CN109303758A - A kind of preparation method of skin maintenance and cosmetic benefits freckle-diminishing capsule - Google Patents

A kind of preparation method of skin maintenance and cosmetic benefits freckle-diminishing capsule Download PDF

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Publication number
CN109303758A
CN109303758A CN201811391289.9A CN201811391289A CN109303758A CN 109303758 A CN109303758 A CN 109303758A CN 201811391289 A CN201811391289 A CN 201811391289A CN 109303758 A CN109303758 A CN 109303758A
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preparation
follows
water
decoction
volumes
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李方瑞
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Qinghai Jingzhuzangyao High-Tech Industry Ltd By Share Ltd
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Qinghai Jingzhuzangyao High-Tech Industry Ltd By Share Ltd
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Priority to CN201811391289.9A priority patent/CN109303758A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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Abstract

The invention discloses a kind of preparation methods of skin maintenance and cosmetic benefits freckle-diminishing capsule.The preparation method include the following steps: using ethanol water refluxing extraction root of kirilow rhodiola, the fleece-flower root and Radix Angelicae Sinensis mixture at least three times, combined extract, filtering, recycling ethyl alcohol obtain solution；Using the mixture of steam distillation processing safflower and azalea, volatile oil and the dregs of a decoction are obtained；The dregs of a decoction are merged with fructus lycii and Radix Astragali, are added water to cook at least three times, collecting decoction filters to get filtrate；(4) filtrate is merged with above-mentioned solution, is condensed into thick paste；By crushing pearl at pearl powder；Thick paste and pearl powder are mixed, then crushes after drying and obtains fine powder；Fine powder and volatile oil are mixed, are packed into capsule to obtain the final product.The present invention, instead of radix rehmanniae recen and Rehmannia glutinosa in original formulation, is used as medicine with safflower and Du Juan volatile oil with safflower and azalea, further shortens the drug effect time, and improve treated effect.

Description

A kind of preparation method of skin maintenance and cosmetic benefits freckle-diminishing capsule
Technical field
The present invention relates to a kind of preparation methods of skin maintenance and cosmetic benefits freckle-diminishing capsule, belong to cosmetic technical field.
Background technique
Chloasma is that the acquired irregular brown pigment of the face occurred is calm, it is considered that its with endocrine disturbance, The factors such as solarization, mood are related, and disease incidence is in rising trend in recent years, and age of onset tends to rejuvenation.
This disease there is no the treatment method of special efficacy at present.Hydrochinone Cream, retinoid drug have certain effect, but there is also not Foot: curative effect improves when Hydrochinone Cream high concentration, but irritation aggravates, and prolonged application can lead to exogenous chloasma；Vitamin A acid works Slowly, need or so continuous medication half a year gradually effective.Brilliant pearl stonecrop spot removal capsule is selected from high crude drug, with root of kirilow rhodiola, Huang The composition such as stilbene, safflower, pearl, has effects that blood-activating and qi-promoting, treating chloasma and acne, achieves definite curative effect for treating chloasma, And patient tolerability is good, but some patientss are not very obvious using rear curative effect or onset time is slow, it is therefore desirable to match to existing Side is adjusted, and to shorten the time from medication to action, and improves treated effect.
Summary of the invention
The object of the present invention is to provide a kind of preparation methods of skin maintenance and cosmetic benefits freckle-diminishing capsule, and present invention employs vapor steamings Evaporate the safflower of method extraction and the volatile oil of azalea, the raising significant in efficacy of prepared freckle-diminishing capsule.
The preparation method of freckle-diminishing capsule provided by the present invention, includes the following steps:
(1) mixture for using ethanol water refluxing extraction root of kirilow rhodiola, the fleece-flower root and Radix Angelicae Sinensis at least three times, merges and extracts Liquid, filtering, recycling ethyl alcohol obtain solution；
(2) using the mixture of steam distillation processing safflower and azalea, volatile oil and the dregs of a decoction are obtained；
(3) dregs of a decoction that step (2) obtains are merged with fructus lycii and Radix Astragali, adds water to cook at least three times, merges and decoct Liquid filters to get filtrate；
(4) filtrate that step (3) obtains is merged with the solution that step (1) obtains, is condensed into thick paste；
(5) by crushing pearl at pearl powder；
(6) thick paste that step (4) obtains and the pearl powder that step (5) obtain are mixed, then after drying Crushing obtains fine powder；
(7) fine powder that step (6) obtains and the volatile oil that step (2) obtain are mixed, are packed into capsule to obtain the final product；
The quality proportioning for preparing each raw material of the freckle-diminishing capsule is as follows:
The quality proportioning of each raw material of the freckle-diminishing capsule is specially
In above-mentioned preparation method, in step (1), in the ethanol water volumn concentration of ethyl alcohol be 65%~ 75%, such as 70%.
