JP3820402B2 - Oral composition and gum - Google Patents

Description

  When the present invention is applied to a tooth, a light scattering layer is formed in the enamel layer of the tooth, and an oral composition and gum capable of shielding the intrinsic tooth coloring layer (oral composition and gum). Is hereinafter referred to as a “tooth whitening composition”).

  Tooth coloring is exogenous coloring where coloring matter adheres to the tooth surface due to tartar, plaque, smoking, or customary eating and drinking such as coffee or tea, etc., and dentin is colored due to aging etc. It depends on intrinsic coloring such as when the color is visible through high enamel, or when the enamel itself is colored by the use of a drug such as tetracycline during the enamel formation stage. Therefore, in order to fundamentally whiten the teeth, it is necessary to deal with not only exogenous coloring but also intrinsic coloring.

  Conventionally, various physical or chemical methods have been reported as means for whitening teeth. As a physical method, in addition to removal by polishing, a method of removing a colored substance using n-butyl ether or butyl butyrate (Patent Document 1, Patent Document 2), or covering a tooth using a ceramic veneer or the like. There are ways to improve color tone. As chemical methods, a method for promoting remineralization with an oral composition containing hydroxyapatite (Patent Document 3, Patent Document 4), an oxidative bleaching method using a peroxide (Patent Document 5), A method of using a tooth whitening composition in which a self-curing calcium phosphate compound and a fluorine compound are mixed with an oxide (Patent Document 6), and an oral composition containing a liquefied calcium phosphate compound promotes remineralization of enamel. A method (Patent Document 7) and the like are known.

  However, the method using ceramic veneer or the like needs to delete the tooth quality, and the use and treatment of a dentist is necessary for the use of this method. And the treatment by specialists must be expensive. The method of oxidative bleaching using a peroxide requires the use of a peroxide at a concentration that enables oxidative bleaching of teeth, and therefore must be performed carefully in accordance with expert guidance.

  The method of promoting tooth remineralization using calcium phosphate compounds such as hydroxyapatite is mainly to make the teeth healthy by repairing the enamel surface with apatite, but the whitening effect is sufficient I can't say that.

  Recently, Patent Document 8 discloses that (A) a fluorine ion supply component of 0.02 to 0.7 mass% (in terms of fluorine atom) and (B) an acid having a pKa (25 ° C.) of 2.5 to 6.0. A composition for oral cavity containing 0.1 to 5 mol / kg of a compound and a salt thereof and (C) 5 to 90% by mass of water, and the composition itself or a 30% by mass aqueous solution of the composition having a pH of 3 to 5.5. It describes a method for giving whiteness and gloss to the tooth surface using an object.

  The composition for oral cavity described in the said patent document 8 forms a calcium fluoride layer in a tooth surface, and gives white and gloss to the tooth surface.

JP-A-1-203316 JP-A-1-104004 JP-A-1-305020 JP-A-9-202718 Japanese Patent Publication No. 6-8248 JP-A-11-116421 JP-A-8-319224 JP-A-2002-37721

  An object of the present invention is to provide a composition that gives an excellent whitening effect to teeth based on a completely different principle from a conventionally known method.

  When the endogenous coloring substance is deposited deep in the enamel layer of the tooth, the enamel layer itself is usually transparent, so that the color is transparent to the outside and the tooth looks yellow. Here, when a light scattering layer is formed inside the tooth enamel layer, this light scattering layer functions as a shielding layer, it is not necessary to remove these intrinsic coloring substances, and the teeth appear white. become. For this purpose, it is not necessary for the shielding layer to simply prevent the endogenous coloring substance deposited in the deep part of the enamel layer from being visible from the outside, and the shielding layer itself must appear white.

The present invention realizes the above idea, and is a toothpaste composition containing the following components (A), (B), (C) and (D),
(A) Fluorine ion supply component 0.02-0.2 mass% (fluorine atom conversion),
(B) Malic acid and / or tartaric acid and its salt 0.03-0.3 mol / kg,
(C) potassium ion 0.03-0.5 mol / kg,
(D) water,
When the toothpaste composition is diluted to 30% by mass with water, the pH is 3 to 5.5 and does not contain calcium ions, and the toothpaste composition is applied to teeth. Sometimes, a tooth whitening composition in which a light scattering layer that shields endogenous coloring substances in the enamel layer of a tooth is formed, and a method for whitening teeth using the tooth whitening composition are provided.

