CN109198348A - A kind of incretin peptide solid beverage and its application - Google Patents
A kind of incretin peptide solid beverage and its application Download PDFInfo
- Publication number
- CN109198348A CN109198348A CN201710524138.5A CN201710524138A CN109198348A CN 109198348 A CN109198348 A CN 109198348A CN 201710524138 A CN201710524138 A CN 201710524138A CN 109198348 A CN109198348 A CN 109198348A
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- Prior art keywords
- solid beverage
- peptide solid
- incretin
- incretin peptide
- peptide
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Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 101
- 235000013361 beverage Nutrition 0.000 title claims abstract description 71
- 239000007787 solid Substances 0.000 title claims abstract description 70
- MGXWVYUBJRZYPE-YUGYIWNOSA-N incretin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=C(O)C=C1 MGXWVYUBJRZYPE-YUGYIWNOSA-N 0.000 title claims abstract description 57
- 239000000859 incretin Substances 0.000 title claims abstract description 57
- 239000000463 material Substances 0.000 claims abstract description 36
- 239000004615 ingredient Substances 0.000 claims abstract description 31
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 28
- 239000008280 blood Substances 0.000 claims abstract description 27
- 210000004369 blood Anatomy 0.000 claims abstract description 27
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 claims abstract description 23
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000000843 powder Substances 0.000 claims abstract description 21
- 239000002131 composite material Substances 0.000 claims abstract description 19
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 19
- 239000003765 sweetening agent Substances 0.000 claims abstract description 19
- 239000011782 vitamin Substances 0.000 claims abstract description 17
- 229940088594 vitamin Drugs 0.000 claims abstract description 17
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims abstract description 16
- 229940050168 zinc lactate Drugs 0.000 claims abstract description 16
- 235000000193 zinc lactate Nutrition 0.000 claims abstract description 16
- 239000011576 zinc lactate Substances 0.000 claims abstract description 16
- 230000000291 postprandial effect Effects 0.000 claims abstract description 13
- 235000013402 health food Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 235000010469 Glycine max Nutrition 0.000 claims description 35
- 244000068988 Glycine max Species 0.000 claims description 17
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 4
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- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 2
- 108010011485 Aspartame Proteins 0.000 claims description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 2
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- 235000009812 Momordica cochinchinensis Nutrition 0.000 claims description 2
- 235000018365 Momordica dioica Nutrition 0.000 claims description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 2
- 239000004384 Neotame Substances 0.000 claims description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 2
- 229930003268 Vitamin C Natural products 0.000 claims description 2
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 2
- 229960004998 acesulfame potassium Drugs 0.000 claims description 2
- 239000000619 acesulfame-K Substances 0.000 claims description 2
- 239000000605 aspartame Substances 0.000 claims description 2
- 235000010357 aspartame Nutrition 0.000 claims description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 2
- 229960003438 aspartame Drugs 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000009826 distribution Methods 0.000 claims description 2
- 229960000304 folic acid Drugs 0.000 claims description 2
- 235000019152 folic acid Nutrition 0.000 claims description 2
- 239000011724 folic acid Substances 0.000 claims description 2
- 235000009569 green tea Nutrition 0.000 claims description 2
- 235000019412 neotame Nutrition 0.000 claims description 2
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 claims description 2
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- 229940013618 stevioside Drugs 0.000 claims description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 2
- 239000011691 vitamin B1 Substances 0.000 claims description 2
- 239000011726 vitamin B6 Substances 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
- 239000011718 vitamin C Substances 0.000 claims description 2
- 239000004376 Sucralose Substances 0.000 claims 1
- 235000019408 sucralose Nutrition 0.000 claims 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 15
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 10
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- 150000001720 carbohydrates Chemical class 0.000 description 6
- 235000014633 carbohydrates Nutrition 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- 229930006000 Sucrose Natural products 0.000 description 5
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
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- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 235000008452 baby food Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
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- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
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- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 108010038983 glycyl-histidyl-lysine Proteins 0.000 description 1
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- 230000036039 immunity Effects 0.000 description 1
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- 230000000968 intestinal effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 235000011073 invertase Nutrition 0.000 description 1
- 239000001573 invertase Substances 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
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- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention provides a kind of incretin peptide solid beverages, are made of the raw material of following mass parts: major ingredient: L-arabinose 40-69 and soy peptide powder 30-59；Auxiliary material: zinc lactate 0.02-0.04, composite sweetener 0.3-0.5, essence 0.2-0.4 and multi-vitamins 0.08-0.12.Incretin peptide solid beverage of the present invention shows that the smoothness of postprandial blood sugar nearly reaches 100% to the effect test of the unstable diabetic population of postprandial blood sugar.Incretin peptide solid beverage of the present invention, to inhibit diabetes patient containing the zooming effect of blood glucose after confectionery, there is significant hypoglycemic effect by inhibiting the activity of small intestine alpha-glucosidase in human body in mucous membrane of small intestine.The present invention provides application of the incretin peptide solid beverage in the health food for preparing preventing/treating diabetes.Raw material sources of the present invention are abundant, and product stability is good, and preparation is simple, are suitable for industrialized production, there is biggish application value.
