting solution of the first auxiliary material; respectively drying the aired grape seeds, the sophora japonica and the auxiliary material II and crushing into powder for later use;

s3, mixing the raw materials: uniformly mixing the powdery starch, sucrose powder, mannitol, grape seeds, sophora flower and the second auxiliary material in the step S2, adding the mixture into the extracting solution of the first auxiliary material, uniformly stirring, concentrating and drying to obtain medicinal powder;

s4, preparation of the medicament: adding carboxymethyl cellulose into the medicinal material powder prepared in the step S3, uniformly mixing, granulating, drying, sieving, granulating, adding talcum powder and magnesium stearate, uniformly mixing, and tabletting to obtain the compound tablet for reducing blood pressure and blood fat.

The specific structure of the extraction tank in the step S2 is as follows:

the extraction tank comprises a tank main body, a stirring component and an extrusion component, wherein the stirring component and the extrusion component are arranged in the tank main body, the extrusion component comprises a fixed plate and a lifting plate, the fixed plate is horizontally arranged at the upper end in the tank main body, the lifting plate is arranged at the lower end in the tank main body, the rotating shaft is vertically arranged on the axis of the tank main body and penetrates through the top of the tank main body, a positive and negative rotating motor is connected and erected above the top of the tank main body, a sealing bearing is arranged at the position of the top of the tank main body, through which the rotating shaft penetrates, the lower end of the rotating shaft is connected to the inner bottom of the tank main body through a bearing, the fixed plate is fixedly sleeved on the rotating shaft, the rotating shaft is positioned below the fixed plate, a sliding block is arranged on the threaded part in a matched and sleeved mode through threads, a vertical penetrating sliding, the lifting plate is sleeved outside the sliding block, an annular through hole is formed between the lifting plate and the sliding block, a linkage supporting plate used for connecting the lifting plate and the sliding block is arranged in the annular through hole, and two ends of the linkage supporting plate are respectively connected with the lifting plate and the sliding block in a sliding mode;

the stirring assembly comprises a rotating sleeve ring and stirring plates, wherein the rotating sleeve ring is positioned above the lifting plate and sleeved outside the rotating shaft, the stirring plates are fixedly connected with the rotating sleeve ring at equal intervals along the circumferential side of the rotating sleeve ring, the length direction of each stirring plate is positioned in the radial direction of the tank main body, the inner ring surface of the rotating sleeve ring is positioned outside the guide rod, at least two vertically arranged driving rods are fixed on the bottom surface of the fixed plate at equal intervals around the circumferential side of the rotating shaft, the driving rods are aligned with the annular through holes, the rotating sleeve ring is provided with jacks which the driving rods are in one-to-one correspondence and are respectively aligned;

the bottom of jar main part is fixed with the supporting leg that supports subaerial, the top of jar main part is fixed with the support that is used for supporting positive reverse motor, the top of jar main part is connected with pressure release pipe and manometer, one side upper end of jar main part is connected with the inlet tube, the middle part of stating jar main part is connected with the drain pipe, just all be equipped with the ooff valve on inlet tube and the drain pipe.

Furthermore, the blood pressure and blood fat reducing compound preparation also comprises 15-25 parts of hawthorn, and the hawthorn, grape seeds, sophora japonica and auxiliary materials are synchronously processed in the preparation method. The hawthorn contains a large amount of vitamin C and trace elements, can reduce blood pressure and blood sugar, can improve and promote cholesterol excretion to reduce blood fat, and prevent hyperlipidemia; the lipase contained in the hawthorn can also promote the digestion of fat and reduce fat accumulation; the hawthorn can also relax blood vessels, and can promote blood circulation to remove blood stasis, thereby promoting the blood circulation of a human body and relieving hypertension. In addition, flavonoids, vitamin C, carotene and other substances contained in the hawthorn can block and reduce the generation of free radicals, so that the immunity of the organism can be enhanced, and the disease resistance of the human body can be improved.

Furthermore, the compound preparation for reducing blood pressure and blood fat also comprises 10-20 parts by weight of longan, and in the preparation method, the longan, the grape seeds, the sophora flower and auxiliary materials are synchronously treated. The longan has the functions of tonifying qi and enriching blood, and can promote the health of the blood circulation system of a human body.

