CN109328197A - 用于治疗具有补体c5多态性的患者的抗c5抗体 - Google Patents
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662346683P | 2016-06-07 | 2016-06-07 | |
| US62/346,683 | 2016-06-07 | ||
| PCT/IB2017/053245 WO2017212375A1 (en) | 2016-06-07 | 2017-06-01 | Anti-c5 antibody for treating patients with complement c5 polymorphism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109328197A true CN109328197A (zh) | 2019-02-12 |
Family
ID=59078125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780034701.9A Pending CN109328197A (zh) | 2016-06-07 | 2017-06-01 | 用于治疗具有补体c5多态性的患者的抗c5抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190225678A1 (enExample) |
| EP (1) | EP3464351A1 (enExample) |
| JP (1) | JP2019521105A (enExample) |
| CN (1) | CN109328197A (enExample) |
| WO (1) | WO2017212375A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY196006A (en) | 2016-06-14 | 2023-03-06 | Regeneron Pharma | Anti-C5 Antibodies and Uses Thereof |
| KR20200098528A (ko) | 2017-12-13 | 2020-08-20 | 리제너론 파아마슈티컬스, 인크. | 항-c5 항체 조합물 및 이의 용도 |
| MX2022001896A (es) | 2019-08-16 | 2022-06-02 | Regeneron Pharma | Formulaciones anti-c5 de alta concentracion. |
| WO2021081277A1 (en) | 2019-10-25 | 2021-04-29 | Regeneron Pharmaceuticals, Inc. | Dosing regimens for treating or preventing c5-associated diseases |
| CN118251491A (zh) | 2021-10-28 | 2024-06-25 | 瑞泽恩制药公司 | 用于敲除C5的CRISPR/Cas相关方法及组合物 |
| CN119409815B (zh) * | 2025-01-07 | 2025-04-08 | 天辰生物医药(苏州)有限公司 | 抗人补体c5 vhh抗体及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102170906A (zh) * | 2008-08-05 | 2011-08-31 | 诺瓦提斯公司 | 靶定补体蛋白c5的抗体的组合物和方法 |
| WO2014047500A1 (en) * | 2012-09-21 | 2014-03-27 | Alexion Pharmaceuticals, Inc. | Screening assays for complement component c5 antagonists |
| CN105143261A (zh) * | 2013-01-31 | 2015-12-09 | 首尔大学校产学协力团 | C5抗体以及用于预防和治疗补体-相关的疾病的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0985039B1 (en) | 1997-06-12 | 2008-02-20 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| KR20100015773A (ko) * | 2007-03-22 | 2010-02-12 | 노파르티스 아게 | Ｃ５ 항원 및 그의 용도 |
| CA2742802C (en) * | 2008-11-10 | 2019-11-26 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
| EP2563813B1 (en) * | 2010-04-30 | 2015-08-26 | Alexion Pharmaceuticals, Inc. | Anti-c5a antibodies and methods for using the antibodies |
| GB201410116D0 (en) * | 2014-06-06 | 2014-07-23 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| WO2016117346A1 (en) * | 2015-01-22 | 2016-07-28 | Chugai Seiyaku Kabushiki Kaisha | A combination of two or more anti-c5 antibodies and methods of use |
-
2017
- 2017-06-01 EP EP17731296.4A patent/EP3464351A1/en not_active Withdrawn
- 2017-06-01 US US16/306,654 patent/US20190225678A1/en not_active Abandoned
- 2017-06-01 JP JP2018563888A patent/JP2019521105A/ja active Pending
- 2017-06-01 CN CN201780034701.9A patent/CN109328197A/zh active Pending
- 2017-06-01 WO PCT/IB2017/053245 patent/WO2017212375A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102170906A (zh) * | 2008-08-05 | 2011-08-31 | 诺瓦提斯公司 | 靶定补体蛋白c5的抗体的组合物和方法 |
| WO2014047500A1 (en) * | 2012-09-21 | 2014-03-27 | Alexion Pharmaceuticals, Inc. | Screening assays for complement component c5 antagonists |
| CN105143261A (zh) * | 2013-01-31 | 2015-12-09 | 首尔大学校产学协力团 | C5抗体以及用于预防和治疗补体-相关的疾病的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017212375A1 (en) | 2017-12-14 |
| US20190225678A1 (en) | 2019-07-25 |
| EP3464351A1 (en) | 2019-04-10 |
| JP2019521105A (ja) | 2019-07-25 |
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