  That is, when the composition for oral cavity according to the present invention is applied to a tooth or chewing gum is chewed, it exists in a slight gap between enamel trabeculae constituting the enamel layer of the tooth (hereinafter referred to as “trabecular gap”). The calcium phosphate that is converted into fine particles containing fluorine (hereinafter referred to as “fluorine-containing fine particles”) forms a light scattering layer that causes irregular reflection with respect to light from the outside. As a result, endogenous coloring matter deposited inside the enamel layer, which had been seen through until now, appeared white and was shielded by an opaque light scattering layer, making it possible to make teeth appear white.

  By applying the composition for tooth whitening of the present invention to the oral cavity, a high whitening effect on the intrinsic coloring of the teeth is recognized. Therefore, it is easy to whiten the teeth through daily oral care or regular use of chewing gum. Is extremely useful.

  In particular, by adding potassium ions to the tooth whitening composition of the present invention, and further using a buffer system consisting of malic acid and / or tartaric acid and its salt, the composition itself has a weak acidity, sourness. Other taste elements are also mild, so the feeling of use is improved. Moreover, the taste and fragrance can be adjusted by adding a sweetening ingredient, a fragrance or the like as required. Therefore, it is possible to provide a composition for oral cavity that has a better feeling for the user.

  The organic acid or inorganic acid is used to maintain the oral cavity in an acidic pH environment when the tooth whitening composition of the present invention is included in the mouth. The organic acid or inorganic acid used for the tooth whitening composition is not particularly limited as long as it can be used in the oral cavity.

  Examples of the inorganic acid include hydrochloric acid, sulfuric acid, carbonic acid, phosphoric acid and the like. Examples of organic acids include monobasic acids such as formic acid, acetic acid and propionic acid; dibasic acids such as oxalic acid, succinic acid, fumaric acid, adipic acid and maleic acid; lactic acid, glycolic acid, tartaric acid, malic acid, citric acid Hydroxycarboxylic acids such as acids, ascorbic acid, gluconic acid and glyceric acid; acidic amino acids such as glutamic acid and aspartic acid; keto acids such as pyruvic acid, acetoacetic acid and levulinic acid; aromatic carboxylic acids such as benzoic acid and salicylic acid; ethylenediamine And polycarboxylic acids such as tetraacetic acid.

  Two or more organic acids or inorganic acids may be used in combination. Further, in order to keep the pH in the oral cavity more stable, a buffer system may be prepared by combining salts thereof with an organic acid and / or an inorganic acid.

  Among organic acids and inorganic acids, it is preferable to use one or more selected from acetic acid, lactic acid, malic acid, tartaric acid, citric acid, glycolic acid, succinic acid and phosphoric acid from the viewpoint of effect, and further to the oral cavity. Lactic acid, malic acid, and tartaric acid are more preferable from the viewpoints of improving the taste and flavor of the composition, ease of availability of raw materials, and cost reduction.

  In order to form a light scattering layer that is white and has a high shielding property, it is preferable that the fluorine-containing fine particles are formed to an appropriate depth of the tooth enamel layer. From this point of view, as the organic acid and / or inorganic acid contained in the tooth whitening composition, one that can form a buffer system that maintains a pH of 3 to 6 in the oral cavity to which the tooth whitening composition is applied is used. In particular, pH 4-5 is preferred.

  The fluorine ion supply component is not particularly limited as long as it can be used in the oral cavity. For example, sodium fluoride, potassium fluoride, ammonium fluoride, lithium fluoride, monofluorophosphate (for example, sodium monofluorophosphate) Inorganic fluorides such as potassium monofluorophosphate and ammonium monofluorophosphate) and organic fluorides such as amine fluorides. Among them, sodium fluoride, mono Sodium fluorophosphate, tin fluoride, lithium fluoride, and ammonium fluoride are preferred. Of these, monofluorophosphate supplies monofluorophosphate ions first, not fluorine ions, and gradually supplies fluorine ions in the oral cavity.