Further, in step S2 of the preparation method of the blood pressure and blood fat lowering compound preparation, the first auxiliary material is extracted for 3-5 times, each time for 2-4 hours, and the filtrate is combined to obtain the extract of the first auxiliary material. The effective component of the first auxiliary material can be fully extracted.

Furthermore, an inner annular groove surrounding the sliding block is formed in the outer side face of the sliding block of the extraction tank, an outer annular groove surrounding the sliding block is formed in the inner side face of the lifting plate, two ends of the linkage supporting plate are located in the inner annular groove and the outer annular groove respectively, and at least two linkage supporting plates are arranged in the annular through hole at equal intervals along the circumferential side of the annular through hole. The sliding connection of the linkage supporting plate is effectively realized through the arrangement of the inner annular groove and the outer annular groove, and the movement track of the linkage supporting plate pushed by the driving rod to rotate is met; the linkage supporting plates are arranged at equal intervals, so that the sliding block and the lifting plate can be supported in a balanced manner.

Further, draw the jar all attached jar of main part's of week side of fixed plate inside wall, and set up on the fixed plate with the stirring board one-to-one and respectively the bar mouth of lining up. The medicinal materials in the tank main body can be extruded, and the strip-shaped opening can allow water to pass through the fixing plate and enter the tank main body; at the in-process that the lifter plate rose, the stirring board rose thereupon, and the stirring board can insert in corresponding bar mouth to the minimum distance that allows between reducible fixed plate and the lifter plate, and then can strengthen the extrusion effect to the medicinal material.

Further, draw the jar all attached jar of main part's of week side of lifter plate inside wall, evenly seted up the filtration pore on the lifter plate, week side equidistant of lifter plate is fixed with two at least lugs, just set up on the inside wall of jar main part and supply the lug gliding spout from top to bottom. Set up like this and can prevent that the medicinal material from getting into the space below the lifter plate, the circulation of the liquid of being convenient for of filtration pore, the limiting displacement that can lead to the removal of lifter plate is carried out to the mating reaction of spout and lug.

Further, the free end of the stirring plate of the extraction tank is fixedly provided with a scraper attached to the inner side wall of the tank body, and the top of the scraper is lower than that of the stirring plate. The scraper blade can scrape the inside wall of the tank body, so that a scaling layer can be prevented from being formed on the inside wall of the tank body, and the tank body can be cleaned conveniently.

Further, the scraper of the extraction tank is in the shape of a ring. Can be comparatively comprehensive clean the inside wall of jar main part.

Further, draw the jar the feed inlet that is less than the fixed plate is seted up on the upper portion of jar main part, the outside cover that jar main part corresponds feed inlet place height is equipped with lantern ring casing, the medial surface of lantern ring casing laminates completely with the lateral surface of jar main part, and offers the breach that can align with the feed inlet on the lantern ring casing, the below of lantern ring casing supports has the spacing layer board of fixing on jar main part, the inlet tube is located the top of lantern ring casing. Rotate the lantern ring casing and align with the feed inlet to the breach, can drop into jar main part with the medicinal material of waiting to draw in, put in and finish the back and rotate lantern ring casing and make breach and feed inlet dislocation can realize convenient operation to the sealing of feed inlet.

3. Advantageous effects

(1) The blood pressure and blood fat reducing compound preparation provided by the invention contains grape seeds, and procyanidine components in the grape seeds can reduce oxidative substances in blood plasma and improve the oxidation resistance in a human body to minimize oxidative stress of the human body, so that the inhibition of low-density lipoprotein oxidation modification is strengthened, and the postprandial hyperlipidemia is improved. The grape seeds can inhibit the formation of thrombus, effectively play the roles of reducing blood fat and blood pressure, effectively protect cardiovascular and cerebrovascular vessels, reduce cholesterol, prevent arteriosclerosis, maintain the proper permeability of capillary vessels, increase the strength of the blood vessels and reduce the fragility of the capillary vessels, thereby comprehensively strengthening the blood vessels of a human body and providing a powerful guarantee for the blood circulation of the human body.

