CN112137918A - Stable weak-acid whitening agent composition and preparation method thereof - Google Patents
Stable weak-acid whitening agent composition and preparation method thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a stable weak acid whitening agent composition and a preparation method thereof, wherein the composition comprises the following raw materials in parts by weight: 5-10 parts of 3-o-ethyl ascorbic acid ether, 3-6 parts of nicotinamide, 2-5 parts of alpha-arbutin, 1-3 parts of butanediol, 1-3 parts of emulsifier, 0.5-2.0 parts of jojoba seed oil, 0.5-2.0 parts of meadowfoam seed oil, 0.5-2.0 parts of tocopherol acetate, 0.1-0.5 part of carbomer, 0.1-0.5 part of triethanolamine, 0.01-0.05 part of citric acid and the balance of water added to 100 parts. The preparation method disclosed by the invention respectively intervenes and damps the early stage, the middle stage and the final stage of melanin formation, and simultaneously the preparation method also carries out micro-emulsification coating on the four whitening components to improve the stability of the whitening components, and improves the absorptivity of the whitening agent, the skin compatibility and the stability of the invention by regulating the pH value, so that the whitening agent which is high in skin absorptivity and extremely high in stability and can comprehensively inhibit activation of the tyrosinase at the initial stage, resist oxidation and antagonism in the middle conversion process and prevent melanin transportation at the final stage is obtained.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a stable weak-acid whitening agent composition and a preparation method thereof.
Background
With the improvement of living standard, people pay more and more attention to facial skin care. Consumer survey results show that skin care accounts for the first three requirements, moisturizing/hydrating, whitening and anti-aging. The need for whitening skin care has always been a focus of asian attention to skin care needs. Consumers expect whitening skin care products that are mild, comprehensive in whitening and have good results and that are not irritating to the skin after use. The whitening and freckle-removing products on the market are various in types, but the general problems are as follows: 1. the product is unstable and is easy to be oxidized: the active ingredients that inhibit melanin formation are very easily oxidized and not easily stored. 2. The use effect is not obvious: the components for whitening and removing freckles are too single, cannot be controlled globally in the whole process of forming melanin in skin, or the absorption rate of the product is too low. 3. There may be contraband or exceeding of limited components such as hormones: some merchants still add forbidden ingredients of cosmetics such as hydroquinone and the like with quick whitening and freckle removing effects in order to improve the whitening and freckle removing effects of the products. Therefore, how to develop a safe and stable skin care product scheme with whitening and skin brightening effects becomes a difficult point in the current cosmetic industry.
Disclosure of Invention
The invention provides a stable weak-acid whitening agent composition and a preparation method thereof, aiming at the defects of the existing whitening and freckle removing products on the market. The whitening agent has the advantages that 3-O-ethyl ascorbic acid ether, alpha-arbutin extraction, tocopherol acetate and nicotinamide which can inhibit the activity of tyrosinase, reduce the accumulation of tyrosinase, damp the oxidation of melanin in the formation process and reduce the transfer of melanin to the surface layer of skin are added into raw materials, intervention and damping are respectively carried out from the initial stage, the middle stage and the final stage of melanin formation, the three components are coated in a micro-emulsion mode to improve the stability of the three components, and the absorption rate of the whitening agent and the compatibility of the skin are improved by adjusting the pH value of the whitening agent, so that the whitening agent which has high comprehensive skin absorption rate and extremely high stability and can inhibit the activation of melanin from the initial stage, oxidize anti-antagonism at the middle stage and prevent the transportation of melanin and decompose the melanin at the final stage is obtained.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a stable weak acid whitening agent composition comprises the following raw materials in parts by weight: 5-10 parts of 3-o-ethyl ascorbic acid ether, 3-6 parts of nicotinamide, 2-5 parts of alpha-arbutin, 1-3 parts of butanediol, 1-3 parts of emulsifier, 0.5-2.0 parts of jojoba seed oil, 0.5-2.0 parts of meadowfoam seed oil, 0.5-2.0 parts of tocopherol acetate, 0.1-0.5 part of carbomer, 0.1-0.5 part of triethanolamine, 0.01-0.05 part of citric acid and the balance of water added to 100 parts.
