CN109331074A - A kind of Chinese medicine composition and its preparation method and application with senile-resistant efficacy - Google Patents
A kind of Chinese medicine composition and its preparation method and application with senile-resistant efficacy Download PDFInfo
- Publication number
- CN109331074A CN109331074A CN201811585039.9A CN201811585039A CN109331074A CN 109331074 A CN109331074 A CN 109331074A CN 201811585039 A CN201811585039 A CN 201811585039A CN 109331074 A CN109331074 A CN 109331074A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine composition
- powder
- preparation
- tree peony
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Toxicology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of Chinese medicine composition and its preparation method and application with senile-resistant efficacy, the raw material for preparing of the Chinese medicine composition are grouped as by the group of following mass percentage: tree peony 20-50%, gardenia 10-30%, Astragalus membranacus root 10-30%, glossy privet seed 10-30%.The Chinese medicine composition of the invention aging ingredient containing there are many, is matched four kinds of Chinese medicines using best proportion, reasonable component formula, each active constituent complements each other, can be synergistic, the cosmetic property being prepared is mild, and can generate fast long-acting anti-aging effects.
Description
Technical field
The invention belongs to the field of Chinese medicines, it is related to a kind of Chinese medicine composition and its preparation method and application, more particularly to a kind of
Chinese medicine composition and its preparation method and application with senile-resistant efficacy.
Background technique
With advancing age, human epidermal cell metabolism frequency slows down, and epidermal barrier ability also gradually weakens therewith；Add
The stimulation of external environmental, ultraviolet irradiation, skin is easy to appear just line, microgroove, wrinkle, and the skins such as senile plaque are existing
As.
The mechanism of aging is at present also in conceptual phase, and there are somatic mutation theory, free radical theory, neuroendocrines
Adjust a variety of mechanism theories such as theory.Organism is growed in intensity in the process autoxidation reaction of aging, such as can cause DNA
The generation of the free radical of expression is damaged, the aging of cell makes organism gradually lose the Scavenging activity to free radical, excessive
Free radical cause skin to stimulating growth factor reagency weaken, in cycles, to accelerate the aging of organism；From raising
The oxidation resistance of skin delays senescence, and has that timeliness is short, the advantages such as quick, but as epidermis is periodically metabolized, resists
Oxidability cannot obtain long-acting guarantee.Theory of traditional Chinese medical science think the aging of people be it is gradually changed from inside to outside, mainly by
Caused by the insufficiency of vital energy and blood of human body, qi depression to blood stasis, the deficiency of liver-yin and kidney-yin, therefrom medical knowledge view, which supports lining, long-acting can delay declining for organism
Always, but there is the deficiency that time-consuming.While how quickly removing the free radical of skin, enhance skin intrinsic antioxidative ability,
The generation of microgroove is reduced, the purpose of reaching delay skin aging is the technological difficulties of this field.
CN107007501A discloses a kind of anti-apolexis composition, and the anti-apolexis composition includes ginseng extract, wood
Crafty extract and Arillus Longan extract.Three is complementary on mechanism of action, and the anti-aging effects being used in combination become apparent from.This
The preparation method for inventing the anti-apolexis composition provided is simple, saves production hour, can keep active constituent in preparation process
Stability can also make product have apparent radicals scavenging effect.
CN108451811A discloses a kind of delay aging drug facial mask, contains compound aging ingredient in the face mask of traditional Chinese medicine:
10-15 parts of the fleece-flower root, 15-20 parts of fructus lycii, 12-18 parts of ginkgo leaf, 8-12 parts of Radix Angelicae Sinensis, 9-15 parts of mulberries, 6-10 parts of tealeaves, Hu Luo
Foretell 11-16 parts；Synergy, good penetrability and easy the advantages that absorbing that the compound aging ingredient has, it can quickly penetrate into simultaneously quilt
Skin Cell absorbs, and maintains the eubolism of Skin Cell, so that Skin Cell is chronically at health status, Skin Cell is certainly
The enhancing of body anti-aging ability, is not easy loose or lesion；The facial mask reaches anti-aging effects, medicine to improve skin itself resistance
Imitate gentle, anti-aging effects are good, and have no toxic side effect.
CN105030610A discloses a kind of anti-apolexis composition, comprising basic components and is scattered in the basic components
In the anti-aging factor, the anti-aging factor be selected from soybean germ extract, wheat malt germ extract, safflower plumule extract
At least three kinds in object, maize germ extract.Soybean germ extract, wheat malt germ extract, safflower germ extracts, jade
At least three kinds in rice germ extracts generate synergistic effect on antisenility between each other, can cooperate with and promote collagen synthesis, fast
Speed smooths skin lines, repairs impaired skin, to achieve the purpose that delaying skin aging.
But the above prior art is difficult to achieve the effect that therefore quick, the long-acting anti-aging ability for improving skin is developed
A kind of drug that can alleviate aging fast long-actingly is necessary.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of Chinese medicine composition and preparation method thereof and answer
With especially providing a kind of Chinese medicine composition and its preparation method and application with senile-resistant efficacy.
In order to achieve that object of the invention, the invention adopts the following technical scheme:
In a first aspect, the present invention provides a kind of Chinese medicine composition, the Chinese medicine composition prepares raw material by following quality
The group of percentage composition is grouped as: tree peony 20-50%, gardenia 10-30%, Astragalus membranacus root 10-30%, glossy privet seed 10-30%.
Wherein, flavonoids rich in, anthocyan, Polyphenols, protein, amino acids in tree peony, tool
There is extremely strong oxidation resistance, can directly remove O2-、H2O2Isoreactivity oxygen is presently found with compared with strong anti-oxidation ability
One of reactive compound, there is significant senile-resistant efficacy.
Gardenia mainly contains the compounds such as iridoids, flavonoids, Diterpenes, phenolic acid class and organic acid ester,
The cape jasmine flower extract of extremely low concentration just has stronger elimination free radical ability.
Astragalus membranacus contain astragalus polyose, astragaloside, flavonoids, amino acid, alkaloid, protein, vitamin and
Various trace elements, main chemical compositions are the ingredients such as triterpene saponin, flavonoids, polysaccharide, and wherein astragalus polyose is not only
It can increase with age and reduced superoxide dismutase levels, reduce the generation of free radical, but also there is drop
The content of peroxide in low blood plasma, to reduce the energy of established lipofuscin in the formation or even scavenger-cell of lipofuscin
Power, wherein astragalus polyose, which the aging phenomenons such as increases for pigment deposition, free radical because of caused by light aging, autoxidation, to be had
Brilliant improvement.
Glossy privet mainly contains the ingredients such as terpene, flavonoids, benzene oxygen alcohol glycoside, fatty acid, and the fruit of glossy privet, which has, delays organism
The effect of aging, this is because the oleanolic acid, polysaccharide, iridoids chemicals in glossy privet fruit extract can be preferably clear
Except free radical, body is improved to the defence capability of free radical, inhibits the erythrocyte hemolysis of free yl induction, to extend cell
Time-to-live.