(2) The compound preparation for reducing blood pressure and blood fat provided by the invention contains sophora japonica, and the lacrimycin contained in the sophora japonica can reduce the cholesterol content in blood, inhibit hypertension and achieve the effect of reducing blood fat. Flos Sophorae Immaturus contains abundant rutin component, and rutin is vitamin P, and has effects of reducing capillary permeability and fragility; the lacrimycin contained in the sophora flower can regulate cardiac output and contraction, plays a role in protecting a cardiovascular system, can relatively comprehensively strengthen human blood vessels, and provides a powerful guarantee for human blood circulation.

(3) The compound preparation for reducing blood pressure and blood fat provided by the invention contains at least one of angelica, salvia miltiorrhiza, safflower, red paeony root and platycodon root, and the angelica, the salvia miltiorrhiza, the safflower, the red paeony root and the platycodon root can promote blood circulation to remove blood stasis and expand blood vessels, thereby being beneficial to eliminating thrombus and promoting the medicine to play the roles of reducing blood fat and blood pressure.

(4) The compound preparation for reducing blood pressure and blood fat provided by the invention contains at least any one of red date, banana, peach, orange, apple, kiwi fruit and mint. The red dates, bananas, peaches, oranges, apples, kiwifruits and mints are daily food, and the red dates, the bananas, the peaches, the oranges, the apples, the kiwifruits and the mints are rich in potassium, can buffer the harmful effect of sodium, and reduce blood volume to reduce blood pressure; they also contain more vitamin C, nicotinic acid, etc., and have protective effect on blood vessel. In addition, the addition of red date, banana, peach, orange, apple, kiwi fruit, mint and the like can also improve the taste of the medicinal preparation.

(5) The blood pressure and lipid lowering compound preparation provided by the invention mainly plays a role in the blood pressure and lipid lowering of grape seeds and sophora flowers, promotes blood circulation by the functions of promoting blood circulation by removing blood stasis and dilating blood vessels of at least any one of angelica, salvia miltiorrhiza, safflower, red paeony root and platycodon grandiflorum so as to strengthen the blood pressure and lipid lowering effect, also strengthens the blood pressure lowering effect by the function of reducing blood volume of at least any one of red dates, bananas, peaches, oranges, apples, kiwi fruits and mint, realizes the multi-target and multi-mechanism play of curative effects, can strengthen the vascular system of a human body comprehensively, and provides a powerful guarantee for the blood circulation of the human body.

(6) The extraction tank adopted in the preparation method disclosed by the invention only needs to start the positive and negative rotating motor, so that the lifting plate can carry the medicinal material to move up and down in a reciprocating manner in the tank main body, and meanwhile, the stirring plate moves up and down along with the lifting plate and can keep a rotating state, so that the medicinal material can be uniformly contacted with a water body, and the extraction uniformity is improved; and the in-process of flowing back after extracting can make the lifter plate rise to medicinal material and fixed plate contact to can extrude the medicinal material after extracting, realize the filter-pressing to the medicinal material, can make the extract fully discharge, can improve the sufficiency that the medicinal material extracted.

In conclusion, the compound preparation can play the effects of reducing blood pressure and blood fat in multiple targets and multiple mechanisms, can comprehensively strengthen the vascular system of the human body, and provides powerful guarantee for the blood circulation of the human body; the extraction tank adopted in the preparation method is uniform and sufficient in extraction, and is convenient to operate.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is an enlarged view of the structure of the area A in FIG. 1;

FIG. 3 is a schematic top view of the slide 26 and lifter plate 22;

FIG. 4 is a schematic top view of the rotating collar 28 and stir plate 21;

fig. 5 is a top view of the fixing plate 9.

Reference numerals: 1. a liquid outlet pipe; 2. a canister body; 3. filtering holes; 4. a squeegee; 5. a chute; 6. a collar housing; 7. a feed inlet; 8. a threaded portion; 9. a fixing plate; 10. a pressure relief pipe; 11. sealing the bearing; 12. a support; 13. a positive and negative rotation motor; 14. a pressure gauge; 15. a rotating shaft; 16. a strip-shaped opening; 17. a water inlet pipe; 18. a drive rod; 19. a limiting supporting plate; 20. a guide bar; 21. a stirring plate; 22. a lifting plate; 23. a bearing; 24. supporting legs; 25. a linkage supporting plate; 26. a slider; 27. a jack; 28. rotating the lantern ring; 29. an inner annular groove; 30. an outer annular groove; 31. an annular port; 32. and (4) a guide hole.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings and examples.