  In order to make it possible to form a light-scattering layer, it is necessary to mix | blend a fixed amount of organic acid and / or an inorganic acid with the composition for tooth whitening of this invention. However, when these organic acids and / or inorganic acids are present in a large amount, when the oral composition is included in the mouth or when chewing gum is chewed, the acidity is felt strongly, so that some users feel resistance taste. Cases can arise.

  On the other hand, when potassium ions are added to the composition for whitening the teeth of the present invention, the potassium ions can strengthen the effect of the acid (inorganic acid and / or organic acid) to be blended in the composition. Even if the amount is small, the light scattering layer can be formed. Further, by reducing the content of the acid blended in the composition, the taste of the tooth whitening composition is improved and the feeling of use is improved.

  The supply component of potassium ions is not particularly limited as long as it can be used in the oral cavity, and various potassium salts can be used. For example, potassium hydroxide, potassium fluoride, potassium chloride, potassium bromide, potassium phosphate, potassium carbonate, potassium malate, potassium citrate, potassium tartrate, potassium metaphosphate, potassium pyrophosphate, potassium sorbate, potassium nitrate, asparagine Potassium acid, potassium alginate and the like can be mentioned, and potassium hydroxide, potassium fluoride, potassium chloride, potassium malate, potassium citrate and potassium phosphate are preferred from the viewpoint of flavor and storage stability.

  Moreover, it is preferable to add a potassium ion to the composition for a tooth whitening as a counter ion of the essential component or arbitrary components in this invention. For example, potassium ions can be added by using potassium fluoride as a fluorine ion supply component, or preparing a buffer system using a potassium salt or potassium hydroxide together with an organic acid and / or an inorganic acid. .

  The potassium ion content is 0.1 to 5% by mass, 0.5% in the oral composition from the viewpoint of obtaining an excellent tooth whitening effect while sufficiently reducing the acid concentration in the oral composition. It is preferable to contain in the ratio of -3 mass%.

  In addition to the above components, the composition for whitening teeth of the present invention includes, for example, foaming agents, foaming aids, abrasives, wetting agents, binders, bulking agents, sweeteners, preservatives, bactericides, medicinal ingredients, and adhesives. Agents, pigments, dyes, fragrances and the like can be appropriately contained. Moreover, combined use, such as polyethyleneglycol which is a whitening component used conventionally, is not restrict | limited.

  The tooth whitening composition of the present invention is prepared into a dosage form such as a solution, a gel, or a paste, and is used for oral cavity such as powder dentifrice, moisturizing dentifrice, toothpaste, liquid dentifrice, mouthwash, etc. It can be used as a composition or a chewing gum. In any of these dosage forms, polyethylene glycol, propylene glycol, glycerin, sorbitol, maltitol, xylitol, lactitol, erythritol and the like can be contained for the purpose of a wetting agent or a thickening agent. Further, as a thickening agent for a solution-like composition or as a gelling agent for a gel-like composition, as a binder for a paste-like composition, carboxymethylcellulose sodium, hydroxyethylcellulose, carboxyvinyl polymer, xanthan gum, carrageenan, alginic acid Sodium, hydroxypropyl cellulose, guar gum, sodium chondroitin sulfate and the like can be contained. In particular, in the case of a high salt concentration due to the buffer solution system, a nonionic polymer, that is, hydroxyethyl cellulose, guar gum, hydroxypropyl cellulose, or the like can be contained.

Particularly, the tooth whitening composition having a good taste is a composition containing the following components (A), (B), (C), and (D), and the composition is water: An example of the composition for the oral cavity having a pH of 3 to 5.5 when diluted to 30% by mass can be given.
(A) Fluorine ion supply compound 0.02 to 0.2% by mass (in terms of fluorine atom),
(B) Malic acid and / or tartaric acid and its salt 0.03-0.5 mol / kg,
(C) potassium ion 0.03-0.5 mol / kg,
(D) water,
(E) Other optional components as required

  This formulation is a combination of malic acid and / or tartaric acid and its salts with good taste and high buffer capacity, and the addition of potassium ions to reduce the acid content, thereby reducing the content of the enamel in the teeth. In addition, the effect of forming a light scattering layer is high, and the acidity is suppressed and the feeling of use is excellent.

  A pH environment in the same range as a buffer system composed of malic acid and / or tartaric acid and its salt can be obtained by a buffer system using other acidic compounds, but a buffer composed of malic acid and / or tartaric acid and its salt. In the liquid system, fluorine-containing fine particles can be sufficiently formed even in a state where the acid concentration is low, and the acidity is suppressed, so that the taste is particularly excellent.

