JP2007024743A - Medicine casting system and elution tester using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicine casting system capable of simultaneously facilitating medicine casting operations and making them highly accurate. <P>SOLUTION: The medicine casting system 28 is provided with a casting hole 60 provided for a vessel lid 18; a medicine holding cup 62 including a cup main body 68 made of a hollow body and provided for the casting hole 60 in such a way as to be freely attached and removed, an inner lid 70 provided for a lower part of the cup main body 68 in such a way as to be freely attached and removed, and an inside fixing means 72 for holding the lower part of the cup main body 68 and the inner lid 70 at standby and releasing their holding when mounted to the casting hole 60; a bottom lid 64 provided for a lower part of the vessel lid 18 for freely opening and closing the casting hole 60; and an automatic lid opening means 66 for positioning the bottom lid 64 over the casting hole 60 with the inner lid 70 in such a way that the casting hole 60 may be closed at standby and retracting the bottom lid 64 from over the casting hole 60 with the inner lid 70 in such a way that the casting hole 60 may be opened when a switch 52 is pressed at the time of an instruction for casting. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an improvement in a mechanism for simultaneously and easily improving the accuracy and accuracy of a drug input operation.

Conventionally, in order to test how long a component of an orally administered drug dissolves and is absorbed in the stomach and small intestine, a dissolution test is performed, for example, according to the following procedure.
That is, in the dissolution test, generally, a test solution such as an aqueous hydrochloric acid solution simulating gastric juice is placed in a vessel, and the drug to be tested (dosage form such as tablet, capsule, sinker, granule, powder) in the test solution in the vessel. Insert. While stirring this with a paddle, a certain amount of solution is collected at regular intervals. The absorbance of the collected solution is measured with a spectrophotometer. The concentration of the component is calculated based on the measurement result, and the change in dissolution rate over time is obtained.

  By the way, the test solution in the vessel is usually set to 37 degrees to imitate the human body. The test lasts for several hours to several tens of hours. During this time, the test solution may evaporate and the concentration may increase, so the vessel is covered. In addition, this test system (vessel, paddle, test liquid collecting mechanism, etc.) is usually tested in parallel in 6 to 8 sets.

  At the start of the dissolution test, for example, the vessel lids of a plurality of 6 to 8 vessels are opened, the drug to be tested is put into each, the vessel lid is put on, and then the rotation of the paddle is started. This is the starting point for the test. The pharmacopoeia stipulates that this should be started immediately after the drug is introduced, and promptly is generally interpreted as within 30 seconds. This time of 30 seconds is a time that can be carried out reasonably even if the operator performs the loading operation by hand. However, it is desirable that the time difference between the injection of the medicines between the vessels and the time difference until the paddle rotation is started after the injection can cause an error in the test, and is preferably zero. In addition, mistakes may occur in the operation of throwing in several vessels in a short time.

For this reason, in the dissolution test, it is very important to facilitate the drug introduction work and improve the accuracy.
Conventionally, it is conceivable to use the following drug injection device in order to perform the drug injection operation simply and allow the drug to be input into a plurality of vessels at the same timing (see, for example, Patent Document 1).

This medicine injection device has a beaker with a bottom, and a plurality of beakers are installed so that the opening at the top of the beaker takes an upward position during standby and the upper opening of the beaker takes an oblique position at the time of injection. At the same time, it comprises a holding table that is rotatably supported, a pinion gear, a rack gear, and the like, and includes a switching mechanism for switching the beaker attitude and an operation knob for operating the switching of the beaker attitude by the switching mechanism.
And in this chemical | medical agent injection | throwing-in apparatus, an operator operates an operation knob and a switching mechanism inclines a plurality of beakers simultaneously, and performs chemical | medical agent injection | pouring to a several vessel simultaneously.
JP 2004-198332 A

However, there is still room for further improvement in the drug charging operation even in the conventional drug charging apparatus.
Further, in the above-described conventional method, a room for further improvement has been left for improving the accuracy of the drug input operation.
However, conventionally, there has been no appropriate technique capable of simultaneously solving the further ease of drug input operation and higher accuracy.
The present invention has been made in view of the above-described problems of the prior art, and its object is to provide a drug input device capable of simultaneously facilitating and increasing the accuracy of the drug input operation, and a dissolution tester using the same. Is to provide.

  In order to achieve the above-mentioned object, a medicine injection device according to the present invention includes an insertion hole, a medicine holding cup, a bottom lid, a switch, and an automatic lid opening means.

Here, the charging hole is provided in the vessel lid, and is used for dropping the medicine into the vessel when a charging instruction is given.
The medicine holding cup is detachably provided in the charging hole of the vessel lid, and includes a cup body, an inner lid, and an inner side fixing means. The cup body is a hollow body. The inner lid is detachably provided at the lower part of the cup body, is positioned on the charging hole so that the charging hole is closed during standby, and the charging hole is opened when a charging instruction is given. As shown in FIG. The middle fixing means holds the lower part of the cup body and the inner lid during standby, and releases the lower part of the cup body and the inner lid when attached to the charging hole.
The bottom lid is provided at the lower portion of the vessel lid so as to be able to open and close the insertion hole, and includes an inner lid receptacle and a bottom side fixing means. The inner lid receptacle is for receiving the inner lid when the medicine holding cup is attached to the charging hole. The bottom side fixing means holds the inner lid on the inner lid receiver when the medicine holding cup is attached to the charging hole. The bottom lid is positioned on the charging hole together with the inner lid so that the charging hole is closed during standby, and the inner lid is opened together with the inner lid so that the charging hole is opened when charging is instructed. Retreat from above the insertion hole.

