CN109331127A - 一种治疗痛风的中药组合物及其制备方法 - Google Patents
一种治疗痛风的中药组合物及其制备方法 Download PDFInfo
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- CN109331127A CN109331127A CN201811484221.5A CN201811484221A CN109331127A CN 109331127 A CN109331127 A CN 109331127A CN 201811484221 A CN201811484221 A CN 201811484221A CN 109331127 A CN109331127 A CN 109331127A
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Abstract
本发明涉及一种治疗痛风的中药组合物及其制备方法,所述治疗痛风的中药组合物的原料组分包括黄连、黄柏、绿豆、土茯苓、紫草、紫苏、薏仁、赤芍、虎杖、蒲公英、山慈姑、光慈姑、木瓜、川牛膝、桑枝、水蛭、防己、萆薢、皮硝和朴硝。将各个原材料进行适当重量配比,最终制备得到具有清热利湿、凉血通络、解毒散积功效的中药组合物,对治疗痛风具有很好的疗效,临床总有效率达到80%。本发明所述中药组合物配伍科学、疗效显著、见效迅速,且无毒副作用。本发明所述中药组合物的制备方法简单易行,条件温和且稳定性好,易于推广。
Description
技术领域
本发明属于中医药技术领域,具体涉及一种治疗痛风的中药组合物及其制备方法。
背景技术
痛风是一种常见且复杂的关节炎类型,各个年龄段均可能罹患本病,男性发病率高于女性。痛风患者经常会在夜晚出现突然性的关节疼,发病急,关节部位出现严重的疼痛、水肿、红肿和炎症,疼痛感慢慢减轻直至消失,持续几天或几周不等。当疼痛发作时,患者会在半夜熟睡中疼醒,有患者描述疼痛感类似于大脚趾被火烧一样。最常发病的关节是大脚趾,但发病的关节不限于此,还常见于手部的关节、膝盖、肘部等。发病的关节最终会红肿、发炎,水肿后组织变软,活动受限,最后影响日常生活。如果没有及时治疗,拖延的后果是疼痛感将越来越强,让人难以忍受。而且关节本身也会受到损害,骨质会被腐蚀,导致关节变形,整个发病过程肾脏也会受损,严重的会发生肾结石甚至是肾衰竭,危及生命。
现代医学认为,痛风病是因嘌呤代谢异常,使尿酸增高,尿酸盐沉积在关节软骨与滑膜间,令周围组织急性发炎所致。临床上治疗目标非常明确,有高尿酸血症就有痛风,没有高尿酸血症就没有痛风,治疗的目标是长期控制血尿酸在目标值。然而,事实上,中国痛风降尿酸治疗血尿酸3个月达标率仅为29.12%,6个月达标率也仅有38.20%。传统医学将其归属于热痹范畴,病因是因湿、热、瘀、毒流注关节,引起红肿热痛而致。中医药治疗痛风的方法有其独特优势,大量的临床实践不断证实中医药的临床疗效。现有的治疗痛风的中药种类繁多,但治疗效果有待提高,因此还需要开发疗效更好的治疗痛风的药物。
发明内容
为了解决现有技术存在的上述问题,本发明提供了一种疗效显著、见效迅速的治疗痛风的中药组合物及其制备方法,所述治疗痛风的中药组合物具有清热利湿、凉血通络、解毒散积的功效,对治疗痛风具有很好的疗效。