Description
Technical field
The present invention relates to health foods, and in particular to a kind of solid beverage more particularly to a kind of incretin peptide solid beverage.
Background technique
Diabetes (diabetes mellitus, DM) are as caused by a variety of pathogenic factors such as inherent cause, environmental factor
It is the endocrine metabolism disease mainly showed with carbohydrate metabolism disturbance with hypoinsulinism.Diabetes can cause it is a variety of simultaneously
Send out disease.On the one hand, the long-standing hyperglycemia of diabetic will lead to the chronic lesion and function barrier of various tissue nerves
Hinder.These complication are also that diabetes are lethal and the main reason for disable.On the other hand, diabetic is due to insulin secretion
Protein synthesis slows down in deficiency, liver and muscle, and catabolism is hyperfunction, easily generation negative nitrogen balance, causes resistance to decline, sternly
Nitrogenous metabolites increase in severe one blood, and urine urea nitrogen and organic acid concentration increase, and interfere water and acid-base balance, aggravate dehydration and
Acid poisoning；Diabetic is caused energy supply insufficient, is mobilized breaks down proteins function due to carbohydrate metabolism exception.
It however, the cause of disease of diabetes not yet illustrates completely so far, can not temporarily eradicate, mostly use the method for symptomatic treatment, drug control greatly.
Diabetic is generally treated with insulin or other drugs, but due to insulin higher cost, intramuscular injection is used
Inconvenience, and other chemicals have certain side effect to be unsuitable for taking for a long time.
L-arabinose is a kind of novel low calorie sweetener, is widely present in the leather shell of fruit and coarse food grain, because can
The activity for inhibiting invertase in human body intestinal canal, to be provided with
Chinese patent 01818856.7 disclose it is a kind of for improving the food and beverage of diabetic conditions, it is characterized in that containing
There are L-arabinose and sucrose as active constituent, wherein L-arabinose is 0.5~90% relative to the ratio of sucrose.The hair
It is bright to indicate that L-arabinose has the function of that postprandial blood glucose levels is inhibited to increase, blood glucose level and treatment glycosuria are also reduced to it
The validity of disease is verified.But it does not account for demand of the diabetes patient in terms of nutrition equilibrium.
Peptides are the low peptide mixtures (soybean peptide, wheat peptide etc.) that protein obtains after hydrolysis, must ammonia
Base acid content is abundant, and easy to digest and absorb, research shows that peptides have reducing blood lipid, adjust immunity of organism effect, blood pressure lowering,
The effects of antifatigue and hypoglycemic.CN101732698 and CN105708934 is disclosed in peptides to be inhibited containing alpha-glucosidase
Agent can not be influenced when it is used together with carbohydrate with carbohydrate by amount of insulin secretion, inhibit blood glucose rise.Greatly
Beans peptide is that a kind of amino acid forms complete complete protein, containing Several Active Peptides, has a variety of physiological activity, right
Diabetes patient has medical treatment and prevention effect.As a kind of novel and multifunctional nourishing ingredient, soy peptide powder can be widely used in guarantor
Health food, infant food, sports food, fermented product and clinical nutritive preparations etc., preferably further research and development.Above-mentioned document
It does not report that L-arabinose and soy peptide powder are used in combination and reaches hypoglycemic effect.
Summary of the invention
Technical problem to be solved by the present invention lies in overcome above-mentioned shortcoming, researching and designing L-arabinose and soybean
The health food that Gly-His-Lys are used in combination.