And before attaching this chemical | medical agent holding cup to this injection | pouring hole, this chemical | medical agent injection apparatus hold | maintains this cup main body lower part and this inner lid by this inner side fixing means.
In the medicine charging device, the holding of the lower part of the cup body and the inner lid by the middle fixing means is released during standby, and the holding of the inner lid and the bottom lid by the bottom fixing means is not performed. Has been done.
When the switch is pressed at the time of charging instruction, the medicine charging device has the bottom lid by the automatic lid opening means while the bottom lid fixing means holds the inner lid and the bottom lid inner lid receiver. And the inner lid is retracted, the charging hole is opened, and the drug in the drug holding cup falls into the vessel through the charging hole of the vessel lid.

<Drug holding cup>
In the medicine injection device of the present invention, the inner lid includes an upper flange projecting outside the upper portion of the outer peripheral wall and a lower flange projecting outward of the lower portion of the outer peripheral wall.
The cup body includes an upper outer peripheral wall whose outer peripheral wall is larger in diameter than the charging hole and a lower outer peripheral wall having substantially the same diameter as the charging hole. The cup main body includes an upper inner peripheral wall whose inner peripheral wall is smaller than the outer diameter of the inner lid upper flange and a lower inner peripheral wall that is substantially the same diameter or slightly larger than the insertion hole.
The middle-side fixing means includes a claw member that is pivotally supported by the cup body side portion so as to be swingable and that allows the middle lid to be detachably attached to the lower end of the upper inner peripheral wall of the cup body.
The inner lid receiver of the bottom lid is formed in a recess having a slightly larger diameter than the lower flange on the inner lid.

And before attaching the said medicine holding cup to the said vessel lid, this chemical | medical agent injection apparatus makes the said inner lid the said cup main body so that the said inner side fixing means may cover the said inner lid upper flange with the said nail | claw member. Hold.
When the medicine holding cup is attached to the vessel lid, the medicine charging device releases the holding of the inner lid upper flange and the cup body by the claw member and receives the inner lid on the bottom lid In this state, it is preferable that the bottom lid fixing means holds the inner lid lower flange and the bottom lid.

<Automatic lid opening means>
In the medicine injection device of the present invention, the lid opening means further includes a rotating means. The turning means supports the bottom lid so as to be rotatable like a hinge with respect to the vessel lid, and the bottom lid is placed in the middle so that the insertion hole of the vessel lid is opened when the medicine is charged. It rotates with the lid.
Here, it is preferable that the switch includes a lever, a contact member, and a pressing member. The lever is pivotally supported by the vessel lid so as to be swingable. The contact member is provided at the upper end of the lever, and has a contact surface that is pressed when a closing instruction is given. The pressing member presses the bottom lid to the bottom of the vessel lid during standby, and releases the bottom lid from being pressed to the bottom of the vessel lid when a medicine is charged.

  Then, the medicine charging device is configured such that when the charging instruction is made, the bottom lid is held together with the inner lid by the rotating means while the inner lid is held by the inner lid receiver of the bottom lid by the bottom-side fixing means. It is preferable that the charging hole is rotated to open.

<Push bar>
In the medicine injection device of the present invention, it is preferable to provide a push rod.
Here, the push rod is located at a position spaced apart from the switch in the standby state, and is moved toward or away from the switch so as to descend and push the switch when the turn-on instruction is issued. Move up and down.

<Pneumatic drug blow-off means>
In the medicine injection device according to the present invention, it is preferable to include a pneumatic medicine blowing means for forcibly dropping the medicine in the medicine holding cup into the vessel.
The pneumatic drug blow-off means includes a blow-off body, a supply means, a line, a valve, and an air control means.
Here, the blow-off body is provided on the medicine holding cup so as to cover the upper opening of the medicine holding cup.
The supply means is for supplying air to be sent to the blow-off body.
The line is for supplying air from the supply means to the blow-off body.
The said valve | bulb is provided between the said supply means and the said blow-off main body, and adjusts the air to this blow-off main body.
The air control means controls the operation of the valve so that the air of the air supply means is sent to the blow-off body for a desired amount or time.

  And the air from the said air supply means is sent to the said chemical | medical agent holding cup via the said blow-off main body, and the chemical | medical agent in this chemical | medical agent holding cup is forcedly blown down into the said vessel.

<Dissolution tester>
In order to achieve the above object, the dissolution tester according to the present invention is a dissolution tester equipped with the drug injection device of the present invention, comprising a thermostatic water bath, a vessel, a vessel lid, a stirring means, and a push rod. And a moving means, a movement control means, a storage means, and a test control means.
Here, the constant temperature water tank is filled with constant temperature water for maintaining the inside of the vessel at a desired temperature.
The vessel is filled with a test solution used for the dissolution test of the drug.
The vessel lid is provided on the vessel.
The stirring means stirs the inside of the vessel.
The push bar is provided so as to be movable up and down with respect to the switch.
The moving means moves the push bar up and down.
The movement control means controls the vertical movement of the push bar by the movement means so that the vertical position of the push bar with respect to the switch is a desired contact position or separation position.
The storage means stores a dissolution test program for automatically performing the dissolution test of the drug.
The test control means automatically starts the dissolution test simultaneously with the loading instruction by the push rod based on the dissolution test program of the storage means.

