CN109330910A - It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted - Google Patents
It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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Abstract
Sprayable emulsion is prepared using inside and outside phase density difference is adjusted the invention discloses a kind of, belong to cosmetic field, by weight, including following ingredient: 2~20 parts of Sucrose acetoisobutyrate, 3~18 parts of caprylic/capric triglyceride, 2~15 parts of glycerol, 0.1~6 part of trehalose, 0.1~0.5 part of EDETATE SODIUM, 0.05~2 part of organic acid, 0.1~0.5 part of pungent glycol, 0.05~2 part of Sensiva SC50,0.2~5 part of 1,3-PD, surplus are water.The present invention adjusts inside and outside phase density greater than 1 food additives Sucrose acetoisobutyrate to prepare stable low viscosity sprayable emulsion by selection density, solves that existing emulsion viscosity is big, the poor technical problem of stability.
Description
Technical field
The present invention relates to cosmetic field, in particular to it is a kind of prepared using inside and outside phase density difference is adjusted sprayable emulsion and
Preparation method.
Background technique
Routine application class product item of the lotion as adult nursing product is generally divided into oil-in-water type and Water-In-Oil by emulsification type
Two kinds of systems of type, lotion on the market are mostly viscosity 2500mPa.S or so, have half mobility or nonflowing character, cannot be good
Manner of packing applied to the aerosol type container with spray head.It is most in terms of protective system to use conventional preservatives ingredient, office
It is sex-limited larger, and easily cause the bad association of consumer.
Patent No. 201710366738.3, patent name was a kind of patent that microemulsion is spraying, on September 20th, 2017
Specific open the following contents: by weight, 1 part of oil components, 0.25 part of emulsifier, PEG 30-80mol, ion inactive
0.75-0.80 parts of agent, it is sprayed base-material 99-110 parts, the translucent microemulsion that can be prepared has by spraying to be sprayed not with existing
The same appearance, and by the oil components increase-volume translucent of existing lotion and height can be stablized, there is it to skin fine
Moisturizing, supplement oil, increase skin water lock moistening effect.
But technical solution disclosed in the patent of invention can not make existing sprayable emulsion have extremely low viscosity and
Stability is good, and conventional mating ejection can be used, do not add preservative, the technology for enabling consumers to that large area is facilitated to use is asked
Topic.
Summary of the invention
Sprayable emulsion and preparation method are prepared using inside and outside phase density difference is adjusted the purpose of the present invention is to provide a kind of,
The sprayable emulsion has extremely low viscosity, and conventional mating ejection can be used, and more convenient large area uses；Avoid people to conventional anti-
Fear caused by the adding ingredients such as rotten agent, it is above-mentioned described in background technology to solve the problems, such as.
To achieve the above object, the invention provides the following technical scheme: a kind of prepared using inside and outside phase density difference is adjusted
Sprayable emulsion, it is characterised in that: by weight, including following ingredient: 2~20 parts of Sucrose acetoisobutyrate, caprylic/capric
3~18 parts of triglycerides, 2~15 parts of glycerol, 0.1~6 part of trehalose, 0.1~0.5 part of EDETATE SODIUM, organic acid 0.05~
2 parts, 0.1~0.5 part of pungent glycol, 0.05~2 part of Sensiva SC50,0.2~5 part of 1,3- propylene glycol, surplus be water.
Further, the glycosyl of the Sucrose acetoisobutyrate is the food grade sucrose molecule of plant origin, has life
Object degradation property and toxicologic properties can enhance the stability of oily phase in formula system, and density is 1.15g/ml (25 DEG C), lead to
The phase density of the oily phase of adjustment is crossed to adjust inside and outside phase density.
Further, the caprylic/capric triglyceride is that height clearly spends tasteless grease, relative density 0.920-
0.960g/ml(25℃)。
Further, the derivative of the caprylic/capric triglyceride category palm oil or coconut oil, frequently as moisturizing factor
Base-material.
Further, the Cremophor RH40 is a kind of nonionic solubilizer and emulsifier.
Further, the organic acid is decoyl hydroximic acid, has selective chelation.