Examples

17 parts of grape seeds;

30 parts of sophora japonica;

15 parts of an auxiliary material;

20 parts of a second auxiliary material;

60 parts of starch;

9 parts of sucrose powder;

5 parts of mannitol;

wherein the first auxiliary material is angelica; the auxiliary materials II comprise bananas, peaches and apples, and the weight part ratio of the auxiliary materials II is 2:2: 1;

the preparation method of the compound preparation for reducing blood pressure and blood fat comprises the following steps:

s2, raw material treatment: weighing powdery starch, sucrose powder and mannitol according to the weight part ratio, and the grape seeds, the sophora flower, the first auxiliary material and the second auxiliary material which are dried in the step S1 respectively, dividing all the dried auxiliary materials into small pieces or small pieces, putting the small pieces or small pieces into a gauze bag, tying the bag opening, putting the gauze bag into an extraction tank for 3 times of extraction, extracting for 4 hours each time, and combining filtrates to obtain an extracting solution of the first auxiliary material; respectively drying the aired grape seeds, the sophora japonica and the auxiliary material II and crushing into powder for later use;

The specific structure of the extraction tank in the step S2 is as follows:

as shown in fig. 1, draw jar including jar main part 2 and locate jar 2 inside stirring subassembly and extrusion subassembly, extrusion subassembly is including respectively the level locate jar main part 2 in the fixed plate 9 of upper end with locate jar main part 2 in the lifter plate 22 of lower extreme to and vertically locate jar main part 2 on the axis and run through the axis of rotation 15 at its top, the motor 13 that just reverses of jar main part 2 top is located to the upper end link of axis of rotation 15, the position department that the top of jar main part 2 supplied axis of rotation 15 to pass is equipped with sealed bearing 11, the lower extreme of axis of rotation 15 passes through bearing 23 and connects in the interior bottom of jar main part 2, fixed suit is on axis of rotation 15 for fixed plate 9, axis of rotation 15 is located the below of fixed plate 9 and is equipped with screw thread portion 8, as shown in fig. 2, just screw thread adaptation cover is equipped with 26 on screw thread portion 8, be fixed with on the bearing 23 and vertically run through slider 26 and upwards extend to lead the The guide rod 20 and the slide block 26 are provided with a guide hole 32 on the upper cover for the guide rod 20 to pass through, as shown in fig. 3, the lifting plate 22 is sleeved outside the slide block 26, an annular through hole 31 is formed between the lifting plate 22 and the slide block 26, a linkage supporting plate 25 for connecting the lifting plate 22 and the slide block 26 is arranged in the annular through hole 31, and two ends of the linkage supporting plate 25 are respectively connected with the lifting plate 22 and the slide block 26 in a sliding manner;

the stirring assembly comprises a rotating sleeve ring 28 which is positioned above the lifting plate 22 and sleeved outside the rotating shaft 15 and stirring plates 21 which are fixedly connected with each other at equal intervals along the peripheral side of the rotating sleeve ring 28, and the length direction of each stirring plate 21 is positioned in the radial direction of the tank main body 2, as shown in fig. 2 and 4, the inner annular surface of the rotating sleeve ring 28 is positioned outside the guide rod 20, at least two vertically arranged driving rods 18 are fixed on the bottom surface of the fixing plate 9 at equal intervals around the peripheral side of the rotating shaft 15, the driving rods 18 are aligned with the annular through holes 31, the rotating sleeve ring 28 is provided with insertion holes 27 which are in one-to-one correspondence with the driving rods 18 and are respectively aligned with the driving rods 18, and the;

as shown in fig. 1, the bottom of tank main body 2 is fixed with support leg 24 that supports subaerial, the top of tank main body 2 is fixed with support 12 that is used for supporting motor 13 that is just reversing, the top of tank main body 2 is connected with pressure release pipe 10 and manometer 14, one side upper end of tank main body 2 is connected with inlet tube 17, the middle part of tank main body 2 is connected with drain pipe 1, just all be equipped with the ooff valve on inlet tube 17 and the drain pipe 1.