本发明所采用的技术方案为:
一种治疗痛风的中药组合物,原料组分包括:
黄连12-18重量份、黄柏12-18重量份、绿豆24-36重量份、土茯苓24-36重量份、紫草16-24重量份、紫苏24-36重量份、薏仁24-36重量份、赤芍12-18重量份、虎杖16-24重量份、蒲公英16-24重量份、山慈姑12-18重量份、光慈姑12-18重量份、木瓜24-36重量份、川牛膝12-18重量份、桑枝24-36重量份、水蛭5-7重量份、防己8-12重量份、萆薢12-18重量份、皮硝8-12重量份、朴硝8-12重量份。
进一步优选所述治疗痛风的中药组合物的原料组分包括:
黄连15重量份、黄柏15重量份、绿豆30重量份、土茯苓30重量份、紫草20重量份、紫苏30重量份、薏仁30重量份、赤芍15重量份、虎杖20重量份、蒲公英20重量份、山慈姑15重量份、光慈姑15重量份、木瓜30重量份、川牛膝15重量份、桑枝30重量份、水蛭6重量份、防己10重量份、萆薢15重量份、皮硝10重量份、朴硝10重量份。
进一步的,所述药物组合物的剂型为丸剂或膏剂。
所述治疗痛风的中药组合物的制备方法,包括以下步骤:
(1)将所述各原料进行除杂、清洗、晾干,之后与酒拌匀,得到拌酒原料;
(2)将所述拌酒原料进行文火炒制,得到酒炙后原料;
(3)将所述酒炙后原料纳米粉碎,得到粉碎后原料;向所述粉碎后原料中加入蜂蜜,搅拌均匀,制成细丸,即得到所述治疗痛风的中药组合物。
进一步的,步骤(1)中,选用的酒为酒精度数为52%Vol-63%Vol的白酒;所述原料与酒精的质量比为10:(1-2)。
进一步的,步骤(3)中,原料粉碎后的粒径为20-100nm。
进一步的,步骤(3)中,蜂蜜为油菜花蜂蜜;粉碎后原料与油菜花蜂蜜的质量比为(3-5):1;每粒细丸质量为0.1g-0.3g。
进一步的,服用方法为成人每天2次,每次9-12g,早晚空腹时服药,温开水送服,服药后60-90分钟再进食,儿童用量减半。
进一步的,外用方法为将药丸用温开水泡成糊浆状,直接覆盖性敷于患部,再取医用纱布做外部固定,1小时左右可止痛。
所述治疗痛风的中药组合物的制备方法,包括以下步骤:
(1)将以上所述各原料进行除杂、清洗、晾干,加水浸泡后大火煎煮,随后转文火煎煮,过滤得到滤液;
(2)将所述滤液浓缩成膏,得到所述治疗痛风的中药组合物。
进一步的,步骤(1)中,原料与水的质量比为1:(2-4),浸泡时间为1-3h;大火煎煮时间为3-7min;文火煎煮时间为40-140min;过滤使用300-800目滤网。
进一步的,步骤(2)中,浓缩时温度为35-45℃。
进一步的,服用方法为成人每天2次,每次120-150ml,早晚空腹时将药膏温热后再服,服药后60-90分钟才能进食,儿童用量减半。
进一步的,外用方法为将本膏直接涂抹于患部,1小时左右可止痛。
下面对本发明中原料所产生的作用进行简单叙述。
黄连,味苦,性寒;归心、胃、肝、大肠经。功效主治:清热燥湿,泻火解毒。用于胃肠湿热,呕吐,泻痢,高热神昏,心烦不寐,血热吐衄,疮疡肿毒,脓耳,湿疮,胃火牙痛。
黄柏,味苦,性寒;归肾、膀胱、大肠经。功效主治:清热燥湿。泻火解毒,退虚热。用于湿热泻痢,黄疸,带下,热毒疮疡,湿疹,阴虚发热。
绿豆,味甘,性寒;归心、胃经。功效主治:清热解毒,消暑。用于痈肿疮毒,暑热烦渴。
