CN110025497A - A kind of sunscreen composition and preparation method thereof containing Sucrose acetoisobutyrate - Google Patents
A kind of sunscreen composition and preparation method thereof containing Sucrose acetoisobutyrate Download PDFInfo
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- CN110025497A CN110025497A CN201910294100.2A CN201910294100A CN110025497A CN 110025497 A CN110025497 A CN 110025497A CN 201910294100 A CN201910294100 A CN 201910294100A CN 110025497 A CN110025497 A CN 110025497A
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- Prior art keywords
- ester
- peg
- sunscreen
- poly
- sunscreen composition
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- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 119
- 239000000203 mixture Substances 0.000 title claims abstract description 114
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 81
- UVGUPMLLGBCFEJ-SWTLDUCYSA-N sucrose acetate isobutyrate Chemical compound CC(C)C(=O)O[C@H]1[C@H](OC(=O)C(C)C)[C@@H](COC(=O)C(C)C)O[C@@]1(COC(C)=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@@H](COC(C)=O)O1 UVGUPMLLGBCFEJ-SWTLDUCYSA-N 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 238000006243 chemical reaction Methods 0.000 claims abstract description 38
- 239000007787 solid Substances 0.000 claims abstract description 36
- 238000003756 stirring Methods 0.000 claims abstract description 29
- 239000002270 dispersing agent Substances 0.000 claims abstract description 23
- 238000010792 warming Methods 0.000 claims abstract description 15
- 239000012535 impurity Substances 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 10
- -1 Pentyl ester Chemical class 0.000 claims description 64
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 26
- KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-Hydroxyoctadecanoic acid Natural products CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 claims description 21
- 229930006000 Sucrose Natural products 0.000 claims description 20
- 239000005720 sucrose Substances 0.000 claims description 20
- 150000002148 esters Chemical class 0.000 claims description 17
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 16
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 claims description 13
- 238000000265 homogenisation Methods 0.000 claims description 12
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 claims description 11
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 claims description 11
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 11
- 229940068171 ethyl hexyl salicylate Drugs 0.000 claims description 11
- 229960004881 homosalate Drugs 0.000 claims description 11
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 11
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical compound C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims description 9
- 229960000601 octocrylene Drugs 0.000 claims description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 9
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims description 8
- VKOYQDIAMIJENL-UHFFFAOYSA-N 3-ethyl-2-hexoxyphenol Chemical compound CCCCCCOC1=C(O)C=CC=C1CC VKOYQDIAMIJENL-UHFFFAOYSA-N 0.000 claims description 8
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
- 229910000420 cerium oxide Inorganic materials 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- JDRSMPFHFNXQRB-IBEHDNSVSA-N decyl glucoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JDRSMPFHFNXQRB-IBEHDNSVSA-N 0.000 claims description 8
- 229960001679 octinoxate Drugs 0.000 claims description 8
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 claims description 8
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
- 229920001296 polysiloxane Polymers 0.000 claims description 8
- 239000004408 titanium dioxide Substances 0.000 claims description 8
- 239000011787 zinc oxide Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- KQNPFQTWMSNSAP-UHFFFAOYSA-N alpha-isobutyric acid Natural products CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims description 7
- 239000012964 benzotriazole Substances 0.000 claims description 7
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 claims description 7
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 7
- RRLOOYQHUHGIRJ-UHFFFAOYSA-M sodium;ethyl sulfate Chemical compound [Na+].CCOS([O-])(=O)=O RRLOOYQHUHGIRJ-UHFFFAOYSA-M 0.000 claims description 7
- KGNFCMBVSSCAGC-UHFFFAOYSA-N C(=O)OC(C1=CC=CC=C1)=O.C(C)N(OC1=CC=CC=C1)CC Chemical compound C(=O)OC(C1=CC=CC=C1)=O.C(C)N(OC1=CC=CC=C1)CC KGNFCMBVSSCAGC-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- AFDXODALSZRGIH-QPJJXVBHSA-N (E)-3-(4-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(\C=C\C(O)=O)C=C1 AFDXODALSZRGIH-QPJJXVBHSA-N 0.000 claims description 5