  That is, since the buffer solution system consisting of malic acid and / or tartaric acid and its salt as component (B) has a strong buffering capacity, the ability to maintain a pH environment for forming fluorine-containing fine particles in the oral cavity is particularly excellent. When compared with other buffer systems of the same concentration, the tooth whitening effect is remarkably high, and even when the amount of use is reduced to reduce the acid concentration, an excellent whitening effect on the teeth can be obtained.

  In addition, malic acid and tartaric acid are both contained in foods such as fruits and wines, and not only can suppress acidity, but also have a good taste and safety, so that the composition for oral use has a good taste. Can be prepared.

  Examples of the salt of malic acid or tartaric acid include sodium salt, potassium salt, arginine salt, ammonium salt, and the like, and alkali metal salts of sodium salt and potassium salt are preferable. In preparing the composition of the present invention, malic acid or tartaric acid salt may be added directly, but organic acids such as malic acid and tartaric acid and alkalis such as sodium hydroxide and potassium hydroxide are separately added. Then, a buffer system of an acidic compound and its salt may be formed in the composition.

  In the above formulation, it is particularly preferable to use the component (B) as a source of potassium ions, in which case malic acid and / or tartaric acid and its potassium salt are mixed, or malic acid and / or A buffer system is formed by neutralizing tartaric acid with potassium hydroxide.

  Malic acid and / or tartaric acid and its salt in component (B) are malic acid and / or tartaric acid and their salts in the oral composition of the present invention from the viewpoint of obtaining a high whitening effect while sufficiently suppressing acidity. The total amount is preferably 0.03 to 0.5 mol / kg, more preferably 0.05 to 0.3 mol / kg. In order to provide sufficient buffering capacity, it is preferable that the ratio of acid to salt is 10 to 1 to 1 to 10 in terms of molar ratio.

  In the composition for oral cavity of the present invention, the potassium ion as the component (C) has an excellent tooth whitening effect while sufficiently reducing the acid concentration of the malic acid and / or tartaric acid of the component (B). 0.03 to 0.5 mol / kg, particularly 0.05 to 0.3 mol / kg.

  Moreover, it is preferable that content of the water which is a component (D) is 5-90% in the composition of this invention. In order to exhibit the buffering capacity, it is essentially necessary to be in an aqueous solution state. Also, water is necessary to supply fluorine ions immediately to the enamel.

  Furthermore, the oral composition of the above formulation is important in that the pH when the composition is diluted to 30% by mass with water is 3 to 5.5 in order to effectively form fluorine-containing fine particles. is there. In order to maintain the strength of the teeth, the pH is preferably 3 or more. A more preferred pH is pH 4-5.

  In the said prescription, it is preferable to contain an anionic surfactant as an arbitrary component (E) in order to further enhance the whitening effect of the teeth. As the anionic surfactant, higher alkyl sulfate ester salts, N-alkyl sarcosine salts, and higher fatty acid monoglyceride monosulfate are preferable. The number of carbon atoms of the alkyl group or fatty acid residue of these surfactants is preferably 8 to 24, particularly 8 to 18. Further, as the salt of these surfactants, alkali metal salts, ammonium salts, and organic amine salts are preferable. The surfactant is preferably contained in the composition of the present invention in an amount of 0.1 to 5% by mass, particularly 0.2 to 2% by mass, from the viewpoint of tooth whitening effect.

  The composition for tooth whitening of this invention can be manufactured according to the general manufacturing method of the composition for tooth whitening according to the dosage form. For example, in the case of a toothpaste, purified water, abrasive, wetting agent, binder, flavoring agent, preservative, sweetener, buffer solution component and fluoride ion supply component, and other medicinal components as necessary After measuring the prescribed amount of each of the above components, they can be produced by mixing according to certain production conditions, swelling the binder, and further adding an abrasive and a foaming agent and defoaming and mixing. If necessary, the pH may be adjusted after preparing the composition.