In above-mentioned preparation method, in step (1), the condition of the ethanol water refluxing extraction is as follows:
Three times using mixture described in the ethanol water refluxing extraction；
The condition extracted for the first time is as follows: using the ethanol water refluxing extraction 1~6 hour of 4~8 times of volumes, Such as use the ethanol water refluxing extraction 3 hours of 6 times of volumes；
Second of condition extracted is as follows: using the ethanol water refluxing extraction 1~3 hour of 2~6 times of volumes, Such as use the ethanol water refluxing extraction 2 hours of 4 times of volumes；
The condition that third time is extracted is as follows: the ethanol water refluxing extraction 0.5~1.5 using 2~6 times of volumes is small When, such as use the ethanol water refluxing extraction 1 hour of 4 times of volumes.
In above-mentioned preparation method, in step (2), the steam distillation includes the following steps:
The safflower and the azalea crushed 50 meshes, then obtain Aqueous extracts using water refluxing extraction；Using just Hexane extracts the Aqueous extracts, obtains water phase and organic phase, and the organic phase is the transparent oily liquid with aromatic odor, warp It is drying to obtain the volatile oil；The dregs of a decoction are obtained by filtration in the water phase；
The condition of the refluxing extraction is as follows:
Using the water refluxing extraction 3~7 hours of 4~8 times of volumes, the water refluxing extraction 5 of 6 times of volumes is such as used Hour；
Anhydrous sodium sulfate can be used to be dried.
In above-mentioned preparation method, in step (3), the condition of the decoction is as follows:
It is decocted three times using water；
The condition decocted for the first time is as follows: being decocted 1~5 hour using the water of 4~8 times of volumes, such as uses the water of 6 times of volumes It decocts 3 hours；
Second of condition decocted is as follows: being decocted 1~3 hour using the water of 2~6 times of volumes, such as uses the water of 4 times of volumes It decocts 2 hours；
The condition that third time decocts is as follows: being decocted 0.5~1.5 hour using the water of 2~6 times of volumes, such as uses 4 times of volumes Water decoct 1 hour.
In above-mentioned preparation method, in step (4), the relative density of the thick paste is 1.30~1.35 (50 DEG C).
In above-mentioned preparation method, in step (5), the partial size of the pearl powder is 70~80 μm (200 mesh).
In above-mentioned preparation method, in step (6), the condition of the drying is as follows:
Using micro-wave vacuum method, in low firepower, first 13 minutes are intermittent heating (open and stop for 1 minute 1 minute), later For laser heating, 24 DEG C~39 DEG C of temperature are controlled, vacuum degree -0.084MPa.
The partial size of the fine powder is 70~80 μm (200 mesh).
The preparation method of skin maintenance and cosmetic benefits freckle-diminishing capsule provided by the invention, compared with former preparation method, advantage and feature exist In:
(1) with safflower and azalea instead of the radix rehmanniae recen and Rehmannia glutinosa in original formulation.Safflower has blood circulation, stagnation resolvation It relieves pain, the function of promoting blood circulation and detoxication, for treating the diseases such as dysmenorrhea, traumatic injury, arthralgia, coronary heart disease.Azalea contains Huang The effective components such as ketone, Diterpenes have the effects that antibechic, eliminating the phlegm, relieving asthma, is anti-inflammatory, analgesia, additionally to cardiovascular, nerve System plays a variety of effects.
(2) it is used as medicine with safflower and Du Juan volatile oil, further shortens the drug effect time, and it is effective to improve treatment Rate.Flos Carthami volatile oil has identified 48 kinds of volatile chemical components, including 7,9- docosane ketone, caryophyllene oxide at present Deng, by construct disease network model find these ingredients in the treatment of the diseases such as tumour, cirrhosis, hyperlipidemia, myocardial ischemia In play a significant role.Cuckoo flowers volatile oil has identified 62 kinds of volatile components at present, it is known that wherein δ-cadinene, γ-Du Loose alkene, bulnesol and α-cadinol have phlegm-dispelling functions, and guaiol and bulnesol have antitussive effect.
Specific embodiment
Experimental method used in following embodiments is conventional method unless otherwise specified.
The materials, reagents and the like used in the following examples is commercially available unless otherwise specified.