Further, EDETATE SODIUM can chelated metal ions, for overcome may occur change
Color phenomenon.
In addition, the preparation method of sprayable emulsion is prepared using inside and outside phase density difference is adjusted the invention also discloses a kind of,
Include the following steps:
S1: Sucrose acetoisobutyrate is weighed by specified amount and is put into oily phase pot, heating is opened, is heated to 75 while stirring
DEG C, it makes it completely dissolved；
S2: after component is completely dissolved in step 1, caprylic/capric triglyceride is weighed, Cremophor RH40 is thrown
Enter in oily phase pot, be heated to 90-95 DEG C, stirring is to being completely dissolved and 15-30min is kept to sterilize；
S3: weighing deionized water by specified amount and be put into kettle, opens high-speed stirred, and EDETATE SODIUM, seaweed are added one by one
Sugar and glycerol stir 10-20min to after being uniformly dispersed；
S4: kettle heating is opened, is heated to 90-95 DEG C while stirring, and 15-30min is kept to sterilize；
S5: opening vacuum, and the ingredient in kettle is pumped into emulsion pot, and the ingredient in oily phase pot is then pumped into emulsion pot
In, high-speed stirred 10-20min；
S6: opening cooling water, slow down speed of agitator, continues stirring cooling；
S7: 45 DEG C are cooled to hereinafter, according to the rules by organic acid, pungent glycol, Sensiva SC50,1,3-PD
Amount is added in emulsion pot, and unlatching stirs at low speed, and continues to stir 5-10min, process keeps negative pressure；
S8: it is cooled to 38-44 DEG C, sampling, it is qualified to examine, filtering and discharging.
Compared with prior art, the beneficial effects of the present invention are:
1. by selecting density inside and outside to adjust for the food additives Sucrose acetoisobutyrate of 1.15g/ml (25 DEG C)
Phase density keeps inside and outside phase density close, and the low viscosity stability of emulsion prepared when the density contrast of interior foreign minister is smaller is better.
2. the present invention, which is not added with, limits the use of preservative ingredient, it is not easy to cause during consumer's purchase is with use bad
Think.
3. solving existing half mobility or nonflowing character lotion being applied to extrusion type more, it is not easily applicable to aerosol type
Status.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical solution in the embodiment of the present invention carries out clear；Completely retouch
It states, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments, based on the present invention
In embodiment, every other implementation obtained by those of ordinary skill in the art without making creative efforts
Example, shall fall within the protection scope of the present invention.
Embodiment one:
It is a kind of to prepare sprayable emulsion using inside and outside phase density difference is adjusted, by weight, including following ingredient: acetic acid is different
2 parts of butyric acid sucrose ester, 3 parts of caprylic/capric triglyceride, 2 parts of glycerol, 0.1 part of trehalose, 0.1 part of EDETATE SODIUM, organic acid
0.05 part of class, 0.1 part of pungent glycol, 0.05 part of Sensiva SC50,0.2 part of 1,3- propylene glycol, surplus are water.
It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted, comprising the following steps:
Step 1: Sucrose acetoisobutyrate is weighed by specified amount and is put into oily phase pot, heating is opened, heats while stirring
To 75 DEG C, make it completely dissolved；
Step 2: after component is completely dissolved in step 1, caprylic/capric triglyceride, Cremophor RH40 are weighed
It puts into oily phase pot, is heated to 90-95 DEG C, stirring is to being completely dissolved and 15-30min is kept to sterilize；
Step 3: weighing deionized water by specified amount and be put into kettle, open high-speed stirred, one by one be added EDETATE SODIUM,
Trehalose and glycerol stir 10-20min to after being uniformly dispersed；
Step 4: kettle heating is opened, is heated to 90-95 DEG C while stirring, and 15-30min is kept to sterilize；
Step 5: opening vacuum, and the ingredient in kettle is pumped into emulsion pot, and the ingredient in oil cauldron is then pumped into emulsification
In pot, high-speed stirred 10-20min；
Step 6: opening cooling water, slow down speed of agitator, continues stirring cooling；
Step 7: 45 DEG C are cooled to hereinafter, by organic acid, pungent glycol, Sensiva SC50,1,3-PD according to rule
It is quantitatively adding in emulsion pot, unlatching stirs at low speed, and continues to stir 5-10min, process keeps negative pressure；
Step 8: it is cooled to 38-44 DEG C, sampling, it is qualified to examine, filtering and discharging.