  When the composition for oral whitening according to the present invention is applied to teeth or chewing gum is chewed to bring the composition for whitening of teeth or its component into contact with the teeth, the components of the composition for whitening of teeth become saliva in the oral cavity. Etc., a buffer system capable of keeping a constant pH more stable is formed. In the state where the pH of the mixed buffer system in the oral cavity is kept acidic, the tooth enamel layer changes due to the action of acid in the calcium phosphate existing in the gaps of the enamel trabeculae that make up the enamel layer. Arise.

  In this case, fluorine-containing fine particles are formed not only on the tooth surface but also in the space between the trabeculae by the components of the tooth whitening composition.

  That is, the calcium phosphate present in the space between the small columns is changed to fluorine-containing fine particles to form a partial structure having a low refractive index, thereby forming a light scattering layer that causes irregular reflection with respect to light from the outside. As a result, the teeth reflected appear white because the color reflected by the light scattering layer appears white. In addition, the colored layer in the deep part of the intrinsic tooth enamel layer that was visible from the outside through the enamel layer, which was originally transparent, was blocked by the above-mentioned white and opaque light scattering layer. Coloring disappears from the outside. Then, the teeth appear white and beautiful by the irregular reflection action and shielding action of the light scattering layer in the enamel layer.

  Usually, the light scattering layer is formed between 500 μm from the surface of the tooth enamel layer. From the viewpoint of obtaining sufficient whiteness and shielding properties, the thickness of the light scattering layer is preferably 50 μm or more.

  Fluorine-containing fine particles are formed mainly by calcium fluoride in the oral cavity maintained at a certain range of acidic pH, by reacting the fluorine ions of the fluorine ion supply compound with the tooth components and saliva components. Usually, however, other components such as calcium phosphate / fluoride complex are also included.

  When potassium ions are added to the tooth whitening composition, potassium ions have a larger ionic radius than sodium ions and lithium ions, so that the bond with the acid is weakened. In addition, when divalent calcium ions of hydroxyapatite and monovalent potassium ions are substituted, a charge imbalance occurs, so that carbonate ions or hydrogen phosphate ions enter instead of phosphoric acid as a counter ion, and hydroxyapatite crystals are formed. It is generally considered to be fragile. This means that the addition of potassium ions increases the dissolving power of the acid in the tooth whitening composition in hydroxyapatite.

  In other words, the presence of potassium ions increases the solubility of the acid in hydroxyapatite, and even if the amount of inorganic acid and / or organic acid in the tooth whitening composition is reduced, it exists in the interlamellar space between enamels. The reactivity of the calcium phosphate content is increased, and the action of forming fluorine-containing fine particles in the gap can be maintained. As a result, by adding potassium ions, it is possible to reduce the content of inorganic acids and / or organic acids in the tooth whitening composition without reducing the ability to form a light scattering layer. Become.

Example A Series <Preparation of Oral Composition>
According to the composition shown in Table A1, toothpastes of Examples A1-1 to A1-3 and Comparative Examples A1-1 to A1-3 were prepared. Moreover, according to the composition shown in Table A2, liquid toothpastes of Examples A2-1 to A2-3 and Comparative Examples A2-1 to A2-3 were prepared. Moreover, according to the composition shown in Table A3, mouthwashes of Examples A3-1 to A3-3 and Comparative Examples A3-1 to A3-3 were prepared. Moreover, according to the composition shown in Table A4, the mouth fresheners of Examples A4-1 to A4-3 and Comparative Examples A4-1 to A4-3 were prepared. Moreover, according to the composition shown in Table A5, chewing gums of Examples A5-1 to A5-3 and Comparative Examples A5-1 to A5-3 were prepared.

<Evaluation method>
(1) Presence / absence of light scattering layer The compositions shown in Tables A1 and A2 were diluted to 30% by mass with ion-exchanged water, and bovine teeth (the surface was mirror-polished) were immersed in this diluted solution for 40 hours. Moreover, cow's teeth (the surface was mirror-polished) were immersed in the compositions shown in Table A3 and Table A4 for 40 hours. Further, in the case of Table A5, after making the chewing gum fine, ion-exchanged water was added so that the concentration became 30% by mass, and the cow's teeth (the surface was mirror-polished) were immersed in the well-stirred solution for 40 hours. .