The medicine charging device according to the present invention includes the cup body and the holding cup including an inner lid detachably provided at the lower part of the cup body, and the bottom lid provided with a charging hole at the lower part of the vessel lid so as to be freely opened and closed. And the automatic lid opening means for opening the bottom lid together with the inner lid of the holding cup when the switch is pressed during the dispensing instruction, further facilitating the drug loading operation and high accuracy. At the same time.

<Drug holding cup>
In the medicine injection device according to the present invention, the inner lid includes the upper flange and the lower flange, the cup body includes the upper outer peripheral wall, the lower outer peripheral wall, the upper inner peripheral wall, and the lower inner peripheral wall, Further, since the middle side fixing means includes the claw member, it is possible to further facilitate the drug charging operation and increase the accuracy at the same time.

<Automatic lid opening means>
In the medicine injection device according to the present invention, the automatic lid opening means includes the rotation means, and the switch includes the lever, the contact member, and the pressing member, thereby further facilitating the medicine injection operation. And high accuracy can be achieved at the same time.

<Push bar>
The medicine injection device according to the present invention is provided with the push rod, thereby making it possible to further facilitate and improve the accuracy of the medicine injection operation.

<Pneumatic drug blow-off means>
In the medicine injection device according to the present invention, by providing the air type medicine blow-off means, it is possible to further facilitate and improve the accuracy of the medicine introduction work regardless of the dosage form.

Since the dissolution tester and the dissolution tester according to the present invention are provided with the drug injection device according to the present invention, it is possible to further facilitate and improve the accuracy of the dissolution test at the same time.

Hereinafter, an embodiment of the present invention will be described with reference to the drawings.
Dissolution Tester FIG. 1 shows a schematic configuration of a dissolution tester equipped with a drug input device according to one embodiment of the present invention. FIG. 4A is a view of the dissolution tester as viewed from the side, and FIG. 4B is a view of the drug input device as viewed from above. In this embodiment, an example using the paddle method will be described.
The dissolution tester 10 shown in the figure includes a constant temperature water bath 12, a water bath lid 14, a vessel 16, a vessel lid 18, a rotating shaft 20, a stirring means 22, an electric motor 24, a test liquid collecting means 26, The medicine input device 28, the push rod 30, the moving means 32, the movement control means 34, the storage means 36, and the test control means 38 are provided.

Here, the constant temperature water tank 12 is filled with constant temperature water 40 for maintaining the inside of the vessel 16 at a desired temperature.
The water tank lid 14 is provided in the upper opening of the constant temperature water tank 12 and holds the desired portion of the vessel 16 in the constant temperature water 40 in the constant temperature water tank 12.
The vessel 16 has a hemispherical bottom, and contains a drug 42 and a test solution 44. Prior to the start of the test, only the test solution 44 is placed in the vessel 16, and the medicine 42 is held in the medicine feeding device 28. At the start of the test, the medicine 42 of the medicine feeding device 28 is placed in the test solution 44 in the vessel 16.
The vessel lid 18 has a circular shape and is detachably provided in the upper opening of the vessel 16.
The rotary shaft 20 hangs down from the lower portion of the head 46, is inserted into the vessel 16 through a shaft hole 45 provided at the approximate center of the vessel lid 18, and is provided rotatably.
The stirring means 22 is made of, for example, a paddle and is provided at the lower end of the rotating shaft 20 and stirs the inside of the vessel 16.
The electric motor 24 rotates each rotating shaft 20 via a belt. The electric motor 24 is connected to the rotation control means 48, and the rotation control means 48 is connected to the test control means 38.
The test liquid collecting means 26 includes a suction nozzle held by the holder 50 and collects the test liquid 44.

The medicine loading device 28 automatically places the medicine 42 into the vessel 16 when the switch 52 is pressed when the medicine 42 is instructed to be placed.
That is, the push rod 30 is located at a position spaced apart upward from the switch 52 during standby, and moves up and down in a direction in which the push rod 30 abuts or separates from the switch 52 so as to descend and push the switch 52 when instructed. .
The moving means 32 moves the push rod 30 up and down via the column 54, the head 46 or the holder 50. That is, the push rod 30 hangs down from the holder 50 and moves up and down together with the holder 50. The holder 50 moves up and down together with the head 46 to a specific vertical position. Below the specific vertical position, only the holder 50 moves up and down while the head 46 remains stationary.
The movement control means 34 controls the vertical movement of the push bar 30 by the movement means 32 so that the vertical position of the push bar 30 with respect to the switch 52 is a desired contact position or separation position.
The storage means 36 forms a part of the computer 37, for example, and stores a dissolution test program for automatically performing the dissolution test of the drug 42.
The test control means 38 constitutes a part of the computer 37, for example, and starts the dissolution test simultaneously with the introduction of the drug 42 by the push rod 30 based on the dissolution test program in the storage means 36.