In this embodiment, as shown in fig. 3, an outer side surface of the slide block 26 of the extraction pot is formed with an inner annular groove 29 surrounding a circumference thereof, an inner side surface of the lifting plate 22 is formed with an outer annular groove 30 surrounding a circumference thereof, both ends of the linkage supporting plate 25 are respectively located in the inner annular groove 29 and the outer annular groove 30, and at least two linkage supporting plates 25 are arranged in the annular through opening 31 at equal intervals along a circumferential side thereof. The sliding connection of the linkage supporting plate 25 is effectively realized through the arrangement of the inner annular groove 29 and the outer annular groove 30, and the movement track of the linkage supporting plate 25 which is pushed by the driving rod 18 to rotate is met; the equidistant linkage supporting plate 25 can realize the balanced support of the sliding block 26 and the lifting plate 22.

In the present embodiment, as shown in fig. 1 and 5, the fixed plate 9 of the extraction tank is attached to the inner side wall of the tank body 2, and the fixed plate 9 is provided with strip-shaped openings 16 corresponding to the stirring plates 21 one by one and aligned with each other. The medicinal materials in the tank main body 2 can be extruded, and the strip-shaped opening 16 can be used for allowing water to pass through the fixing plate 9 and enter the tank main body 2; in the ascending process of the lifting plate 22, the stirring plate 21 ascends along with the ascending process, and the stirring plate 21 can be inserted into the corresponding strip-shaped opening 16, so that the allowed minimum distance between the fixing plate 9 and the lifting plate 22 can be shortened, and the extrusion effect on medicinal materials can be enhanced.

In this embodiment, as shown in fig. 1, the inner side wall of the extraction tank is attached to the inner side wall of the tank main body 2 on the circumferential side of the lifting plate 22, the lifting plate 22 is uniformly provided with filtering holes 3, at least two lugs are fixed on the circumferential side of the lifting plate 22 at equal intervals, and the inner side wall of the tank main body 2 is provided with a chute 5 for the lugs to slide up and down. Set up like this and can prevent that the medicinal material from getting into the space below the lifter plate 22, filtration pore 3 can be convenient for the circulation of liquid, and the limiting displacement that can lead to lifter plate 22 is carried out to the mating reaction of spout 5 and lug.

In this embodiment, as shown in fig. 1 and 4, a scraper 4 attached to the inner wall of the tank body 2 is fixed to the free end of the stirring plate 21 of the extraction tank, and the top of the scraper 4 is lower than the top of the stirring plate 21. The scraper 4 can scrape the inner side wall of the tank main body 2, so that a scaling layer can be prevented from being formed on the inner wall of the tank main body 2, and the tank main body 2 can be cleaned conveniently.

In this embodiment, the scraper 4 of the extraction tank is configured in the shape of a ring. The inner side wall of the tank main body 2 can be cleaned relatively comprehensively.

In this embodiment, as shown in fig. 1, draw the jar a feed inlet 7 that is less than fixed plate 9 is seted up on the upper portion of jar main part 2, jar main part 2 corresponds the outside cover of feed inlet 7 place height and is equipped with lantern ring casing 6, the medial surface of lantern ring casing 6 and the lateral surface of jar main part 2 laminate completely, and set up the breach that can align with feed inlet 7 on the lantern ring casing 6, the below of lantern ring casing 6 supports there is spacing layer board 19 of fixing on jar main part 2, inlet tube 17 is located the top of lantern ring casing 6. Rotate lantern ring casing 6 and align with feed inlet 7 to the breach, can drop into jar main part 2 with the medicinal material of waiting to draw in, put in and finish the back and rotate lantern ring casing 6 and make breach and 7 misplaces of feed inlet and can realize sealing convenient operation to feed inlet 7.

The concrete action principle of the extraction tank is as follows:

after the first auxiliary material is put into the tank main body 2 through the feed inlet 7, a water body is poured into the tank main body 2 through the water inlet pipe 17, the first auxiliary material falls on the lifting plate 22, the forward and reverse rotation motor 13 is started intermittently and alternately in forward and reverse rotation to directly drive the rotating shaft 15 to rotate, the fixing plate 9 rotates along with the rotating shaft and drives the driving rod 18 to rotate, and the driving rod 18 is inserted into the jack 27, so that the rotating of the driving rod 18 can drive the rotating lantern ring 28 to rotate, the stirring plate 21 is driven to rotate around the rotating shaft 15, the medicinal materials on the lifting plate 22 are effectively stirred, and uniform extraction is facilitated; meanwhile, the threaded part 8 rotates along with the rotation of the rotating shaft 15, and the guide rod 20 penetrates through the sliding block 26, so that the sliding block 26 moves upwards or downwards along the threaded part 8, the sliding block 26 pushes the lifting plate 22 to move through the linkage supporting plate 25, the lifting plate 22 pushes the rotating sleeve ring 28 to move, specifically, in the process that the lifting plate 22 ascends, the rotating sleeve ring 28 drives the stirring plate 21 to move upwards along with the lifting plate, and in the moving process, the stirring plate 21 is in a one-way rotating state; in-process that the lifter plate 22 descends, it drives stirring board 21 and descends thereupon to rotate lantern ring 28 under the effect of gravity, and remove in-process stirring board 21 and be in the antiport state, then in the extraction process of medicinal material, only through a motor that just reverses, can make lifter plate 22 carry the medicinal material and carry out reciprocating type removal from top to bottom in jar main part 2, and simultaneously, stirring board 21 reciprocates thereupon and can keep the rotation state, thereby can realize the even contact of medicinal material and water, improve the homogeneity of extracting, and at the in-process of drawing back flowing back, start motor 13 that reverses, make lifter plate 22 rise, contact to medicinal material and fixed plate 9, can extrude the medicinal material after extracting, the realization is to the filter-pressing of medicinal material, can make the extract fully discharge, can improve the sufficiency that the medicinal material drawed.

Example 2

18 parts of grape seeds;

27 parts of sophora flower;

14 parts of an auxiliary material;

22 parts of a second auxiliary material;

62 parts of starch;

10 parts of sucrose powder;

4 parts of mannitol;

15 parts of hawthorn.

Wherein the first auxiliary material is red paeony root; the auxiliary materials II comprise red dates and oranges, and the weight portion ratio of the red dates to the oranges is 3: 2.

The preparation method of the compound preparation for reducing blood pressure and blood fat is different from that of the embodiment 1 in that:

synchronously processing the hawthorn, grape seeds, sophora flower and auxiliary materials;

in step S2, extraction was performed 4 times, each for 3 hours.

The rest is the same as example 1.

The hawthorn contains a large amount of vitamin C and trace elements, can reduce blood pressure and blood sugar, can improve and promote cholesterol excretion to reduce blood fat, and prevent hyperlipidemia; the lipase contained in the hawthorn can also promote the digestion of fat and reduce fat accumulation; the hawthorn can also relax blood vessels, and can promote blood circulation to remove blood stasis, thereby promoting the blood circulation of a human body and relieving hypertension. In addition, flavonoids, vitamin C, carotene and other substances contained in the hawthorn can block and reduce the generation of free radicals, so that the immunity of the organism can be enhanced, and the disease resistance of the human body can be improved.

Example 3

19 parts of grape seeds;

25 parts of sophora flower;

13 parts of an auxiliary material;

25 parts of a second auxiliary material;

63 parts of starch;

8 parts of sucrose powder;

4 parts of mannitol;

and 25 parts of hawthorn.

Wherein the auxiliary materials I are salvia miltiorrhiza and safflower, and the weight part ratio of the auxiliary materials I is 4: 1; the auxiliary materials II are kiwi fruit and mint, and the weight portion ratio of the kiwi fruit to the mint is 1: 3.

The rest is the same as example 2.

Example 4

20 parts of grape seeds;

22 parts of sophora flower;

12 parts of an auxiliary material;

27 parts of a second auxiliary material;

64 parts of starch;

10 parts of sucrose powder;

3 parts of mannitol;

10 parts of longan.

Wherein the auxiliary materials I comprise Chinese angelica, red paeony root and platycodon root, and the weight part ratio of the Chinese angelica to the red paeony root to the platycodon root is 1:1: 1; and the auxiliary material II is citrus.

synchronously processing longan, grape seeds, sophora flower and auxiliary materials II;

in step S2, extraction was performed 5 times, each for 2 hours.

The longan has the functions of tonifying qi and enriching blood, and can promote the health of the blood circulation system of a human body.

The rest is the same as example 1.