The change in whiteness of cattle teeth immersed in a color difference meter was measured, and the color difference was shown using the CIE-1976 L ^* a ^* b ^* color system (JIS Z8729- (1980)). The three-dimensional coordinate system using L ^* a ^* b ^* can represent the interrelationship of colors with a scale close to color sense (FIG. 1). In FIG. 1, the vertical axis L ^* indicates the luminous brightness, and a ^* and b ^* indicate the chromaticity. In the L ^* a ^* b ^* color system, the closer the b ^* value is to 0, the less yellowish the whiteness is.

As shown in Table A6, b ^* is greatly reduced by the treatment of the oral composition according to the present invention, and the value approaches 0. This means that the tooth pieces are no longer yellow and white.

  The teeth treated with the oral composition of each Example were measured with a color difference meter and confirmed to be white (Table A6). The teeth of the cow that were confirmed to be white were broken, and the cut surface was photographed with a microscope. It was confirmed whether or not a light scattering layer was formed under the enamel surface (FIG. 2). A sample in which a light scattering layer was observed (FIG. 2A) was marked with ◯, and a sample in which a light scattering layer was not recognized (FIG. 2B) was marked with ×.

(2) Existence of whitening effect The composition shown in Tables A1 and A2 is diluted to 30% by mass with ion-exchanged water, and the bovine teeth (surface is mirror-polished) photographed beforehand in this diluted solution for 40 hours Soaked. Further, bovine teeth (the surface was mirror-polished) photographed in advance in the compositions shown in Tables A3 and A4 were immersed for 40 hours. Furthermore, in the case of Table A5, after making the chewing gum fine, ion-exchanged water was added so that the concentration was 30% by mass, and the bovine teeth photographed beforehand (the surface was mirror-polished) in the well-stirred solution Soaked for 40 hours.

  After raising the cow's teeth, the teeth were photographed. A panel of 15 people who took photographs of the teeth before and after treatment was evaluated as ◎ if all were judged to be white, ◯ if more than half were judged white, and x otherwise. The results of evaluation are shown in Tables A1 to A5, respectively.

<Overall results>
In the toothpaste of Examples A1-1 to A1-3, the formation of a light scattering layer was recognized inside the enamel layer of the tooth, and the whitening effect was also observed, whereas in the toothpaste of Comparative Example A1-1 In addition, the toothpaste of Comparative Example A1-2 contains a fluorine ion supply compound but does not contain an organic acid and / or an inorganic acid. In the toothpaste No. -3, since the amount of the organic acid was large, no light scattering layer was found inside the enamel layer of the tooth.

  In the liquid toothpaste of Examples A2-1 to A2-3, the formation of a light scattering layer was recognized inside the enamel layer of the tooth and the whitening effect was also observed, whereas in the liquid toothpaste of Comparative Example A2-1 In addition, the liquid toothpaste of Comparative Example A2-2 contains an organic acid but does not contain a fluorine ion supply compound. In addition, the liquid toothpaste of Comparative Example A2-2 contains a fluorine ion supply compound but does not contain an organic acid and / or an inorganic acid. In the liquid toothpaste No. -3, since the amount of the organic acid was large, the formation of a light scattering layer was not observed inside the tooth enamel layer.

  In the mouthwashes of Examples A3-1 to A3-3, the formation of a light scattering layer was recognized inside the tooth enamel layer, and the whitening effect was also observed, whereas the mouthwash of Comparative Example A3-1 In the liquid, the organic acid is included but the fluorine ion supply compound is not included. In the mouthwash of Comparative Example A3-2, the fluorine ion supply compound is included but the organic acid and / or the inorganic acid is not included. In the mouthwash of Comparative Example A3-3, since the amount of the organic acid was large, formation of a light scattering layer was not observed inside the enamel layer of the teeth.

  In the mouth fresheners of Examples A4-1 to A4-3, the formation of a light scattering layer was observed inside the enamel layer of the teeth and the whitening effect was also observed, whereas the mouth refresher of Comparative Example A4-1 The agent contains an organic acid but does not contain a fluorine ion supply compound, and the mouth freshener of Comparative Example A4-2 contains a fluorine ion supply compound but does not contain an organic acid and / or an inorganic acid. In the mouth freshener of Comparative Example A4-3, since the amount of the organic acid was large, the formation of a light scattering layer was not observed inside the enamel layer of the teeth.