Embodiment two:
It is a kind of to prepare sprayable emulsion using inside and outside phase density difference is adjusted, by weight, including following ingredient: acetic acid is different
8 parts of butyric acid sucrose ester, 10 parts of caprylic/capric triglyceride, 8 parts of glycerol, 3 parts of trehalose, 0.3 part of EDETATE SODIUM, organic acid
0.5 part, 0.3 part of pungent glycol, 1 part of Sensiva SC50,2 parts of 1,3- propylene glycol, surplus be water.
It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted, comprising the following steps:
Step 1: Sucrose acetoisobutyrate is weighed by specified amount and is put into oily phase pot, heating is opened, heats while stirring
To 75 DEG C, make it completely dissolved；
Step 2: after component is completely dissolved in step 1, caprylic/capric triglyceride, PEG-40 hydrogenated castor are weighed
Oil is put into oily phase pot, is heated to 90-95 DEG C, and stirring is to being completely dissolved and 15-30min is kept to sterilize；
Step 3: weighing deionized water by specified amount and be put into kettle, open high-speed stirred, one by one be added EDETATE SODIUM,
Trehalose and glycerol stir 10-20min to after being uniformly dispersed；
Step 4: kettle heating is opened, is heated to 90-95 DEG C while stirring, and 15-30min is kept to sterilize；
Step 5: opening vacuum, and the ingredient in kettle is pumped into emulsion pot, and the ingredient in oil cauldron is then pumped into emulsification
In pot, high-speed stirred 10-20min；
Step 6: opening cooling water, slow down speed of agitator, continues stirring cooling；
Step 7: 45 DEG C are cooled to hereinafter, by organic acid, pungent glycol, Sensiva SC50,1,3-PD according to rule
It is quantitatively adding in emulsion pot, unlatching stirs at low speed, and continues to stir 5-10min, process keeps negative pressure；
Step 8: it is cooled to 38-44 DEG C, sampling, it is qualified to examine, filtering and discharging.
Embodiment three:
It is a kind of to prepare sprayable emulsion using inside and outside phase density difference is adjusted, by weight, including following ingredient: acetic acid is different
6 parts of butyric acid sucrose ester, 10 parts of caprylic/capric triglyceride, 10 parts of glycerol, 2 parts of trehalose, 0.2 part of EDETATE SODIUM, organic acid
1.0 parts of class, 0.1 part of pungent glycol, 2 parts of Sensiva SC50,5 parts of 1,3- propylene glycol, surplus are water.
It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted, comprising the following steps:
Step 1: Sucrose acetoisobutyrate is weighed by specified amount and is put into oily phase pot, heating is opened, heats while stirring
It makes it completely dissolved；
Step 2: after component is completely dissolved in step 1, caprylic/capric triglyceride, PEG-40 hydrogenated castor are weighed
Oil is put into oily phase pot, is heated to 90-95 DEG C, and stirring is to being completely dissolved and 15-30min is kept to sterilize；
Step 3: weighing deionized water by specified amount and be put into kettle, open high-speed stirred, one by one be added EDETATE SODIUM,
Trehalose and glycerol stir 10-20min to after being uniformly dispersed；
Step 4: kettle heating is opened, is heated to 90-95 DEG C while stirring, and 15-30min is kept to sterilize；
Step 5: opening vacuum, and the ingredient in kettle is pumped into emulsion pot, and the ingredient in oil cauldron is then pumped into emulsification
In pot, high-speed stirred 10-20min；
Step 6: opening cooling water, slow down speed of agitator, continues stirring cooling；
Step 7: 45 DEG C are cooled to hereinafter, by organic acid, pungent glycol, Sensiva SC50,1,3-PD according to rule
It is quantitatively adding in emulsion pot, unlatching stirs at low speed, and continues to stir 5-10min, process keeps negative pressure；
Step 8: it is cooled to 38-44 DEG C, sampling, it is qualified to examine, filtering and discharging.