Example 5

20 parts of grape seeds;

20 parts of sophora japonica;

10 parts of an auxiliary material;

30 parts of a second auxiliary material;

65 parts of starch;

8 parts of sucrose powder;

5 parts of mannitol;

20 parts of longan.

Wherein the auxiliary materials I are salvia miltiorrhiza and platycodon grandiflorum, and the weight part ratio of the auxiliary materials I to the auxiliary materials II is 1: 2; the second auxiliary material is red date and mint, and the weight portion ratio of the red date to the mint is 3: 1.

The rest is the same as example 4.

The compound preparation can exert the blood pressure and blood fat reducing effects in multiple targets and multiple mechanisms, can more comprehensively strengthen the blood vessel system of a human body, and provides powerful guarantee for the blood circulation of the human body; the extraction tank adopted in the preparation method is uniform and sufficient in extraction, and is convenient to operate.

It should be understood by those skilled in the art that the above embodiments are only for illustrating the present invention and are not to be used as a limitation of the present invention, and that changes and modifications to the above embodiments are within the scope of the claims of the present invention as long as they are within the spirit and scope of the present invention.

Claims

1. The compound preparation for reducing blood pressure and blood fat is characterized by comprising the following raw materials in parts by weight:

17-20 parts of grape seeds;

20-30 parts of sophora japonica;

10-15 parts of a first auxiliary material;

20-30 parts of a second auxiliary material;

60-65 parts of starch;

8-10 parts of sucrose powder;

3-5 parts of mannitol;

s2, raw material treatment: weighing powdery starch, sucrose powder and mannitol according to the weight part ratio, and the grape seeds, the sophora flower, the first auxiliary material and the second auxiliary material which are dried in the step S1 respectively, dividing all the dried auxiliary materials into small pieces or small pieces, filling the small pieces or small pieces into a gauze bag, tying the bag opening, and putting the gauze bag into an extraction tank for extraction to obtain an extracting solution of the first auxiliary material; drying the aired grape seeds, the sophora japonica and the auxiliary material II respectively and crushing into powder for later use;

s4, preparation of the medicament: adding carboxymethyl cellulose into the medicinal material powder prepared in the step S3, uniformly mixing, granulating, drying, sieving, granulating, adding talcum powder and magnesium stearate, uniformly mixing, and tabletting to obtain the compound tablet for reducing blood pressure and blood fat;

the specific structure of the extraction tank in the step S2 is as follows:

the extracting tank comprises a tank body (2), a stirring assembly and an extruding assembly, wherein the stirring assembly and the extruding assembly are arranged inside the tank body (2), the extruding assembly comprises a fixed plate (9) which is horizontally arranged at the upper end in the tank body (2) and a lifting plate (22) which is arranged at the lower end in the tank body (2), and a rotating shaft (15) which is vertically arranged on the axis of the tank body (2) and penetrates through the top of the fixed plate, a forward and reverse rotating motor (13) which is arranged above the top of the tank body (2) is connected to the upper end of the rotating shaft (15), a position where the rotating shaft (15) passes through is arranged at the top of the tank body (2), the lower end of the rotating shaft (15) is connected to the inner bottom of the tank body (2) through a bearing (23), the fixed sleeve of the fixed plate (9) is arranged on the rotating shaft (15), and a threaded part (8), a sliding block (26) is sleeved on the threaded portion (8) in a threaded matching mode, a guide rod (20) which vertically penetrates through the sliding block (26) and upwards extends to the height of the upper end of the threaded portion (8) is fixed on the bearing (23), a guide hole (32) for the guide rod (20) to penetrate through is formed in the upper cover of the sliding block (26), the lifting plate (22) is sleeved on the outer side of the sliding block (26), an annular through hole (31) is formed between the lifting plate (22) and the sliding block (26), a linkage supporting plate (25) used for connecting the lifting plate (22) and the sliding block (26) is arranged in the annular through hole (31), and two ends of the linkage supporting plate (25) are respectively in sliding connection with the lifting plate (22) and the sliding block (26);