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 5
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims description 5
- 229940048848 lauryl glucoside Drugs 0.000 claims description 5
- 229940091554 lauryl peg-9 polydimethylsiloxyethyl dimethicone Drugs 0.000 claims description 5
- YZUUTMGDONTGTN-UHFFFAOYSA-N nonaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCO YZUUTMGDONTGTN-UHFFFAOYSA-N 0.000 claims description 5
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 2
- GJYCVCVHRSWLNY-UHFFFAOYSA-N 2-butylphenol Chemical compound CCCCC1=CC=CC=C1O GJYCVCVHRSWLNY-UHFFFAOYSA-N 0.000 claims 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 4
- AFDXODALSZRGIH-UHFFFAOYSA-N p-coumaric acid methyl ether Natural products COC1=CC=C(C=CC(O)=O)C=C1 AFDXODALSZRGIH-UHFFFAOYSA-N 0.000 claims 4
- 125000003698 tetramethyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 229930182470 glycoside Natural products 0.000 claims 3
- 150000002338 glycosides Chemical class 0.000 claims 3
- 239000000377 silicon dioxide Substances 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- GNNILMDCYQGMRH-UHFFFAOYSA-N formyl benzoate Chemical compound O=COC(=O)C1=CC=CC=C1 GNNILMDCYQGMRH-UHFFFAOYSA-N 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 claims 1
- 230000003760 hair shine Effects 0.000 claims 1
- 230000035699 permeability Effects 0.000 abstract description 3
- 238000009776 industrial production Methods 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 description 12
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 239000002537 cosmetic Substances 0.000 description 7
- 235000010983 sucrose acetate isobutyrate Nutrition 0.000 description 7
- IBZAZKLZUCSBJF-UHFFFAOYSA-N C(CCCC)(=O)OCCC(C)C.COC1=CC=C(C=CC(=O)O)C=C1 Chemical compound C(CCCC)(=O)OCCC(C)C.COC1=CC=C(C=CC(=O)O)C=C1 IBZAZKLZUCSBJF-UHFFFAOYSA-N 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- NCIAZCLIFWUDPR-UHFFFAOYSA-N 2-butyl-3,4,5,6-tetramethylphenol Chemical compound CCCCC1=C(C)C(C)=C(C)C(C)=C1O NCIAZCLIFWUDPR-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 229940088608 peg-9 polydimethylsiloxyethyl dimethicone Drugs 0.000 description 3
- OOCCDEMITAIZTP-QPJJXVBHSA-N (E)-cinnamyl alcohol Chemical compound OC\C=C\C1=CC=CC=C1 OOCCDEMITAIZTP-QPJJXVBHSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- UUGLJVMIFJNVFH-UHFFFAOYSA-N Hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1 UUGLJVMIFJNVFH-UHFFFAOYSA-N 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- OOCCDEMITAIZTP-UHFFFAOYSA-N allylic benzylic alcohol Natural products OCC=CC1=CC=CC=C1 OOCCDEMITAIZTP-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 150000003445 sucroses Chemical class 0.000 description 2
- OUCGLXKNITVPJS-OUKQBFOZSA-N 2-ethylhexyl (e)-3-phenylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=CC=C1 OUCGLXKNITVPJS-OUKQBFOZSA-N 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 244000147568 Laurus nobilis Species 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- UBLAMKHIFZBBSS-UHFFFAOYSA-N Valeriansaeure-isopentylester Natural products CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002168 ethanoic acid esters Chemical class 0.000 description 1
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- JBIASUUIWKZOJM-UHFFFAOYSA-N n-ethyl-n-phenoxyethanamine Chemical compound CCN(CC)OC1=CC=CC=C1 JBIASUUIWKZOJM-UHFFFAOYSA-N 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229910021420 polycrystalline silicon Inorganic materials 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001797 sucrose acetate isobutyrate Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Abstract
The invention discloses a kind of sunscreen compositions containing Sucrose acetoisobutyrate, raw material including following mass percent: solid inorganic sun-screening agent 30~70%, Orangic sunscreen 10~67% and dispersing agent 3~20%, the dispersing agent are Sucrose acetoisobutyrate.The invention also discloses the preparation methods of the sunscreen composition, and Orangic sunscreen and dispersing agent are put into reaction kettle respectively, are warming up to 45~60 DEG C, stir evenly, then are pumped into solid inorganic sun-screening agent, stir evenly, homogeneous, filtering and impurity removing.Sunscreen composition of the present invention is low in cost, and preparation method is simple, adapts to large-scale industrial production, and when being applied to emulsified make-up, the phenomenon that can improving unstable formula permeability, product stability can also be correspondinglyd increase.
Description
Technical field
The present invention relates to cosmetic technical field, in particular to a kind of sunscreen composition containing Sucrose acetoisobutyrate
And preparation method thereof.