Example IV:
It is a kind of to prepare sprayable emulsion using inside and outside phase density difference is adjusted, by weight, including following ingredient: acetic acid is different
15 parts of butyric acid sucrose ester, 15 parts of caprylic/capric triglyceride, 13 parts of glycerol, 4 parts of trehalose, 0.4 part of EDETATE SODIUM, organic acid
1 part of class, 0.3 part of pungent glycol, 1 part of Sensiva SC50,3 parts of 1,3- propylene glycol, surplus are water.
It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted, comprising the following steps:
Step 1: Sucrose acetoisobutyrate is weighed by specified amount and is put into oily phase pot, heating is opened, heats while stirring
It makes it completely dissolved；
Step 2: after component is completely dissolved in step 1, caprylic/capric triglyceride, PEG-40 hydrogenated castor are weighed
Oil is put into oily phase pot, is heated to 90-95 DEG C, and stirring is to being completely dissolved and 15-30min is kept to sterilize；
Step 3: weighing deionized water by specified amount and be put into kettle, open high-speed stirred, one by one be added EDETATE SODIUM,
Trehalose and glycerol stir 10-20min to after being uniformly dispersed；
Step 4: kettle heating is opened, is heated to 90-95 DEG C while stirring, and 15-30min is kept to sterilize；
Step 5: opening vacuum, and the ingredient in kettle is pumped into emulsion pot, and the ingredient in oil cauldron is then pumped into emulsification
In pot, high-speed stirred 10-20min；
Step 6: opening cooling water, slow down speed of agitator, continues stirring cooling；
Step 7: 45 DEG C are cooled to hereinafter, by organic acid, pungent glycol, Sensiva SC50,1,3-PD according to rule
It is quantitatively adding in emulsion pot, unlatching stirs at low speed, and continues to stir 5-10min, process keeps negative pressure；
Step 8: it is cooled to 38-44 DEG C, sampling, it is qualified to examine, filtering and discharging.
Embodiment five:
It is a kind of to prepare sprayable emulsion using inside and outside phase density difference is adjusted, by weight, including following ingredient: acetic acid is different
20 parts of butyric acid sucrose ester, 18 parts of caprylic/capric triglyceride, 15 parts of glycerol, 6 parts of trehalose, 0.5 part of EDETATE SODIUM, organic acid
2 parts of class, pungent glycol
0.5 part, 2 parts of Sensiva SC50,5 parts of 1,3- propylene glycol, surplus be water.
It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted, comprising the following steps:
Step 1: Sucrose acetoisobutyrate is weighed by specified amount and is put into oily phase pot, heating is opened, heats while stirring
It makes it completely dissolved；
Step 2: after component is completely dissolved in step 1, caprylic/capric triglyceride, PEG-40 hydrogenated castor are weighed
Oil is put into oily phase pot, is heated to 90-95 DEG C, and stirring is to being completely dissolved and 15-30min is kept to sterilize；
Step 3: weighing deionized water by specified amount and be put into kettle, open high-speed stirred, one by one be added EDETATE SODIUM,
Trehalose and glycerol stir 10-20min to after being uniformly dispersed；
Step 4: kettle heating is opened, is heated to 90-95 DEG C while stirring, and 15-30min is kept to sterilize；
Step 5: opening vacuum, and the ingredient in kettle is pumped into emulsion pot, and the ingredient in oil cauldron is then pumped into emulsification
In pot, high-speed stirred 10-20min；
Step 6: opening cooling water, slow down speed of agitator, continues stirring cooling；
Step 7: 45 DEG C are cooled to hereinafter, by organic acid, pungent glycol, Sensiva SC50,1,3-PD according to rule
It is quantitatively adding in emulsion pot, unlatching stirs at low speed, and continues to stir 5-10min, process keeps negative pressure；
Step 8: it is cooled to 38-44 DEG C, sampling, it is qualified to examine, filtering and discharging.