  In the chewing gums of Examples A5-1 to A5-3, the formation of a light scattering layer was recognized inside the tooth enamel layer, and the whitening effect was also observed, whereas in the chewing gum of Comparative Example A5-1, The chewing gum of Comparative Example A5-2 contains an acid but does not contain a fluoride ion supply compound, and also contains a fluoride ion supply compound but does not contain an organic acid and / or an inorganic acid. In the chewing gum, since a large amount of organic acid was added, no light scattering layer was formed inside the enamel layer of the teeth.

Example B Series <Preparation of Oral Composition>
According to the composition shown in Table B1, toothpastes of Examples B1 to B3 and Comparative Examples B1 to B3 were prepared. Moreover, according to the composition shown in Table B2, liquid toothpastes of Examples B4 to 6 and Comparative Examples B4 to 6 were prepared. Furthermore, according to the composition shown in Table B3, mouth washes of Examples B7 to 9 and Comparative Examples B7 to 9 were prepared.

<Evaluation method>
(1) Taste Evaluation Ten subjects (5 men and 5 women) took 1g of toothpaste or liquid toothpaste on a toothbrush used everyday, brushed freely for about 2 minutes, and evaluated according to the following criteria did. Further, the mouthwash was evaluated according to the following criteria in the same manner after containing 5 ml of mouthwash in the mouth and rinsing for about 15 seconds.
The case where it was acceptable was marked with ◯, and the case where it was not acceptable was marked with X. Those in which more than half were ○ were accepted and others were rejected.

(2) Presence / absence of light scattering layer The compositions shown in Tables B1 and B2 were diluted to 30% by mass with ion-exchanged water, and bovine teeth (the surface was mirror-polished) were immersed in this diluted solution for 40 hours. Moreover, cow's teeth (the surface was mirror-polished) were immersed in the composition shown in Table B3 for 40 hours.
Then, the presence or absence of the light scattering layer was evaluated by the same procedure as the evaluation method (1) of Example A series. The results are shown in Table B4. The b ^* value was significantly reduced by the treatment of the oral composition according to the present invention, and the value approached 0, so that it was confirmed that the tooth pieces were no longer yellow and white.

  In addition, the cut section of the cow's teeth that were confirmed to be whitened by the treatment with the oral composition of each example of the present invention was confirmed by the same procedure and evaluation criteria as in Example A series, and a light scattering layer was recognized. What was obtained (FIG. 1A) was evaluated as ◯, and what the light scattering layer was not observed (FIG. 1B) was evaluated as ×.

(3) Existence of whitening effect The composition shown in Tables B1 and B2 is diluted to 30% by mass with ion-exchanged water, and the bovine teeth (surface is mirror-polished) photographed beforehand in this diluted solution for 40 hours Soaked. In addition, bovine teeth (the surface was mirror-polished) photographed beforehand were immersed in the composition shown in Table B3 for 40 hours.
After raising the cow's teeth, the teeth were photographed and evaluated according to the following criteria. Fifteen people took pictures of the teeth before and after the treatment, and judged whether they were white or not changed. In addition, it was judged that what was felt to have lost the gloss was not changed even if it turned white. And it was evaluated as ◎ if all were judged to be white, ○ if judged more than half were white, and x otherwise. The results of evaluation are shown in Tables B1 to B3, respectively.

<Overall results>
In the toothpaste of Examples B1 to B3, the amount of organic acid and / or inorganic acid required is sufficient by adding potassium ions, and a light scattering layer is formed inside the enamel layer of the tooth. The whitening effect is excellent and the taste is good. On the other hand, in the toothpaste of Comparative Example B1, since the amount of organic acid and / or inorganic acid used is low, the taste is good, but a light scattering layer cannot be formed, and a whitening effect is also observed. There wasn't. In addition, Comparative Example B2 and Comparative Example B3 have a large amount of organic acid and / or inorganic acid used, and therefore cannot form a light scattering layer, are slightly lower in terms of whitening effect, and have a bad taste. It was a result.

  In the liquid toothpaste of Examples B4 to B6, by adding potassium ions, the amount of the required organic acid and / or inorganic acid is sufficient, a light scattering layer can be formed, and the whitening effect is excellent. And the taste is good. In contrast, in the liquid toothpaste of Comparative Example B4, the amount of organic acid and / or inorganic acid used was low, so the taste was good, but a light scattering layer could not be formed, and no whitening effect was observed. . Further, Comparative Example B5 and Comparative Example B6 have a bad taste due to the large amount of organic acid and / or inorganic acid used, and further, no light scattering layer is formed, and the whitening point is slightly low. there were.