The Chinese medicine composition of the invention aging ingredient containing there are many, is matched four kinds of Chinese medicines using optimal ratio
5, reasonable component formula, each active constituent complements each other, can be synergistic, and the cosmetic property being prepared is mild, and can produce
Raw fast long-acting anti-aging effects.
The mass percentage of the tree peony can for 20%, 25%, 30%, 32%, 35%, 38%, 40%, 42%,
45%, 46%, 48% or 50% etc..
The mass percentage of the gardenia can be 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%
Or 30% etc..
The mass percentage of the Astragalus membranacus root can for 10%, 12%, 15%, 18%, 20%, 22%, 25%,
28% or 30% etc..
The mass percentage of the glossy privet seed can be 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%
Or 30% etc..
Preferably, the tree peony is derived from including any one in peony, peony leaves, tree peony stem or tree peony root or at least
Two kinds of combination, described two combinations such as peony and peony leaves, tree peony stem and tree peony root, peony leaves and tree peony stem etc..
Preferably, the raw material for preparing of the Chinese medicine composition is grouped as by the group of following mass percentage: tree peony 35%,
Gardenia 25%, Astragalus membranacus root 25%, glossy privet seed 15%.
Preferably, the raw material for preparing of the Chinese medicine composition is grouped as by the group of following mass percentage: tree peony 35%,
Gardenia 20%, Astragalus membranacus root 20%, glossy privet seed 25%.
Second aspect, the present invention provide a kind of preparation method of Chinese medicine composition as described above, the preparation method packet
Include following steps:
(1) medicinal material pre-processes: after tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed respectively, then being broken into powder, mixes
Conjunction obtains mixed-powder；
(2) primary to extract: first being added in the mixed-powder obtained to step (1) and extracts reagent, is impregnated, later will
Extracting solution filtering, concentration, drying, obtain dried powder；
(3) second extraction: second is added in the dried powder obtained to step (2) and extracts reagent, carries out ultrasonic extraction, obtains
To crude extract to get arrive the Chinese medicine composition.
In the present invention, step (1) it is described by tree peony process method particularly includes: take tree peony to be washed with deionized water, go
Except the xylem fractionation exocuticle of root and stem, wherein exocuticle is in 5-20% (such as 5%, 8%, 10%, 12%, 15%, 18%
Or 20% etc.) dipping 1-5h (such as 1h, 2h, 3h, 4h or 5h etc.) fried dry afterwards in ethanol water, wherein colored and leaf is in 40-80
It is dried under DEG C (such as 40 DEG C, 45 DEG C, 50 DEG C, 55 DEG C, 60 DEG C, 65 DEG C, 70 DEG C, 75 DEG C or 80 DEG C etc.).
Preferably, step (1) it is described by gardenia process method particularly includes: take gardenia to be washed with deionized water,
It is dried under 40-80 DEG C (such as 40 DEG C, 45 DEG C, 50 DEG C, 55 DEG C, 60 DEG C, 65 DEG C, 70 DEG C, 75 DEG C or 80 DEG C etc.).
Preferably, step (1) is described processes Astragalus membranacus root method particularly includes: takes Astragalus membranacus root deionized water
Clean, steamed under 60-100 DEG C (60 DEG C, 70 DEG C, 80 DEG C, 90 DEG C or 100 DEG C etc.) 3-5h (such as 3h, 3.5h, 4h, 4.5h or
5h etc.) after, under 50-80 DEG C (such as 50 DEG C, 55 DEG C, 60 DEG C, 65 DEG C, 70 DEG C, 75 DEG C or 80 DEG C etc.) dry 5-10h (such as
5h, 6h, 7h, 8h or 10h etc.), it is done under 20-30 DEG C (such as 20 DEG C, 21 DEG C, 22 DEG C, 24 DEG C, 26 DEG C, 28 DEG C or 30 DEG C etc.)
Dry 1-12h (1h, 2h, 4h, 6h, 8h, 10h or 12h etc.), finally again 50-80 DEG C (such as 50 DEG C, 55 DEG C, 60 DEG C, 65 DEG C,
70 DEG C, 75 DEG C or 80 DEG C etc.) under dry 5-10h (5h, 6h, 7h, 8h, 9h or 10h etc.).
Preferably, step (1) the glossy privet seed processes method particularly includes: takes glossy privet seed to be washed with deionized water, removes
It is water-soluble to be sealed in the acetic acid that concentration is 1-10% (1%, 2%, 3%, 4%, 5%, 6%, 8% or 10% etc.) for impurity and carpopodium
In liquid, water proof heats 3-8h (3h, 4h, 5h, 6h, 7h or 8h etc.), in 50-80 DEG C of (such as 50 DEG C, 55 DEG C, 60 DEG C, 65 DEG C, 70
DEG C, 75 DEG C or 80 DEG C etc.) under be dried.
Chinese medicine composition of the present invention respectively prepares raw material respectively after above-mentioned special processing mode, can be substantially
Degree ground improves the content of active constituent in raw material, and the common toxic side effect of Chinese medicine can be effectively reduced；Meanwhile also making tree peony, Cape jasmine
Sub- flower, pod membrane Radix Astragali bitter cold property also well improved, so that it is preferably played pharmacological property.
Preferably, the granularity of step (1) described powder be 60-100 mesh, such as 60 mesh, 65 mesh, 70 mesh, 75 mesh, 80 mesh,
85 mesh, 90 mesh, 95 mesh or 100 mesh etc..
In the present invention, step (2) first Extraction solvent be 40-80% ethanol water, such as 40%, 45%,
50%, 60%, 70% or 80% etc..
Preferably, the mass ratio of step (2) first Extraction solvent and the mixed-powder is (8-20): 1, such as 8:
1,10:1,12:1,14:1,15:1,16:1,17:1,18:1 or 20:1 etc..
Preferably, the temperature of step (2) described immersion is 40-70 DEG C, such as 40 DEG C, 45 DEG C, 50 DEG C, 55 DEG C, 60 DEG C, 65
DEG C or 70 DEG C etc..
Preferably, the number of step (2) described immersion is 2-6 times, such as 2 times, 3 times, 4 times, 5 times or 6 are inferior, each 2-
3h, such as 2h, 2.2h, 2.4h, 2.5h, 2.6h, 2.8h or 3h etc..
Preferably, step (2) concentration is reduced pressure.
Preferably, step (2) drying is vacuum drying, and drying temperature is 40-70 DEG C, such as 40 DEG C, 45 DEG C, 50
DEG C, 55 DEG C, 60 DEG C, 65 DEG C or 70 DEG C etc..
In the present invention, it is deionized water that step (3) described second, which extracts reagent,.