Preferably, the emulsifier comprises cetearyl olive oleate or/and sorbitan olive oleate.
Preferably, the stable weak acid whitening agent composition is prepared from the following raw materials in parts by weight: 6 parts of 3-o-ethyl ascorbic acid ether, 5 parts of nicotinamide, 3 parts of alpha-arbutin, 2 parts of butanediol, 2 parts of an emulsifier, 1 part of jojoba seed oil, 1 part of chinaroot greenbrier seed oil, 1 part of tocopherol acetate, 0.2 part of carbomer, 0.2 part of triethanolamine, 0.02 part of citric acid and 72.58 parts of water.
The invention also provides a preparation method of the stable weak acid whitening agent composition, which comprises the following steps:
(1) weighing water, carbomer and butanediol according to the raw material ratio, and uniformly stirring and mixing to obtain a water phase;
(2) stirring and mixing the emulsifier, the jojoba seed oil, the white chinlon seed oil and the tocopherol acetate uniformly to prepare an oil phase;
(3) dissolving citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin at low temperature respectively;
(4) adding the water phase and the oil phase into an emulsification reaction kettle, heating, homogenizing and mixing the phases, adding triethanolamine, sequentially adding citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin, and stirring uniformly to obtain the whitening agent.
Compared with the prior art, the invention has the advantages and beneficial effects that:
the whitening agent has the advantages that 3-O-ethyl ascorbic acid ether, alpha-arbutin extraction, tocopherol acetate and nicotinamide which can inhibit the activity of tyrosinase, reduce the accumulation of tyrosinase, damp the oxidation of melanin in the formation process and reduce the transfer of melanin to the surface layer of skin are added into raw materials, intervention and damping are respectively carried out from the initial stage, the middle stage and the final stage of melanin formation, the three components are coated in a micro-emulsion mode to improve the stability of the three components, and the stability, the absorption rate and the skin fusion of the whitening agent are improved by adjusting the pH value of the whitening agent, so that the whitening agent which has high comprehensive skin absorption rate and extremely high stability and can inhibit the activation of melanin from the initial stage, oxidize and resist antagonism in the middle stage and prevent the transportation and decomposition of melanin from the final stage is obtained. The whitening agent provided has wide application in the field of cosmetics, such as cosmetic products such as skin cream, skin lotion, skin gel, skin essence or skin lotion.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments. It should be emphasized that the following description is merely exemplary in nature and is not intended to limit the scope of the invention or its application.
Example 1
A stable weak acid whitening agent composition is prepared from the following raw materials in parts by weight: 6 parts of 3-o-ethyl ascorbyl ether, 5 parts of nicotinamide, 3 parts of alpha-arbutin, 2 parts of butanediol, 2 parts of cetearyl olive oleate, 1 part of jojoba seed oil, 1 part of meadowfoam seed oil, 1 part of tocopherol acetate, 0.2 part of carbomer, 0.2 part of triethanolamine, 0.02 part of citric acid and 72.58 parts of water.
The preparation method comprises the following steps:
(1) weighing water, carbomer and butanediol according to the raw material ratio, heating to 75 ℃, and uniformly stirring and mixing to obtain a water phase;
(2) heating cetearyl olive oleate, jojoba seed oil, meadowfoam seed oil and tocopherol acetate to 75 ℃, and uniformly stirring and mixing to obtain an oil phase;
(3) respectively dissolving citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin at low temperature;
(4) heating the emulsification reaction kettle to 75 ℃, starting stirring, pumping the water phase and the oil phase for phase combination, starting homogenizing and emulsifying for 10min, adding triethanolamine, cooling to 45 ℃, sequentially adding citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin, stirring for 20min, and fully and uniformly stirring to obtain the whitening agent.