Background technique
Sucrose acetoisobutyrate, English name: Sucrose Acetate Iso-butyrate, SAIB, a kind of sucrose
Derivative, the sucrose ester for thering are 8 hydroxyls to be replaced in sucrose molecule by isobutyryl and acetyl group, i.e. isobutyryl and acetyl (acid)
Sucrose mixed ester, contain several different foreign body objects.Because the ratio of acetic acid esters and isobutyrate is about 2:6, also known as oxalic acid six
Isobutyric acid sucrose ester (Sucrose Diacetate Hexaisobutyrate).It is clarification thick liquid, flavour and smell alcohol
With.30 DEG C or less are coagulated for solid, and 30-40 DEG C of when is in semi-fluid viscous fluid, and 40 DEG C the above are mobile liquids.It is not soluble in water, it is readily soluble
In most organic solvents, such as arene, alkanones, ketone etc..Relative density 1.14-1.15 is a kind of excellent density
Regulator.
SAIB is typically used as food additives, such as stabilizer, weighting agent, and the clouding agent of soft drink can prevent beverage from going out
Existing " cyclic arrangement ", " missible oil precipitation phenomenon " and " segregation phenomenon ", SAIB have the characteristic of lipoid, can be used for adjusting the close of oily phase
Degree.SAIB is also used in controlled release drug transmission system, is divided into injection or oral.It is generated since it causes the variation of viscosity
The adherency that biology mixes, the release time of drug (such as hormone) is controllable in related drugs transmission system.SAIB and another
Paper can be improved to the stability of light and heat close to cellulose in the refractive index of kind of sucrose derivative (eight benzoic ether of sucrose),
Impressionability makes cellophane paper.
In the prior art, existing powder dispersing agent is at high price, using limited.The sun-proof dispersion liquid of nano inorganic is ground,
The method for being generally used ball milling or sand milling is processed, and milling time is one hour to four hours, is also needed after grinding
Abrasive media separation can be obtained into sunscreen composition.Such operating procedure is cumbersome, and required equipment is expensive, and production time-consuming also compares
It is long.There are certain defects in terms of stability and usability for existing sunscreen composition, and most sunscreen compositions are in long term storage mistake
Journey can lead to precipitated and separated there is a phenomenon where powder is assembled, and stability is poor.For the slurry precipitated, if before taking not
Can be stirred, then will affect the content of effective substance, cause it is unstable between produced product batches, for emulsifying
Type sunscreen cosmetic is easily unstable fuel-displaced.Therefore, research and develop a kind of novel sunscreen composition for being used to prepare sunscreen product have become it is urgent
It is essential and wants.Currently, not finding the related data being added in sunscreen composition using Sucrose acetoisobutyrate as dispersing agent
Document and patent.
Summary of the invention
In view of the deficienciess of the prior art, on the one hand the purpose of the present invention is that providing one kind contains Sucrose Acetate acid sugarcane
The sunscreen composition of sugar ester.
In order to achieve the above object, the technical solution of the present invention is as follows:
A kind of sunscreen composition containing Sucrose acetoisobutyrate, the raw material including following mass percent: solid without
Machine sun-screening agent 30~70%, Orangic sunscreen 10~67% and dispersing agent 3~20%, the solid inorganic sun-screening agent are titanium dioxide
One or more of titanium, zinc oxide, cerium oxide, the Orangic sunscreen are p- methoxycinnamate isoamyl valerate, methoxy
Base 2-Ethylhexyl cinnamate, ethylhexyl salicylate, Uvinul T 150, Homosalate, Octocrilene, diethylamino oxybenzene first
Acyl group hexyl-benzoate, ethyl hexyl oxy phenol anisyl triazine, methylene bis-benzotriazolyl tetramethyl butyl phenol, poly- silicon
One or more of oxygen alkane -15, Diethylhexyl Butamido Triazon, the dispersing agent are Sucrose Acetate acid sucrose
Ester, poly- hydroxy stearic acid, poly- hydroxy stearic acid ester, PEG-10 Polydimethylsiloxane, PEG-9 polydimethylsiloxanes ethyl poly- two
Methylsiloxane, lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, the poly- diformazan of cetyl PEG/PPG-10/1
Radical siloxane, polyglyceryl polysiloxanes, Plantacare 818, laruyl alcohol sodium sulfovinate, lauryl glucoside, in polyglycereol esters
One or more.