土茯苓,味甘、淡,性平;归肝、胃经。功效主治:解毒,除湿,通利关节。用于湿热淋浊,带下,热毒疮痈,梅毒,肢体拘挛。
紫草,味甘,性寒;归心、肝经。功效主治:清热凉血,活血,解毒,透疹。用于热毒斑疹,热毒疮疡。
紫苏,味辛,性温;归肺、脾经。功效主治:发汗解表,行气宽中。用于风寒表证,脾胃气滞,胸闷,呕吐,妊娠呕吐。
薏仁,味甘、淡,性寒;归脾、胃、肺经。功效主治:利水渗湿,健脾止泻,祛湿除痹,清热排脓。用于小便不利,水肿,脚气,脾虚泄泻,风湿痹痛,筋脉挛急,肺痈,肠痈。
赤芍,味苦,性微寒;归肝经。功效主治:清热凉血,活血化瘀,止痛。用于血热妄行,吐衄发斑,瘀血经闭,跌打损伤,热毒疮疡,肝火目赤。
虎杖,味苦,性寒;归肝、胆、肺经。功效主治:活血止痛,清热利湿,解毒,化痰止咳。用于血滞经闭,风湿痹痛,跌打伤痛,湿热黄疸,淋浊带下,烫伤,疮痈肿毒,肺热咳嗽。
蒲公英,味苦、甘,性寒;归肝,胃经。功效主治:清热解毒,利湿。用于热毒疮疡,黄疸,热淋,目赤肿痛。
山慈姑,味甘、微辛,性寒;归肝、胃、肺经。功效主治:清热解毒,消肿散结。用于痈疽恶疮,瘰疬结核,咽痛喉痹,蛇、虫咬伤。
光慈姑,味甘,性寒;归肺、肝经。功效主治:解毒散结,行血化瘀。治咽喉肿痛,瘰疬,痈疽,疮肿,产后瘀滞。
木瓜,味酸,性温;归肝、脾经。功效主治:舒筋活络,化湿和胃。用于风湿痹痛,筋脉拘挛,脚气肿痛,吐泻转筋。
川牛膝,味甘、微苦,性平;归肝、肾经。功效主治:逐瘀通经,通利关节,利尿通淋。用于经闭癓瘕,胞衣不下,关节痹痛,足痿筋挛,尿血血淋,跌扑损伤。
桑枝,味苦,性平;归肝经。功效主治:祛风通络。用于风湿痹痛,肢体疼痛,四肢拘挛。
水蛭,味咸、苦,性平;归肝经。功效主治:破血逐瘀。用于经闭,癥瘕,跌打损伤。
防己,味苦、辛,性寒;归膀胱、肾、脾经。功效主治:祛风湿,止痛,利水。用于风湿痹痛,水肿胀满,脚气浮肿。
萆薢,味苦,性平;归肝、胃、膀胱经。功效主治:利湿浊,祛风湿。用于膏淋,白浊,带下,风湿痹痛,腰痛。
皮硝,味咸、苦,性寒;归胃,大肠经。功效主治:泻下软坚,清热泻火。用于实热积滞,大便燥结,咽痛口疮,目赤肿痛。
朴硝,味咸、苦,性寒;归胃、大肠经。功效主治:泻下软坚,清热泻火。用于实热积滞,大便燥结,咽痛口疮,目赤肿痛。
本发明的有益效果为:
本发明所述的治疗痛风的中药组合物,以黄连、黄柏、绿豆、土茯苓、防己青热利湿;以虎杖、蒲公英、山慈姑、光慈姑解毒散积;以紫草、紫苏、薏仁、赤芍、木瓜、水蛭活血通络;以桑枝、川牛膝引药入手足关节;以皮硝、朴硝、萆薢即可峻猛解攻积化毒的效力,又可利便,使邪有出路。山慈姑含有秋水仙碱,有促进尿酸排泄作用,与诸药合用,治疗痛风病具有确切疗效。本发明所述治疗痛风的中药组合物具有清热利湿、凉血通络、解毒散积的功效,对治疗痛风具有很好的疗效,临床总有效率达到80%。本发明配伍科学、疗效显著、见效迅速,无毒副作用,制备方法简单易行,条件温和且稳定性好,易于推广。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将对本发明的技术方案进行详细的描述。显然,所描述的实施例仅仅是本发明的一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式,都属于本发明所保护的范围。