Example 2
A stable weak acid whitening agent composition is prepared from the following raw materials in parts by weight: 8 parts of 3-o-ethyl ascorbyl ether, 4 parts of nicotinamide, 2.5 parts of alpha-arbutin, 1.8 parts of butanediol, 2.5 parts of cetearyl olive oleate, 1.5 parts of jojoba seed oil, 0.8 part of meadowfoam seed oil, 1.5 parts of tocopherol acetate, 0.4 part of carbomer, 0.3 part of triethanolamine, 0.05 part of citric acid and 76.65 parts of water.
The preparation method comprises the following steps:
(1) weighing water, carbomer and butanediol according to the raw material ratio, heating to 70 ℃, and uniformly stirring and mixing to obtain a water phase;
(2) heating cetearyl olive oleate, jojoba seed oil, meadowfoam seed oil and tocopherol acetate to 70 ℃, and uniformly stirring and mixing to obtain an oil phase;
(3) respectively dissolving citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin at low temperature;
(4) heating the emulsification reaction kettle to 75 ℃, starting stirring, pumping the water phase and the oil phase for phase combination, starting homogenizing and emulsifying for 10min, adding triethanolamine for homogenizing for 5min, sequentially adding citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin, stirring for 20min, and fully mixing uniformly to obtain the whitening agent.
Example 3
A stable weak acid whitening agent composition is prepared from the following raw materials in parts by weight: 7 parts of 3-o-ethyl ascorbic acid ether, 6 parts of nicotinamide, 4.5 parts of alpha-arbutin, 1.5 parts of butanediol, 1.5 parts of sorbitan olivate, 1.8 parts of jojoba seed oil, 1.2 parts of meadowfoam seed oil, 1.5 parts of tocopherol acetate, 0.3 part of carbomer, 0.4 part of triethanolamine, 0.03 part of citric acid and 74.27 parts of water.
The preparation method comprises the following steps:
(1) weighing water, carbomer and butanediol according to the raw material ratio, heating to 65 ℃, and uniformly stirring and mixing to obtain a water phase;
(2) heating emulsifier, jojoba seed oil, white chinlon oil and tocopherol acetate to 65 ℃, and stirring and mixing uniformly to obtain an oil phase;
(3) respectively dissolving citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin at low temperature;
(4) heating the emulsification reaction kettle to 75 ℃, starting stirring, pumping the water phase and the oil phase for phase combination, starting homogenizing and emulsifying for 20min, adding triethanolamine for homogenizing for 5min, cooling to 45 ℃, sequentially adding citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin, stirring for 20min, and fully and uniformly mixing to obtain the whitening agent.
Example 4
A stable weak acid whitening agent composition is prepared from the following raw materials in parts by weight: 9 parts of 3-o-ethyl ascorbic acid ether, 4 parts of nicotinamide, 4.5 parts of alpha-arbutin, 1.5 parts of butanediol, 1.8 parts of sorbitan olivate, 1.5 parts of jojoba seed oil, 1 part of meadowfoam seed oil, 1.2 parts of tocopherol acetate, 0.4 part of carbomer, 0.3 part of triethanolamine, 0.03 part of citric acid and 74.77 parts of water.
The preparation method comprises the following steps:
(1) weighing water, carbomer and butanediol according to the raw material ratio, heating to 60 ℃, and uniformly stirring and mixing to obtain a water phase;
(2) heating sorbitan olivate, jojoba seed oil, white chinlon oil and tocopherol acetate to 70 ℃, and stirring and mixing uniformly to obtain an oil phase;
(3) respectively dissolving citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin at low temperature;
(4) heating an emulsification reaction kettle to 75 ℃, pumping the water phase and the oil phase into a phase mixing and emulsifying machine, homogenizing for 10min, adding triethanolamine, homogenizing for 5min, cooling to 45 ℃, sequentially adding citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin, homogenizing for 5min, and fully and uniformly stirring to obtain the whitening agent.
