CN109289078A - A kind of long-acting bacteriostatic adhesive bandage - Google Patents
A kind of long-acting bacteriostatic adhesive bandage Download PDFInfo
- Publication number
- CN109289078A CN109289078A CN201811298085.0A CN201811298085A CN109289078A CN 109289078 A CN109289078 A CN 109289078A CN 201811298085 A CN201811298085 A CN 201811298085A CN 109289078 A CN109289078 A CN 109289078A
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- China
- Prior art keywords
- long
- adhesive bandage
- layer
- acting bacteriostatic
- spongy layer
- Prior art date
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Links
- 239000000853 adhesive Substances 0.000 title claims abstract description 67
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 67
- 230000003385 bacteriostatic effect Effects 0.000 title claims abstract description 39
- 239000003814 drug Substances 0.000 claims abstract description 60
- 229940079593 drug Drugs 0.000 claims abstract description 47
- 229920001661 Chitosan Polymers 0.000 claims abstract description 24
- 229920002678 cellulose Polymers 0.000 claims abstract description 24
- 239000001913 cellulose Substances 0.000 claims abstract description 24
- VNHBYKHXBCYPBJ-UHFFFAOYSA-N 5-ethynylimidazo[1,2-a]pyridine Chemical compound C#CC1=CC=CC2=NC=CN12 VNHBYKHXBCYPBJ-UHFFFAOYSA-N 0.000 claims abstract description 19
- ZHNUHDYFZUAESO-UHFFFAOYSA-N formamide Substances NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 125000003944 tolyl group Chemical group 0.000 claims abstract description 15
- 239000000243 solution Substances 0.000 claims description 28
- 239000004745 nonwoven fabric Substances 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 239000011505 plaster Substances 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000004080 punching Methods 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 18
- 208000027418 Wounds and injury Diseases 0.000 abstract description 18
- 239000012530 fluid Substances 0.000 abstract description 8
- 230000001408 fungistatic effect Effects 0.000 abstract description 6
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000029663 wound healing Effects 0.000 abstract description 4
- 230000001580 bacterial effect Effects 0.000 abstract description 2
- 238000007599 discharging Methods 0.000 abstract description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 241000894006 Bacteria Species 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 230000008901 benefit Effects 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000002439 hemostatic effect Effects 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000009134 Myrica cerifera Nutrition 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 244000061457 Solanum nigrum Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010417 needlework Methods 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
Abstract
The invention belongs to field of medicaments, and in particular to a kind of long-acting bacteriostatic adhesive bandage.Long-acting bacteriostatic adhesive bandage provided by the invention includes carcass, the spongy layer of chitosan and cellulose composition, 6; 6 '-two fluoro- 3; 3 '-bisglyoxalines simultaneously [1; 2-a] pyridine and 5- caproyl -2- methyl-N-o tolyl -3- formamide composition porous drug layer, the spongy layer is between the carcass and the porous drug layer.Adhesive bandage provided by the invention contains porous drug layer, contained drug can effectively inhibit bacterial multiplication, and blood and wound tissue fluid can be made to enter spongy layer by aperture while discharging drug, spongy layer provided by the invention can absorb rapidly blood and tissue fluid simultaneously, with fungistatic effect, gnotobasis can be preferably maintained, wound healing is promoted.
Description
Technical field
The invention belongs to field of medicaments, and in particular to a kind of long-acting bacteriostatic adhesive bandage.
Background technique
Adhesive bandage is a kind of medical product for often using in people's life, inevitably in daily life in people's lives
In be easy to appear some small wounds, most common is exactly adhesive bandage.Although but common adhesive bandage can stop wound with
External environment, but these adhesive bandages cannot inhibit bacterium well during use, and due to wound tissue's liquid
Exudation can be such that wound is impregnated by tissue fluid, to be unfavorable for wound healing.
106267308 A of Chinese patent application CN discloses a kind of adhesive bandage, which is that the wound for the treatment of and nursing wound can
Patch, it includes adhesive tape, cotton fiber or isolated film, adhesive tape both ends bonding plastics paper, its main feature is that applying on cotton fiber
If one has wound and is stopped blooding rapid, healing fastly by the non-woven fabrics with hemostasis, antiinflammation containing soybean fiber, and
Production cost is low, uses rear more environmentally-friendly effect.But the adhesive bandage can not be antibacterial for a long time, thus in use
It is unsatisfactory to the healing effect of wound.