  As described above, the dissolution tester 10 according to this embodiment tests a plurality of test systems (such as the vessel 16, the stirring means 22, the test liquid collecting means 26, etc.), for example, 6 to 8 test systems in parallel. Since each test system is provided with the drug injection device 28, the dissolution test can be further facilitated and highly accurate at the same time.

By the way, in order to facilitate and improve the dissolution test, it is very important to facilitate and improve the accuracy of drug injection work.
The medicine was put into the vessel by the operator's hand. In this case, one drug was sequentially added to each of 6 to 8 vessels, and the dissolution test was started at the time when the introduction of the drugs to all the vessels was completed.
According to the pharmacopoeia, the test should be started within 30 seconds after the drug is put into the test solution in the vessel, and it is not deviated from the standard. The time difference between several seconds to several tens of seconds was included in the test time between the introduced vessel and the last one, which was an obstacle to precise testing.

Under such circumstances, in order to facilitate and increase the accuracy of the drug charging operation, for example, it may be possible to use the drug charging device described in Patent Document 1 or the like.
However, even in the above-described conventional drug injection device, the drug injection operation is still mainly performed by the operator's manual operation. After the drug is input by this manual operation, the operation for starting the test again is performed. It is not fully automated because it needs to be done.
For this reason, it is possible to set drugs in each vessel in advance, and automatically and simultaneously add these drugs under computer control, so that the test can be started immediately. Development was strongly desired.

Therefore, for complete fully automatic operation of the dissolution test, it is preferable that the medicine injection device 28 includes the push rod 30 as described above.
The push rod 30 is located above the switch 52 as shown in FIG. 2 at the time of standby, and descends at the time of input instruction, and pushes the switch 52 as shown in FIG.

2A and 2B show the state of the test system during standby. FIG. 2A is a view of the drug injection device 28 as viewed from above, and FIG. 2B is a view of the drug input device 28 as viewed from below. FIG. (C) is a view of the medicine injection device 28 as viewed from the side.
3A and 3B show the state of the test system at the time of injection instruction. FIG. 3A is a view of the medicine injection device 28 as viewed from above, and FIG. 3B is a view of the medicine insertion device 28 as viewed from below. FIG. (C) is a view of the medicine injection device 28 as viewed from the side.

In the standby state as shown in FIG. 2, the push rod 30 is positioned away from the switch 52 upward.
In such a standby state, the holding of the lower portion of the cup body 68 and the inner lid 70 by the middle fixing means 72 is released, and the holding of the inner lid 70 and the bottom lid 64 by the bottom fixing means 76 is performed. ing.

On the other hand, when the push-in bar 30 is lowered and the switch 52 is pushed at the time of the insertion instruction as shown in FIG. 3, the automatic cover is kept while the bottom cover 64 is held by the bottom fixing means 76 The bottom lid 64 is rotated together with the inner lid 70 by the opening means 66.
In this way, the automatic lid opening means 66 retracts the inner lid 70 and the bottom lid 64 from above the charging hole 60, the charging hole 60 is opened, and the drug 42 in the drug holding cup 62 is charged into the charging hole 60. To the inside of the vessel 16, that is, into the test solution 44.

  As described above, in the medicine loading device 28 according to the present embodiment, the push rod 30 pushes the switch 52 to automatically place the medicine 42 at the time of loading instruction, thereby further facilitating and increasing the accuracy of the medicine 42 loading operation. Can be achieved simultaneously.

  Further, for complete fully automatic operation of the dissolution test, it is also preferable that the medicine injection device 28 further has the following configuration.

In this embodiment, in order to further facilitate and increase the accuracy of the drug 42 loading operation, the drug loading device 28 includes a loading hole 60, a drug holding cup 62, a bottom lid 64, and an automatic operation. A lid opening means 66.

  Here, the charging hole 60 is provided in the vessel lid 18 and is used for dropping the drug 42 into the vessel 16 when a charging instruction is given.

The medicine holding cup 62 is detachably provided in the insertion hole 60 of the vessel lid 18 and includes a cup body 68, an inner lid 70, and an inner side fixing means 72.
Here, the cup body 68 is formed of a hollow body.
The inner lid 70 is detachably provided at the lower part of the cup body 68, and is positioned on the charging hole 60 so that the charging hole 60 is closed during standby. Further, the inner lid 70 is retracted from above the charging hole 60 so that the charging hole 60 is opened when the charging instruction is given.
The middle fixing means 72 holds the cup body 68 and the inner lid 70 during standby. The middle fixing means 72 releases the holding of the cup body 68 and the inner lid 70 when the medicine holding cup 62 is attached to the insertion hole 60 of the vessel lid 18.

The bottom cover 64 is provided in the lower part of the vessel cover 18 so that the insertion hole 60 can be opened and closed, and includes an inner cover receiver 74 and a bottom side fixing means 76.
Here, the inner lid receiver 74 is configured to receive the inner lid 70 when the medicine holding cup 62 is attached to the charging hole 60 of the vessel lid 18.
The bottom-side fixing means 76 holds the inner lid 70 when the medicine holding cup 62 is attached to the charging hole 60 of the vessel lid 18.
The bottom cover 64 is positioned on the input hole 60 together with the inner cover 70 so that the input hole 60 is closed during standby. The bottom lid 64 is retracted from the top of the charging hole 60 together with the inner lid 70 so that the charging hole 60 is opened when a charging instruction is given.