Preferably, the raw material including following mass percent: solid inorganic sun-screening agent 50%, Orangic sunscreen 40% and point
Powder 10%, the solid inorganic sun-screening agent be one or more of titanium dioxide, zinc oxide, cerium oxide, it is described to have
Machine sun-screening agent is p- methoxycinnamate isoamyl valerate, ethylhexyl methoxy cinnamate, ethylhexyl salicylate, ethylhexyl three
Piperazine ketone, Homosalate, Octocrilene, the own ester of diethylamino oxybenzene formylbenzoate, ethyl hexyl oxy phenol anisyl triazine, Asia
Methyl is double-benzotriazole base tetramethyl butyl phenol, Dimethicodiethylbenzalmalonate, one of Diethylhexyl Butamido Triazon or
Two or more, the dispersing agent is Sucrose acetoisobutyrate, poly- hydroxy stearic acid, poly- hydroxy stearic acid ester, PEG-10 poly- two
Methylsiloxane, PEG-9 Polydimethylsiloxyethyl Dimethicone, lauryl PEG-9 polydimethylsiloxanes ethyl are poly-
Dimethyl siloxane, cetyl PEG/PPG-10/1 dimethyl silicone polymer, polyglyceryl polysiloxanes, Plantacare 818, the moon
One or more of cinnamic alcohol sodium sulfovinate, lauryl glucoside, polyglycereol esters.
Preferably, the raw material including following mass percent: solid inorganic sun-screening agent 30%, Orangic sunscreen 67% and point
Powder 3%, the solid inorganic sun-screening agent be one or more of titanium dioxide, zinc oxide, cerium oxide, it is described organic
Sun-screening agent is p- methoxycinnamate isoamyl valerate, ethylhexyl methoxy cinnamate, ethylhexyl salicylate, ethylhexyl triazine
Ketone, Homosalate, Octocrilene, the own ester of diethylamino oxybenzene formylbenzoate, ethyl hexyl oxy phenol anisyl triazine, methylene
One of base pair-benzotriazole base tetramethyl butyl phenol, Dimethicodiethylbenzalmalonate, Diethylhexyl Butamido Triazon or two
Kind or more, the dispersing agent is Sucrose acetoisobutyrate, poly- hydroxy stearic acid, poly- hydroxy stearic acid ester, the poly- diformazan of PEG-10
Radical siloxane, PEG-9 Polydimethylsiloxyethyl Dimethicone, lauryl PEG-9 polydimethylsiloxanes ethyl poly- two
Methylsiloxane, cetyl PEG/PPG-10/1 dimethyl silicone polymer, polyglyceryl polysiloxanes, Plantacare 818, laurel
One or more of alcohol sulfuric ester sodium, lauryl glucoside, polyglycereol esters.
Preferably, the raw material including following mass percent: solid inorganic sun-screening agent 70%, Orangic sunscreen 10% and point
Powder 20%, the solid inorganic sun-screening agent be one or more of titanium dioxide, zinc oxide, cerium oxide, it is described to have
Machine sun-screening agent is p- methoxycinnamate isoamyl valerate, ethylhexyl methoxy cinnamate, ethylhexyl salicylate, ethylhexyl three
Piperazine ketone, Homosalate, Octocrilene, the own ester of diethylamino oxybenzene formylbenzoate, ethyl hexyl oxy phenol anisyl triazine, Asia
Methyl is double-benzotriazole base tetramethyl butyl phenol, Dimethicodiethylbenzalmalonate, one of Diethylhexyl Butamido Triazon or
Two or more, the dispersing agent is Sucrose acetoisobutyrate, poly- hydroxy stearic acid, poly- hydroxy stearic acid ester, PEG-10 poly- two
Methylsiloxane, PEG-9 Polydimethylsiloxyethyl Dimethicone, lauryl PEG-9 polydimethylsiloxanes ethyl are poly-
Dimethyl siloxane, cetyl PEG/PPG-10/1 dimethyl silicone polymer, polyglyceryl polysiloxanes, Plantacare 818, the moon
One or more of cinnamic alcohol sodium sulfovinate, lauryl glucoside, polyglycereol esters.
Preferably, the solid inorganic sun-screening agent is the nano-titanium dioxide that partial size is 10~200nm.
Preferably, the dispersing agent is Sucrose acetoisobutyrate.
On the other hand, the present invention also provides a kind of preparation sides of sunscreen composition containing Sucrose acetoisobutyrate
Method, comprising the following steps:
(1) Orangic sunscreen and dispersing agent are weighed respectively according to formula ratio, then put into reaction kettle, be warming up to 45~60
DEG C, it stirs evenly, obtains the first mixture；
(2) by reaction kettle be evacuated to pressure be -0.5~-0.2Mpa vacuum state, while while vacuumizing by solid without
Machine sun-screening agent is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get acetic acid is contained using the third mixture that 300~500 meshes obtain step (3)
The sunscreen composition of isobutyric acid sucrose ester；
Preferably, the partial size for the sunscreen composition containing Sucrose acetoisobutyrate that the step (4) obtains be 30~
200nm。
Sunscreen composition of the present invention can be applied in various types of sunscreen cosmetics, can be oil-in-water type emulsion
Cosmetics, water-in-oil emulsified cosmetic or pure oil-based cosmetic preparation.