Embodiment 1,
Each component is weighed according to the following recipe:
It is prepared by the following method:
1) by root of kirilow rhodiola, the fleece-flower root, Radix Angelicae Sinensis with 70% ethanol water (volume) refluxing extraction three times, for the first time using use The ethyl alcohol that 6 times of medicinal material volume extracts 3 hours, is extracted 2 hours using 4 times of medicinal material volume of ethyl alcohol for the second time, uses medicine for the third time The ethyl alcohol that 4 times of material volume extracts 1 hour, combined extract, filtration, recycles ethyl alcohol, and acquired solution is spare；
2) using steam distillation processing safflower and azalea, dry safflower 80g and azalea 200g are taken, with common Pulverizer crushes and crosses 50 meshes, is then uniformly mixed, and is boiled refluxing extraction 5 hours with the boiling of 6 times of volumes, is extracted using n-hexane Water intaking extract obtains water phase and organic phase, and the organic phase is the transparent oily liquid with aromatic odor, waves through being drying to obtain Hair oil；Water phase is through being obtained by filtration the dregs of a decoction.
3) dregs of a decoction that step 2) obtains are merged with fructus lycii, Radix Astragali, is added water to cook three times, use medicinal material volume for the first time 6 times of water decocts 3 hours, is decocted 2 hours using 4 times of medicinal material volume of water for the second time, uses 4 times of medicinal material volume of water for the third time It decocts 1 hour, collecting decoction filters to obtain filtrate.
4) filtrate obtained by step 3) is merged with step 1) acquired solution, being concentrated into relative density is 1.30~1.35 (50 DEG C) thick paste it is spare；
5) by sieve after crushing pearl at fine powder, partial size is 70 μm~80 μm (200 mesh)；
6) it by thick paste that step 4) obtains and the fine powder that step 5) obtains, mixes, micro-wave vacuum (low fire in use Power, first 13 minutes are intermittent heating, open and stop within 1 minute 1 minute, are later laser heating, control 24 DEG C -39 DEG C of temperature, vacuum Degree -0.084MPa.), it is ground into fine powder, granularity is 70 μm~80 μm (200 mesh)；
7) fine powder for obtaining step 6) sprays the volatile oil as made from step 2), mixes, and is packed into capsule to obtain the final product.
Comparative example 1,
Each component is weighed according to the following recipe:
It is prepared by the following method:
1) root of kirilow rhodiola, the fleece-flower root and Radix Angelicae Sinensis (are used for the first time three times with 70% ethanol water (volume) refluxing extraction It is extracted 3 hours with 6 times of medicinal material volume of 70% ethyl alcohol, is extracted 2 hours using 4 times of medicinal material volume of 70% ethyl alcohol for the second time, the Extracted 1 hour using 4 times of medicinal material volume of 70% ethyl alcohol three times), merge extracting solution three times, ethyl alcohol is recovered under reduced pressure, is condensed into cream, Dry, to be ground into fine powder spare, partial size is 70 μm~80 μm (200 mesh)；
2) fructus lycii, radix rehmanniae recen, Rehmannia glutinosa and Radix Astragali boiling (are decocted 3 using 6 times of medicinal material volume of water for the first time three times Hour, decocted 2 hours using 4 times of medicinal material volume of water, decocted 1 hour using 4 times of medicinal material volume of water for the third time for the second time), Merge that extracting solution filtering three times, concentration, (low firepower in use, first 13 minutes are intermittent heating to micro-wave vacuum, open 1 point Clock stops 1 minute, is later laser heating, controls 24 DEG C~39 DEG C of temperature, vacuum degree -0.084MPa.) fine powder is obtained, partial size is 70 μ M~80 μm (200 mesh)；
3) by sieve after crushing pearl at fine powder, granularity is 70 μm~80 μm (200 mesh)；
4) add auxiliary material to mix well fine powder obtained by step 1), step 2) and step 3), sterilize, dosing is filled with starch supplementary material It is encapsulated to obtain the final product.
The capsule that embodiment 1 and comparative example 1 are prepared respectively is used for clinic by embodiment 2, and to it for original disease Curative effect is compared
In order to compare with brilliant pearl freckle-diminishing capsule today of brilliant pearl stonecrop spot removal capsule prepared by the present invention and original method preparation Curative effect, the brilliant pearl hospital of traditional Chinese hospital, Beijing is included in 120 patient with chloasma, and is randomly divided into A group and B group, each 60.Wherein A group The brilliant pearl stonecrop spot removal for using original method to prepare using brilliant pearl stonecrop spot removal capsule for treating (embodiment 1) prepared by the present invention, B group Capsule for treating (comparative example 1).Two groups be 2 times a day, one time 4,3 months are as a treatment course.