Preferably, the mass ratio of step (3) second Extraction solvent and the dried powder is (10-20): 1, such as
10:1,11:1,12:1,14:1,15:1,16:1,18:1,19:1 or 20:1 etc..
Preferably, the power of step (3) described ultrasonic extraction be 30-80KHz, such as 30KHz, 40KHz, 50KHz,
60KHz, 70KHz or 80KHz etc..
Preferably, the temperature of step (3) described ultrasonic extraction is 40-80 DEG C, such as 40 DEG C, 45 DEG C, 50 DEG C, 55 DEG C, 60
DEG C, 65 DEG C, 70 DEG C, 75 DEG C or 80 DEG C etc..
Preferably, the time of step (3) described ultrasonic extraction be 30-100min, such as 30min, 40min, 50min,
60min, 70min, 80min, 90min or 100min etc..
The third aspect, the present invention provide a kind of Chinese medicine composition concentrate, and the Chinese medicine composition concentrate is the institute on
What the Chinese medicine composition process stated was purified and was concentrated to get.
Fourth aspect, the present invention provide a kind of preparation method of Chinese medicine composition concentrate as described above, the preparation
Method includes the following steps:
(I) it purifies: the Chinese medicine composition being obtained into filtrate with filtering with microporous membrane, then filtrate is carried out with macroreticular resin
Elution, obtains eluent；
(II) it is concentrated: the eluent that step (I) obtains is concentrated.
Preferably, the aperture of step (I) described miillpore filter be 0.2-0.5 μm, such as 0.2 μm, 0.25 μm, 0.3 μm,
0.4 μm, 0.45 μm or 0.5 μm etc..
Preferably, the model D101 or AB-8 of step (I) described macroporous resin column.
Preferably, eluent used in step (I) described elution is 70% ethanol water.
Preferably, described be concentrated in vacuum concentrator of step (II) is concentrated, and temperature is 40-80 DEG C, such as 40 DEG C,
45 DEG C, 50 DEG C, 55 DEG C, 60 DEG C, 65 DEG C, 70 DEG C, 75 DEG C or 80 DEG C etc..
Preferably, step (II) concentration is is concentrated into whole quality and the mass ratio of step (1) described mixed-powder is
1:(5-20), such as 1:5,1:6,1:8,1:10,1:12,1:15,1:16,1:18 or 1:20 etc..
As the preferred technical solution of the present invention, the preparation method of the Chinese medicine composition concentrate includes the following steps:
(1) medicinal material pre-processes: after tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed respectively, then being broken into powder, mixes
Conjunction obtains mixed-powder；
(2) primary to extract: 40-80% ethanol water being added in the mixed-powder obtained to step (1), is mixed with described
The mass ratio for closing powder is (8-20): 1；It carries out impregnating 2-6 times, each 2-3h at 40-70 DEG C, later filter extracting solution,
It is concentrated under reduced pressure, is dried in vacuo at 40-70 DEG C, obtain dried powder；
(3) second extraction: deionized water is added in the dried powder obtained to step (2), with the dried powder
Mass ratio is (10-20): 1；Ultrasonic extraction 30-100min, ultrasonic power 30-80KHz are carried out at 40-80 DEG C, are obtained thick
Extracting solution to get arrive the Chinese medicine composition；
(4) it purifies: the Chinese medicine composition that step (3) obtains being obtained into filtrate with 0.2-0.5 μm of filtering with microporous membrane, then is used
The macroreticular resin of model D101 or AB-8 elute filtrate, and eluent is 70% ethanol water, obtain eluent；
(5) it is concentrated: the eluent that step (4) obtains being concentrated in 40-80 DEG C of vacuum concentrator, is concentrated into end
The mass ratio of quality and step (1) described mixed-powder is 1:(5-20).
5th aspect, the present invention provide a kind of cosmetics, include in as described above in the raw material composition of the cosmetics
Drug composition includes Chinese medicine composition concentrate as described above.
Preferably, the cosmetics are lotion, Essence or mask.
Preferably, the additive amount of the Chinese medicine composition or Chinese medicine composition concentrate in cosmetics is 0.1-30%,
Such as 0.1%, 0.5%, 1%, 2%, 5%, 8%, 10%, 15%, 20% or 30% etc., preferably 0.5-20%.
Preferably, the cosmetics raw material composition in further include additive, the additive include solvent, emulsifier,
In preservative or thickener any one or at least two combination, it is described two combinations such as solvent and emulsifier, anti-
Rotten agent and thickener, emulsifier and preservative etc..
Compared with prior art, the present invention has following beneficial effect:
Four kinds of Chinese medicines are carried out compatibility, reasonable component formula, each activity using best proportion by Chinese medicine composition of the invention
Ingredient complements each other, can be synergistic, can remove ultra-oxygen anion free radical and hydroxy radical, have significant anti-aging function
Effect.By the Chinese medicine composition be applied to cosmetics in, make the product property being prepared stablize, have good moisturizing, it is crease-resistant,
Anti- pigmented spots and other effects.
Specific embodiment
Further to illustrate technological means and its effect adopted by the present invention, below in conjunction with preferred implementation of the invention
Example to further illustrate the technical scheme of the present invention, but the present invention is not limited in scope of embodiments.
Embodiment 1
The present embodiment provides a kind of Chinese medicine composition concentrate with anti-aging effects, the Chinese medicine composition concentrate
The raw material for preparing be grouped as by the group of following mass percentage: tree peony 35%, gardenia 25%, Astragalus membranacus root 25%, female
Loyal seed 15%.
Preparation method includes the following steps:
Tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed as follows respectively:
It takes tree peony to be washed with deionized water, removes the xylem fractionation exocuticle of root and stem, wherein exocuticle is in 10% second
Fried dry after dipping 4h in alcohol solution, wherein colored and leaf is dried at 60 DEG C；Gardenia is taken to be washed with deionized water, 60
It is dried at DEG C；Astragalus membranacus root is taken to be washed with deionized water, after steaming 3h at 80 DEG C, the dry 8h at 70 DEG C, 25
10h is dried at DEG C, finally dries 8h at 70 DEG C again；It takes glossy privet seed to be washed with deionized water, removes impurity and carpopodium, sealing
In the acetic acid aqueous solution that concentration is 4%, water proof heats 7h, is dried at 60 DEG C.
After tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed respectively, then it is broken into powder, is mixed to get mixed powder
End；60% ethanol water is added into mixed-powder, the mass ratio with the mixed-powder is 15:1, is carried out at 60 DEG C
It impregnates 3 times, each 2h, is dried in vacuo later by extracting solution filtering, reduced pressure, at 60 DEG C, obtains dried powder；To obtaining
Dried powder in deionized water is added, be 15:1 with the mass ratio of the dried powder, ultrasonic extraction carried out at 60 DEG C
45min, ultrasonic power 55KHz, obtains crude extract；Filtrate is obtained with 0.2 μm of filtering with microporous membrane, then with model D101
Macroreticular resin filtrate is eluted, eluent be 70% ethanol water, obtain eluent；By obtained eluent 40
DEG C vacuum concentrator in be concentrated, the mass ratio for being concentrated into whole quality and aforementioned mixed-powder is 1:10, is obtained in described
Drug composition concentrate (I).
