CN109276716B - 用在病毒性疾病的治疗中的mek抑制剂 - Google Patents

用在病毒性疾病的治疗中的mek抑制剂 Download PDF

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CN109276716B
CN109276716B CN201810617076.7A CN201810617076A CN109276716B CN 109276716 B CN109276716 B CN 109276716B CN 201810617076 A CN201810617076 A CN 201810617076A CN 109276716 B CN109276716 B CN 109276716B
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pharmaceutically acceptable
acceptable salt
oseltamivir
inhibitor
mek
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CN109276716A (zh
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S·普莱施卡
O·普兰兹
S·路德维格
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Attribution Therapy Co ltd
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Attribution Therapy Co ltd
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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CN201810617076.7A 2012-10-08 2013-10-08 用在病毒性疾病的治疗中的mek抑制剂 Active CN109276716B (zh)

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US201261711136P 2012-10-08 2012-10-08
US61/711136 2012-10-08
CN201380064116.5A CN105101999B (zh) 2012-10-08 2013-10-08 用在病毒性疾病的治疗中的mek抑制剂

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US (2) US9566281B2 (https=)
EP (1) EP2903649A1 (https=)
JP (2) JP6294889B2 (https=)
KR (1) KR102174576B1 (https=)
CN (2) CN109276716B (https=)
AU (1) AU2013328824B2 (https=)
BR (1) BR112015007616B1 (https=)
CA (1) CA2886138C (https=)
EA (1) EA028605B1 (https=)
WO (1) WO2014056894A1 (https=)

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EA039897B1 (ru) 2014-05-16 2022-03-24 Атрива Терепьютикс Гмбх Применение ингибитора мек для лечения коинфекции, включающей бактериальную инфекцию и инфекцию, вызванную вирусом гриппа
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ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
US11903917B2 (en) * 2017-10-17 2024-02-20 Atriva Therapeutics Gmbh MEK-inhibitor for the treatment of viral and bacterial infections
US20190298669A1 (en) * 2018-03-29 2019-10-03 Atriva Therapeutics Gmbh Ci-1040 for the treatment of viral diseases
EP3860598B1 (en) 2018-10-03 2023-09-06 Jyväskylän Yliopisto Vemurafenib and salts thereof for use in the treatment of enteroviral infections
CN109765324B (zh) * 2018-11-27 2021-03-30 苏州科技大学 一种mek1蛋白潜在抑制剂的筛选方法
AU2020243160A1 (en) 2019-03-19 2021-10-14 Atriva Therapeutics Gmbh Rsk inhibitors in the treatment of virus diseases
LU101183B1 (en) 2019-04-16 2020-10-16 Atriva Therapeutics Gmbh Novel mek-inhibitor for the treatment of viral and bacterial infections
WO2021037956A1 (en) 2019-08-27 2021-03-04 Atriva Therapeutics Gmbh Combinations of mek inhibitors with cap-dependent endonuclease inhibitors
EP4041212B1 (en) * 2019-10-08 2025-07-23 Atriva Therapeutics GmbH Mek inhibitors for the treatment of hantavirus infections
WO2021214296A1 (en) * 2020-04-24 2021-10-28 Johann Wolfgang Goethe-Universität Frankfurt am Main Treatment of corona virus infections
CN111529532A (zh) * 2020-05-05 2020-08-14 华中科技大学同济医学院附属协和医院 曲美替尼在制备治疗肺部炎症性疾病药物及促进Tfh细胞分化药物中的应用
CN111494620A (zh) * 2020-05-05 2020-08-07 华中科技大学同济医学院附属协和医院 曲美替尼在制备疫苗中的应用
CN112137994B (zh) * 2020-09-15 2022-10-14 中山大学 小分子化合物在制备抗丝状病毒药物中的应用

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CN109276716A (zh) 2019-01-29
WO2014056894A1 (en) 2014-04-17
AU2013328824A1 (en) 2015-04-30
BR112015007616A2 (pt) 2017-08-08
KR20150097464A (ko) 2015-08-26
CA2886138A1 (en) 2014-04-17
EA201590703A1 (ru) 2015-07-30
BR112015007616B1 (pt) 2022-08-09
CN105101999B (zh) 2018-07-17
EA028605B1 (ru) 2017-12-29
CN105101999A (zh) 2015-11-25
EP2903649A1 (en) 2015-08-12
JP6294889B2 (ja) 2018-03-14
US20150224103A1 (en) 2015-08-13
AU2013328824B2 (en) 2018-04-05
KR102174576B1 (ko) 2020-11-06
JP2015534562A (ja) 2015-12-03
CA2886138C (en) 2021-10-12
US9566281B2 (en) 2017-02-14
US20170209450A1 (en) 2017-07-27

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