The automatic lid opening means 66 includes a switch 52.
Here, it is assumed that the switch 52 is pressed when an instruction to put the medicine 42 held in the medicine holding cup 62 into the vessel 16 is given.
Then, the automatic lid opening means 66 positions the bottom lid 64 on the charging hole 60 together with the inner lid 70 so that the charging hole 60 is closed during standby. Further, the automatic lid opening means 66 retracts the bottom lid 64 from the insertion hole 60 together with the inner lid 70 so that the insertion hole 60 is opened when the switch 52 is pressed during the insertion instruction.

In this embodiment, the cup main body 68 and the inner lid 70 are held by the middle fixing means 72 before the medicine holding cup 62 is attached to the charging hole 60 of the vessel lid 18.
Further, in this embodiment, when the medicine holding cup 62 is attached to the charging hole 60 of the vessel lid 18, the holding of the cup body 68 and the inner lid 70 by the middle side fixing means 72 is released, and the bottom side fixing means 76. The inner lid 70 and the bottom lid 64 are held by the above.
In the present embodiment, when the switch 52 is pressed during the insertion instruction, the bottom lid 64 and the bottom lid 64 by the automatic lid opening means 66 and the bottom lid 64 and the bottom lid 64 are held while the bottom lid fixing means 76 is held. The inner lid 70 is rotated.
As a result, the charging hole 60 is opened, so that the drug 42 in the drug holding cup 62 falls into the vessel 16 through the charging hole 60 of the vessel lid 18.

  As described above, the medicine injection device 28 according to the present embodiment includes the cup body 68 and the holding cup 62 including the inner lid 70 detachably provided at the lower portion of the cup body 68, and the insertion hole 60 at the lower portion of the vessel lid 18. Since the bottom lid 64 provided so as to be freely opened and closed and the automatic lid opening means 66 for automatically rotating the bottom lid 64 together with the inner lid 70 when a loading instruction is given, the loading operation of the medicine 42 is further improved. Simplification and high accuracy can be achieved at the same time.

By the way, the medicine injection device has been considered conventionally. In the conventional method, it is necessary to incline the beaker itself when the medicine is added. However, if the method of tilting the beaker itself is used, the beaker may not be tilted satisfactorily, so that the medicine in the beaker may not be smoothly injected. Also, it may take some time for the beaker to tilt and the drug to be introduced.
On the other hand, in the present embodiment, the inner lid 70 can be freely attached to and detached from the lower portion of the cup body 68, and the lower portion of the medicine holding cup 62 is opened only by rotating the bottom lid 64 together with the inner lid 70. The drug 42 falls naturally. For this reason, in this embodiment, compared with the conventional method, the medicine 42 is charged very smoothly with a simpler configuration. For this reason, in the present embodiment, it does not take time to complete the injection of the medicine 42.

<Drug holding cup>
As shown in FIG. 4, the inner lid 70 includes an upper flange 80 that projects outward from the upper portion of the outer peripheral wall and a lower flange 82 that projects outward from the lower portion of the outer peripheral wall.
The cup body 68 includes an upper outer peripheral wall 84 whose outer peripheral wall is larger in diameter than the charging hole 60, and a lower outer peripheral wall 86 having substantially the same diameter as the charging hole 60. The cup body 68 includes an upper inner peripheral wall 88 whose inner peripheral wall is smaller than the outer diameter of the upper flange 80 of the inner lid 70, and a lower inner peripheral wall 90 that is substantially the same diameter or slightly larger than the insertion hole 60.
The middle fixing means 72 includes a claw member 92 that is pivotally supported by the side portion of the cup body 68 and that allows the inner lid 70 to be detachably attached to the lower end of the upper inner peripheral wall 88 of the cup body 68.
The middle lid receiver 74 of the bottom lid 64 is formed in a recess having a slightly larger diameter than the lower flange 82 of the middle lid 70.

Then, before attaching the medicine holding cup 62 to the vessel lid 18, the middle fixing means 72 holds the middle lid 70 on the cup body 68 so that the upper flange 80 of the middle lid 70 is held by the claw member 92.
When the medicine holding cup 62 is attached to the vessel lid 18, the holding of the upper flange 80 of the inner lid 70 and the cup body 68 by the claw member 92 of the inner fixing means 72 is released. At this time, the bottom flange 64 and the bottom lid 64 are held by the bottom fixing means 76 while the middle lid 70 is received by the middle lid receiver 74 of the bottom lid 64. .
At the time of loading instruction, the bottom lid 64 is rotated together with the inner lid 70 by the automatic lid opening means 66 while the inner lid 70 is held by the middle lid receiver 74 of the bottom lid 64 by the bottom-side fixing means 76, and the vessel The opening of the lid is open.

  As described above, in the medicine loading device 28 according to the present embodiment, the medicine holding cup 62 includes the cup body 68, the inner lid 70, and the middle side fixing means 72, and the bottom lid 64 is the middle lid receiver 74 and the bottom side fixing means 76. By including the above, it is possible to further facilitate the introduction work of the medicine 42 and increase the accuracy at the same time.

