JP2013163656A - Dentifrice - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a dentifrice capable of causing not only recalcification of enamelum but also calcification of cementum or dentin.SOLUTION: In a dentifrice, ≥60 wt.% of a solid component blended in the dentifrice is calcium compounds. Preferably ≥80 wt.% of the solid component blended in the dentifrice is calcium compounds. As the calcium compounds, one or two or more kinds selected from calcium carbonate, calcium phosphate and calcium fluoride are preferably used.

Description

  The present invention relates to a dentifrice excellent in abrasiveness and calcification of tooth surfaces in the oral cavity.

  Many dentifrices currently on the market contain a fluorine compound, and for example, calcium fluoride, sodium fluoride, sodium monofluorophosphate, etc. are widely used (for example, see Patent Document 1). It is known that when a small amount of fluoride ion is present in saliva, the fluoride ion promotes the remineralization of enamel by utilizing the phosphate ion and calcium ion in saliva together with the strengthening of the tooth. Furthermore, since fluorine ions may inhibit the growth of bacteria in the oral cavity, fluorine compounds can be said to be effective components for dentifrices.

  It is also widely known that when a hydroxyapatite, which is an inorganic component of a tooth, is added to a dentifrice, the hydroxyapatite is taken into the tooth and the enamel is strengthened. On the other hand, ultrafine particles such as CPP-ACP (Casein phosphopeptide-amorphous calcium phosphate) with a particle size of about 2 nm are also included in the recalcification of enamel due to diffusion of amorphous calcium phosphate into the tooth. It is known to effectively promote Thus, various attempts have been made to dentifrice from the viewpoint of enamel reinforcement.

  However, in an aging society in recent years, gingiva regresses due to aging, and fragile cementum and dentin parts are exposed, and the cementum and dentin parts often cause hypersensitivity. Cement and dentin also tend to be caries. Therefore, in order to strengthen the dentin, it is meaningful to promote not only remineralization of the conventional enamel part but also calcification of cementum and dentin. That is, if remineralization of the enamel portion and calcification of dentin and cementum are simultaneously performed, a dentifrice that can be widely used for dentin strengthening can be obtained.

JP-A-10-330234

  Then, this invention makes it a subject to provide the dentifrice which can cause not only the remineralization of enamel but also the mineralization of cementum and dentin.

  As a result of diligent research to achieve the above-mentioned problems, the present inventors surprisingly cemented and dentin calcified when a calcium compound that has been conventionally used as an abrasive is blended in a dentifrice at a high concentration. The present invention has also been found to promote the remineralization of enamel at the same time.

  That is, the present invention is a dentifrice characterized in that 60% by weight or more of the solid component blended in the dentifrice is a calcium compound, and particularly preferably a dentifrice in which 80% by weight or more of the solid component is a calcium compound. It is. Further, the dentifrice is paste-like and preferably contains 0.1% by weight or more of caseinfophosphopeptide-amorphous calcium phosphate, and the calcium compound is selected from calcium carbonate, calcium phosphate and calcium fluoride. Or it is a preferable dentifrice that it is 2 or more types.

  The dentifrice according to the present invention is an excellent dentifrice capable of not only causing remineralization of enamel but also promoting calcification of cementum and dentin.

  As the calcium compound used in the dentifrice according to the present invention, calcium compounds conventionally used in dentifrices can be used without particular limitation. Specifically, a wide variety of calcium compounds such as calcium carbonate, tricalcium phosphate, dicalcium phosphate, primary calcium phosphate, hydroxyapatite, carbonate apatite, calcium octaphosphate, calcium fluoride, calcium lactate, calcium tartrate, and calcium citrate can be used. Substances processed based on these calcium compounds are also included. For example, so-called CPP-ACP in which amorphous calcium phosphate is treated with caseinfophosphopeptide is also effective. Particularly preferred among these calcium compounds are calcium carbonate, calcium phosphate, and calcium fluoride. Calcium phosphate is not limited to primary calcium phosphate, secondary calcium phosphate, tertiary calcium phosphate, etc. but includes a wide range of compositions, including hydroxyapatite, fluoroapatite, carbonate apatite, etc., and partially substituted apatites of these mixtures, and phosphate ions And a compound composed mainly of calcium ions.

  These calcium compounds are required to be 60% by weight or more of the solid component blended in the dentifrice. In particular, in order to further promote dentin calcification, it is preferable to blend a calcium compound of 80% by weight or more of the solid component. In some cases, the dentifrice according to the present invention is supplied in powder form as a powder dentifrice, and a product form used as a paste with water or the like at the time of use is also possible. In addition, when the state which can be used as a dentifrice is assumed, the upper limit of the ratio with respect to the solid component of the calcium compound mix | blended with a dentifrice is 92 to 97 weight%.

  In addition, when calcium compounds are used as a dentifrice, it is preferable to use particles with a grain size of 100 microns or less because the feeling of use is improved when the roughness is less, but the particle size is particularly limited. is not.