Curative effect determinate standard are as follows: calculated and integrated with the sum of skin lesion area and skin color score.Skin lesion area scoring: area ≤5cm21 point is obtained, 5cm2< area≤10cm22 points are obtained, area > 10cm2Obtain 3 points；Skin color scoring: it is light brown to obtain 1 point, Dark brown obtains 2 points, and dark brown obtains 3 points.
Therapeutic index (%)=(total mark after total mark-treatment before treating)/total mark × 100% before treating.Curative effect refers to Number > 90% be cure, therapeutic index 60%~90% be it is effective, therapeutic index 30%~59% be progress, therapeutic index < 30% is invalid.The time that onset time=from starting medication therapeutic index is 30%.Total effective rate=(recovery from illness number of cases+aobvious Imitate number of cases)/total number of cases × 100%, total effective rate=(recovery from illness number of cases+effective number of cases+effective number of cases)/total number of cases × 100%.
Two groups of average onset times and Comparison of therapeutic are as shown in table 1.
The average onset time of two groups of table 1 A, B and Comparison of therapeutic
By the data in table 1 it is found that the average onset time of A group is only (12.7 ± 3.2) day, considerably shorter than B group (28.5 ± 2.6) day (P < 0.05) shows to work faster with brilliant pearl stonecrop spot removal capsule prepared by the present invention, this is for patient Treatment confidence is established, enhancing curative compliance is of great significance.
In addition, two groups of A, B of total effective rate is respectively 86.6% and 80.0%, statistical significance (P > is had not yet been reached in difference 0.05), but the obvious effective rate of A group is 60.0%, and significantly larger than 36.6% (P < 0.05) of B group, this shows with prepared by the present invention Its obvious effective rate of brilliant pearl stonecrop spot removal capsule is better than the brilliant pearl stonecrop spot removal capsule of original method preparation, and the latter's treatment results are only presented Progressive accounting is higher.
In terms of adverse reaction, A group and B group respectively have 1 of short duration gastrointestinal reaction occur, but are slightly, not influence to control It treats, and completes the treatment of a course for the treatment of.
The capsule that embodiment 1 and comparative example 1 are prepared respectively is used for clinic by embodiment 3, and to it for new indication Curative effect is compared
The brilliant pearl hospital of traditional Chinese hospital, Beijing is in the process for being used for chloasma treatment with brilliant pearl stonecrop spot removal capsule prepared by the present invention In, it is found that the medicine also has curative effect to the female patient of qi stagnation and blood stasis type primary dysmenorrhea, therefore has carried out preliminary observation to this.It will 60 qi stagnation and blood stasis type primary dysmenorrhea patient 60 are randomly divided into treatment group and control group, and every group each 30.Treatment group uses With brilliant pearl stonecrop spot removal capsule for treating prepared by the present invention, control group is controlled using the brilliant pearl stonecrop spot removal capsule of original method preparation It treats, treats 3 months altogether, observe curative effect and pretherapy and post-treatment visual analogue scale (VAS).
Two groups of curative effects are more as shown in table 2, and pretherapy and post-treatment VAS scoring is as shown in table 3.
The Clinical efficacy comparison of table 2 treatment group and control group
Group Number of cases Recovery from illness It is effective In vain Total effective rate
Treatment group 30 15 10 5 83.3%
Control group 30 6 12 12 60.0%
VAS scoring is compared before and after treatment for 3 treatment group of table and control group
Note: compared with * is preceding with group treatment, P < 0.05；# is compared with after control group treatment, P < 0.05.
Due to being preliminary observation, therefore placebo group is not set.But from the above still as it can be seen that crystalline substance prepared by the present invention Pearl stonecrop spot removal capsule, total effective rate 83.3% are significantly higher than the brilliant pearl stonecrop spot removal capsule (60.0%) of original method preparation, It is also significantly improved to pretherapy and post-treatment VAS scoring simultaneously, and better than the brilliant pearl stonecrop spot removal capsule of original method preparation.
Brilliant pearl stonecrop spot removal capsule prepared by the present invention is main to become compared with brilliant pearl stonecrop spot removal capsule prepared by original method Change is with safflower and azalea instead of the radix rehmanniae recen and Rehmannia glutinosa in original method, and is extracted with steam distillation red Colored and azalea volatile oil.