<Automatic lid opening means>
In the medicine injection device 28, the automatic lid opening means 66 includes a turning means 94 and a switch 52.
Here, the rotating means 94 supports the bottom lid 64 so as to be rotatable like a hinge with respect to the vessel lid 18, and the bottom lid 64 is opened so that the insertion hole 60 is opened when the medicine 42 is introduced. It rotates together with the inner lid 70.
The switch 52 includes a lever 98, a contact member 99, and a pressing member 100.
The lever 98 is pivotally supported by the vessel lid 18 so as to be swingable.
The contact member 99 is provided at the upper end of the lever 98 and has a contact surface that is pressed when the medicine 42 is charged.
The pressing member 100 presses the bottom lid 64 to the lower portion of the vessel lid 18 during standby. The pressing member 100 releases the pressing of the bottom lid 64 to the lower portion of the vessel lid 18 when the medicine 42 is introduced.

  In the present embodiment, by configuring the automatic lid opening means 66 as described above, it is possible to further facilitate the introduction work of the medicine 42 and improve the accuracy at the same time.

The dissolution tester 10 provided with the medicine injection device 28 according to the present embodiment is configured as described above, and the operation thereof will be described in more detail below.
<Before attaching the medicine holding cup to the vessel lid>
In the present embodiment, first, the medicine 42 is set in the medicine holding cup 62.
That is, in this embodiment, before attaching the medicine holding cup 62 to the vessel lid 18, the medicine holding cup 62 holds the inner lid 70 as shown in FIG. 4.
For this reason, in this embodiment, when the medicine 42 is put in the medicine holding cup 62, the medicine 42 can be held only by the medicine holding cup 62.
Thereby, in this embodiment, the medicine 42 can be easily set with the medicine holding cup 62 removed from the dissolution tester 10.
After the medicine 42 is set in the medicine holding cup 62, it is attached to the vessel lid 18.

<Standby>
FIG. 5A shows a top view of the vessel lid 18 to which the medicine holding cup 62 is attached, and FIG. 5B shows an enlarged view of the inlet 60 formed in the vessel lid 18. .

As described above, the vessel lid 18 is formed with the insertion port 60 into which the medicine holding cup is inserted and attached.
The vessel lid 18 is also formed with a shaft hole 45 for passing the rotation shaft as described above. The vessel lid 18 is also formed with a notch 101 for passing a temperature sensor and a suction nozzle of the sample liquid collecting means.

When the medicine holding cup 62 is attached to the vessel lid 18 as shown in the figure, the inner lid 70 is released from the middle fixing means 72 of the medicine holding cup 62 and is held by the bottom side fixing means 76 of the bottom lid 64. Is done.
That is, the charging hole 60 of the vessel lid 18 is basically circular, but a groove 102 is formed at the place where the inside fixing means of the medicine holding cup is inserted.
For this reason, the medicine holding cup 62 is inserted into the vessel lid 18 so that the middle fixing means hits the groove 102. Subsequently, when the medicine holding cup 62 is rotated with respect to the vessel lid 18, a portion located above the middle fixing means 72 is pushed inward by the slope 104 formed following the groove 102. Then, because of the lever principle, the claw member 92 positioned at the lower portion of the middle fixing means 72 is detached from the edge of the middle lid 70, so that the middle lid 70 is released from the cup body 68.
Further, when the medicine holding cup 62 is inserted into the vessel lid 18, the inner lid 70 enters the inner lid receiver 74 of the bottom lid 64 and is held by the bottom side fixing means 76 such as a ball attached to the side wall of the inner lid receiver 74. Is done.
As a result, the medicine holding cup 62 is in the state shown in FIG. 6, that is, the holding of the lower portion of the cup body 68 and the inner lid 70 by the middle side fixing means 72 is released, and the bottom side fixing means 76 The inner lid 70 and the bottom lid 64 are held.
In such a standby state, the medicine loading device 28 waits for a medicine loading instruction from the push rod 30.

<When ordering>
That is, at the time of standby as described above, the bottom lid 64 is stopped by the pressing member 100 of the automatic lid opening means 66, but the switch 52 of the automatic lid opening means 66 is brought into contact with the push rod 30 of the dissolution tester 110. When the member 99 is pressed, the pressing member 100 is removed by the lever principle, and the bottom cover 64 is opened together with the inner cover 70 by the force of the spring. Then, the medicine 42 in the medicine holding cup 62 is automatically charged into the vessel 16 as shown in FIG.

Simultaneously with the loading of the drug 42, in this embodiment, the dissolution test program starts the dissolution test, there is no delay in the test start time, and the timing of loading the drug 42 into the plurality of vessels 16 No difference occurs.
Therefore, in the present embodiment, it is possible to further facilitate the introduction work of the medicine 42 and increase the accuracy at the same time. In other words, in this embodiment, since the drug 42 can be simultaneously and fully loaded into up to eight vessels 16 under the control of the dissolution test program and the dissolution test can be started, the management of the test time has jumped. Can be done accurately.

