CN109331011A - 树胶脂毒素的用途及采用树胶脂毒素的药物 - Google Patents

树胶脂毒素的用途及采用树胶脂毒素的药物 Download PDF

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CN109331011A
CN109331011A CN201811272724.6A CN201811272724A CN109331011A CN 109331011 A CN109331011 A CN 109331011A CN 201811272724 A CN201811272724 A CN 201811272724A CN 109331011 A CN109331011 A CN 109331011A
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resiniferatoxin
drug
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周笑涵
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/02—Nasal agents, e.g. decongestants

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Abstract

本发明公开了树胶脂毒素的用途及采用树胶脂毒素的药物，树胶脂毒素用于制作治疗高反应性鼻炎的药物，采用树胶脂毒素的药物，可取树胶脂毒素原液，用0.9％的生理盐水稀释成0.1～1μmol/L的溶液，然后在溶液中加入聚碘维酮2.0g/L、无水乙醇20ml/L，摇匀后形成药液保藏，药液装入鼻腔喷雾瓶中，药液雾化后使用。本发明用药次数少，治疗效果好，对患者刺激性小。

Description

树胶脂毒素的用途及采用树胶脂毒素的药物
技术领域
本发明涉及药物技术领域，特别涉及一种树胶脂毒素的用途及采用树胶脂毒素的药物。
背景技术
鼻炎是临床上最常见的疾病，以发作性鼻痒、喷嚏、流涕为主要症状的鼻炎称之为“高反应性鼻炎”，主要包括“过敏性鼻炎(变应性鼻炎)、血管运动性鼻炎”。目前，治疗高反应性鼻炎的方法主要为鼻用激素、抗组胺、抗白三烯等药抗炎、抗过敏，脱敏治疗，以及中药制剂等。总体来说，这些治疗的效果是暂时控制症状，每天必须用药，停药即复发。
树胶脂毒素(resiniferatoxin，RTX)是从大戟类树胶植物的乳汁中分离出来的一种超强的辣椒素同源物，其具有与辣椒素相似的生物学活性；辣椒素类药物能选择性抑制痛觉神经，而对正常的触压觉、本体感觉和运动神经无影响。
发明内容
本发明是为了解决现有治疗高反应性鼻炎的药物治疗的效果只是暂时控制症状，每天必须用药，停药即复发的问题，提供一种树胶脂毒素的用途及采用树胶脂毒素的药物，只需用药数次，即可数周、数月控制甚至治愈鼻炎症状。
为了实现上述目的，本发明采用以下技术方案，树胶脂毒素的用途，所述的树胶脂毒素用于制作治疗高反应性鼻炎的药物。
采用树胶脂毒素的药物，取树胶脂毒素原液，用0.9％的生理盐水稀释成0.1～1μmol/L的溶液，然后在溶液中加入聚碘维酮2.0g/L、无水乙醇20ml/L，摇匀后形成药液保藏。本方案提出的各组分用量，可以等比增加或减少。
作为优选，所述的药液装入鼻腔喷雾瓶中，所述药液雾化后使用。
高反应性鼻炎患者鼻腔粘膜神经末梢存在高敏感的辣椒素受体，在过敏原、各种理化因素刺激下发作鼻痒、喷嚏、流涕，应用辣椒素受体脱敏剂-辣椒素鼻腔喷雾或鼻腔局部涂药能有效的治疗高反应性鼻炎，但辣椒素治疗的最大缺点是刺激性过强，限制了其使用，并没有在临床推广使用；树胶脂毒素RTX与辣椒素为同源物，具有与辣椒素相似的生物学活性，本发明采用一种与辣椒素治疗原理完全不同的、快速神经脱敏疗法，筛选出用树胶脂毒素制备成鼻用药剂，只需用药数次，即可数周、数月控制甚至治愈鼻炎症状，而且没有明显毒副作用。并且具有明显的优点：1、无明显的刺激性，基本上没有疼痛感觉；2、作用强大，RTX的作用强度比辣椒素高1 000倍；3、脱敏效果好，持续时间比辣椒素长，使用次数少。
因此，本发明具有如下有益效果：用药次数少，治疗效果好，对患者刺激性小。
具体实施方式
下面对本发明做进一步的描述。
树胶脂毒素的用途，树胶脂毒素用于制作治疗高反应性鼻炎的药物；
采用树胶脂毒素的药物，取树胶脂毒素原液，用0.9％的生理盐水稀释成0.1mol/L，或者0.5mol/L，或者1μmol/L的溶液，然后在溶液中加入聚碘维酮2.0g/L、无水乙醇20ml/L，摇匀后形成药液保藏；
药液装入鼻腔喷雾瓶中，药液雾化后使用。
具体使用过程是，制取药液后，装入市场常用的5ml鼻腔喷雾瓶，患者将喷雾瓶喷嘴伸入鼻腔，连续喷雾两揿，每天1次，连用3天～1周，重症者可连续用2周，即可达到较佳效果。

Claims (3)

1.一种树胶脂毒素的用途，其特征在于，所述的树胶脂毒素用于制作治疗高反应性鼻炎的药物。
2.一种采用树胶脂毒素的药物，其特征在于，取树胶脂毒素原液，用0.9％的生理盐水稀释成0.1～1μmol/L的溶液，然后在溶液中加入聚碘维酮2.0g/L、无水乙醇20ml/L，摇匀后形成药液保藏。
3.根据权利要求2所述的采用树胶脂毒素的药物，其特征是，所述的药液装入鼻腔喷雾瓶中，所述药液雾化后使用。
CN201811272724.6A 2018-10-30 2018-10-30 树胶脂毒素的用途及采用树胶脂毒素的药物 Pending CN109331011A (zh)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020867A1 (en) * 1996-11-15 1998-05-22 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pharmaceutical compositions containing vanilloid agonists in combination with vanilloid antagonists
CN104906029A (zh) * 2015-05-22 2015-09-16 中山瑞福医疗器械科技有限公司 一种鼻腔制剂及其制备方法和应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020867A1 (en) * 1996-11-15 1998-05-22 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pharmaceutical compositions containing vanilloid agonists in combination with vanilloid antagonists
CN104906029A (zh) * 2015-05-22 2015-09-16 中山瑞福医疗器械科技有限公司 一种鼻腔制剂及其制备方法和应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
小林太刀夫: "《图说家庭医学大典》", 31 January 2002, 文汇出版社 *
李笑敏等: "复方聚维酮碘滴鼻液的制备", 《中国基层医药》 *

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