Claims (7)

1. a kind of preparation method of freckle-diminishing capsule, includes the following steps:
(1) using ethanol water refluxing extraction root of kirilow rhodiola, the fleece-flower root and Radix Angelicae Sinensis mixture at least three times, combined extract, Filtering, recycling ethyl alcohol obtain solution；
(2) using the mixture of steam distillation processing safflower and azalea, volatile oil and the dregs of a decoction are obtained；
(3) dregs of a decoction that step (2) obtains are merged with fructus lycii and Radix Astragali, is added water to cook at least three times, collecting decoction, mistake Filter to obtain filtrate；
(4) filtrate that step (3) obtains is merged with the solution that step (1) obtains, is condensed into thick paste；
(5) by crushing pearl at pearl powder；
(6) thick paste that step (4) obtains and the pearl powder that step (5) obtain are mixed, is then crushed after drying Obtain fine powder；
(7) fine powder that step (6) obtains and the volatile oil that step (2) obtain are mixed, are packed into capsule to obtain the final product；Preparation The quality proportioning of each raw material of the freckle-diminishing capsule is as follows:
2. preparation method according to claim 1, it is characterised in that: in step (1), ethyl alcohol in the ethanol water Volumn concentration is 65%~75%.
3. preparation method according to claim 1 or 2, it is characterised in that: in step (1), the ethanol water reflux The condition of extraction is as follows:
Three times using mixture described in the ethanol water refluxing extraction；
The condition extracted for the first time was as follows: using the ethanol water refluxing extraction 1~5 hour of 4~8 times of volumes；
Second of condition extracted was as follows: using the ethanol water refluxing extraction 1~4 hour of 2~6 times of volumes；
The condition that third time is extracted was as follows: using the ethanol water refluxing extraction 0.5~1.5 hour of 2~6 times of volumes.
4. preparation method according to any one of claim 1-3, it is characterised in that: in step (2), the vapor steams The method of evaporating includes the following steps:
Then the safflower and the azalea obtain Aqueous extracts using water refluxing extraction through pulverizing and sieving；Using n-hexane extraction The Aqueous extracts obtain water phase and organic phase, and the organic phase is transparent oily liquid, are drying to obtain the volatile oil；Institute It states water phase and the dregs of a decoction is obtained by filtration.
5. preparation method described in any one of -4 according to claim 1, it is characterised in that: in step (3), the item of the decoction Part is as follows:
It is decocted three times using water；
The condition decocted for the first time is as follows: being decocted 1~5 hour using the water of 4~8 times of volumes；
Second of condition decocted is as follows: being decocted 1~4 hour using the water of 2~6 times of volumes；
The condition that third time decocts is as follows: being decocted 0.5~1.5 hour using the water of 2~6 times of volumes.
6. preparation method according to any one of claims 1-5, it is characterised in that: in step (5), the pearl powder Partial size is 70~80 μm.
7. preparation method according to claim 1 to 6, it is characterised in that: in step (6), the item of the drying Part is as follows:
Using micro-wave vacuum method, in low firepower, it is later laser heating that first 13 minutes, which are intermittent heating, controls temperature It is 24 DEG C~39 DEG C, vacuum degree is -0.084MPa.
CN201811391289.9A 2018-11-21 2018-11-21 A kind of preparation method of skin maintenance and cosmetic benefits freckle-diminishing capsule Pending CN109303758A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1733141A (en) * 2005-08-17 2006-02-15 师宇 New preparation for curing chloasma and acne
CN1931282A (en) * 2006-09-26 2007-03-21 兰玉岐 Chinese medicine composition for promoting blood circulation to eliminate spots and its prepn process
CN101485782A (en) * 2008-01-16 2009-07-22 北京天科仁祥医药科技有限公司 Chinese medicinal composition for dissolving stasis and eliminating plaque and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005060308A (en) * 2003-08-13 2005-03-10 National Institute Of Advanced Industrial & Technology Agent for enhancing and promoting production of adiponectin
CN106728651B (en) * 2017-03-16 2020-10-30 南京中医药大学 Preparation method and quality detection method of rhizoma cyperi four-ingredient granules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1733141A (en) * 2005-08-17 2006-02-15 师宇 New preparation for curing chloasma and acne
CN1931282A (en) * 2006-09-26 2007-03-21 兰玉岐 Chinese medicine composition for promoting blood circulation to eliminate spots and its prepn process
CN101485782A (en) * 2008-01-16 2009-07-22 北京天科仁祥医药科技有限公司 Chinese medicinal composition for dissolving stasis and eliminating plaque and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杨俊杰等: "《中药化学实用技术》", 29 February 2016, 重庆大学出版社 *

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Application publication date: 20190205