实施例1
本实施例提供一种治疗痛风的中药组合物,原料组分包括:
黄连12g、黄柏12g、绿豆24g、土茯苓24g、紫草16g、紫苏24g、薏仁24g、赤芍12g、虎杖16g、蒲公英16g、山慈姑12g、光慈姑12g、木瓜24g、川牛膝12g、桑枝24g、水蛭5g、防己8g、萆薢12g、皮硝8g、朴硝8g。
所述治疗痛风的中药组合物的制备方法,包括以下步骤:
(1)将所述原料进行除杂、清洗、晾干,之后与酒精度数为52%Vol的白酒拌匀,所述原料与酒精的质量比为10:1,得到拌酒原料;
(2)将所述拌酒原料文火炒制颜色至加深,得到酒炙后原料;
(3)将酒炙后原料纳米粉碎至粒径为20nm,得到粉碎后原料;向所述粉碎后原料中加入1/3质量的油菜花蜂蜜,搅拌均匀,制成每粒重0.1g的细丸,即得到所述治疗痛风的中药组合物。
实施例2
本实施例提供一种治疗痛风的中药组合物,原料组分包括:
黄连18g、黄柏18g、绿豆36g、土茯苓36g、紫草24g、紫苏36g、薏仁36g、赤芍18g、虎杖24g、蒲公英24g、山慈姑18g、光慈姑18g、木瓜36g、川牛膝18g、桑枝36g、水蛭7g、防己12g、萆薢18g、皮硝12g、朴硝12g。
所述治疗痛风的中药组合物的制备方法,包括以下步骤:
(1)将所述原料进行除杂、清洗、晾干,之后与酒精度数为63%Vol的白酒拌匀,所述原料与酒精的质量比为10:2,得到拌酒原料;
(2)将所述拌酒原料文火炒制颜色至加深,得到酒炙后原料;
(3)将酒炙后原料纳米粉碎至粒径为100nm,得到粉碎后原料;向所述粉碎后原料中加入1/5质量的油菜花蜂蜜,搅拌均匀,制成每粒重0.3g的细丸,即得到所述治疗痛风的中药组合物。
实施例3
本实施例提供一种治疗痛风的中药组合物,原料组分包括:
黄连15g、黄柏15g、绿豆30g、土茯苓30g、紫草20g、紫苏30g、薏仁30g、赤芍15g、虎杖20g、蒲公英20g、山慈姑15g、光慈姑15g、木瓜30g、川牛膝15g、桑枝30g、水蛭6g、防己10g、萆薢15g、皮硝10g、朴硝10g。
所述治疗痛风的中药组合物的制备方法,包括以下步骤:
(1)将所述原料进行除杂、清洗、晾干,之后与酒精度数为60%Vol的白酒拌匀,所述原料与酒精的质量比为20:3,得到拌酒原料;
(2)将所述拌酒原料文火炒制颜色至加深,得到酒炙后原料;
(3)将酒炙后原料纳米粉碎至粒径为60nm,得到粉碎后原料;向所述粉碎后原料中加入1/4质量的油菜花蜂蜜,搅拌均匀,制成每粒重0.2g的细丸,即得到所述治疗痛风的中药组合物。
实施例4
本实施例提供一种治疗痛风的中药组合物,原料组分包括:
黄连12g、黄柏12g、绿豆24g、土茯苓24g、紫草16g、紫苏24g、薏仁24g、赤芍12g、虎杖16g、蒲公英16g、山慈姑12g、光慈姑12g、木瓜24g、川牛膝12g、桑枝24g、水蛭5g、防己8g、萆薢12g、皮硝8g、朴硝8g。
所述治疗痛风的中药组合物的制备方法,包括以下步骤:
(1)将所述各原料进行除杂、清洗,加入2倍质量的纯净水浸泡1h,大火煎煮3min,随后转文火煎煮40min,使用300目滤网过滤得到滤液;
(2)将所述滤液在温度为35℃下浓缩成膏,得到所述治疗痛风的中药组合物。
实施例5
本实施例提供一种治疗痛风的中药组合物,原料组分包括:
黄连18g、黄柏18g、绿豆36g、土茯苓36g、紫草24g、紫苏36g、薏仁36g、赤芍18g、虎杖24g、蒲公英24g、山慈姑18g、光慈姑18g、木瓜36g、川牛膝18g、桑枝36g、水蛭7g、防己12g、萆薢18g、皮硝12g、朴硝12g。
所述治疗痛风的中药组合物的制备方法,包括以下步骤:
(1)将所述各原料进行除杂、清洗,加入4倍质量的纯净水浸泡3h,大火煎煮7min,随后转文火煎煮140min,使用800目滤网过滤得到滤液;
(2)将所述滤液在温度为45℃下浓缩成膏,得到所述治疗痛风的中药组合物。
实施例6
本实施例提供一种治疗痛风的中药组合物,原料组分包括:
黄连15g、黄柏15g、绿豆30g、土茯苓30g、紫草20g、紫苏30g、薏仁30g、赤芍15g、虎杖20g、蒲公英20g、山慈姑15g、光慈姑15g、木瓜30g、川牛膝15g、桑枝30g、水蛭6g、防己10g、萆薢15g、皮硝10g、朴硝10g。
所述治疗痛风的中药组合物的制备方法,包括以下步骤:
(1)将所述各原料进行除杂、清洗,加入3倍质量的纯净水浸泡2h,大火煎煮5min,随后转文火煎煮90min,使用600目滤网过滤得到滤液;
(2)将所述滤液在温度为40℃下浓缩成膏,得到所述治疗痛风的中药组合物。
实验例
对实施例3所得治疗痛风的中药组合物进行效果试验
1、试验对象:痛风患者319名。
2、试验过程:使用本发明制得的中药组合物,让受试者使用3个月,随后询问受试者服用效果,每隔1个月回访一次。
3、试验结果判断标准:(1)有效:复查尿酸较治疗前下降,关节病灶部位红肿疼痛较治疗前减轻;(2)显效:较参与实验的其他患者尿酸下降明显,关节病灶部位红肿疼痛明显减轻;(3)治愈:复查尿酸在正常值范围,关节病灶部位红肿疼痛消失。
4、试验结果:见表1。
表1试验结果
治疗效果 | 有效 | 显效 | 治愈 |
人数 | 255 | 217 | 198 |
百分率(%) | 80 | 68 | 62 |
从表1中可以看出,本发明所述治疗痛风的中药组合物对患者的痛风症状具有较好疗效,有效率达到80%,也充分证实本发明所述中药组合物对痛风的治疗效果。
典型案例
1、丁某,男,40岁。于2日前饮酒后突然感到右拇趾关节剧烈疼痛,难以忍受,局部肿胀,有灼热感,行动困难,大便干,小便黄。查:舌苔黄厚,脉滑数,右足第一趾关节肿大,压疼明显,触之灼热,化验血常规:Hb130g/L,WBC8.9ⅹ109/L,RBC4.5ⅹ1012/L,ESR25mm/h,RF(-),CRP(+)血尿酸539umol/L。诊断为:急性痛风性关节炎。采用本药物膏剂治疗,每次130ml,每天3次,餐前60分钟温服。服药当晚疼痛减轻;第2天关节胀大明显减小;续服6天临床症状消失。改服丸剂,每次12g,每天3次,餐前60分钟温开水送服,20日后复查:ESR14mm/h,RF(-),CRP(-),血尿酸血尿酸367umol/L。嘱其少进含嘌呤类食物,随访2年末复发。
2、齐某,男,36岁。日前饮酒后突然右足剧痛,不能着地,症见右足背红肿,各趾跖屈时甚痛,压痛明显,舌红,苔黄厚,脉弦。化验血常规血沉:32mm/h,血尿酸:610umol/L,诊断为:急性痛风。采用本药物膏剂治疗,每次130ml,每天3次,餐前60分钟温服。服药当晚疼痛减轻;第2天足背红肿疼痛明显缓解;续服7天临床症状消失。改服丸剂,每次12g,每天3次,餐前60分钟温开水送服,24日后复查:化验血常规、血沉、血尿酸均接近正常。再做巩固治疗14天后血尿酸恢复正常。嘱其少进含嘌呤类食物,随访2年末复发。