Embodiment 2
The present embodiment provides a kind of Chinese medicine composition concentrate with anti-aging effects, the Chinese medicine composition concentrate
The raw material for preparing be grouped as by the group of following mass percentage: tree peony 35%, gardenia 20%, Astragalus membranacus root 20%, female
Loyal seed 25%.
Preparation method includes the following steps:
Tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed as follows respectively:
It takes tree peony to be washed with deionized water, removes the xylem fractionation exocuticle of root and stem, wherein exocuticle is in 15% second
Fried dry after dipping 5h in alcohol solution, wherein colored and leaf is dried at 70 DEG C；Gardenia is taken to be washed with deionized water, 70
It is dried at DEG C；Astragalus membranacus root is taken to be washed with deionized water, after steaming 5h at 60 DEG C, the dry 6h at 60 DEG C, 25
5h is dried at DEG C, finally dries 5h at 60 DEG C again；It takes glossy privet seed to be washed with deionized water, removes impurity and carpopodium, sealing
In the acetic acid aqueous solution that concentration is 8%, water proof heats 5h, is dried at 70 DEG C.
After tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed respectively, then it is broken into powder, is mixed to get mixed powder
End；70% ethanol water is added into mixed-powder, the mass ratio with the mixed-powder is 10:1, is carried out at 70 DEG C
It impregnates 4 times, each 3h, is dried in vacuo later by extracting solution filtering, reduced pressure, at 65 DEG C, obtains dried powder；To obtaining
Dried powder in deionized water is added, be 10:1 with the mass ratio of the dried powder, ultrasonic extraction carried out at 70 DEG C
80min, ultrasonic power 70KHz, obtains crude extract；Filtrate is obtained with 0.5 μm of filtering with microporous membrane, then with model AB-8
Macroreticular resin filtrate is eluted, eluent be 70% ethanol water, obtain eluent；By obtained eluent 60
DEG C vacuum concentrator in be concentrated, the mass ratio for being concentrated into whole quality and aforementioned mixed-powder is 1:15, is obtained in described
Drug composition concentrate (II).
Embodiment 3
The present embodiment provides a kind of Chinese medicine composition concentrate with anti-aging effects, the Chinese medicine composition concentrate
The raw material for preparing be grouped as by the group of following mass percentage: tree peony 45%, gardenia 25%, Astragalus membranacus root 15%, female
Loyal seed 15%.
Preparation method includes the following steps:
Tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed as follows respectively:
It takes tree peony to be washed with deionized water, removes the xylem fractionation exocuticle of root and stem, wherein exocuticle is in 20% second
Fried dry after dipping 5h in alcohol solution, wherein colored and leaf is dried at 80 DEG C；Gardenia is taken to be washed with deionized water, 75
It is dried at DEG C；Astragalus membranacus root is taken to be washed with deionized water, after steaming 4h at 100 DEG C, the dry 9h at 80 DEG C, 25
12h is dried at DEG C, finally dries 10h at 80 DEG C again；It takes glossy privet seed to be washed with deionized water, removes impurity and carpopodium, it is close
It is encapsulated in the acetic acid aqueous solution that concentration is 10%, water proof heats 4h, is dried at 80 DEG C.
After tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed respectively, then it is broken into powder, is mixed to get mixed powder
End；75% ethanol water is added into mixed-powder, the mass ratio with the mixed-powder is 19:1, is carried out at 50 DEG C
It impregnates 4 times, each 3h, is dried in vacuo later by extracting solution filtering, reduced pressure, at 50 DEG C, obtains dried powder；To obtaining
Dried powder in deionized water is added, be 20:1 with the mass ratio of the dried powder, ultrasonic extraction carried out at 60 DEG C
100min, ultrasonic power 40KHz, obtains crude extract；Filtrate is obtained with 0.4 μm of filtering with microporous membrane, then uses model
The macroreticular resin of D101 elutes filtrate, and eluent is 70% ethanol water, obtains eluent；The eluent that will be obtained
It is concentrated in 80 DEG C of vacuum concentrator, the mass ratio for being concentrated into whole quality and aforementioned mixed-powder is 1:20, obtains institute
State Chinese medicine composition concentrate (III).
Embodiment 4
The present embodiment provides a kind of Chinese medicine composition concentrate with anti-aging effects, the Chinese medicine composition concentrate
The raw material for preparing be grouped as by the group of following mass percentage: tree peony 25%, gardenia 15%, Astragalus membranacus root 30%, female
Loyal seed 30%.
Preparation method includes the following steps:
Tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed respectively, it is same as Example 1 to process mode.
After tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed respectively, then it is broken into powder, is mixed to get mixed powder
End；75% ethanol water is added into mixed-powder, the mass ratio with the mixed-powder is 19:1, is carried out at 50 DEG C
It impregnates 4 times, each 3h, is dried in vacuo later by extracting solution filtering, reduced pressure, at 50 DEG C, obtains dried powder；To obtaining
Dried powder in deionized water is added, be 20:1 with the mass ratio of the dried powder, ultrasonic extraction carried out at 60 DEG C
100min, ultrasonic power 40KHz, obtains crude extract；Filtrate is obtained with 0.4 μm of filtering with microporous membrane, then uses model
The macroreticular resin of D101 elutes filtrate, and eluent is 70% ethanol water, obtains eluent；The eluent that will be obtained
It is concentrated in 80 DEG C of vacuum concentrator, the mass ratio for being concentrated into whole quality and aforementioned mixed-powder is 1:20, obtains institute
State Chinese medicine composition concentrate (IV).
Comparative example 1-4
Comparative example 1-4 provides the Chinese medical extract concentrate of 4 kinds of one-components, and respectively comparative example 1 (extract by tree peony
Object), comparative example 2 (cape jasmine flower extract), comparative example 3 (Astragalus membranacus root extract), comparative example 4 (glossy privet fruit extract).Its
Preparation method is same as Example 1.
Comparative example 5
This comparative example provides a kind of Chinese medicine composition concentrate without processing, the system of the Chinese medicine composition concentrate
Standby raw material is grouped as by the group of following mass percentage: tree peony 35%, gardenia 25%, Astragalus membranacus root 25%, glossy privet seed
15%.
Preparation method includes the following steps:
It is dry after tree peony, gardenia, Astragalus membranacus root, glossy privet seed are washed with deionized water respectively, then it is broken into powder, it mixes
Conjunction obtains mixed-powder；Deionized water is added into mixed-powder, the mass ratio with the mixed-powder is 15:1, at 60 DEG C
Lower progress ultrasonic extraction 45min, ultrasonic power 55KHz obtain crude extract；Subsequent operation is consistent with embodiment 1, is obtained
To the Chinese medicine composition concentrate (V).