Compared with prior art, the invention has the following beneficial effects:
(1) present invention is coagulated at 30 DEG C or less for solid, 40 DEG C or more using Sucrose acetoisobutyrate as dispersing agent
For mobile liquid, so that sunscreen composition of the present invention viscosity under the storage condition of room temperature is higher, powder is not susceptible to assemble
Precipitating, stability is high, and when use only needs slightly to be warming up to 40 DEG C or more, becomes to flow shape liquid, can conveniently take.
(2) sunscreen composition of the present invention is low in cost, and preparation method is simple, adapts to large-scale industrial production.
(3) when sunscreen composition of the present invention is applied to emulsified make-up, the phenomenon that unstable formula permeability can be improved,
Product stability can also be correspondinglyd increase.This is because Sucrose acetoisobutyrate relative density is larger, 1.141~
Between 1.151, this improves the density of oily phase in system integrally, therefore reduces close between water-oil phase in emulsification system
It is poor to spend, and finally product stability is improved.
Specific embodiment
It to facilitate the understanding of the present invention, below will be to invention is more fully described.But the present invention can be to be permitted
Mostly different form is realized, however it is not limited to embodiment described herein.On the contrary, purpose of providing these embodiments is makes
It is more thorough and comprehensive to the understanding of the disclosure.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
The specific formula of embodiment 1-6 sunscreen composition of the present invention is as shown in table 1, and raw material is according to quality hundred in formula
Divide than meter.
1 embodiment 1-6 sunscreen composition composition formula of table
The preparation method of the sunscreen composition of the present invention of embodiment 1 the following steps are included:
(1) p- methoxycinnamate isoamyl valerate and Sucrose acetoisobutyrate are put into reaction kettle respectively, is warming up to 45
It~60 DEG C, stirs evenly, obtains the first mixture；
(2) reaction kettle is evacuated to the vacuum state that pressure is -0.5~-0.2Mpa, while by nanometer two while vacuumizing
Titanium oxide is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get institute of the present invention using the third mixture that 300~500 meshes obtain step (3)
State sunscreen composition.
The preparation method of the sunscreen composition of the present invention of embodiment 2 the following steps are included:
(1) Dimethicodiethylbenzalmalonate and Sucrose acetoisobutyrate are put into reaction kettle respectively, is warming up to 45~60 DEG C, stirs
It mixes uniformly, obtains the first mixture；
(2) reaction kettle is evacuated to the vacuum state that pressure is -0.5~-0.2Mpa, while by nanometer two while vacuumizing
Titanium oxide is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get institute of the present invention using the third mixture that 300~500 meshes obtain step (3)
State sunscreen composition.
The preparation method of the sunscreen composition of the present invention of embodiment 3 the following steps are included:
(1) ethylhexyl salicylate and Sucrose acetoisobutyrate are put into reaction kettle respectively, are warming up to 45~60 DEG C,
It stirs evenly, obtains the first mixture；
(2) reaction kettle is evacuated to the vacuum state that pressure is -0.5~-0.2Mpa, while by nanometer two while vacuumizing
Titanium oxide is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get institute of the present invention using the third mixture that 300~500 meshes obtain step (3)
State sunscreen composition.
The preparation method of the sunscreen composition of the present invention of embodiment 4 the following steps are included:
(1) Homosalate and Sucrose acetoisobutyrate are put into reaction kettle respectively, is warming up to 45~60 DEG C, stirring is equal
It is even, obtain the first mixture；
(2) reaction kettle is evacuated to the vacuum state that pressure is -0.5~-0.2Mpa, while by nanometer two while vacuumizing
Titanium oxide is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get institute of the present invention using the third mixture that 300~500 meshes obtain step (3)
State sunscreen composition.
The preparation method of the sunscreen composition of the present invention of embodiment 5 the following steps are included:
(1) Octocrilene and Sucrose acetoisobutyrate are put into reaction kettle respectively, is warming up to 45~60 DEG C, stirring is equal
It is even, obtain the first mixture；
(2) reaction kettle is evacuated to the vacuum state that pressure is -0.5~-0.2Mpa, while by nanometer two while vacuumizing
Titanium oxide is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get institute of the present invention using the third mixture that 300~500 meshes obtain step (3)
State sunscreen composition.