  The solid component blended in the dentifrice is a substance that becomes a solid in a dry state or a sales form at 23 ° C. before being blended. Similarly, the liquid component in the present invention is a substance that becomes liquid in the same state. As solid components other than calcium compounds, compounds conventionally used in dentifrices may be used freely. For example, including an abrasive for dentifrice, a fluorine ion supply compound, a filler, etc. is not limited.

  Other solid components include saccharides that have been used conventionally. For example, sugars such as sorbitol, xylitol, mannitol, maltitol, and lactitol are used for improving taste. Further, as a thickener, silica compounds, celluloses such as carboxymethyl cellulose and hydroxyethyl cellulose, and water-soluble polymers such as starch can be used. These are not particularly limited.

  The dentifrice according to the present invention may use a liquid component for pasting described later. Examples of the liquid component include liquid polyethylene glycol, ethylene glycol, propylene glycol, glycerin, and water. Further, as an additive to the liquid component, a surfactant for enhancing the cleaning effect and foaming effect of the dentifrice can be used without particular limitation.

  As a form of the dentifrice, in addition to the powder form described above, a dentifrice usually adjusted to a paste form is preferred in order to enhance convenience. In this case, a paste-like dentifrice is prepared by adding an inorganic component such as a water-soluble polymer or fine powdered silica to the liquid component. In the dentifrice adjusted to such a paste, the proportion of the calcium compound is preferably 30% by weight or more of the total weight. More preferably, it contains a calcium compound at a high concentration of 40% by weight or more of the total weight of the dentifrice prepared in a paste form.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to a following example.

<Example 1>
As shown in Table 1, as solid components, 30 parts by weight of calcium carbonate, 1 part by weight of sodium fluoride, 2 parts by weight of xylitol, 2 parts by weight of sorbitol, 3 parts by weight of sodium carboxymethylcellulose, 2 parts by weight of sodium lauryl sulfate, ethyl paraben 0.2 parts by weight was blended, and 5 parts by weight of propylene glycol, 20 parts by weight of # 600 polyethylene glycol, 20 parts by weight of water, and 1 part by weight of fragrance were added as liquid components, and a paste dentifrice was prepared with a mixer.

  The enamel portion and dentin portion of the bovine teeth were cut, and the exposed surface was covered with a resin except for a range of about 1 mm × 2 mm. An artificial caries was prepared by immersing lactic acid and calcium lactate buffer adjusted to pH 4 in a solution thickened with 5% methylcellulose for 5 days. Thereafter, the dentifrice of Example 1 was applied, 2 cc of saliva was added, and the application and saliva were changed once a day. This operation was repeated for 5 days. The X-ray image of the dentifrice application surface was confirmed with a CT microscope, and the calcification degree of the enamel and dentin surfaces was compared with that without the dentifrice application. Dentin mineralization was clearly progressing. In addition, remineralization of enamel has been achieved by 30%.

<Examples 2 to 7>
A paste dentifrice was prepared in the same manner as in Example 1 with the formulation shown in Table 1, and the same test as in the Example was performed. The results are summarized in Table 1.

<Comparative Example 1>
As solid components, 10 parts by weight of calcium carbonate, 1 part by weight of sodium fluoride, 3 parts by weight of xylitol, 1 part by weight of sorbitol, 2 parts by weight of silica gel, 2 parts by weight of sodium carboxymethylcellulose, 2 parts by weight of sodium lauryl sulfate, 0.2% of methyl paraben Part by weight was blended, 15 parts by weight of glycerin, 15 parts by weight of water and 1 part by weight of fragrance were added as liquid components, and a paste dentifrice was prepared by a mixer.

  When the same test as in Example 1 was performed, almost no dentin calcification was observed, and only 10% of enamel remineralization was achieved.

<Comparative example 2>
As solid components, 10 parts by weight of hydroxyapatite, 1 part by weight of sodium fluoride, 3 parts by weight of xylitol, 1 part by weight of sorbitol, 2% by weight of silica gel, 2 parts by weight of sodium carboxymethylcellulose, 2 parts by weight of sodium lauryl sulfate, 0.2% of methylparaben Part by weight was blended, and 10 parts by weight of glycerin, 15 parts by weight of water and 1 part by weight of fragrance were added as liquid components, and a paste dentifrice was prepared using a mixer.

  When the same test as in Example 1 was performed, almost no dentin calcification was observed, and only 20% of enamel remineralization was achieved.

<Table 1>

  From Table 1, it can confirm that the dentifrice which concerns on this invention advances the calcification of dentin. Moreover, even if the compounding quantity of the fluoride was equivalent or less compared with the conventional dentifrice with respect to the enamel, it was confirmed that there was an effect of promoting remineralization.

Claims (4)

  A dentifrice characterized in that 60% by weight or more of a solid component blended in a dentifrice is a calcium compound.   The dentifrice of Claim 1 whose 80 weight% or more of the solid component mix | blended with a dentifrice is a calcium compound.   The dentifrice according to claim 1 or 2, further comprising 0.1% by weight or more of caseinfophosphopeptide-amorphous calcium phosphate.   The dentifrice according to any one of claims 1 to 3, wherein the calcium compound is one or more selected from calcium carbonate, calcium phosphate, and calcium fluoride.