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种治疗痛风的中药组合物,其特征在于,原料组分包括:
黄连12-18重量份、黄柏12-18重量份、绿豆24-36重量份、土茯苓24-36重量份、紫草16-24重量份、紫苏24-36重量份、薏仁24-36重量份、赤芍12-18重量份、虎杖16-24重量份、蒲公英16-24重量份、山慈姑12-18重量份、光慈姑12-18重量份、木瓜24-36重量份、川牛膝12-18重量份、桑枝24-36重量份、水蛭5-7重量份、防己8-12重量份、萆薢12-18重量份、皮硝8-12重量份、朴硝8-12重量份。
2.根据权利要求1所述的治疗痛风的中药组合物,其特征在于,原料组分包括:
黄连15重量份、黄柏15重量份、绿豆30重量份、土茯苓30重量份、紫草20重量份、紫苏30重量份、薏仁30重量份、赤芍15重量份、虎杖20重量份、蒲公英20重量份、山慈姑15重量份、光慈姑15重量份、木瓜30重量份、川牛膝15重量份、桑枝30重量份、水蛭6重量份、防己10重量份、萆薢15重量份、皮硝10重量份、朴硝10重量份。
3.根据权利要求1-2任一项所述治疗痛风的中药组合物,所述药物组合物的剂型为丸剂或膏剂。
4.一种权利要求1-3任一项所述治疗痛风的中药组合物的制备方法,其特征在于,包括以下步骤:
(1)将所述各原料进行除杂、清洗、晾干,之后与酒拌匀,得到拌酒原料;
(2)将所述拌酒原料进行文火炒制,得到酒炙后原料;
(3)将所述酒炙后原料纳米粉碎,得到粉碎后原料;向所述粉碎后原料中加入蜂蜜,搅拌均匀,制成细丸,即得到所述治疗痛风的中药组合物。
5.根据权利要求4所述治疗痛风的中药组合物的制备方法,其特征在于,步骤(1)中,选用的酒为酒精度数为52%Vol-63%Vol的白酒;所述原料与酒的质量比为10:(1-2)。
6.根据权利要求4所述治疗痛风的中药组合物的制备方法,其特征在于,步骤(3)中,原料粉碎后的粒径为20-100nm。
7.根据权利要求4所述治疗痛风的中药组合物的制备方法,其特征在于,步骤(3)中,蜂蜜为油菜花蜂蜜;粉碎后原料与油菜花蜂蜜的质量比为(3-5):1;每粒细丸质量为0.1g-0.3g。
8.一种权利要求1-3任一项所述治疗痛风的中药组合物的制备方法,其特征在于,包括以下步骤:
(1)将所述各原料进行除杂、清洗,加水浸泡后大火煎煮,随后转文火煎煮,过滤得到滤液;
(2)将所述滤液浓缩成膏,得到所述治疗痛风的中药组合物。
9.根据权利要求8所述治疗痛风的中药组合物的制备方法,其特征在于,步骤(1)中,原料与水的质量比为1:(2-4),浸泡时间为1-3h;大火煎煮时间为3-7min;文火煎煮时间为40-140min;过滤使用300-800目滤网。
10.根据权利要求8所述治疗痛风的中药组合物的制备方法,其特征在于,步骤(2)中,浓缩时温度为35-45℃。
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