The preparation method of the sunscreen composition of the present invention of embodiment 6 the following steps are included:
(1) ethylhexyl methoxy cinnamate and Sucrose acetoisobutyrate are put into reaction kettle respectively, is warming up to 45
It~60 DEG C, stirs evenly, obtains the first mixture；
(2) reaction kettle is evacuated to the vacuum state that pressure is -0.5~-0.2Mpa, while by nanometer two while vacuumizing
Titanium oxide is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get institute of the present invention using the third mixture that 300~500 meshes obtain step (3)
State sunscreen composition.
The specific formula of comparative example 1-4 sunscreen composition of the present invention is as shown in table 2, and raw material is according to quality hundred in formula
Divide than meter.
2 comparative example 1-4 sunscreen composition composition formula of table
| Material name | Example 1 (%) | Example 2 (%) | Example 3 (%) | Example 4 (%) |
| P- methoxycinnamate isoamyl valerate | 67 | 0 | 0 | 0 |
| Dimethicodiethylbenzalmalonate | 0 | 60 | 0 | 0 |
| Ethylhexyl salicylate | 0 | 0 | 52 | 0 |
| Homosalate | 0 | 0 | 0 | 40 |
| Nano-titanium dioxide | 30 | 35 | 40 | 50 |
| Poly- hydroxy stearic acid | 3 | 5 | 8 | 10 |
The preparation method of the sunscreen composition of the present invention of comparative example 1 the following steps are included:
(1) p- methoxycinnamate isoamyl valerate and poly- hydroxy stearic acid are put into reaction kettle respectively, is warming up to 45~60
DEG C, it stirs evenly, obtains the first mixture；
(2) reaction kettle is evacuated to the vacuum state that pressure is -0.5~-0.2Mpa, while by nanometer two while vacuumizing
Titanium oxide is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get institute of the present invention using the third mixture that 300~500 meshes obtain step (3)
State sunscreen composition.
The preparation method of the sunscreen composition of the present invention of comparative example 2 the following steps are included:
(1) Dimethicodiethylbenzalmalonate and poly- hydroxy stearic acid are put into reaction kettle respectively, is warming up to 45~60 DEG C, stirring is equal
It is even, obtain the first mixture；
(2) reaction kettle is evacuated to the vacuum state that pressure is -0.5~-0.2Mpa, while by nanometer two while vacuumizing
Titanium oxide is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get institute of the present invention using the third mixture that 300~500 meshes obtain step (3)
State sunscreen composition.
The preparation method of the sunscreen composition of the present invention of comparative example 3 the following steps are included:
(1) ethylhexyl salicylate and poly- hydroxy stearic acid are put into reaction kettle respectively, is warming up to 45~60 DEG C, stirring
Uniformly, the first mixture is obtained；
(2) reaction kettle is evacuated to the vacuum state that pressure is -0.5~-0.2Mpa, while by nanometer two while vacuumizing
Titanium oxide is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get institute of the present invention using the third mixture that 300~500 meshes obtain step (3)
State sunscreen composition.
The preparation method of the sunscreen composition of the present invention of comparative example 4 the following steps are included:
(1) Homosalate and poly- hydroxy stearic acid are put into reaction kettle respectively, are warming up to 45~60 DEG C, stir evenly,
Obtain the first mixture；
(2) reaction kettle is evacuated to the vacuum state that pressure is -0.5~-0.2Mpa, while by nanometer two while vacuumizing
Titanium oxide is pumped into from reactor bottom, and stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixing that step (2) is obtained
Object is stirred until homogeneous, and high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get institute of the present invention using the third mixture that 300~500 meshes obtain step (3)
State sunscreen composition.
To the partial size and stability test of above-described embodiment 1-6 and comparative example 1-4 sunscreen composition prepared, wherein stable
Property test 30min is centrifuged under the conditions of 2500r/min, the results are shown in Table 3.
3 embodiment 1-6 of table and comparative example 1-4 test result
As shown in Table 3, the sunscreen composition partial size of embodiment 1-6 preparation meets the requirements, and centrifugation is stablized not stratified, thus may be used
Judge that it has good stability in long-term storage process；The sunscreen composition of comparative example 1-4 preparation is not due to containing second
Sour isobutyric acid sucrose ester, partial size are not meeting in range, and all cash in centrifugal stability test to be layered, and thus can determine whether
In long-term storage process aggregation layering can occur for product.Show the Sucrose acetoisobutyrate in inventive formulation as dispersion
Agent has good stability.
Sunscreen composition of the present invention is applied in oil-in-water type suncream by embodiment 7-12 respectively, and specific formula is such as
Shown in table 4, component is according to mass percent meter in formula.