Comparative example:
A kind of common lotion on the market, the ingredient comprising following weight proportion: 8 parts of glycerol, PEG-100 stearate 1
Part, 1 part of stearine, PEG-40 anhydrous sorbitol are hard
0.5 part of resin acid ester, 0.5 part of Phosphoric acid monohexadecyl ester potassium, 2 parts of cetanol, 5 parts of dormant oil, 3 parts of dimethyl silicone polymer,
0.3 part of carbomer, 0.06 part of sodium hydroxide, 0.72 part of Phenoxyethanol, 0.08 part of Sensiva SC50,0.05 part of EDETATE SODIUM,
0.3 part of essence, surplus are water.
A kind of preparation method of common lotion on the market, comprising the following steps:
Step 1: by PEG-100 stearate, stearine, PEG-40 Span60, cetanol
Phosphate potassium, cetanol, dormant oil, dimethyl silicone polymer are added in oily phase pot after mixing according to dosage part, are heated to 90-95
DEG C, stirring is to being completely dissolved and 15min is kept to sterilize；
Step 2: being put into kettle for water, and opening stirring has bigger whirlpool seat, opens stirring and EDTA bis- is added one by one
Sodium, carbomer, glycerol, 5-10min is to being completely dispersed for stirring；
Step 3: kettle heating is opened, is heated to 90-95 DEG C while stirring, and 15min is kept to sterilize；
Step 4: opening vacuum, and the ingredient in kettle is pumped into emulsion pot, and the ingredient in oil cauldron is then pumped into emulsification
In pot, 5-10min is stirred；
Step 5: keeping negative pressure, starting homogeneous switch, and the time is set as 3-6min；
Step 6: opening cooling water temperature, slows down speed of agitator, and process keeps negative pressure；
Step 7: sodium hydroxide is added according to deal when being cooled to 50 DEG C, stirs at low speed 5-15min；
Step 8: 45 DEG C are cooled to hereinafter, by Phenoxyethanol, Sensiva SC50, essence addition emulsion pot, continues to stir
3-5min is mixed, process keeps negative pressure；
Step 9: it is cooled to 38-44 DEG C, sampling, it is qualified to examine, filtering and discharging.
Component Sucrose acetoisobutyrate is adjusted that inside and outside phase density is not added in comparative example, and conventional emulsifier is utilized
Emulsification system, wherein causing the lotion prepared to have higher to make stable system joined carbomer as thickener
Viscosity, and can not be sprayed using common spraying device, secondly joined in comparative example and limit the use of preservative Phenoxyethanol,
Easily cause the bad association of consumer during consumer's purchase and use.
In conclusion a kind of prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted, it is close by selecting
Degree is greater than 1 food additives Sucrose acetoisobutyrate to adjust inside and outside phase density, keeps inside and outside phase density close, when inside and outside
The low viscosity stability of emulsion that phase density difference more hour prepares is better.Secondly, the present invention, which is not added with, limits the use of preservative ingredient,
It is not easy to cause bad association during consumer's purchase is with use, the emulsion viscosity for solving existing lotion is big, stability
The technical problems such as poor, while consumer is more trusted when in use.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art within the technical scope of the present disclosure, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (8)
1. a kind of prepare sprayable emulsion using inside and outside phase density difference is adjusted, it is characterised in that: by weight, including as follows at
Point: 2~20 parts of Sucrose acetoisobutyrate, 3~18 parts of caprylic/capric triglyceride, 2~15 parts of glycerol, trehalose 0.1~6
Part, 0.1~0.5 part of EDETATE SODIUM, 0.05~2 part of organic acid, 0.1~0.5 part of pungent glycol, Sensiva SC50 0.05~2
Part, 0.2~5 part of 1,3- propylene glycol, surplus are water.
2. a kind of sprayable emulsion is prepared using inside and outside phase density difference is adjusted according to claim 1, it is characterised in that: second
The glycosyl of sour isobutyric acid sucrose ester is the food grade sucrose molecule of plant origin, has biodegradability and toxicologic properties,
The stability of oily phase can be enhanced in formula system, density is 1.15g/ml (25 DEG C), is adjusted by adjusting the phase density of oily phase
Whole inside and outside phase density.