Embodiment 5
The present embodiment provides a kind of mask with senile-resistant efficacy, preparing for the mask contains Chinese medicine in raw material
Composition concentrated solution (I), the constituent of the mask are as shown in table 1.
Table 1
Preparation method includes the following steps:
(1) by A phase xanthan gum and Sodium Hyaluronate disperse in glycerol after put into emulsion pot, by EDETATE SODIUM, hydroxyl
Ethyl cellulose is directly thrown into emulsion pot, is warming up to 80 DEG C, is dispersed with stirring to uniform；
(2) parahydroxyacet-ophenone in B phase is previously heated to dissolve in butanediol transparent, under the conditions of 60 DEG C, added
Enter to emulsion pot, is dispersed with stirring to uniform；
(3) it is cooled to 45 DEG C, C phase is added, be dispersed with stirring to being completely dissolved；
(4) 37 DEG C are cooled to, is stirred evenly, vacuumizing and defoaming, 200 mesh filtering and dischargings.
Comparative example 6-10
Comparative example 6-10 provides 5 kinds of masks with senile-resistant efficacy, and the mask prepares raw material and embodiment 5
Difference be only that " Chinese medicine composition concentrate (I) " replaced with into " peony extract ", " Cape jasmine made from comparative example 1-4 respectively
" Chinese medicine composition concentrate made from sub- flower extract ", " Astragalus membranacus root extract ", " glossy privet fruit extract " and comparative example 5
(IV) ", other are all the same, and preparation method is also identical.
Embodiment 6
The present embodiment provides a kind of Essence with senile-resistant efficacy, preparing for the Essence contains Chinese medicine in raw material
Composition concentrated solution (I), the constituent of the Essence are as shown in table 2.
Table 2
Preparation method includes the following steps:
(1) Sodium Hyaluronate, xanthan gum and glycerol are stirred to being uniformly dispersed in advance, and carbomer is made into mass fraction
For 1% aqueous dispersions；
(2) A phase raw material Prunus Amygdalus Dulcis Oil, saualane, methyl hydroxybenzoate, Nipasol, Tween-20, polysorbate -60 are thrown
Enter into oily phase pot, be heated to 80 DEG C, be stirred until homogeneous, ring five dimethyl silicone polymer is added before emulsifying；
(3) by the glycerol pre-processed in step (1), Sodium Hyaluronate, xanthan gum and EDETATE SODIUM investment emulsification
In pot, 80 DEG C are heated to, stirring is complete to dissolving；
(4) A phase is quickly pumped into emulsion pot, after addition, with the rate emulsifying 5- of 3000-5000rpm
10min is persistently stirred with the rate of 1000-2000rpm after emulsification and is started to cool down；
(5) 65 DEG C are cooled to, the carbomer aqueous dispersions that prepared mass fraction is 1% in step (1) are added, with
The rate homogeneous of 3000-5000rpm 2 minutes；
(6) it is cooled to 45 DEG C, is added C phase, stirring is to being uniformly dissolved；
(7) vacuum defoamation after temperature is down to 35 DEG C, 200 mesh filtering and dischargings.
Comparative example 11
The present embodiment provides a kind of common Essence, the Essence prepare raw material and the difference of embodiment 6 is only that
" Chinese medicine composition concentrate (I) " is removed, other are all the same, and preparation method is also identical.
Comparative example 12
The present embodiment provides a kind of Essence, the difference for preparing raw material and embodiment 6 of the Essence be only that by " in
Drug composition concentrate (I) " replaces with " Chinese medicine composition concentrate (IV) " made from comparative example 5, other are all the same, preparation side
Method is also identical.
Product made from embodiment 1-6 and comparative example 1-12 is respectively enterd into following testing experiment:
Embodiment 7
Anti-oxidation efficacy evaluation test
By product made from embodiment 1-4 and comparative example 1-5, it is configured to 1% sample solution with deionized water, carries out such as
Lower test:
(1) ultra-oxygen anion free radical Scavenging activity evaluation test
The Tris-HCl buffer solution 4.5mL for taking 0.05mol/L pH=8.2, preheats 20min in 25 DEG C of water-baths.Again
The pyrogallol solution of 1mL sample solution and 0.4mL 25mol/L is added, after mixing, reacts 5min in 25 DEG C of water-baths, is added
The HCl of 1mL 8mol/L terminates reaction.Make reference with Tris-HCl buffer solution, absorbance value is surveyed at 299nm.Blank control
Group substitutes sample solution with the solvent of 1mL sample solution.
The calculation formula of ultra-oxygen anion free radical clearance rate is as follows:
Ultra-oxygen anion free radical clearance rate (%)=[1- (A2/A1)] × 100%
In formula, A1 is the absorbance value of blank control group, and A2 is the absorbance value of sample sets.Test result is as shown in table 3.
(2) Hydroxyl radical-scavenging merit rating is tested
2mmol/L FeSO is sequentially added in 25mL cuvette43mL, 1mmol/L H2O23mL shakes up, and is subsequently added into
6mmol/L salicylic acid 3mL, shakes up, and takes out after 37 DEG C of heating water bath 15min, surveys its absorbance；It is separately added into certain density
Sample solution shakes up, and continues heating water bath 15min, takes out and surveys its absorbance.
The calculation formula of Scavenging action to hydroxyl free radical is as follows:
Scavenging action to hydroxyl free radical (%)=[A1-A2-(A1-A3)]/A1× 100%
In formula, A1、A2、A3System after the absorbance value of reaction system, sample scavenging hydroxyl before respectively non-sample-adding product
Absorbance value, after sample solvent scavenging hydroxyl system absorbance value.Test result is as shown in table 3.
Table 3
| Pilot project | Ultra-oxygen anion free radical clearance rate (%) | Scavenging action to hydroxyl free radical (%) |
| Embodiment 1 | 99.33 | 93.87 |
| Embodiment 2 | 92.22 | 93.59 |
| Embodiment 3 | 92.35 | 91.47 |
| Embodiment 4 | 92.57 | 91.48 |
| Comparative example 1 | 43.65 | 44.29 |
| Comparative example 2 | 41.54 | 45.83 |
| Comparative example 3 | 52.18 | 41.27 |
| Comparative example 4 | 17.53 | 16.72 |
| Comparative example 5 | 60.23 | 65.92 |
According to above-mentioned test result it is found that product made from embodiment 1-4 to superoxide anion clearance rate be up to 92% with
On, to Scavenging action to hydroxyl free radical 91% or more, illustrate that the Chinese medicine composition of the present invention with senile-resistant efficacy has significantly
Removing free radical antioxidant effect.And single medicinal material is unsatisfactory to the clearance rate of free radical in comparative example, illustrates composition
Between synergistic effect it is significant, Chinese medicine composition is higher than single medicinal material to superoxide anion and Scavenging action to hydroxyl free radical, has good
Anti-aging effects.Meanwhile only having without the Chinese medicine composition for processing preparation to the clearance rate of free radical in comparative example 5
60%, also not significant to the Scavenging activity of hydroxy radical, this explanation has more by the Chinese medicine composition that particular form processes
Strong removing free radical oxidation resistance.