4 embodiment 7-12 oil-in-water type formula of sun screen of table
The preparation method of above-described embodiment 7-12 and control group suncream, comprising the following steps:
(1) component A and component B are put into different reaction kettles respectively and are warming up to 82 DEG C respectively；
(2) under stirring, component B is added in component A, and homogeneous stirs 5min, obtains mixture；
(3) stirring of mixture that step (2) obtains is cooled to 45 DEG C, component C is then added, after mixing evenly to get
Suncream.
Fuel-displaced test is carried out to suncream prepared by above-described embodiment 7-12 and control group, under the conditions of 2500r/min from
Heart 30min, the results are shown in Table 5.
5 embodiment 7-12 of table and control group suncream test result
As shown in Table 5, embodiment 7-12 is due to being added to the suncream centrifugation that embodiment 1-6 sunscreen composition prepares
It is not fuel-displaced, and control group then show as it is fuel-displaced.Therefore, bad for stability, it is centrifuged fuel-displaced formula, addition contains Sucrose Acetate
After the sunscreen composition of sour sucrose ester, its centrifugal stability can be improved.Show that sunscreen composition of the present invention is applied to emulsifying
When cosmetic, the phenomenon that unstable formula permeability can be improved.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the general of this field
For logical technical staff, the invention may be variously modified and varied, all within the spirits and principles of the present invention, made
What modification, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of sunscreen composition containing Sucrose acetoisobutyrate, it is characterised in that: the original including following mass percent
Material: solid inorganic sun-screening agent 30~70%, Orangic sunscreen 10~67% and dispersing agent 3~20%, the solid inorganic are sun-proof
Agent is one or more of titanium dioxide, zinc oxide, cerium oxide, and the Orangic sunscreen is that p- methoxy cinnamic acid is different
Pentyl ester, ethylhexyl methoxy cinnamate, ethylhexyl salicylate, Uvinul T 150, Homosalate, Octocrilene, two
The own ester of second ammonia oxybenzene formylbenzoate, ethyl hexyl oxy phenol anisyl triazine, di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl fourth
One or more of base phenol, Dimethicodiethylbenzalmalonate, Diethylhexyl Butamido Triazon, the dispersing agent are acetic acid
Isobutyric acid sucrose ester, poly- hydroxy stearic acid, poly- hydroxy stearic acid ester, PEG-10 Polydimethylsiloxane, PEG-9 poly dimethyl silicon
Oxygen ethyl dimethyl silicone polymer, lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, cetyl PEG/PPG-
10/1 dimethyl silicone polymer, Plantacare 818, laruyl alcohol sodium sulfovinate, lauryl glucoside, gathers polyglyceryl polysiloxanes
One or more of glyceride type.
2. the sunscreen composition according to claim 1 containing Sucrose acetoisobutyrate, it is characterised in that: including following
The raw material of mass percent: solid inorganic sun-screening agent 50%, Orangic sunscreen 40% and dispersing agent 10%, the solid inorganic are anti-
Solarization agent is one or more of titanium dioxide, zinc oxide, cerium oxide, and the Orangic sunscreen is p- methoxy cinnamic acid
Isopentyl ester, ethylhexyl methoxy cinnamate, ethylhexyl salicylate, Uvinul T 150, Homosalate, Octocrilene,
The own ester of diethylamino oxybenzene formylbenzoate, ethyl hexyl oxy phenol anisyl triazine, di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl
One or more of butylphenol, Dimethicodiethylbenzalmalonate, Diethylhexyl Butamido Triazon, the dispersing agent are second
Sour isobutyric acid sucrose ester, poly- hydroxy stearic acid, poly- hydroxy stearic acid ester, PEG-10 Polydimethylsiloxane, PEG-9 poly dimethyl
Silica ethyl dimethyl silicone polymer, lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, cetyl PEG/
PPG-10/1 dimethyl silicone polymer, polyglyceryl polysiloxanes, Plantacare 818, laruyl alcohol sodium sulfovinate, lauryl glucose
One or more of glycosides, polyglycereol esters.
3. the sunscreen composition according to claim 1 containing Sucrose acetoisobutyrate, it is characterised in that: including following
The raw material of mass percent: solid inorganic sun-screening agent 30%, Orangic sunscreen 67% and dispersing agent 3%, the solid inorganic are anti-
Solarization agent is one or more of titanium dioxide, zinc oxide, cerium oxide, and the Orangic sunscreen is p- methoxy cinnamic acid
Isopentyl ester, ethylhexyl methoxy cinnamate, ethylhexyl salicylate, Uvinul T 150, Homosalate, Octocrilene,
The own ester of diethylamino oxybenzene formylbenzoate, ethyl hexyl oxy phenol anisyl triazine, di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl
One or more of butylphenol, Dimethicodiethylbenzalmalonate, Diethylhexyl Butamido Triazon, the dispersing agent are second
Sour isobutyric acid sucrose ester, poly- hydroxy stearic acid, poly- hydroxy stearic acid ester, PEG-10 Polydimethylsiloxane, PEG-9 poly dimethyl
Silica ethyl dimethyl silicone polymer, lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, cetyl PEG/
PPG-10/1 dimethyl silicone polymer, polyglyceryl polysiloxanes, Plantacare 818, laruyl alcohol sodium sulfovinate, lauryl glucose
One or more of glycosides, polyglycereol esters.