3. a kind of sprayable emulsion is prepared using inside and outside phase density difference is adjusted according to claim 1, it is characterised in that: pungent
Acid/Triglyceride DDD is that height clearly spends tasteless grease, and relative density is 0.920-0.960g/ml (25 DEG C).
4. a kind of sprayable emulsion is prepared using inside and outside phase density difference is adjusted according to claim 3, it is characterised in that: institute
The derivative for stating caprylic/capric triglyceride category palm oil or coconut oil, frequently as the base-material of moisturizing factor.
5. a kind of sprayable emulsion is prepared using inside and outside phase density difference is adjusted according to claim 1, it is characterised in that: institute
Stating Cremophor RH40 is a kind of nonionic solubilizer and emulsifier.
6. a kind of sprayable emulsion is prepared using inside and outside phase density difference is adjusted according to claim 1, it is characterised in that: institute
Stating organic acid is decoyl hydroximic acid, has selective chelation.
7. according to claim 1 a kind of sprayable emulsion is prepared using inside and outside phase density difference is adjusted, it is characterised in that:
EDETATE SODIUM can chelated metal ions, for overcome may occur metachromatism.
8. a kind of preparation according to claim 1-7 for preparing sprayable emulsion using phase density difference inside and outside adjusting
Method, characterized by the following steps:
S1: weighing Sucrose acetoisobutyrate by specified amount and put into oily phase pot, open heating, be heated to 75 DEG C while stirring,
It makes it completely dissolved；
S2: after component is completely dissolved in step 1, caprylic/capric triglyceride is weighed, Cremophor RH40 puts into oily phase
In pot, it is heated to 90-95 DEG C, stirring is to being completely dissolved and 15-30min is kept to sterilize；
S3: weighing deionized water by specified amount and be put into kettle, open high-speed stirred, one by one be added EDETATE SODIUM, trehalose and
Glycerol stirs 10-20min to after being uniformly dispersed；
S4: kettle heating is opened, is heated to 90-95 DEG C while stirring, and 15-30min is kept to sterilize；
S5: opening vacuum, and the ingredient in kettle is pumped into emulsion pot, and then the ingredient in oily phase pot is pumped into emulsion pot,
High-speed stirred 10-20min；
S6: opening cooling water, slow down speed of agitator, continues stirring cooling；
S7: 45 DEG C are cooled to hereinafter, organic acid, pungent glycol, Sensiva SC50,1,3-PD are measured addition according to the rules
In emulsion pot, unlatching is stirred at low speed, and continues to stir 5-10min, process keeps negative pressure；
S8: it is cooled to 38-44 DEG C, sampling, it is qualified to examine, filtering and discharging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811349588.6A CN109330910A (en) | 2018-11-14 | 2018-11-14 | It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811349588.6A CN109330910A (en) | 2018-11-14 | 2018-11-14 | It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109330910A true CN109330910A (en) | 2019-02-15 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110025497A (en) * | 2019-04-12 | 2019-07-19 | 广州玮弘祺生物科技有限公司 | A kind of sunscreen composition and preparation method thereof containing Sucrose acetoisobutyrate |
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| CN1942166A (en) * | 2004-04-19 | 2007-04-04 | 伊斯曼化学公司 | Skin care compositions |
| CN108542845A (en) * | 2018-05-20 | 2018-09-18 | 山东朱氏药业集团有限公司 | A kind of skin care sunscreen spray and preparation method thereof |
| CN108721132A (en) * | 2018-05-30 | 2018-11-02 | 上海中翊日化有限公司 | A kind of suspension oil droplet toner and preparation method thereof containing Sucrose acetoisobutyrate |
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| CN108542845A (en) * | 2018-05-20 | 2018-09-18 | 山东朱氏药业集团有限公司 | A kind of skin care sunscreen spray and preparation method thereof |
| CN108721132A (en) * | 2018-05-30 | 2018-11-02 | 上海中翊日化有限公司 | A kind of suspension oil droplet toner and preparation method thereof containing Sucrose acetoisobutyrate |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110025497A (en) * | 2019-04-12 | 2019-07-19 | 广州玮弘祺生物科技有限公司 | A kind of sunscreen composition and preparation method thereof containing Sucrose acetoisobutyrate |
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Application publication date: 20190215 |