<Pneumatic drug blow-off means>
In the above configuration, an example in which a tablet is used as the dosage form of the drug 42 has been described. However, the present invention is not limited to this, and can also be used for a powder.
Here, in order to improve the accuracy of the dissolution test, it is also important to reliably supply the drug 42 regardless of the dosage form.
That is, even in a conventional drug input device, for example, a drug input device described in Patent Document 1, powders such as granules and powder can be used as the drug 42 in theory.
However, according to the present inventors, when the dosage form is a powder such as a granule or a powder, a part of the powder may stick to a beaker or the like due to electrostatic force or the like. It was confirmed that the result might give an error.

  Based on the elucidation of the cause that hinders the high accuracy of the dissolution test, the present invention forcibly moves the drug 42 in the drug holding cup 62 into the vessel 16 in order to greatly reduce the residual residual powder. It is preferable to provide a pneumatic powder blowing mechanism (pneumatic drug blowing means) 108 for dropping.

  In FIG. 8, in order to forcibly drop the medicine 42 in the medicine holding cup 62 into the vessel 16, a pneumatic powder blowing mechanism 108 is provided.

The pneumatic dust blow-off mechanism 108 includes a blow-off main body 110, a supply means 112, a line 114, a valve 116, and an air control means 118.
Here, the blow-off body 110 is provided on the upper part of the medicine holding cup 62 so as to cover the upper end opening of the medicine holding cup 62.
The supply means 112 is composed of, for example, an air pump or an air compressor and sends it to the blow-off body 110.
The line 114 is for supplying the air 120 from the supply means 112 to the blow-off body 110.
The valve 116 is composed of, for example, an electromagnetic valve and is provided between the supply unit 112 and the blow-off body 110 and adjusts the air 120 to the blow-off body 110.
The air control means 118 is connected to the computer 37, and based on the dissolution test program of the computer 37, the air 120 of the supply means 112 is supplied for a desired amount or time (for example, a desired constant time or is constant or intermittent). ), The operation of the valve 116 is controlled so as to be sent to the blow-off body 110.

  Then, the air 120 from the supply means 112 is sent to the cup body 68 of the medicine holding cup 62 through the blow-off body 110, and the medicine 42 in the medicine holding cup 62 can be forcibly blown down into the vessel 16. Is preferred.

<O-ring>
In the present embodiment, the space between the medicine holding cup 62 and the blow-off body 110 is sealed to seal the air 120 from leaking, and the elastic O for fixing the blow-off body 110 to the medicine holding cup 62 is used. A ring 122 is provided.

<Upper lid>
Further, in this embodiment, when the medicine 42 is a tablet, capsule, or sinker, the air-type powder blow-off mechanism 108 is not necessary, so that an upper lid (not shown) is placed instead of the blow-off body 110. The evaporation of the test liquid 44 from the medicine holding cup 62 can be reliably prevented.

As described above, in the present embodiment, in the case of powders such as granules and powders, by providing the air-type powder blow-off mechanism 108, not only tablets, capsules and sinkers, but also automatic injection has been extremely difficult conventionally. Powders such as granules and powders can be automatically charged in the same manner as tablets, capsules and sinkers.
Therefore, in this embodiment, it contributes to labor saving of the dissolution test, and the accuracy and precision of the test are dramatically improved. Accordingly, in the present embodiment, it is possible to further facilitate the drug input operation and increase the accuracy at the same time regardless of the dosage form.

  In the above configuration, an example in which a paddle is provided at the lower end of the rotating shaft in order to perform the paddle method has been described, but in order to perform the rotating basket method instead of the paddle method, a cylindrical basket is used instead of the paddle. It can also be provided at the lower end of the rotating shaft.

It is explanatory drawing of schematic structure of the dissolution tester provided with the chemical | medical agent injection apparatus concerning one Embodiment of this invention. It is explanatory drawing of the mode at the time of standby of the chemical | medical agent injection apparatus concerning one Embodiment of this invention. It is explanatory drawing of the mode at the time of the injection instruction | indication of the chemical | medical agent injection apparatus concerning one Embodiment of this invention. It is detailed explanatory drawing of the chemical | medical agent holding cup of the chemical | medical agent injection apparatus concerning one Embodiment of this invention. It is a detailed explanatory view of the vessel lid of the medicine injection device concerning one embodiment of the present invention. It is detailed explanatory drawing at the time of standby of the medicine injection device concerning one embodiment of the present invention. It is a detailed explanatory view at the time of input instruction of the drug input device according to one embodiment of the present invention. It is explanatory drawing of the pneumatic powder blow-off mechanism suitable for the chemical | medical agent injection apparatus concerning one Embodiment of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Dissolution test device 28 Drug injection device 30 Push rod 62 Drug holding cup 64 Bottom lid 66 Automatic lid opening means 70 Middle lid 108 Pneumatic powder blowing mechanism (pneumatic drug blowing means)

Claims (6)