the stirring assembly comprises a rotating sleeve ring (28) and stirring plates (21), wherein the rotating sleeve ring (28) is located above the lifting plate (22) and sleeved on the outer side of the rotating shaft (15), the stirring plates (21) are fixedly connected with the rotating sleeve ring (28) at equal intervals along the peripheral side, the length direction of each stirring plate (21) is located in the radial direction of the tank main body (2), the inner annular surface of each rotating sleeve ring (28) is located on the outer side of the guide rod (20), at least two vertically arranged driving rods (18) are fixed on the bottom surface of the fixing plate (9) around the rotating shaft (15) at equal intervals, the driving rods (18) are aligned with the annular through holes (31), the rotating sleeve ring (28) is provided with insertion holes (27) which correspond to the driving rods (18) one by one and are aligned with the driving rods (18;

the bottom of jar main part (2) is fixed with supports supporting leg (24) subaerial, the top of jar main part (2) is fixed with support (12) that are used for supporting just reversal motor (13), the top of jar main part (2) is connected with pressure release pipe (10) and manometer (14), one side upper end of jar main part (2) is connected with inlet tube (17), the middle part of stating jar main part (2) is connected with drain pipe (1), just all be equipped with the ooff valve on inlet tube (17) and drain pipe (1).

2. The compound preparation for lowering blood pressure and blood fat according to claim 1, wherein the compound preparation for lowering blood pressure and blood fat further comprises 15-25 parts by weight of hawthorn, and the hawthorn, grape seeds, sophora japonica and auxiliary materials are synchronously processed in the preparation method.

3. The compound preparation for lowering blood pressure and blood lipid according to claim 1 or 2, wherein the compound preparation for lowering blood pressure and blood lipid further comprises 10-20 parts by weight of longan, and in the preparation method, longan, grape seeds, sophora japonica and auxiliary materials are synchronously treated.

4. The compound preparation of claim 1, wherein in step S2, the first adjuvant is extracted 3-5 times, each time for 2-4 hours, and the filtrates are combined to obtain the extractive solution of the first adjuvant.

5. A compound preparation for lowering blood pressure and blood lipid according to claim 1, wherein the outer side of the slide block (26) of the extraction pot used in the preparation method is provided with an inner annular groove (29) surrounding the circumference thereof, the inner side of the lifting plate (22) is provided with an outer annular groove (30) surrounding the circumference thereof, the two ends of the linkage supporting plate (25) are respectively positioned in the inner annular groove (29) and the outer annular groove (30), and at least two linkage supporting plates (25) are arranged in the annular through opening (31) at equal intervals along the circumference thereof.

6. The compound preparation for lowering blood pressure and blood lipid according to claim 1, wherein the extraction tank is characterized in that the fixed plate (9) is attached to the inner side wall of the tank body (2) at the periphery of the extraction tank, and the fixed plate (9) is provided with strip-shaped openings (16) which are in one-to-one correspondence with the stirring plates (21) and are respectively aligned with the stirring plates.

7. The compound preparation for lowering blood pressure and blood lipid according to claim 1, wherein the extraction tank used in the preparation method comprises an inner sidewall of the tank body (2) attached to the periphery of the lifting plate (22), the lifting plate (22) is uniformly provided with filtration pores (3), at least two bumps are fixed on the periphery of the lifting plate (22) at equal intervals, and a sliding groove (5) for the bumps to slide up and down is formed on the inner sidewall of the tank body (2).

8. The compound preparation for lowering blood pressure and blood lipid according to claim 1, wherein the free end of the stirring plate (21) of the extraction tank used in the preparation method is fixed with a scraper (4) attached to the inner side wall of the tank body (2), and the top of the scraper (4) is lower than the top of the stirring plate (21).

9. The compound preparation for lowering blood pressure and blood lipid according to claim 8, wherein the scraper (4) of the extraction tank used in the preparation method is in the shape of a ring.

10. The compound preparation for reducing blood pressure and blood fat according to claim 1, wherein the upper part of the tank main body (2) of the extraction tank used in the preparation method is provided with a feed inlet (7) lower than the fixing plate (9), the outer side of the tank main body (2) corresponding to the height of the feed inlet (7) is sleeved with a lantern ring shell (6), the inner side surface of the lantern ring shell (6) is completely attached to the outer side surface of the tank main body (2), the lantern ring shell (6) is provided with a notch capable of aligning with the feed inlet (7), a limiting supporting plate (19) fixed on the tank main body (2) is supported below the lantern ring shell (6), and the water inlet pipe (17) is positioned above the lantern ring shell (6).