Embodiment 8
Skin moisture content and skin water loss (TEWL) test
Cosmetics made from embodiment 5-6, comparative example 6-12 are chosen to carry out skin moisture content and skin water loss
(TEWL) it tests, moisture measurement is using universally acknowledgedMethod --- capacitance method, moisture of skin
It is lost TEWL and parameter is very important to the function of assessment moisture of skin protective layer.With the aging of skin, the water conservation of skin
Ability gradually decreases, the easier drying of skin, and the numerical value that skin moisture is lost TEWL is lower.Test the test equipment that uses for
Skin moisture content Corneometer test probe and skin moisture are lost Tewameter TM300 test probe (Germany
Courage+Khazaka company).
Test method specifically:
The age is chosen in 35~55 years old aging skin women 140, is randomly divided into 7 groups, every group 20.15 before recipient site
It cannot use any product (cosmetics or topical drug or health care product for oral administration).Before test, it is desirable that subject cleans face simultaneously
Enter within 2 hours 22 ± 1 DEG C of temperature after cleaning, sit quietly 30min in the constant temperature and humidity room of humidity 50 ± 5%, and keeps loosening
State.
5 groups are chosen by random table in experiment, carries out half of face test, side is the embodiment 4 containing Chinese medical extract, another
Side is comparative example 6-10；Remaining 2 groups of sides are the embodiment 5 containing Chinese medical extract, and the other side is comparative example 11-
12；The left and right nasolabial groove part for choosing volunteer carries out skin moisture content measuring and moisture loss (TEWL) test, takes 3 values
Average value as nasolabial groove water content data (D0) and nasolabial groove skin moisture be lost (TEWL) data (D0).Test
After, volunteer need to use according to regulations, and a side face smears a kind of product, and another side face smears another product.In use, making
With the right hand smear the right facial area, using left hand smear left side facial area, forbid cross contamination and as required daily morning and evening 2 times into
Row product is smeared, continuous 28 days on probation, and requires being paid a return visit for the 14th day (D14) and the 28th day (D28) for test.Each time
The lighting condition of point should be consistent: curtain closing, illumination appropriate.Subject is in bed recumbency.The inclined angle of bed is each
Time point should all be consistent.The position of bed must mark on the ground, to ensure the consistency of the position of D14 and D28.Together
The test of one volunteer is completed by the same survey crew.Test result is as shown in table 4.
Table 4
| Test index | D14 moisture content | D28 moisture content | D14TEWL | D28TEWL |
| Embodiment 5 | 20.28 | 29.21 | -20.39 | -33.97 |
| Embodiment 6 | 19.73 | 34.92 | -18.85 | -32.33 |
| Comparative example 6 | 10.32 | 14.53 | -11.02 | -13.96 |
| Comparative example 7 | 11.25 | 14.01 | -10.99 | -14.67 |
| Comparative example 8 | 12.00 | 13.69 | -10.81 | -12.58 |
| Comparative example 9 | 11.56 | 14.26 | -11.29 | -14.91 |
| Comparative example 10 | 10.89 | 13.78 | -8.65 | -10.11 |
| Comparative example 11 | 11.31 | 12.25 | -5.94 | -9.21 |
| Comparative example 12 | 13.57 | 16.51 | -10.38 | -13.92 |
According to above-mentioned test result it is found that Essence, mask containing the Chinese medicine composition with senile-resistant efficacy are to skin
The repair of skin water holding capacity is than Essence and mask, the face paste containing the Chinese medicine composition without processing containing single medicinal material
Film and Essence without Chinese medicine composition become apparent from, and during the Essence ratio containing the Chinese medicine composition without processing is free of
The Essence of drug composition is slightly good to skin moisturizing ability, but far below the maintenance containing the Essence by processing Chinese medicine composition
Effect.
Embodiment 9
VISIA skin analysis evaluation experimental
VISIA skin image analyzer, can be from just by 12,000,000 pixel camera heads using multiple spectrum image science and technology
Face, left side, the angle shot of right side three are imaged three times in three kinds of standard white light, transversal plane polarized light, ultraviolet light light sources,
Therefore VISIA face-image analysis system can the pigmented spots of network analysis subject's skin of face, texture, pore, wrinkle, ultraviolet
Linear light spot, steady color spot, red color area, sclererythrin provide accurate, quantitative analysis foundation for skin.Before record subject's test
The pigmented spots of rear face, wrinkle, texture, absolute score value represents the area and intensity that skin holds sign detected value, for observing skin
The change situation of property, therefore choose the absolute resulting data of score value (front, left side, right side test result are averaged)
As analytical standard and data statistics foundation.All data of every subject are inputted into computer, measurement result is compared,
It is statistically analyzed analysis subjects skin's feature and indices data.The test equipment used is tested as VISIA face figure
As analysis system (CANFIELD scientific & technical corporation of the U.S.).
Test method specifically:
Aging skin women 30 of the age at 30-40 years old is chosen, is randomly divided into 3 groups, every group of 10 people, respectively using implementation
Example 6, comparative example 11 and comparative example 12.Subject needs to be used continuously, daily 2 progress product smearings of morning and evening, continuously
It is 28 days on probation, and require being paid a return visit for the 14th day (D14) and the 28th day (D28) for test.The test of the same subject is by same
One survey crew completes.
Any product (cosmetics or topical drug or health care product for oral administration) cannot be used within 15 days before recipient site.Using unified
Face cleaning product to face carry out thoroughly clean after, gently wiped with paper handkerchief it is dry, room temperature be 22 DEG C ± 2 DEG C, relative humidity 40
In ± 2% room, with the mug shot of VISIA face-image analyzer shooting tester, analyzed area after waiting for quietly 15 minutes
The interference of retroreflective regions and hair should be avoided as far as possible.Subject facial (including front, left side, right side) is shot,
Resulting absolute score value is subjected to data statistics, records pigmented spots, texture, wrinkle, pore, red color area and the purple of subject's face
The detection data of matter.Test result is as shown in table 5.
Table 5
According to above-mentioned test result it is found that embodiment 6 has apparent change to the pigmented spots of subject, wrinkle, texture
Effect is seen, and compares 11 there is no any improvement, the effect of comparative example 12 is little.Illustrate to be used for a long time added with this hair
The Essence of Chinese medicine composition in bright with senile-resistant efficacy can reach good and remove wrinkle, desalinate pigmented spots, smooth line
The effect of reason.