Example 5
A stable weak acid whitening agent composition is prepared from the following raw materials in parts by weight: 7.5 parts of 3-o-ethyl ascorbyl ether, 5 parts of nicotinamide, 3.5 parts of alpha-arbutin, 1.5 parts of butanediol, 2.5 parts of sorbitan olivil oleate, 1 part of jojoba seed oil, 1.5 parts of meadowfoam seed oil, 1.5 parts of tocopherol acetate, 0.4 part of carbomer, 0.3 part of triethanolamine, 0.04 part of citric acid and 75.26 parts of water.
The preparation method comprises the following steps:
(1) weighing water, carbomer and butanediol according to the raw material ratio, heating to 70 ℃, and uniformly stirring and mixing to obtain a water phase;
(2) heating sorbitan olivate, jojoba seed oil, white chinlon oil and tocopherol acetate to 70 ℃, and stirring and mixing uniformly to obtain an oil phase;
(3) respectively dissolving citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin at low temperature;
(4) heating an emulsification reaction kettle to 75 ℃, pumping the water phase and the oil phase into a phase mixing and emulsifying machine, homogenizing for 10min, adding triethanolamine, homogenizing for 5min, cooling to 45 ℃, sequentially adding citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin, homogenizing for 5min, and fully and uniformly stirring to obtain the whitening agent.
Test of whitening Effect
The whitening agents prepared in examples 1 to 5 were used to prepare a cream, and the cream was tested according to the test method for whitening and spot-removing effects of the T/ZHCA001-2018 cosmetic. The results are shown in Table 1, with a test cycle of 28 days, each morning and evening application. Wherein the inclusion conditions of the subject are: volunteers aged 18-60 who meet the test requirements are randomly grouped into 30 groups, namely 25 female volunteers and 5 male volunteers; those with epidermal pigmentation in the skin of the intended area of the face or forearm in the curved side; or the tested area of the face and the forearm curve side has no epidermal pigmentation, and the average whiteness value is between 10 and 41 degrees when the skin is measured for 5 times at different positions in the tested area by an intelligent skin tester. The cream obtained in example 1 was subjected to a stability test, and the test results are shown in table 2.
The preparation method of the face cream comprises the following steps:
(1) heating water, glyceryl polyether-26, butanediol, nicotinamide, C12-20 alkyl glucoside, PEG-100 stearate, betaine, ethylhexyl methoxycinnamate, panthenol, carbomer, methyl hydroxybenzoate and sodium hyaluronate to 75 deg.C, and dispersing and dissolving to obtain phase A material.
(2) Heating caprylic/capric triglyceride, squalane, sorbitan olivine oleate, cetostearyl alcohol, meadowfoam seed oil, jojoba seed oil, cetyl ethyl hexanoate, beeswax, stearic acid, tocopherol acetate and propyl hydroxybenzoate to 75 deg.C, and dispersing and dissolving to obtain phase B material. Uniformly mixing cyclopentadimethylsiloxane, polydimethylsiloxane and dimethiconol in advance for later use to obtain a C-phase material.
(3) Respectively dissolving the E-phase materials of citric acid, 3-o-ethyl ascorbic acid, nicotinamide and alpha-arbutin at low temperature.
(4) Stirring and heating the emulsion reaction kettle to 75 ℃, opening the vacuum pressure at 0.04Mpa, and pumping the A-phase materials into the emulsion reaction kettle. Pumping the B phase material into the reaction kettle, uniformly stirring for 10 minutes, adding the C phase material into the reaction kettle, uniformly stirring for 5 minutes, adding the triethanolamine D phase material into the reaction kettle, homogenizing for 5 minutes, stirring for 15 minutes, and then vacuumizing and cooling.
(5) When the temperature is reduced to 45 ℃, adding the phase E materials of citric acid, 3-o-ethyl ascorbic acid, nicotinamide and alpha-arbutin in turn, and stirring for 20 minutes.
(6) Sampling and detecting whether the product is qualified or not and discharging.
(7) And standing, filling and packaging after the material body is qualified, and warehousing after the finished product is qualified.