A charging hole provided on the vessel lid, for dropping the medicine into the vessel at the time of charging instruction,
A cup body made of a hollow body is detachably provided in the charging hole of the vessel lid, and is detachably provided on the lower part of the cup body, and is placed on the charging hole so that the charging hole is closed during standby. An inner lid that is retracted from above the charging hole so that the charging hole is open when the charging instruction is made, and holds the lower part of the cup body and the inner lid during standby, and A medicine holding cup including an inner side fixing means for releasing the holding of the lower part of the cup body and the inner lid when attached;
The charging hole is provided at the bottom of the vessel lid so as to be freely opened and closed, and when the drug holding cup is attached to the charging hole, an inner lid receiver for receiving the inner lid, and the drug holding cup is attached to the charging hole Sometimes includes a bottom fixing means for holding the inner lid to the inner lid receptacle, and is positioned on the charging hole together with the inner lid so that the charging hole is closed during standby, and when the charging instruction is given A bottom lid that retracts from above the charging hole together with the inner lid so that the hole is in an open state;
Including a switch that is pressed when an instruction to put the medicine in the medicine holding cup into the vessel is made, and the bottom lid is positioned on the charging hole together with the inner lid so that the charging hole is closed during standby. And an automatic lid opening means for retracting the bottom lid from the charging hole together with the inner lid so that the charging hole is opened when the switch is pressed during the charging instruction;
With
Before attaching the medicine holding cup to the charging hole of the vessel lid, the lower part of the cup body and the inner lid are held by the middle fixing means,
During standby, the holding of the lower part of the cup body and the inner lid by the middle fixing means is released, and the holding of the inner lid and the bottom lid by the bottom fixing means is performed,
When the switch is pressed during the loading instruction, the inner lid and the bottom lid are held by the bottom-side fixing means, and the inner lid and the bottom lid by the automatic lid opening means The medicine charging device is characterized in that the charging hole is opened, the charging hole is opened, and the drug in the drug holding cup falls into the vessel through the charging hole. In the medicine injection device according to claim 1,
The inner lid includes an upper flange projecting outside the outer peripheral wall upper part, and a lower flange projecting outside the outer peripheral wall lower part,
The cup main body includes an upper outer peripheral wall whose outer peripheral wall is larger in diameter than the charging hole and a lower outer peripheral wall having substantially the same diameter as the charging hole, and the inner peripheral wall of the cup main body is the inner lid Including an upper inner peripheral wall smaller than the outer diameter of the upper flange and a lower inner peripheral wall substantially the same diameter or slightly larger than the insertion hole,
Further, the middle side fixing means includes a claw member that is pivotally supported on the cup body side portion so as to be swingable, and that allows the middle lid to be detachably attached to a lower end of an upper inner peripheral wall of the cup body.
The inner lid receiver is formed in a recess having a slightly larger diameter than the inner lid lower flange,
Before attaching the medicine holding cup to the vessel lid, the inner side fixing means holds the inner lid on the cup body so that the upper flange of the inner lid is covered with the claw member,
During standby, the holding of the upper lid flange and the cup body by the claw member of the middle fixing means is released, and the bottom fixing means is in a state where the middle lid is received by the middle lid receiver of the bottom lid The medicine feeding device, wherein the inner lid lower flange and the bottom lid are held by the above. In the medicine injection device according to claim 1 or 2,
The lid opening means rotatably supports the bottom lid like a hinge with respect to the vessel lid,
A pivoting means for pivotally driving the bottom lid together with the inner lid so that the throwing hole is in an open state when a throwing instruction is given;
Including
The switch includes a lever pivotally supported on the vessel lid,
An abutting member provided at an upper end of the lever and having an abutting surface to be pressed at the time of input;
A pressing member that performs pressing to the bottom of the vessel lid at the time of standby, and releases the pressing of the bottom lid to the bottom of the vessel lid at the time of loading instruction;
Including
When the charging is instructed, the bottom lid is rotated together with the inner lid by the rotating means in a state where the inner lid is held by the inner lid receiver of the bottom lid by the bottom-side fixing means. A medicine injection device characterized by being in an open state. In the medicine injection device according to any one of claims 1 to 3,
It is located at a position spaced above the switch during the standby, and has a push rod that moves up and down in a direction to contact or separate from the switch so as to descend and push the switch when the turn-on instruction is issued. A drug injection device characterized by the above. In the medicine injection device according to any one of claims 1 to 4,
Pneumatic drug blow-off means for forcibly dropping the drug in the drug holding cup into the vessel,
The pneumatic drug blow-off means includes a blow-off body provided on the drug holding cup so as to cover an upper opening of the drug holding cup,
Means for supplying air to the blow-off body;
A line for supplying air from the supply means to the blow-off body;
A valve provided between the supply means and the blow-off body, for adjusting air to the blow-off body;
An air control means for controlling the operation of the valve so that air from the air supply means is sent to the blow-off body for a desired amount or time;
The air from the air supply means is sent to the medicine holding cup through the blow-off body, and the medicine in the medicine holding cup is forcibly blown down into the vessel. Input device. A dissolution tester comprising the drug injection device according to any one of claims 1 to 5,
A constant temperature water tank containing constant temperature water for maintaining the inside of the vessel at a desired temperature;
A vessel containing a test solution used for the dissolution test of the drug;
A vessel lid provided on the vessel;
Stirring means for stirring the inside of the vessel;
A push bar provided so as to be movable up and down with respect to the switch;
Moving means for moving the push bar up and down;
Movement control means for controlling the vertical movement of the push bar by the moving means so that the vertical position of the push bar with respect to the switch is a desired contact position or separation position;
Storage means for storing a dissolution test program for automatically performing the dissolution test of the drug;
Based on the dissolution test program of the storage means, test control means for starting the dissolution test simultaneously with the introduction of the drug by the push rod;
A dissolution tester characterized by comprising:

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