4. the sunscreen composition according to claim 1 containing Sucrose acetoisobutyrate, it is characterised in that: including following
The raw material of mass percent: solid inorganic sun-screening agent 70%, Orangic sunscreen 10% and dispersing agent 20%, the solid inorganic are anti-
Solarization agent is one or more of titanium dioxide, zinc oxide, cerium oxide, and the Orangic sunscreen is p- methoxy cinnamic acid
Isopentyl ester, ethylhexyl methoxy cinnamate, ethylhexyl salicylate, Uvinul T 150, Homosalate, Octocrilene,
The own ester of diethylamino oxybenzene formylbenzoate, ethyl hexyl oxy phenol anisyl triazine, di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl
One or more of butylphenol, Dimethicodiethylbenzalmalonate, Diethylhexyl Butamido Triazon, the dispersing agent are second
Sour isobutyric acid sucrose ester, poly- hydroxy stearic acid, poly- hydroxy stearic acid ester, PEG-10 Polydimethylsiloxane, PEG-9 poly dimethyl
Silica ethyl dimethyl silicone polymer, lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, cetyl PEG/
PPG-10/1 dimethyl silicone polymer, polyglyceryl polysiloxanes, Plantacare 818, laruyl alcohol sodium sulfovinate, lauryl glucose
One or more of glycosides, polyglycereol esters.
5. the sunscreen composition according to claim 1-4 containing Sucrose acetoisobutyrate, it is characterised in that:
The solid inorganic sun-screening agent is the nano-titanium dioxide that partial size is 10~200nm.
6. the sunscreen composition according to claim 1-4 containing Sucrose acetoisobutyrate, it is characterised in that:
The dispersing agent is Sucrose acetoisobutyrate.
7. a kind of preparation side of the sunscreen composition according to claim 1-6 containing Sucrose acetoisobutyrate
Method, it is characterised in that: the following steps are included:
(1) Orangic sunscreen and dispersing agent are weighed respectively according to formula ratio, then put into reaction kettle, be warming up to 45~60 DEG C,
It stirs evenly, obtains the first mixture；
(2) reaction kettle is evacuated to pressure and is the vacuum state of -0.5~-0.2Mpa, while preventing solid inorganic while vacuumizing
It shines agent to be pumped into from reactor bottom, stirring to solid inorganic sun-screening agent is completely wet, obtains the second mixture；
(3) temperature of reaction kettle is maintained at 45~60 DEG C, opens high pressure mode, the second mixture that step (2) obtains is stirred
It mixes to uniform, high speed homogenization 15-20Min obtains third mixture；
(4) removal of impurities is filtered to get Sucrose Acetate is contained using the third mixture that 300~500 meshes obtain step (3)
The sunscreen composition of sour sucrose ester.
8. preparation method according to claim 7, it is characterised in that: the step (4) obtains sour containing Sucrose Acetate
The partial size of the sunscreen composition of sucrose ester is 30~200nm.
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| CN109330910A (en) * | 2018-11-14 | 2019-02-15 | 青蛙王子（福建）婴童护理用品有限公司 | It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted |
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2019
- 2019-04-12 CN CN201910294100.2A patent/CN110025497A/en active Pending
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| CN1942166A (en) * | 2004-04-19 | 2007-04-04 | 伊斯曼化学公司 | Skin care compositions |
| CN101027541A (en) * | 2004-07-29 | 2007-08-29 | 布隆多控股有限公司 | A colour compensating system |
| US20090004252A1 (en) * | 2004-07-29 | 2009-01-01 | Linda Lowndes | Skin Coating Composition and Uses Thereof |
| CN106333867A (en) * | 2016-10-27 | 2017-01-18 | 广州市玮弘祺生物科技有限责任公司 | Sun-screening composition and preparation method and application thereof |
| CN109330910A (en) * | 2018-11-14 | 2019-02-15 | 青蛙王子（福建）婴童护理用品有限公司 | It is a kind of to prepare sprayable emulsion and preparation method using inside and outside phase density difference is adjusted |
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