CN109288696A - Mixture is used in flank of tooth cleaning - Google Patents

Mixture is used in flank of tooth cleaning Download PDF

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Publication number
CN109288696A
CN109288696A CN201810812006.7A CN201810812006A CN109288696A CN 109288696 A CN109288696 A CN 109288696A CN 201810812006 A CN201810812006 A CN 201810812006A CN 109288696 A CN109288696 A CN 109288696A
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CN
China
Prior art keywords
flank
tooth
mass
tooth cleaning
mixture
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810812006.7A
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Chinese (zh)
Inventor
行田克则
横沼久美子
铃木利弥
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GC Corp
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GC Corp
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Publication date
Application filed by GC Corp filed Critical GC Corp
Priority to CN202311044374.9A priority Critical patent/CN116919835A/en
Publication of CN109288696A publication Critical patent/CN109288696A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20Halogens; Compounds thereof
    • A61K8/21Fluorides; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/412Microsized, i.e. having sizes between 0.1 and 100 microns

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

A kind of flank of tooth cleaning mixture, which is characterized in that comprising 45 mass % or more and 61 mass % median particle diameters below are 5 μm or more and 24 μm calcium carbonate and/or calcirm-fluoride and liquid-like constituents below, and wherein pH value is 9 or more and 10 or less.

Description

Mixture is used in flank of tooth cleaning
Technical field
The flank of tooth that the present invention relates to a kind of for cleaning the flank of tooth (dental surface) is cleaned with mixture (composition (group At object)).
Background technique
When carrying out daily brush teeth using toothbrush or gear division hospital using dedicated flank of tooth cleaning device to patient's flank of tooth into When row cleaning, generally all using flank of tooth cleaning mixture.As existing flank of tooth cleaning mixture, such as there are a kind of high Deploy (mixing) calcium compound concentration it is expected to promote the mixture of flank of tooth calcification again (for example, referring to patent document 1) Deng.
However, deenergizing in existing flank of tooth cleaning mixture with regard to the tooth dirt and/or removing for color spot (stain) of tooth For power, there is also rooms for improvement, therefore a kind of flank of tooth is needed to clean the higher flank of tooth cleaning mixture of ability.
In addition, there is also the flank of tooth to clean the more high then easier injury tooth of ability in existing flank of tooth cleaning mixture The problem of face, therefore the lower flank of tooth cleaning mixture of invasion for needing a kind of pair of flank of tooth to be invaded.
Existing technical literature
Patent document
Patent document 1:(Japan) special open 2013-163656 bulletin.
Summary of the invention
Subject to be solved by the invention
Therefore, problem of the present invention is that, the invasion that a kind of flank of tooth cleaning ability is higher and is invaded to the flank of tooth are provided Property the cleaning of the lower flank of tooth use mixture.
Means for solving the problems
According to the present invention, a kind of flank of tooth cleaning mixture is provided, which is characterized in that include 45 mass % or more and 61 matter Measure % median particle diameter below (median diameter) be 5 μm or more and 24 μm calcium carbonate and/or calcirm-fluoride below and Liquid-like constituents, wherein pH value is 9 or more and 10 or less.
Invention effect
A kind of flank of tooth cleaning of the invention invasion that mixture is that flank of tooth cleaning ability is higher and is invaded to the flank of tooth Property lower, excellent flank of tooth cleaning use mixture.
Specific embodiment
In flank of tooth cleaning mixture of the invention, as flank of tooth cleaning particle, can mix (allotment) calcium carbonate and/ Or calcirm-fluoride.The reason is that the flank of tooth of calcium carbonate and calcirm-fluoride cleaning ability is higher, and to the invasion that the flank of tooth is invaded Property is relatively low.
For the combined amount (blending amount) of calcium carbonate and/or calcirm-fluoride in flank of tooth cleaning mixture, need to be 45 Quality % or more and 61 mass % or less.Its reason is that if it is less than 45 mass %, then the flank of tooth cleans ability and is lower, if super 61 mass % are crossed, then the character of cream (paste) is hardened, and operability is deteriorated.More preferably 49 mass % or more and 55 mass % or less.
In addition, the median particle diameter of particle needs to be 5 μm or more and 24 μm or less for calcium carbonate or calcirm-fluoride.Its The reason is that, the flank of tooth cleans ability and is lower if median particle diameter is less than 5 μm, if it exceeds 24 μm, then the flank of tooth is invaded Invasion get higher.More preferably, median particle diameter is 8 μm or more and 20 μm or less.
In flank of tooth cleaning mixture of the invention, (addition) can be mixed for improving the carbohydrate of taste.As carbohydrate, Such as can enumerate: stevioside, xylitol, D-sorbite, oligosaccharides, acesulfame potassium, trehalose, Aspartame, mannitol, Maltitol, lactitol (stevia, xylitol, sorbitol, oligosaccharides, acesulfame Potassium, trehalose, aspartame, mannitol, maltitol, lactitol) etc..Can be used alone these sugar Any one in class can also be used in mixed way any two or more carbohydrate therein.
For the combined amount (blending amount) of the carbohydrate in flank of tooth cleaning mixture, preferably 1 mass % or more and 5 matter Measure % or less.Its reason is, by for 1 mass % or more, can improve the taste of cream and be easy to use, by for 5 mass % with Under, frank sense can be kept.
In flank of tooth cleaning mixture of the invention, (addition) can be mixed for adjusting the binder of viscosity.As viscous Tie agent, such as can enumerate: mosanom, propylene glycol alginate, carboxymethyl cellulose, sodium carboxymethylcellulose, carboxymethyl are fine Tie up plain calcium, sodium starch glycollate, starch phosphate sodium, Sodium Polyacrylate, carboxypolymethylene, methylcellulose, avicel cellulose, Hydroxyethyl cellulose, hydroxypropyl cellulose, starch, polyvinylpyrrolidone, guar gum, OK a karaoke club tie up bean gum, tara gum, Luo Wang Sub- glue, Arabic gum, bassora gum, Karaya Gum, alginic acid, carrageenan, xanthan gum, gellan gum, curdlan, lactose, shell Polysaccharide, chitosan (sodium alginate, alginic acid propylene glycol ester, carboxymethyl cellulose、sodium carboxymethyl cellulose、calcium carboxymethyl cellulose、 sodium starch glycolate、sodium starch phosphate ester、sodium polyacrylate、 carboxypolymethylene、methyl cellulose、crystalline cellulose、hydroxyethyl cellulose、hydroxypropyl cellulose、starch、polyvinyl pyrrolidone、guar gum、 karavi bean gum、tara gum、tamarind seed gum、gum arabic、tragacanth gum、karaya gum、alginic acid、carrageenan、xanthan gum、gellan gum、curdlan、lactose、chitin、 Chitosan, chitosamine) etc. water soluble polymer.Any one that can be used alone in these binders, can also be right Any two or more binder therein is used in mixed way.
For the combined amount (blending amount) of the binder in flank of tooth cleaning mixture, preferably 0.1 mass % or more And 1 below mass %.Its reason is, by for 0.1 mass % or more, cream can have the viscosity for being easy to invest on toothbrush, by For 1 mass % hereinafter, cream can have the hardness appropriate for being easy to come out from pipe (tube).
In flank of tooth cleaning mixture of the invention, the fluorine compounds of (addition) other than calcirm-fluoride can be mixed.It is logical Addition fluorine compounds are crossed, fluorine ion can be supplied into oral cavity, and there is better prevention of dental caries effect.Except calcirm-fluoride Fluorine compounds, such as can enumerate: sodium fluoride, potassium fluoride, ammonium fluoride, stannous fluoride, sodium monofluorophosphate, single fluorophosphoric acid potassium (sodium fluoride、potassium fluoride、ammonium fluoride、stannous fluoride、 Sodium monofluorophosphate, potassium monofluorophosphate) etc..Can be used alone these fluorine Any one in compound can also be used in mixed way any two or more fluorine compounds therein.
For the combined amount (blending amount) of the fluorine compounds except the calcirm-fluoride in flank of tooth cleaning mixture, preferably 0.025 mass % or more and 0.9 mass % or less.Its reason is, by for 0.025 mass % or more, can have better dental caries Tooth preventive effect, by for 0.9 mass % hereinafter, when routine use, will not have an impact raw body (for example, human body).
In flank of tooth cleaning mixture of the invention, (addition) preservative can be mixed.As preservative, such as can enumerate Out: ethyl-para-hydroxybenzoate, methyl p-hydroxybenzoate (ethylparaben, methylparaben) etc..It can be used alone Any one in these preservatives can also be used in mixed way any two or more preservative therein.
For the combined amount (blending amount) of the preservative in flank of tooth cleaning mixture, preferably 0.1 mass % or more And 0.3 below mass %.The reason is that can have better anti-corrosion effect by for 0.1 mass % or more, by being 0.3 Quality % hereinafter, when routine use raw body (for example, human body) will not be had an impact.
In flank of tooth cleaning mixture of the invention, (addition) liquid-like constituents can be mixed.It, can by adding liquid-like constituents It has an effect as solvent, to carry out livering.In addition, being alternatively arranged as wetting agent and playing a role.As liquid-like constituents, such as It can enumerate: polyethylene glycol, ethylene glycol, propylene glycol, glycerol, chondroitin sulfate (polyethylene glycol, ethylene Glycol, propylene glycol, glycerin, chondroitin sulfate) or its salt etc., water etc..It can be used alone Any one in these liquid-like constituents can also be used in mixed way any two or more liquid-like constituents therein.
For the combined amount (blending amount) of the liquid-like constituents in flank of tooth cleaning mixture, preferably 20 mass % or more And 54 below mass %.Its reason is, by for 20 mass % or more, can be changed to soft paste, by for 54 mass % with Under, drippage is difficult to happen when investing toothbrush etc. above.More preferably 30 mass % or more and 45 mass % or less.
In flank of tooth cleaning mixture of the invention, (addition) surface (interface) activating agent can be mixed.Pass through mixture table Face activating agent, flank of tooth cleaning mixture can be improved cleans (cleaning) effect and/or foaming effect.As surfactant, Such as it can enumerate: lauroyl sodium sulfate, sodium lauroyl sarcosine, sodium lauroylmethyl taurate, lauryl betaine, 16 Sodium alkyl sulfate, sodium lauryl tri(oxyethyl) sulfate, lauryl sulfosuccinic acid ammonium, Texapon Special, Zetesol AP, the moon Osmanthus acyl sodium isethionate, neopelex, dodecyl benzene sulfonic acid triethanolamine, cocoyl isethionate (sodium lauryl sulfate、sodium lauroyl sarcosinate、sodium lauroyl methyl taurate、lauryl betaine、sodium cetyl sulfate、sodium lauryl ether sulfate、 ammonium lauryl sulfosuccinate、ammonium lauryl sulfate、ammonium lauryl ether sulfate、sodium lauroyl isethionate、sodium dodecyl benzene sulfonate、 Triethanolamine dodecylbenzenesulfonate, sodium cocoyl isethionate) etc..
For flank of tooth cleaning mixture of the invention, viscosity is suitable when being 80~400Pas at 25 DEG C (temperature) It in being used in oral cavity, therefore is preferred.More preferably, the viscosity at 25 DEG C is 150~250Pas.
In flank of tooth cleaning mixture of the invention, (addition) can be mixed for adjusting the tackifier of viscosity.As increasing Stick, such as can enumerate: the silica chemical combination of silicic acid anhydride (silicic anhydride), silica gel (silica gel) etc. Object (silica compound).
For flank of tooth cleaning mixture of the invention, pH value needs to be 9 or more and 10 or less.The reason is that If pH, less than 9, the flank of tooth cleans ability and is lower, the stimulation meeting if pH value is more than 10, when using in oral cavity to oral cavity Become larger.
In flank of tooth cleaning mixture of the invention, can also properly mix (addition) colorant, preservative agent, mould inhibitor, The additive of fragrance etc..
[embodiment]
The present invention is described in detail with reference to embodiments, but the present invention is not limited to embodiments below.
1 > of < embodiment
As shown in table 1, to the calcium carbonate of 53 mass % (median particle diameter: 10 μm), the D-sorbite of 3 mass %, 0.6 matter Measure sodium monofluorophosphate, the 0.2 mass % of the sodium carboxymethylcellulose of %, the hydroxyethyl cellulose of 0.8 mass %, 0.5 mass % Methyl p-hydroxybenzoate, the silicic acid anhydride of 0.4 mass %, the purified water of 24.5 mass %, 16 mass % glycerol and 1 matter The fragrance of amount % is deployed (mixing), and is kneaded using mixing machine, has thus been made the flank of tooth paste and has been cleaned with mixing Object.
< embodiment 2~5 and the Comparative Examples 1 to 5 >
Using constituent shown in table 1, and by method similarly to Example 1, the flank of tooth paste is made and has cleaned Use mixture.
[table 1]
[pH value measurement]
For various flank of tooth cleaning mixtures, using pH value analyzer (" hole field makes institute " corporation, D-52) measurement PH value.As a result shown in table 1.
[median particle diameter of calcium carbonate or calcium fluoride particles]
Using laser diffraction/scattering formula particle size distribution analyzer, the intermediate value grain of calcium carbonate or calcium fluoride particles is determined Diameter (volume reference).
[invasion that the flank of tooth is invaded]
In order to which the invasion invaded to the flank of tooth to various flank of tooth cleaning mixtures is evaluated, implement as follows Test.
Using waterproof paper (#4000) and 3 μ of diamond cream, 1 μ and soft object (buff) to ox tooth enamel (enamel) matter surface Mirror ultrafinish is carried out, using as test film.
Then, for the lapped face of test film, using the various flank of tooth cleaning mixtures of 0.1g, and it is clear using the flank of tooth It sweeps and is carried out under conditions of 1940rpm and 1 minute with rubber cup (rubber cup) (" GC society " corporation, PTC Cup II) Flank of tooth cleaning.
For the position for having carried out flank of tooth cleaning, using laser microscope (laser microscope) (" Keyence society " Corporation, VK-X200) arithmetic surface roughness (Ra) is determined.
The aggressive evaluation index invaded to the flank of tooth is as described below.As a result shown in table 1.
Fine: Ra is less than 0.10 μm
Preferable: Ra is 0.10 μm more than and less than 0.15 μm
Bad: Ra is 0.15 μm or more
[flank of tooth cleaning ability]
It is evaluated in order to which the flank of tooth to various flank of tooth cleaning mixtures cleans ability, has carried out following test.
After being ground using waterproof paper (#4000) to ox tooth enamel surface, it is immersed in ferric tannate (iron Tannate it is) 10 minutes in the coloring liquid of principal component, color spot (stain) deposition (deposition) has been carried out, using as test Piece.Later, the color of the test film is determined using spectral photometric colour measuring meter (" Konicaminolta society " corporation, CM-700d).
Then, it for test film, is brushed using the various flank of tooth cleaning mixtures of 0.1g, and using flank of tooth cleaning with PTC (brush), under conditions of 1940rpm and 30 second, flank of tooth cleaning has been carried out.
For the position for having carried out flank of tooth cleaning, color is determined using spectral photometric colour measuring meter, and calculate the flank of tooth Clean the color difference Δ E*ab of the L*a*b* color space of front and back.
The evaluation index that the flank of tooth cleans ability is as described below.As a result shown in table 1.
Fine: Δ E*ab is 10 or more
Preferable: Δ E*ab is 5 more than and less than 10
Bad: Δ E*ab is less than 5
Confirmed by table 1, for the flank of tooth of the invention is cleaned with mixture, invasion that the flank of tooth is invaded compared with It is low, and flank of tooth cleaning ability is also higher.
Based on above-mentioned, the present invention provides a kind of flank of tooth cleaning mixture, which is characterized in that comprising 45 mass % or more and 61 mass % median particle diameters below be 5 μm or more and 24 μm calcium carbonate and/or calcirm-fluoride and liquid-like constituents below, wherein PH value is 9 or more and 10 or less.
Embodiments of the present invention are illustrated above, but above content is not to carry out to the contents of the present invention The content of restriction.

Claims (1)

1. a kind of flank of tooth clean with mixture, characterized by comprising:
45 mass % or more and 61 mass % median particle diameters below are 5 μm or more and 24 μm of calcium carbonate below and/or fluorination Calcium;And
Liquid-like constituents,
Wherein, pH value is 9 or more and 10 or less.
CN201810812006.7A 2017-07-25 2018-07-23 Mixture is used in flank of tooth cleaning Pending CN109288696A (en)

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CN202311044374.9A CN116919835A (en) 2017-07-25 2018-07-23 Tooth surface cleaning mixture

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JP2017143546A JP7126811B2 (en) 2017-07-25 2017-07-25 Tooth cleaning composition

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54157843A (en) * 1978-05-25 1979-12-13 Colgate Palmolive Co Dental cream composition

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JPS582921B2 (en) * 1973-03-20 1983-01-19 ライオン株式会社 toothpaste
JPS60146814A (en) * 1983-12-29 1985-08-02 Lion Corp Tooth paste composition
WO2006003989A1 (en) * 2004-07-06 2006-01-12 Lion Corporation Dentifrice composition
KR101490782B1 (en) * 2008-10-14 2015-02-09 주식회사 엘지생활건강 Toothpaste composition
JP2013163656A (en) 2012-02-10 2013-08-22 Gc Corp Dentifrice
JP2016503036A (en) * 2012-12-24 2016-02-01 コルゲート・パーモリブ・カンパニーColgate−Palmolive Company Oral care composition
WO2016004597A1 (en) * 2014-07-10 2016-01-14 The Procter & Gamble Company Anti-calculus oral compositions
JP6451562B2 (en) * 2015-09-07 2019-01-16 ライオン株式会社 Oral composition

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Publication number Priority date Publication date Assignee Title
JPS54157843A (en) * 1978-05-25 1979-12-13 Colgate Palmolive Co Dental cream composition

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Title
裘炳毅,高志红: "《现代化妆品科学与技术》", 31 March 2016, 中国轻工业出版社 *

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JP7126811B2 (en) 2022-08-29
KR20190011696A (en) 2019-02-07
CN116919835A (en) 2023-10-24
KR102108005B1 (en) 2020-05-07
JP2019026555A (en) 2019-02-21

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