Table 1: whitening test effect of face cream prepared from whitening agent
Table 2: test results of stabilizer for cream prepared from the whitening agent
From the test results, the whitening agent prepared by the invention has good whitening and freckle removing effects and high product stability.
The foregoing is a more detailed description of the invention in connection with specific/preferred embodiments and is not intended to limit the practice of the invention to those descriptions. It will be apparent to those skilled in the art that various substitutions and modifications can be made to the described embodiments without departing from the spirit of the invention, and such substitutions and modifications are to be considered as within the scope of the invention.
Claims (5)
1. A stable weakly acidic whitening composition characterized by: the composite material comprises the following raw materials in parts by weight: 5-10 parts of 3-o-ethyl ascorbic acid ether, 3-6 parts of nicotinamide, 2-5 parts of alpha-arbutin, 1-3 parts of butanediol, 1-3 parts of emulsifier, 0.5-2.0 parts of jojoba seed oil, 0.5-2.0 parts of meadowfoam seed oil, 0.5-2.0 parts of tocopherol acetate, 0.1-0.5 part of carbomer, 0.1-0.5 part of triethanolamine, 0.01-0.05 part of citric acid and the balance of water added to 100 parts.
2. The stable weakly acidic whitening composition of claim 1, characterized in that: the emulsifier comprises cetearyl olive oleate or/and sorbitan olive oleate.
3. A stable weakly acidic whitening composition according to claim 1 or 2, characterized in that: the material is prepared from the following raw materials in parts by weight: 6 parts of 3-o-ethyl ascorbic acid ether, 5 parts of nicotinamide, 3 parts of alpha-arbutin, 2 parts of butanediol, 2 parts of an emulsifier, 1 part of jojoba seed oil, 1 part of chinaroot greenbrier seed oil, 1 part of tocopherol acetate, 0.2 part of carbomer, 0.2 part of triethanolamine, 0.02 part of citric acid and 72.58 parts of water.
4. A method of preparing a stable weakly acidic whitening composition as claimed in any of claims 1 to 3, characterized in that: the method comprises the following steps:
(1) weighing water, carbomer and butanediol according to the raw material ratio, heating, stirring and mixing uniformly to obtain a water phase;
(2) heating, stirring and uniformly mixing an emulsifier, jojoba seed oil, white chinlon oil and tocopherol acetate to prepare an oil phase;
(3) dissolving citric acid, nicotinamide, 3-o-ethyl ascorbic acid ether and alpha-arbutin at low temperature respectively;
(4) adding the water phase and the oil phase into an emulsification reaction kettle for phase combination, heating and homogenizing, adding triethanolamine for continuous homogenization, cooling, sequentially adding citric acid, 3-o-ethyl ascorbic acid ether and alpha-arbutin, and fully and uniformly stirring to obtain the whitening agent.
5. Use of a stable weakly acidic whitening composition as claimed in any of claims 1 to 4 for: the whitening agent composition is applied to cosmetics.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112545963A (en) * | 2020-12-30 | 2021-03-26 | 上海澄穆化妆品有限公司 | Composition with whitening effect, whitening compound preparation and preparation method of whitening compound preparation |
| CN112675100A (en) * | 2021-02-05 | 2021-04-20 | 广州瑞嘉精细化工有限公司 | Whitening skin care composition and preparation method thereof |
| WO2023182857A1 (en) * | 2022-03-24 | 2023-09-28 | 주식회사 엘지생활건강 | Cosmetic composition with improved skin absorption |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112545963A (en) * | 2020-12-30 | 2021-03-26 | 上海澄穆化妆品有限公司 | Composition with whitening effect, whitening compound preparation and preparation method of whitening compound preparation |
| CN112675100A (en) * | 2021-02-05 | 2021-04-20 | 广州瑞嘉精细化工有限公司 | Whitening skin care composition and preparation method thereof |
| WO2023182857A1 (en) * | 2022-03-24 | 2023-09-28 | 주식회사 엘지생활건강 | Cosmetic composition with improved skin absorption |
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