Embodiment 10
Normal individual trial evaluation experimental
Mask made from embodiment 5, comparative example 6-10 is chosen to carry out normal individual trial evaluation test, will in use process
Hope person evaluates the moisturizing degree of mask, glossiness, compact degree and anti-wrinkle effect, and wherein highest is divided into 5 points, minimum to be divided into
1 point, it also can use the arbitrary value between 1-5.Test result is as shown in table 6.
Table 6
| Evaluation result | Embodiment 5 | Comparative example 6 | Comparative example 7 | Comparative example 8 | Comparative example 9 | Comparative example 10 |
| Moisturizing degree | 4.50 | 4.20 | 4.35 | 4.05 | 3.95 | 4.15 |
| Glossiness | 3.55 | 3.25 | 3.40 | 3.35 | 3.65 | 3.50 |
| Compact degree | 3.55 | 3.60 | 3.45 | 3.15 | 3.05 | 3.30 |
| Anti-wrinkle effect | 3.45 | 3.05 | 3.00 | 3.35 | 3.65 | 3.75 |
According to above-mentioned test result it is found that embodiment to moisturizing degree, glossiness, it is compact degree and anti-wrinkle effect improvement in terms of
Effect is all it is obvious that explanation has good containing the mask of the present invention containing the Chinese medicine composition with senile-resistant efficacy
The effect of anti-aging and nourishing for getting well, dry, obscure, relaxation skin can be allowed to be restored to, and water profit is soft and smooth, and gloss is fine and smooth, compact to fill
The health status being full of.
The Applicant declares that the present invention is explained by the above embodiments the Chinese traditional medicine composition with senile-resistant efficacy of the invention
Object and its preparation method and application, but the present invention is not limited to the above embodiments, that is, does not mean that the present invention must rely on
Stating embodiment could implement.It should be clear to those skilled in the art, any improvement in the present invention, produces to the present invention
The equivalence replacement of each raw material of product and addition, the selection of concrete mode of auxiliary element etc., all fall within protection scope of the present invention and
Within the open scope.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this
A little simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, can be combined in any appropriate way, in order to avoid unnecessary repetition, the present invention to it is various can
No further explanation will be given for the combination of energy.
Claims (10)
1. a kind of Chinese medicine composition, which is characterized in that the Chinese medicine composition prepares raw material by following mass percentage
Group is grouped as: tree peony 20-50%, gardenia 10-30%, Astragalus membranacus root 10-30%, glossy privet seed 10-30%.
2. Chinese medicine composition as described in claim 1, which is characterized in that the tree peony is derived from including peony, peony leaves, male
In red stem or tree peony root any one or at least two combination；
Preferably, the raw material for preparing of the Chinese medicine composition is grouped as by the group of following mass percentage: tree peony 35%, cape jasmine
Spend 25%, Astragalus membranacus root 25%, glossy privet seed 15%；
Preferably, the raw material for preparing of the Chinese medicine composition is grouped as by the group of following mass percentage: tree peony 35%, cape jasmine
Spend 20%, Astragalus membranacus root 20%, glossy privet seed 25%.
3. the preparation method of Chinese medicine composition as claimed in claim 1 or 2, which is characterized in that the preparation method includes such as
Lower step:
(1) medicinal material pre-processes: after tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed respectively, then being broken into powder, mixes
To mixed-powder；
(2) primary to extract: first being added in the mixed-powder obtained to step (1) and extracts reagent, is impregnated, will extract later
Liquid filtering, concentration, drying, obtain dried powder；
(3) second extraction: second is added in the dried powder obtained to step (2) and extracts reagent, carries out ultrasonic extraction, obtains thick
Extracting solution to get arrive the Chinese medicine composition.
4. the preparation method of Chinese medicine composition as claimed in claim 3, which is characterized in that step (1) is described to process tree peony
Method particularly includes: it takes tree peony to be washed with deionized water, removes the xylem fractionation exocuticle of root and stem, wherein exocuticle is in 5-
Fried dry after dipping 1-5h in 20% ethanol water, wherein colored and leaf is dried at 40-80 DEG C；
Preferably, step (1) it is described by gardenia process method particularly includes: take gardenia to be washed with deionized water, in 40-80
It is dried at DEG C；
Preferably, step (1) is described processes Astragalus membranacus root method particularly includes: Astragalus membranacus root is taken to be washed with deionized water
Only, after steaming 3-5h at 60-100 DEG C, the dry 5-10h at 50-80 DEG C, the dry 1-12h at 20-30 DEG C, finally again
The dry 5-10h at 50-80 DEG C；
Preferably, step (1) the glossy privet seed processes method particularly includes: takes glossy privet seed to be washed with deionized water, removes impurity
And carpopodium, it is sealed in the acetic acid aqueous solution that concentration is 1-10%, water proof heats 3-8h, is dried at 50-80 DEG C；
Preferably, the granularity of step (1) described powder is 60-100 mesh.
5. the preparation method of Chinese medicine composition as described in claim 3 or 4, which is characterized in that step (2) described first is extracted
Solvent is 40-80% ethanol water；
Preferably, the mass ratio of step (2) first Extraction solvent and the mixed-powder is (8-20): 1；
Preferably, the temperature of step (2) described immersion is 40-70 DEG C；
Preferably, the number of step (2) described immersion is 2-6 times, each 2-3h；
Preferably, step (2) concentration is reduced pressure；
Preferably, step (2) drying is vacuum drying, and drying temperature is 40-70 DEG C.
6. the preparation method of the Chinese medicine composition as described in any one of claim 3-5, which is characterized in that step (3) is described
Second extracts reagent as deionized water；
Preferably, the mass ratio of step (3) second Extraction solvent and the dried powder is (10-20): 1；
Preferably, the power of step (3) described ultrasonic extraction is 30-80KHz；
Preferably, the temperature of step (3) described ultrasonic extraction is 40-80 DEG C；
Preferably, the time of step (3) described ultrasonic extraction is 30-100min.
7. a kind of Chinese medicine composition concentrate, which is characterized in that the Chinese medicine composition concentrate is by claims 1 or 2 institute
What the Chinese medicine composition process stated was purified and was concentrated to get.