108355001 A of Chinese patent application CN discloses a kind of adhesive bandage, which includes tape wrap, in tape wrap
Both ends are respectively arranged with adhered layer, and hemostatic and antibacterial medicine layer is provided in the middle part of tape wrap, circle is provided in the middle part of tape wrap
Through-hole, is provided with stretch fabric band in the circular through hole of tape wrap, and the edge of stretch fabric band is fixed on tape wrap by stickup or needlework
On, hemostatic and antibacterial medicine layer is on the middle part of tape wrap and the surface of stretch fabric band, wherein the hemostatic and antibacterial medicine layer at
The bulk pharmaceutical chemicals for being divided into following parts by weight are prepared: 30 parts of bur, 25 parts of Buddhist temple dish, 18 parts of rhizoma polygoni paleacei, purple stem feather bayberry 20
Part, logical stalk spend 15 parts, 10 parts of narrow leaf Peng Lai Pueraria lobota.The structure setting of the invention is reasonable, be provided on tape wrap circular through hole and
It is provided with stretch fabric band in circular through hole, in finger tip in use, finger tip is protruded into circular through hole, then again tightly wraps tape wrap
, substantially increase its scope of application, strong applicability and practicability is good.But the ingredient that the medicine layer of the adhesive bandage uses is
Traditional Chinese medicine ingredients take effect slowly, and the adhesive bandage cannot inhibit bacterium well, to will affect the healing of wound.
Generally speaking, although existing adhesive bandage also has its fungistatic effect of some inhibiting bacteria and diminishing inflammations and other effects difference and holds
The continuous time is short, and since the exudation of wound tissue fluid causes the adhesive bandage of wound to become moisture state, is more easier to grow
Endophytic bacteria and the healing for being unfavorable for wound.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of long-acting bacteriostatic adhesive bandages.The present invention provides
Long-acting bacteriostatic adhesive bandage contain porous drug layer, the pharmaceutical composition in the porous drug layer can effectively inhibit the proliferation of bacterium,
And blood and wound tissue fluid can be made to enter spongy layer by aperture while discharging drug and be rapidly absorbed, together
When spongy layer provided by the invention can not only absorb the blood and tissue fluid of wound rapidly, moreover it is possible to play certain antibacterial effect
Fruit can preferably maintain gnotobasis, promote wound healing.
A kind of long-acting bacteriostatic adhesive bandage, the spongy layer formed including carcass, chitosan and cellulose, 6,6 '-two is fluoro-
The 3,3 '-bisglyoxalines porous drug that simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o tolyl -3- formamide form
Layer, the spongy layer be located at the carcass and porous state between medicine layer.
Further, the spongy layer area is the 3/10-2/5 of the carcass area.
Further, the spongy layer the preparation method comprises the following steps: being freezed after chitosan solution and cellulose solution are mixed dry
It is dry, squeeze, spongy layer.
Further, the concentration of the chitosan solution is 1-3mg/mL, and the concentration of the cellulose solution is 2-4mg/
ML, wherein the volume ratio of the cellulose solution and the chitosan solution is 2-5:3-7.
Further, the spongy layer with a thickness of 0.1-0.5mm.
Further, the porous drug level product is 1.2-1.5 times of the spongy layer area.
Further, the porous drug layer the preparation method comprises the following steps: by water-soluble as pharmaceutical composition after non-woven fabric perforating
In liquid impregnate 20-40min after freeze-drying to get.
Further, pharmaceutical composition is by 6,6 '-two fluoro- 3 in the porous drug layer, and 3 '-bisglyoxalines are simultaneously [1,2-a]
Pyridine and 5- caproyl -2- methyl-N-o tolyl -3- formamide 4-7:1-3 in mass ratio composition.
Further, pharmaceutical composition is by 6,6 '-two fluoro- 3 in the porous drug layer, 3 '-bisglyoxalines simultaneously [1,2-
A] pyridine and 5- caproyl -2- methyl-N-o tolyl -3- formamide be 5:2 composition in mass ratio.
Further, the punching is that the hole that 200-300 diameter is 0.1-0.3mm is uniformly stamped on non-woven fabrics.
Compared with prior art, present invention has the advantage that
(1) long-acting bacteriostatic adhesive bandage provided by the invention contains 6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine
With the porous drug layer of 5- caproyl -2- methyl-N-o tolyl -3- formamide composition, which can be with long-acting bacteriostatic.
(2) contain aperture on the porous drug layer of long-acting bacteriostatic adhesive bandage provided by the invention, the blood of wound can be made
Liquid and tissue fluid enter intermediate spongy layer by aperture to keep the drying of medicine layer, are further reduced bacteria breed.
(3) spongy layer of long-acting bacteriostatic adhesive bandage provided by the invention is made of chitosan and cellulose, which can
To absorb liquid rapidly and have fungistatic effect, making spongy layer, also bacteria can be prevented from growing under humidified condition, so that it is arrived
Fungistatic effect.
(4) long-acting bacteriostatic adhesive bandage provided by the invention avoids wound and is impregnated for a long time by tissue fluid, can accelerate
Wound healing.
Detailed description of the invention
Fig. 1 adhesive bandage structural schematic diagram
Specific embodiment
The following describes the present invention further through the description of specific embodiments, but it is to limit of the invention that this, which is not,
System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this
The basic thought of invention, is all within the scope of the present invention.
A kind of long-acting bacteriostatic adhesive bandage of embodiment 1
A kind of long-acting bacteriostatic adhesive bandage, structural schematic diagram is as shown in Figure 1, include carcass 1, chitosan and cellulose group
At spongy layer 3,6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o tolyl -
The porous drug layer 2 of 3- formamide composition, the spongy layer is between the carcass and the porous drug layer.
The carcass is non-woven fabrics adhesive plaster.
The spongy layer the preparation method comprises the following steps: by chitosan be dissolved in mass percent be 0.1% acetic acid solution in it is dense
Degree is 1mg/mL chitosan solution, and it is 2mg/mL cellulose solution that cellulose, which is dissolved in deionized water to obtain concentration, by two kinds of solution
It is freeze-dried after 2:3 mixing by volume, squeezes with a thickness of 0.1mm spongy layer.
The porous drug layer the preparation method comprises the following steps: by thickness non-woven fabrics stamp 200 diameters be 0.1mm hole, then
Object room benefit is dipped into 6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o toluene
It is freeze-dried after impregnating 20min in the pharmaceutical composition aqueous solution of base -3- formamide 4:1 in mass ratio composition, obtains porous drug
Layer.
By non-woven fabrics adhesive plaster as bottom, spongy layer and porous drug layer are put respectively to get long-acting bacteriostatic adhesive bandage, institute
3/10 that spongy layer area is the carcass area is stated, the porous drug level product is 1.2 times of the spongy layer area.
A kind of long-acting bacteriostatic adhesive bandage of embodiment 2
A kind of long-acting bacteriostatic adhesive bandage, structural schematic diagram is as shown in Figure 1, include carcass 1, chitosan and cellulose group
At spongy layer 3,6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o tolyl -
The porous drug layer 2 of 3- formamide composition, the spongy layer is between the carcass and the porous drug layer.
The carcass is non-woven fabrics adhesive plaster.
The spongy layer the preparation method comprises the following steps: by chitosan be dissolved in mass percent be 0.1% acetic acid solution in it is dense
Degree is 3mg/mL chitosan solution, and it is 4mg/mL cellulose solution that cellulose, which is dissolved in deionized water to obtain concentration, by two kinds of solution
It is freeze-dried after 5:7 mixing by volume, squeezes with a thickness of 0.5mm spongy layer.
The porous drug layer the preparation method comprises the following steps: by thickness non-woven fabrics stamp 300 diameters be 0.3mm hole, then
Object room benefit is dipped into 6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o toluene
It is freeze-dried after impregnating 40min in the pharmaceutical composition aqueous solution of base -3- formamide 7:3 in mass ratio composition, obtains porous drug
Layer.
By non-woven fabrics adhesive plaster as bottom, spongy layer and porous drug layer are put respectively to get long-acting bacteriostatic adhesive bandage, institute
2/5 that spongy layer area is the carcass area is stated, the porous drug level product is 1.5 times of the spongy layer area.
A kind of long-acting bacteriostatic adhesive bandage of embodiment 3
A kind of long-acting bacteriostatic adhesive bandage, structural schematic diagram is as shown in Figure 1, include carcass 1, chitosan and cellulose group
At spongy layer 3,6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o tolyl -
The porous drug layer 2 of 3- formamide composition, the spongy layer position 3 is between the carcass and the porous drug layer.
The carcass is non-woven fabrics adhesive plaster.
The spongy layer the preparation method comprises the following steps: by chitosan be dissolved in mass percent be 0.1% acetic acid solution in it is dense
Degree is 1-3mg/mL chitosan solution, and it is 2-4mg/mL cellulose solution that cellulose, which is dissolved in deionized water to obtain concentration, by two kinds
It is freeze-dried after solution 3:5 mixing by volume, squeezes with a thickness of 0.3mm spongy layer.
The porous drug layer the preparation method comprises the following steps: by thickness non-woven fabrics stamp 260 diameters be 0.2mm hole, then
Non-woven fabrics is dipped into 6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o toluene
It is freeze-dried after impregnating 30min in the pharmaceutical composition aqueous solution of base -3- formamide 5:2 in mass ratio composition, obtains porous drug
Layer.
By non-woven fabrics adhesive plaster as bottom, spongy layer and porous drug layer are put respectively to get long-acting bacteriostatic adhesive bandage, institute
1/3 that spongy layer area is the carcass area is stated, the porous drug level product is 1.3 times of the spongy layer area.
A kind of long-acting bacteriostatic adhesive bandage of embodiment 4
A kind of long-acting bacteriostatic adhesive bandage, structural schematic diagram is as shown in Figure 1, include carcass 1, chitosan and cellulose group
At spongy layer 3,6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o tolyl -
The porous drug layer 2 of 3- formamide composition, the spongy layer is between the carcass and the porous drug layer.
The carcass is non-woven fabrics adhesive plaster.
The spongy layer the preparation method comprises the following steps: by chitosan be dissolved in mass percent be 0.1% acetic acid solution in it is dense
Degree is 3mg/mL chitosan solution, and it is 3mg/mL cellulose solution that cellulose, which is dissolved in deionized water to obtain concentration, by two kinds of solution
It is freeze-dried after 5:3 mixing by volume, squeezes with a thickness of 0.4mm spongy layer.
The porous drug layer the preparation method comprises the following steps: by thickness non-woven fabrics stamp 200 diameters be 0.1mm hole, then
Object room benefit is dipped into 6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o toluene
It is freeze-dried after impregnating 40min in the pharmaceutical composition aqueous solution of base -3- formamide 5:3 in mass ratio composition, obtains porous drug
Layer.
By non-woven fabrics adhesive plaster as bottom, spongy layer and porous drug layer are put respectively to get long-acting bacteriostatic adhesive bandage, institute
2/5 that spongy layer area is the carcass area is stated, the porous drug level product is 1.2 times of the spongy layer area.
A kind of long-acting bacteriostatic adhesive bandage of comparative example 1
A kind of long-acting bacteriostatic adhesive bandage, structural schematic diagram is as shown in Figure 1, include carcass 1, chitosan and cellulose group
At spongy layer 3,6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine composition porous drug layer 2, the spongy layer position
It porous is stated between medicine layer in the carcass and institute.
The carcass is non-woven fabrics adhesive plaster.
The preparation method of the spongy layer is same as Example 3.
Difference with embodiment 3 is to contain only 6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2- in the porous drug layer
A] pyridine, be free of 5- caproyl -2- methyl-N-o tolyl -3- formamide.
A kind of long-acting bacteriostatic adhesive bandage of comparative example 2
A kind of long-acting bacteriostatic adhesive bandage, structural schematic diagram is as shown in Figure 1, include carcass 1, chitosan and cellulose group
At spongy layer 3,5- caproyl -2- methyl-N-o tolyl -3- formamide composition porous drug layer 2, the spongy layer position
It porous is stated between medicine layer in the carcass and institute.
The carcass is non-woven fabrics adhesive plaster.
The preparation method of the spongy layer is same as Example 3.
Difference with embodiment 3 is that the porous drug layer contains only 5- caproyl -2- methyl-N-o tolyl -3-
Formamide is free of 6,6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine.
The detection of 1 adhesive bandage bacteriostasis property of test example
1, test material: embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1 and comparative example 2 wound obtained can
Patch.
2, test method: by inoculum density is 8.0 × 104CFU/ respectively after 6 groups of adhesive bandage ultraviolet irradiations obtained sterilization
The Escherichia coli and staphylococcus aureus of piece test bacterial number after 30min.
3, test result: the results are shown in Table 1.
1 adhesive bandage bacteriostasis property result of table
As can be seen from the test results, compared with comparative example, the bacteriostasis property of each group embodiment is superior to each comparative example, single
The fluoro- 3,3 '-bisglyoxaline in the 6,6 '-two of one component simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N- o-tolyl -3- first
The addition of amide cannot significantly improve the fungistatic effect of adhesive bandage, but can significantly improve the antibacterial of adhesive bandage when the two combination
Effect.Compared with embodiment 1, embodiment 2, embodiment 4, the fungistatic effect of embodiment 3 is significantly better than other embodiments, for this
The most preferred embodiment of invention.