  In the mouthwashes of Examples B7 to B9, by adding potassium ions, the amount of organic acid and / or inorganic acid required is low, and further, a light scattering layer is formed, thereby whitening. Excellent effect and good taste. On the other hand, in the mouthwash of Comparative Example B7, the amount of organic acid and / or inorganic acid used is low, so the taste is good, but a light scattering layer cannot be formed, and a whitening effect is recognized. There wasn't. Further, Comparative Example B8 and Comparative Example B9 have a bad taste due to the large amount of organic acid and / or inorganic acid used, and further, the formation of a light scattering layer is not recognized, and the whitening effect is slightly low. It was a result.

Example C Series <Preparation of Oral Composition>
According to the composition shown in Table C1, toothpastes of Examples C1 to C3 and Comparative Example C1 were prepared. Moreover, according to the composition shown in Table C2, liquid toothpastes of Examples C4 to C6 and Comparative Example C2 were prepared. Furthermore, according to the composition shown in Table C3, mouth washes of Examples C7 to C9 and Comparative Example C3 were prepared.

<Evaluation method>
(1) Taste Evaluation Fifteen subjects participated and evaluated the taste by the same procedure and evaluation criteria as the evaluation method (1) of Example B series.

(2) Whitening effect Each composition was diluted to 30% by mass with ion-exchanged water, and cow's teeth (the surface was mirror-polished) photographed beforehand were immersed in this diluted solution for 40 hours. After raising, the photograph was taken, the teeth before treatment were compared with the color, and the whitening effect was evaluated by the same procedure and evaluation criteria as the evaluation method (3) of Example B series.

<Overall results>
In the toothpaste of Examples C1 to C3, the amount of organic acid required is sufficient by blending potassium ions, the whitening effect is excellent, and the taste is good, whereas the paste of Comparative Example C1 is used. Toothbrushing has a bad taste due to the large amount of organic acid required, and it contains calcium ions, so it is insufficient in terms of whitening effect.

  In the liquid toothpastes of Examples C4 to C6, the amount of the organic acid required is sufficient by adding potassium ions, the whitening effect is excellent, and the taste is good, whereas the liquid of Comparative Example C2 is liquid. Toothbrushing has a bad taste due to the large amount of organic acid required, and it contains calcium ions, so it is insufficient in terms of whitening effect.

  In the mouthwashes of Examples C7 to C9, by adding potassium ions, the amount of organic acid required is sufficient, the whitening effect is excellent, and the taste is good. The mouthwash has a poor taste due to the large amount of organic acid required, and it contains calcium ions, so it is insufficient in terms of the whitening effect.

It is a figure which shows the correlation of a color by the three-dimensional coordinate system using CIE-1976 L ^* a ^* b ^* color system (JISZ8729- (1980)). It is the photograph which observed the cleavage surface of the cow's tooth with the microscope. (A) is a split section of cattle teeth treated with the composition of the present invention. (B) is a fractured section of an untreated cow tooth.

Claims (2)

A toothpaste composition containing the following components (A), (B), (C) and (D):
(A) Fluorine ion supply component 0.02-0.2 mass% (fluorine atom conversion),
(B) Malic acid and / or tartaric acid and its salt 0.03-0.3 mol / kg,
(C) potassium ion 0.03-0.5 mol / kg,
(D) water,
A toothpaste composition having a pH of 3 to 5.5 when the toothpaste composition is diluted to 30% by mass with water and containing no calcium ions . A toothpaste composition containing the following components (A), (B), (C) and (D):
(A) Fluorine ion supply component 0.02-0.2 mass% (fluorine atom conversion),
(B) Malic acid and / or tartaric acid and its salt 0.03-0.3 mol / kg,
(C) potassium ion 0.03-0.5 mol / kg,
(D) water,
When the toothpaste composition is diluted to 30% by weight with water and has a pH of 3 to 5.5, does not contain calcium ions, and the toothpaste composition is applied to teeth, tooth enamel A toothpaste composition in which a light scattering layer is formed in the quality layer .

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