8. the preparation method of Chinese medicine composition concentrate as claimed in claim 7, which is characterized in that the preparation method includes
Following steps:
(I) it purifies: the Chinese medicine composition being obtained into filtrate with filtering with microporous membrane, then filtrate is washed with macroreticular resin
It is de-, obtain eluent；
(II) it is concentrated: the eluent that step (I) obtains is concentrated；
Preferably, the aperture of step (I) described miillpore filter is 0.2-0.5 μm；
Preferably, the model D101 or AB-8 of step (I) described macroporous resin column；
Preferably, eluent used in step (I) described elution is 70% ethanol water；
Preferably, described be concentrated in vacuum concentrator of step (II) is concentrated, and temperature is 40-80 DEG C；
Preferably, step (II) concentration is 1:(5- for the mass ratio for being concentrated into whole quality and step (1) described mixed-powder
20)。
9. the preparation method of Chinese medicine composition concentrate as claimed in claim 8, which is characterized in that the preparation method includes
Following steps:
(1) medicinal material pre-processes: after tree peony, gardenia, Astragalus membranacus root, glossy privet seed are processed respectively, then being broken into powder, mixes
To mixed-powder；
(2) primary to extract: 40-80% ethanol water to be added in the mixed-powder obtained to step (1), with the mixed powder
The mass ratio at end is (8-20): 1；It carries out impregnating 2-6 times, each 2-3h at 40-70 DEG C, later by extracting solution filtering, decompression
Concentration is dried in vacuo at 40-70 DEG C, obtains dried powder；
(3) second extraction: deionized water is added in the dried powder obtained to step (2), the quality with the dried powder
Than for (10-20): 1；Ultrasonic extraction 30-100min is carried out at 40-80 DEG C, ultrasonic power 30-80KHz obtains coarse extraction
Liquid to get arrive the Chinese medicine composition；
(4) it purifies: the Chinese medicine composition that step (3) obtains being obtained into filtrate with 0.2-0.5 μm of filtering with microporous membrane, then uses model
Macroreticular resin for D101 or AB-8 elutes filtrate, and eluent is 70% ethanol water, obtains eluent；
(5) it is concentrated: the eluent that step (4) obtains being concentrated in 40-80 DEG C of vacuum concentrator, is concentrated into whole quality
Mass ratio with step (1) described mixed-powder is 1:(5-20).
10. a kind of cosmetics, which is characterized in that include in as claimed in claim 1 or 2 in the raw material composition of the cosmetics
Drug composition includes Chinese medicine composition concentrate as claimed in claim 7；
Preferably, the cosmetics are lotion, Essence or mask；
Preferably, the additive amount of the Chinese medicine composition or Chinese medicine composition concentrate in cosmetics is 0.1-30%, preferably
0.5-20%；
It preferably, further include additive in the raw material composition of the cosmetics, the additive includes solvent, emulsifier, anti-corrosion
In agent or thickener any one or at least two combination.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811585039.9A CN109331074B (en) | 2018-12-24 | 2018-12-24 | Traditional Chinese medicine composition with anti-aging effect and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811585039.9A CN109331074B (en) | 2018-12-24 | 2018-12-24 | Traditional Chinese medicine composition with anti-aging effect and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109331074A true CN109331074A (en) | 2019-02-15 |
| CN109331074B CN109331074B (en) | 2021-09-24 |
Family
ID=65297087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811585039.9A Active CN109331074B (en) | 2018-12-24 | 2018-12-24 | Traditional Chinese medicine composition with anti-aging effect and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109331074B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113753A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Spot curing and beautifying preparation |
| CN105106756A (en) * | 2015-09-23 | 2015-12-02 | 谢桂斌 | Traditional Chinese medicine composition for treating age pigment |
| CN106074826A (en) * | 2016-07-15 | 2016-11-09 | 王旭时 | A kind of multi-functional Chinese medicine preparation and preparation method thereof |
| CN108836933A (en) * | 2018-07-26 | 2018-11-20 | 卜俊超 | A kind of preparation method of the anti-wrinkle Essence containing peony extract |
-
2018
- 2018-12-24 CN CN201811585039.9A patent/CN109331074B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113753A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Spot curing and beautifying preparation |
| CN105106756A (en) * | 2015-09-23 | 2015-12-02 | 谢桂斌 | Traditional Chinese medicine composition for treating age pigment |
| CN106074826A (en) * | 2016-07-15 | 2016-11-09 | 王旭时 | A kind of multi-functional Chinese medicine preparation and preparation method thereof |
| CN108836933A (en) * | 2018-07-26 | 2018-11-20 | 卜俊超 | A kind of preparation method of the anti-wrinkle Essence containing peony extract |
Non-Patent Citations (1)
| Title |
|---|
| 吴大真，王雷著: "《花样女人美丽一生》", 31 January 2015, 河北科学技术出版社 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109331074B (en) | 2021-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102641233B (en) | Rhodiola crenulata facial mask with whitening and moisturizing effects | |
| CN112494406A (en) | Whitening and freckle-removing cosmetic and preparation method thereof | |
| CN101849899A (en) | Chinese medicinal compound extract and cosmetics comprising same as active ingredient | |
| CN109157447B (en) | Application of cherokee rose fruit extract in whitening, moisturizing and anti-aging skin care product and preparation method thereof | |
| CN104784507A (en) | Traditional Chinese medicine composition with multiple cosmetic effects and application | |
| CN108938493A (en) | A kind of Chinese medicine composition and its preparation method and application | |
| CN110585048A (en) | Composition with anti-saccharification and anti-oxidation functions and application thereof | |
| CN108714126A (en) | Skin care compositions and the preparation method and application thereof with moisturizing and anti-oxidation efficacy | |
| CN110742843B (en) | Anti-aging traditional Chinese medicine extract of ginseng and glossy ganoderma as well as preparation method and application thereof | |
| CN113304093A (en) | Preparation method of cosmetic raw material composition with whitening and skin-care effects and cosmetic containing raw material composition | |
| CN102871932B (en) | All natural ingredient hair dye and preparation method thereof | |
| CN107951800A (en) | A kind of Chinese medicine composition that there is anti-ageing anti-wrinkle lifting and compact and preparation method thereof | |
| CN108096145A (en) | A kind of delay aging drug composition and its preparation method and application | |
| CN114099391A (en) | Cosmetic composition with whitening, moisturizing and antioxidant effects and preparation method thereof | |
| CN108670933B (en) | Skin care composition with moisturizing, whitening and anti-aging functions and application thereof | |
| CN113288854A (en) | Traditional Chinese medicine formula anti-aging whitening moisturizing mask and preparation method thereof | |
| CN108014056A (en) | Skin relaxes liquid living and method | |
| CN112587455A (en) | Plant composition and herbal whitening and freckle removing sleep mask gel | |
| CN102764226B (en) | Eyebrow nourishing liquid, and preparation method and application thereof | |
| CN109331074A (en) | A kind of Chinese medicine composition and its preparation method and application with senile-resistant efficacy | |
| CN109431951A (en) | A kind of Chinese medicine lightening compositions and preparation method thereof | |
| CN108066189A (en) | There is the anti-ageing ganoderma lucidum skin care compositions for dispelling yellow and its application | |
| CN114931523A (en) | Moistening, whitening and moisturizing essence and preparation method thereof | |
| CN106562913B (en) | External composition with whitening effect, cosmetic preparation and preparation method thereof | |
| CN110101648B (en) | Beauty-care concealer air cushion BB cream |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |