CN109289032A - Wind-solar resources and its preparation process - Google Patents
Wind-solar resources and its preparation process Download PDFInfo
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- CN109289032A CN109289032A CN201811518938.7A CN201811518938A CN109289032A CN 109289032 A CN109289032 A CN 109289032A CN 201811518938 A CN201811518938 A CN 201811518938A CN 109289032 A CN109289032 A CN 109289032A
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- wind
- volatile oil
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- solar resources
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
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- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention relates to a kind of wind-solar resources and its preparation process, which includes: that perilla leaf, radix saposhnikoviae and the root of Dahurain angelica are extracted volatile oil and obtain the first decocting liquid and the dregs of a decoction；By the dregs of a decoction and campanulaceae etc., remaining eight taste medicinal material adds water to cook to obtain the second decocting liquid；Second decocting liquid and first decocting liquid are merged, filtering, filtrate is concentrated into the clear cream that relative density is 1.38~1.42, and spray drying obtains dry extract；The inlet air temperature of spray drying is 115 DEG C~125 DEG C, and 70 DEG C~80 DEG C of leaving air temp, spray velocity is 18rad/min~22rad/min；Dry extract is crushed, crosses 80~100 meshes, obtains dry extract fine powder；Sucrose is crushed, crosses 50~60 meshes, obtains cane sugar powder；Dry extract fine powder, cane sugar powder and dextrin are mixed, using ethyl alcohol as adhesive, pelletized with 10~12 meshes, gained particle is after fluidized drying is handled, then is sieved, and the compound particles that partial size is 10~40 mesh are obtained；It will volatilize oil and carry out total mix with compound particles, obtain wind-solar resources.The process efficiency is high, and the granulation uniformity being prepared is more preferable.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, more particularly to a kind of wind-solar resources and its preparation process.
Background technique
Wind-solar resources agent prescription derives from the Chinese drug standards, by perilla leaf, semen armeniacae amarae, pueraria lobata, radix saposhnikoviae, Chinese ephedra,
The flavour of a drug such as ramulus cinnamomi, campanulaceae, dried orange peel, the root of Dahurain angelica, rhizoma zingiberis and Radix Glycyrrhizae composition, function and cures mainly are as follows: inducing diaphoresis sweating pearl, expelling wind and cold pathogens, use
In anemofrigid cold, to generate heat, headache, aversion to cold is lossless, it coughs, nasal obstruction, the common cold treatment of the symptoms such as watery nasal discharge.
The whole nation has accumulative 50 to carry out company's production wind-solar resources, but professional Chinese medicine produces, R & D Enterprises are few, each public affairs
Department is all made of conventional prescriptions, technique and equipment and implements production.It is uneven, thin easily to occur grain graininess during conventionally produced
Powder is more, recovery rate is lower, and particle dissolve after with the presence of different degrees of breeze, cause undesirable organoleptic effects to patient.
Summary of the invention
Based on this, it is necessary to provide a kind of preparation process of wind-solar resources, can be improved the uniformity of particle, reduce
The generation of fine powder improves the recovery rate of finished product.
A kind of preparation process of wind-solar resources, comprising the following steps:
Perilla leaf, radix saposhnikoviae and the root of Dahurain angelica are extracted into volatile oil and obtain the first decocting liquid and the dregs of a decoction；
The dregs of a decoction and campanulaceae, semen armeniacae amarae, dried orange peel, pueraria lobata, rhizoma zingiberis, Chinese ephedra, Radix Glycyrrhizae and ramulus cinnamomi are added water to cook, obtain
Two decocting liquids；
Second decocting liquid and first decocting liquid are merged, filtering, it is 1.38~1.42 that filtrate, which is concentrated into relative density,
Clear cream (60 DEG C heat survey), spray drying obtains dry extract；The inlet air temperature of the spray drying is 115 DEG C~125 DEG C, out
70 DEG C~80 DEG C of air temperature, spray velocity is 18rad/min~22rad/min；
The dry extract is crushed, crosses 80~100 meshes, obtains dry extract fine powder；Sucrose is crushed, crosses 50~60 meshes,
Obtain cane sugar powder；
The dry extract fine powder, the cane sugar powder and dextrin are mixed, using ethyl alcohol as adhesive, with 10~12 mesh Shai Zhi
Grain, gained particle is after fluidized drying is handled, then is sieved, and obtains the compound particles that partial size is 10~40 mesh；
The volatile oil and the compound particles are subjected to total mix, obtain the wind-solar resources.
The preparation process of above-mentioned wind-solar resources first extracts the water of volatile oil and medicinal material on the basis of not changing prescription
Soluble components, and by water soluble ingredient concentration, it is dry, be ground into fine powder, then pelletize, dry jointly with auxiliary material sucrose, dextrin,
The mesh number for being sieved whole grain and total mix, and controlling temperature that each process parameter is such as spray-dried and speed, pulverizing and sieving,
The granule that granularity is 10~40 mesh is prepared, size distribution more concentrates, and has better mobility and resistance to water soak, no
It easily broken, the advantages that shape rounding is regular, uniform in size, fine powder is few, and difference is small between different batches, homogeneity is good, improves
Product yield；And drying temperature is set as 115 DEG C~125 DEG C in spray-drying process, spray velocity be 18rad/min~
22rad/min can significantly reduce the generation of breeze under the premise of guaranteeing drying effect.
The raw material prescription of the wind-solar resources in one of the embodiments, are as follows: perilla leaf 150g, semen armeniacae amarae
150g, pueraria lobata 150g, radix saposhnikoviae 150g, cortex moutan 200g, Chinese ephedra 100g, ramulus cinnamomi 100g, campanulaceae 100g, dried orange peel 100g, the root of Dahurain angelica
100g, rhizoma zingiberis 100g, Radix Glycyrrhizae 100g, sucrose 444.5g, dextrin 150g.
In one of the embodiments, the dregs of a decoction and campanulaceae, semen armeniacae amarae, dried orange peel, pueraria lobata, rhizoma zingiberis, Chinese ephedra, Radix Glycyrrhizae and
In the step of ramulus cinnamomi adds water to cook three times, the eight taste medicinal material such as the dregs of a decoction and campanulaceae is collectively disposed in cotton bag and carries out described decoct
It boils.
Specifically, by the dregs of a decoction and campanulaceae etc., remaining eight taste medicinal material is placed in cotton bag, is subsequently placed in multi-functional extraction
In tank, water is added and decocts three times, for the first time plus the water of 4 times of medicinal material amounts, the water of decoction 3 hours, second plus 3 times medicinal material amount decoct
2 hours, water decoction 1 hour of third time plus 3 times of medicinal material amounts, filter out decocting liquid.
In one of the embodiments, before the step of volatile oil and the compound particles are carried out total mix,
Include the steps that the volatile oil with cyclodextrin encapsulated:
After the volatile oil is dissolved with ethyl alcohol, it is slowly added into the saturated aqueous solution of cyclodextrin, uses electric mixer
It is stirred, stands refrigeration 40~50 hours, filtering, filter residue obtain the ring paste of the volatile oil after 38 DEG C~42 DEG C dryings
Inclusion compounds；
Then the cyclodextrin inclusion compound of the volatile oil and the compound particles are subjected to total mix.
In one of the embodiments, the cyclodextrin inclusion compound by the volatile oil and the compound particles into
Before row total mix, the cyclodextrin inclusion compound of the volatile oil is added to the compound particles in such a way that compressed air is spraying
In.
In this way, will volatilize oil with after cyclodextrin encapsulated, before carrying out total mix with the compound particles, it is sprayed with compressed air
Mode be added so that the volatile oil cyclodextrin inclusion compound be added more uniform, absorption of the compound particles to volatile oil
It is more fully mixed loss uniform, complete, and that volatile oil can be greatly reduced, so that drug quality and curative effect obtain more effectively
Guarantee.
The amount ratio of the volatile oil and the cyclodextrin is 1mL:(8~12 in one of the embodiments) g.
In this way, by control volatile oil and cyclodextrin amount ratio be 1mL:(8~12) g, can make volatile oil sufficiently into
Enter cyclodextrin molecular cavity inside, forms stable inclusion compound, and will not cause in final products because the amount of cyclodextrin is excessive
Auxiliary material content is more than product standard.
The temperature being stirred is 38 DEG C~42 DEG C in one of the embodiments, the stirring being stirred
Speed is 1500rpm~1800rpm, and the time being stirred is 2~3 hours.
It should be noted that needing to control temperature during preparing inclusion compound, if temperature is excessively high, it will lead to and wave
Hair oil is volatile, if temperature is too low, the viscosity of cyclodextrin be will increase greatly, be unfavorable for forming inclusion compound, influences to include effect.
The step of fluidized drying uses horizontal boiling drier in one of the embodiments, and sets described sleeping
The dryness storehouse temperature of formula boiling drier is 80 DEG C~85 DEG C, and cooling storehouse temperature is 28 DEG C~32 DEG C.In this way, it is dry to can be material
Dry temperature is maintained at 60 DEG C~80 DEG C, when reaching dry and requiring, can be cooled to 40 DEG C~65 DEG C into cooling storehouse, then blowing.
It is appreciated that selecting horizontal boiling drier that granulation is dried to powder, it on the one hand can improve mobility, subtract
Few dust from flying, improves workshop condition, another party is dried using horizontal boiling drier, since hot wind connects extensively with material
Touching, enhances the process of heat and mass, therefore can dry within a short period of time, is greatly improved working efficiency.
The volatile oil is obtained using extraction by steam distillation in one of the embodiments,.
Specifically, suitable quantity of water will be added in perilla leaf, radix saposhnikoviae, root of Dahurain angelica investment multi-function extractor, heating is distilled, until waving
Hair oil evaporates only substantially, collects distillate, slowly carries out redistillation, collects rectifying liquid, obtains the volatile oil.
In one of the embodiments, after fluidized drying processing, the moisture content of the compound particles is
2wt%~3wt%.
Described adhesive is the ethyl alcohol of 70vol% in one of the embodiments,.
Another object of the present invention is to mention a kind of kind of the wind-solar resources being prepared using above-mentioned preparation process.
The wind-solar resources being prepared by the above method, granularity are 10~40 mesh, and size distribution is more concentrated,
With better mobility and resistance to water soak, non-breakable, shape rounding is regular, uniform in size, fine powder is few, poor between different batches
The advantages that different small, homogeneity is good, it is few that particle dissolves rear breeze.
Compared with traditional handicraft, the invention has the following advantages:
(1), preparation process of the invention is on the basis of changing prescription, first extract volatile oil and medicinal material it is water-soluble at
Point, and will volatilize oil with cyclodextrin encapsulated, reduce the volatilization of volatile oil in production process, by water soluble ingredient concentration, dry,
It is ground into fine powder, then pelletizes, dry jointly with auxiliary material sucrose, dextrin, whole grain of being sieved, then is total with cyclodextrin encapsulated volatile oil
It is mixed, and each process parameter is controlled, the granule that granularity is 10~40 mesh is prepared, size distribution is more concentrated, and is had
Have that better mobility and resistance to water soak, non-breakable, shape rounding is regular, uniform in size, fine powder is few, difference between different batches
Small, the advantages that homogeneity is good, product yield is also improved, the recovery rate of particle granula is up to 90%；And by water solubility at
Divide the fine powder for being ground into and capable of crossing 80~100 meshes, is pelletized using the fine powder and cane sugar powder and dextrin, anemofrigid cold can be improved
The solubility property of grain.
(2), the volatile oil for extracting perilla leaf, radix saposhnikoviae and the root of Dahurain angelica is with after cyclodextrin encapsulated, using compression sky before total mix
Gas blowout mist is added, so that volatile oil addition is more uniform, particle absorbs more sufficiently, completely, is not easy to lose, it will be apparent that improve and wave
The utilization rate of hair oil, drug quality and curative effect are more guaranteed.
(3), taking in extraction step will be decocted a drug wrapped with cotton bag after the pack of water-soluble medicinal material, reduce fine fibre and shallow lake
Powder substance is leached in extracting solution, to improve the melting of wind-solar resources.
(4), pelletize after drying steps in, by the temperature of spray drying by 180 DEG C of traditional handicraft be reduced to 115 DEG C~
125 DEG C, speed is down to 18rad/min~22rad/min by original 40rad/min, obviously subtracts while reaching drying effect
The generation of breeze is lacked.
(5), replace traditional drying chamber dry with fluidized drying in granulation process, can further improve particle appearance and
Improve work efficiency, particle grain shape is more regular, size length is more uniform consistent, working efficiency can by former per tour 600 kilograms mention
It rises to and often also remembers 3000 kilograms, the labor intensity of worker is reduced；But also can be reduced fine powder generation, improve operator
Working environment and reduce field management difficulty.
Detailed description of the invention
Fig. 1 is the flow chart of the preparation process of the wind-solar resources of one embodiment of the invention.
Specific embodiment
To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with
Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase
Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
In wind-solar resources preparation process of the embodiment of the present invention, it is both needed to as shown in Figure 1, receiving cream to packing step at D grades
And it is carried out in the environment of the above cleanliness.Specifically, D grades of clean rank requirements: temperature is kept for 18-26 DEG C, relative humidity control
Between 45-65%.Filter should be detected often, and D grades of clean area rates of ventilation answer >=15/h, settling bacteria≤100cfu/4
Hour, suspended particles number partial size >=every cubic metre of 0.5um must not cross 3520000 under static conditions, partial size >=every cubic metre of 5.0um
29000 must not be crossed.
1 wind-solar resources of embodiment and its preparation process
One, prescription
Two, the preparation process of wind-solar resources
Process flow chart referring to Fig.1, the preparation processes of wind-solar resources the following steps are included:
1, ingredient:
It takes and examines qualified medicinal material, by prescription requirements, grouping weighs each medicinal material.
2, volatile oil is extracted:
By in perilla leaf, radix saposhnikoviae, root of Dahurain angelica investment multi-function extractor, adds the water of 3 times of medicinal material amounts, open steam, reflux mentions
Volatile oil is taken, volatile oil about 1L is collected, filters out decocting liquid, it is spare to take out the dregs of a decoction.
It is 1mL:8g according to the amount ratio of volatile oil and beta-cyclodextrin, precision weighs beta-cyclodextrin, is placed in blender, presses
Distilled water is added in 25mL/g, and heating is allowed to be completely dissolved, and is down to 42 DEG C, constant temperature stirs evenly.Add 2 times of anhydrous second into volatile oil
Alcohol dissolution is slowly dropped in beta-cyclodextrin saturated aqueous solution with syringe and (marginal not is needed to enter side stirring), and constant temperature stirs 2 hours
(control mixing speed is 1500rpm~1800rpm), jumps a queue, is cooled to room temperature and moves in 4 DEG C of refrigerators, refrigerate 50 hours, take out
Filter is drained after a small amount of purified water is rinsed, 40 DEG C drying 4 hours, obtain the volatile oil of beta-cyclodextrin inclusion compound, it is spare.
3, it extracts, filter:
The dregs of a decoction after 8 taste such as remaining campanulaceae and extraction volatile oil are packed into cotton bag, is placed in extractor, decocting is added
It boils three times, for the first time plus the water of 4 times of medicinal material amounts, the water of decoction 3 hours, second plus 3 times medicinal material amounts decoct 2 hours, third time
Add the water of 3 times of medicinal material amounts to decoct 1 hour, filters out decocting liquid.Decocting liquid when merging decocting liquid three times and mentioning volatile oil, filtering, by filtrate
It sets in filtrate tanks, it is spare.
4, it is concentrated:
By above-mentioned filtrate, inputs in triple effect evaporator, operated according to Three-effect concentration device operation sequence, filtrate is concentrated
To the medicinal extract that relative density is 1.40 (60 DEG C of heat are surveyed).
5, cream is received:
By the extracting solution thick paste pumping being concentrated between receiving cream, contained with clean stainless steel barrel, it is spare.Cream is received in detection
Rate, every batch of receive to obtain medicinal extract about 690kg, and medicinal extract recovery rate is 28.4%.
6, it is spray-dried:
Set LPG-100 type hig h-speed centrifugal spray drying condition: inlet air temperature is 115 DEG C~125 DEG C, 70 DEG C of leaving air temp
~80 DEG C, spray velocity is 18rad/min~22rad/min；
Medicinal extract is placed in decocting liquid tank after being heated to boiling, opens spray dryer and feeding engine, start to be spray-dried, received
Collect dry extract, dry extract is sealed with the stainless steel barrel of inner sleeve polybag, it is spare.Receive to obtain dry extract about 353kg, yield
It is 51.2%.
7, dry extract crushes:
Dry extract is crushed using SF-320 type high speed disintegrator, sieves with 100 mesh sieve, obtains dry extract fine powder dried and clean not
Become rusty steel drum dress, spare.Dry extract the rate of production of fine powder is 97.8%.
8, sucrose crushes:
It is crushed with 60B type dust suction pulverizer, sucrose is poured into mixing container, is then crushed again, cross 60 mesh
Stainless steel mesh, the plastics barreled of smashed Icing Sugar dried and clean polybag or polyethylene film bag for packing fruits on are spare.
9, it pelletizes:
It is pelletized with CH-400 type trough type mixing machine and YK-160 type oscillating granulator.
Appropriate dextrin, cane sugar powder, dry extract fine powder are weighed in proportion and puts CH-400 groove profile blender into, often mix conjunction 3~5
It after minute, is slowly added to 70% ethyl alcohol and stirs 5~8 minutes, agglomerating, pressure the i.e. scattered softwood held is made.With YK-160 type
Oscillating granulator crosses 12 mesh nylon mesh and pelletizes.
10, dry:
Using PDSS-1 type belt conveyor and FG-60+30B horizontal boiling bed.
Steam valve is opened, boiling-bed drying is started, 80 DEG C~85 DEG C of dryness storehouse temperature is set, 30 DEG C of cooling storehouse temperature, trembles
Bag 25 minute/time of interval time, first preheats 20~25 minutes；Start PDSS-1 type belt conveyor, is evenly distributed on particle
On PDSS-1 type belt conveyor, particle conveying is imported into horizontal boiling bed box body and is dried, dry materials temperature is made
60~80 DEG C are maintained at, reaches dry when particle and requires to open blowing lock 1 that is, when granule moisture level is 2wt%~3wt%.
When being cooled to 40~65 DEG C into cooling storehouse, blowing lock 2 is opened.
11, it sieves:
Being weeded out with the rectangular shaking screen of ZS-1.2 type can be by the fine powder of 40 mesh screens and cannot be by thick of 10 mesh screens
Grain obtains the compound particles that partial size is 10~40 mesh.Calculated yield is 94.5%.
12, total mix:
First with ZKS-4 vacuum feeder by previous process friendship come conforming particle sucking mixing machine in, into mixing machine
After particle sprays cyclodextrin encapsulated volatile oil in such a way that compressed air is spraying, total mix machine inlet lid is sealed, opens
Power supply mixes 10 minutes, keeps its color consistent, moisture≤6.0%, homogeneous particle, which is put into, after mixing is cased with polythene film bag set
Stainless steel barrel or polyethylene film bag for packing fruits on plastic barrel in, it is spare.Yield is 98.5%%.
13, it packs:
It is dispensed with VI type automatic granular packaging machine of DXDK-40, after composite film packaging particle, carries out outer packing.?
During packing, packing machine is first preheated 15~30 minutes, controls longitudinal sealing temperature: 130 DEG C~180 DEG C, control horizontal sealing temperature: 130
DEG C~180 DEG C.
14, it deposits and is put in storage:
After one batch number packaging, warehouse keeper is notified, finished product to be tested is kept in warehouse, finished product to be received is let pass
Audit is single with after product inspection report, handles storage.
Embodiment 2
Embodiment 2 is substantially the same manner as Example 1, the difference is that: not useful cyclodextrin after the extraction volatile oil of step 2
Inclusion；And step 12 total mix step is different, specifically:
First with ZKS-4 vacuum feeder by previous process friendship come conforming particle sucking mixing machine in, into mixing machine
After spraying particles volatile oil, total mix machine inlet lid is sealed, opens power supply, mixes 10 minutes, keeps its color consistent, moisture≤
6.0%, homogeneous particle is put into the plastics of the stainless steel barrel or polyethylene film bag for packing fruits on that are cased with polythene film bag set after mixing
It is spare in bucket.
Detection meter, the utilization rate of volatile oil, volatile oil utilization rate are 65% or so, are lower than 1 volatile oil utilization rate of embodiment
95%.
Embodiment 3
Embodiment 3 is substantially the same manner as Example 1, the difference is that, step 3 is extracted, filtering has all differences, specifically
Are as follows:
The dregs of a decoction after 8 taste such as remaining campanulaceae and extraction volatile oil are placed directly in extractor (not first by medicinal material and the dregs of a decoction
Fill in cotton bag), water is added and decocts three times, adds the water of 4 times of medicinal material amounts for the first time, decocts 3 hours, second plus 3 times of medicinal material amounts
Water decoct 2 hours, the water of third time plus 3 times of medicinal material amounts decocts 1 hour, filters out decocting liquid.Merge decocting liquid three times and mentions volatile oil
When decocting liquid, filtering, filtrate is set in filtrate tanks, it is spare.
The yield of gained medicinal extract is higher than embodiment 1 and embodiment 2 after the decocting liquid concentration of embodiment 3.By Examples 1 to 3 system
After standby wind-solar resources dissolve, the clarity of discovery 3 medical fluid of embodiment is lower than embodiment 1 and embodiment 2.
Comparative example 1
Comparative example 1 is substantially the same manner as Example 2, the difference is that: in step 6 spray-drying process, spray drying
Condition is different, specifically:
Set LPG-100 type hig h-speed centrifugal spray drying condition: inlet air temperature is 175 DEG C~185 DEG C, 90 DEG C of leaving air temp
~100 DEG C, spray velocity is 35rad/min~40rad/min.
Comparative example 2
Comparative example 2 is substantially the same manner as Example 2, the difference is that: step 10 is dry using traditional drying chamber, rather than boils
Drying is risen, specifically:
It pelletizes after wind-solar resources dry extract and cane sugar powder, dextrin are mixed in formulation and technology ratio, particle obtained
About 600kg is put into the heated-air circulation oven of six railway carriages, and first after 60 DEG C of dry 8h, 80 DEG C are continued dry 4h, and lower hole is let cool, then use
10 mesh oscillating granulator whole grains, the particle after whole grain are sieved, obtain 10 mesh to the conforming particle between 40 mesh, grasping
During work, longevity of service, dust is big, and a batch (600kg) needs 18 hours or so, and in operating process, because dry
Grain whole grain is in open environment, and dust is larger, and product yield is low, and a batch yield 60% or so, product particle appearance chromatic difference is big,
Granular size is inhomogenous.
It is low using drying chamber drying efficiency, and a large amount of fine powders and dust can be generated in the drying process.
Comparative example 3
Comparative example 3 is substantially the same manner as Example 2, the difference is that only: the granularity that step 7 dry extract crushes is different,
Specifically: dry extract is crushed using SF-320 type high speed disintegrator, 60 meshes is crossed, it is stainless to obtain dry extract fine powder dried and clean
Steel drum dress, it is spare.Dry extract the rate of production of fine powder is 98.2%.
Performance is carried out to the wind-solar resources that Examples 1 to 3 and comparative example 1~3 are prepared, is as a result seen below
Table.
As seen from the above table, the embodiment of the present invention 1~3 compares comparative example 1~3, and the yield of product is significantly improved, reaches
98% or more, and gained particle rounding is regular, uniform in size, friability is moderate, and it is few that particle dissolves breeze in rear medical fluid.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of preparation process of wind-solar resources, which comprises the following steps:
Perilla leaf, radix saposhnikoviae and the root of Dahurain angelica are extracted into volatile oil and obtain the first decocting liquid and the dregs of a decoction；
It adds water to cook the dregs of a decoction and campanulaceae, semen armeniacae amarae, dried orange peel, pueraria lobata, rhizoma zingiberis, Chinese ephedra, Radix Glycyrrhizae and the ramulus cinnamomi to obtain second and decoct
Liquid；
Second decocting liquid and first decocting liquid are merged, filtering, filtrate be concentrated into relative density be 1.38~1.42 it is clear
Cream, spray drying, obtains dry extract；The inlet air temperature of the spray drying is 115 DEG C~125 DEG C, leaving air temp 70 DEG C~80
DEG C, spray velocity is 18rad/min~22rad/min；
The dry extract is crushed, crosses 80~100 meshes, obtains dry extract fine powder；Sucrose is crushed, crosses 50~60 meshes, is obtained
Cane sugar powder；
The dry extract fine powder, the cane sugar powder and dextrin are mixed, using ethyl alcohol as adhesive, pelletized with 10~12 meshes, institute
Particle is obtained after fluidized drying is handled, then is sieved, the compound particles that partial size is 10~40 mesh are obtained；
The volatile oil and the compound particles are subjected to total mix, obtain the wind-solar resources.
2. the preparation process of wind-solar resources according to claim 1, which is characterized in that the dregs of a decoction and campanulaceae,
In the step of semen armeniacae amarae, dried orange peel, pueraria lobata, rhizoma zingiberis, Chinese ephedra, Radix Glycyrrhizae and ramulus cinnamomi add water to cook three times, by the dregs of a decoction and campanulaceae etc.
Eight taste medicinal materials, which are collectively disposed in cotton bag, carries out the decoction.
3. the preparation process of wind-solar resources according to claim 1, which is characterized in that by the volatile oil and institute
Before stating the step of compound particles carry out total mix, include the steps that the volatile oil with cyclodextrin encapsulated:
After the volatile oil is dissolved with ethyl alcohol, it is slowly added into the saturated aqueous solution of cyclodextrin, is stirred with electric mixer
Mixing, stands refrigeration 40~50 hours, and filtering, filter residue obtain the cyclodextrin packet of the volatile oil after 38 DEG C~42 DEG C dryings
Close object；
Then the cyclodextrin inclusion compound of the volatile oil and the compound particles are subjected to total mix.
4. the preparation process of wind-solar resources according to claim 3, which is characterized in that described by the volatile oil
Cyclodextrin inclusion compound and the compound particles carry out total mix before, by the volatile oil in such a way that compressed air is spraying
Cyclodextrin inclusion compound is added in the compound particles.
5. the preparation process of wind-solar resources according to claim 3, which is characterized in that the volatile oil and the ring
The amount ratio of dextrin is 1mL:(8~12) g.
6. the preparation process of wind-solar resources according to claim 3, which is characterized in that the temperature being stirred
Be 38 DEG C~42 DEG C, the mixing speed being stirred be 1500rpm~1800rpm, the time being stirred be 2~
3 hours.
7. the preparation process of wind-solar resources according to claim 1, which is characterized in that the step of the fluidized drying
Using horizontal boiling drier, and set the dryness storehouse temperature of the horizontal boiling drier as 80 DEG C~85 DEG C, cooling storehouse temperature
Degree is 28 DEG C~32 DEG C.
8. the preparation process of described in any item wind-solar resources according to claim 1~7, which is characterized in that the volatilization
Oil is obtained using extraction by steam distillation.
9. the preparation process of wind-solar resources according to claim 8, which is characterized in that handled through the fluidized drying
Afterwards, the moisture content of the compound particles is 2wt%~3wt%.
10. the wind-solar resources that any one of claim 1~9 preparation process is prepared.
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Effective date of registration: 20221028 Address after: 415600 Anxiang Industrial Park, Changde City, Hunan Province Patentee after: Jiangyou Pharmaceutical (Changde) Co.,Ltd. Address before: 418000 Hexi New District, Hunan, Huaihua Patentee before: HUAIHUA ZHENGHAO PHARMACEUTICAL Co.,Ltd. |