Claims (10)
1. a kind of long-acting bacteriostatic adhesive bandage, which is characterized in that including carcass, chitosan and cellulose composition spongy layer, 6,
6 '-two fluoro- 3,3 '-bisglyoxalines simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o tolyl -3- formamide composition it is more
Hole medicine layer, the spongy layer is located at the carcass and institute porous states between medicine layer.
2. long-acting bacteriostatic adhesive bandage as described in claim 1, which is characterized in that the spongy layer area is the adhesive plaster level
Long-pending 3/10-2/5.
3. long-acting bacteriostatic adhesive bandage as claimed in claim 1 or 2, which is characterized in that the spongy layer the preparation method comprises the following steps: will
It is freeze-dried after chitosan solution and cellulose solution mixing, squeezes, obtains spongy layer.
4. long-acting bacteriostatic adhesive bandage as claimed in claim 3, which is characterized in that the concentration of the chitosan solution is 1-3mg/
The concentration of mL, the cellulose solution are 2-4mg/mL, wherein the volume ratio of the cellulose solution and the chitosan solution
For 2-5:3-7.
5. long-acting bacteriostatic adhesive bandage as claimed in claim 3, which is characterized in that the spongy layer with a thickness of 0.1-0.5mm.
6. long-acting bacteriostatic adhesive bandage as described in claim 1, which is characterized in that the porous drug level product is the sponge
1.2-1.5 times of level product.
7. long-acting bacteriostatic adhesive bandage as claimed in claim 6, which is characterized in that the porous drug layer the preparation method comprises the following steps:
By after non-woven fabric perforating as in pharmaceutical composition aqueous solution impregnate 20-40min after freeze-drying to get.
8. long-acting bacteriostatic adhesive bandage as claimed in claim 7, which is characterized in that in the porous drug layer pharmaceutical composition by
Simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o tolyl -3- formamide press quality to 6,6 '-two fluoro- 3,3 '-bisglyoxalines
It is formed than 4-7:1-3.
9. long-acting bacteriostatic adhesive bandage as claimed in claim 8, which is characterized in that in the porous drug layer pharmaceutical composition by
Simultaneously [1,2-a] pyridine and 5- caproyl -2- methyl-N-o tolyl -3- formamide press quality to 6,6 '-two fluoro- 3,3 '-bisglyoxalines
Than being formed for 5:2.
10. long-acting bacteriostatic adhesive bandage as claimed in claim 7, which is characterized in that the punching is uniformly to beat on non-woven fabrics
Upper 200-300 diameter is the hole of 0.1-0.3mm.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811298085.0A CN109289078B (en) | 2018-11-02 | 2018-11-02 | Long-acting antibacterial band-aid |
| PCT/CN2019/000112 WO2020087765A1 (en) | 2018-11-02 | 2019-05-27 | Long-acting antibacterial band-aid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811298085.0A CN109289078B (en) | 2018-11-02 | 2018-11-02 | Long-acting antibacterial band-aid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109289078A true CN109289078A (en) | 2019-02-01 |
| CN109289078B CN109289078B (en) | 2020-06-19 |
Family
ID=65146470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811298085.0A Active CN109289078B (en) | 2018-11-02 | 2018-11-02 | Long-acting antibacterial band-aid |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN109289078B (en) |
| WO (1) | WO2020087765A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2020087765A1 (en) * | 2018-11-02 | 2020-05-07 | 广东药科大学 | Long-acting antibacterial band-aid |
| CN114010835A (en) * | 2021-10-28 | 2022-02-08 | 安徽同力新材料有限公司 | Production process of ultrahigh-filtration medical breathable bag beneficial to healing |
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| CN109289078B (en) * | 2018-11-02 | 2020-06-19 | 广东药科大学 | Long-acting antibacterial band-aid |
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| CN103027788A (en) * | 2013-01-05 | 2013-04-10 | 吴斌 | Absorbable medical dressing and preparation method thereof |
| CN204169985U (en) * | 2014-09-29 | 2015-02-25 | 广东泰宝医疗科技股份有限公司 | One is compound protects wound dressing |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2020087765A1 (en) * | 2018-11-02 | 2020-05-07 | 广东药科大学 | Long-acting antibacterial band-aid |
| CN114010835A (en) * | 2021-10-28 | 2022-02-08 | 安徽同力新材料有限公司 | Production process of ultrahigh-filtration medical breathable bag beneficial to healing |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020087765A1 (en) | 2020-05-07 |
| CN109289078B (en) | 2020-06-19 |
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