The present invention provides a kind of incretin peptide solid beverage, the primary raw material (major ingredient) of the incretin peptide solid beverage containing L- Ah
Draw uncle's sugar and soy peptide powder.
The content of L-arabinose is that this field is conventional in the incretin peptide solid beverage, and content is preferably 40-69, institute
Stating content unit is mass fraction.
The content of soy peptide powder in the incretin peptide solid beverage is that this field is conventional, and content is preferably 30-59.
The soybean peptide content of the soy peptide powder in terms of butt >=80%, wherein the molecular weight distribution of >=90% soybean peptide
≤10000Dalton。
Incretin peptide solid beverage provided by the invention also contains zinc lactate, composite sweetener, essence and multi-vitamins.
The content of the zinc lactate is that this field is conventional, and content is preferably 0.02-0.04.
The composite sweetener, essence and multi-vitamins are this field routine, and composite sweetener is selected from acesulfame potassium, three
One of chlorine sucrose, Aspartame, stevioside or neotame are a variety of.
The content of the composite sweetener is that this field is conventional, and content is preferably 0.3-0.5.
The essence is selected from one of Green tea essence, black tea essence, balsam pear powder or ginseng extract or a variety of.
The content of the essence is that this field is conventional, and content is preferably 0.2-0.4.
The multi-vitamins are selected from vitamin C, vitamin B1, vitamin B6Or one of folic acid or a variety of.
The content of multi-vitamins in incretin peptide solid beverage of the present invention is that this field is conventional, and content is preferably
0.08-0.12。
Preferably, a kind of incretin peptide solid beverage is made of the raw material of following mass parts: major ingredient: L-arabinose
40-69 and soy peptide powder 30-59；Auxiliary material: zinc lactate 0.02-0.04, composite sweetener 0.3-0.5, essence 0.2-0.4 and compound
Vitamin 0.08-0.12.
In one group of preferred embodiment of the invention, incretin peptide solid beverage is made of the raw material of following mass parts: major ingredient:
L-arabinose 58 and soy peptide powder 41.；Auxiliary material: zinc lactate 0.0265, composite sweetener 0.41, black tea essence 0.3, compound dimension
Raw element 0.1.
On the basis of common knowledge of the art, above-mentioned each optimum condition, can any combination to get each preferable reality of the present invention
Example.
Incretin peptide solid beverage of the present invention can be used health food conventional method and be made.
It is a further object of the present invention to provide incretin peptide solid beverages in the health food for preparing preventing/treating diabetes
In application.
Effect test of the incretin peptide solid beverage of the present invention to the unstable diabetic population of postprandial blood sugar, the results showed that postprandial
The smoothness of blood glucose nearly reaches 100%.
The positive effect of the present invention is that:
Incretin peptide solid beverage provided by the invention is by inhibiting the activity of small intestine alpha-glucosidase in human body, to rise
The zooming effect of blood glucose to after inhibiting diabetes patient to contain confectionery, shows significant hypoglycemic effect；Soybean peptide is
The effective component of alpha-glucosidase restrainer can hinder the effect for alleviating alpha-glucosidase, delay starch, sucrose, low
The digestion of the carbohydrates such as glycan, to achieve the purpose that mitigate blood glucose rise.Due to the mechanism of action and body secretes pancreas of soybean peptide
Island element is unrelated, is not influenced by insulin, therefore plays good booster action to the control of blood glucose；Meanwhile soybean peptide can be
Diabetes patient provides good protein, is human body supplying energy instead of carbohydrate, reduces the decomposition of original protein in vivo,
Basic metabolism is improved, accelerates sugar decomposition, reaches hypoglycemic effect；The two collaboration inhibits the activity of alpha-glucosidase, inhibits glycosuria
Blood glucose quickly increases after patients contain confectionery, to reach hypoglycemic effect, provides for preventing/treating diabetes new effective
Health food.
Raw material sources of the present invention are abundant, and product stability is good, convenient transportation and storage, and preparation is simple, are suitable for industrial metaplasia
It produces, there is biggish application value.
Specific embodiment
The present invention is further illustrated below by the mode of embodiment, but does not therefore limit the present invention to the reality
It applies among a range.In the following examples, the experimental methods for specific conditions are not specified, according to conventional methods and conditions, or according to quotient
The selection of product specification.
Agents useful for same of the embodiment of the present invention and raw material are commercially available.
The execution standard QB/T4321 of L-arabinose；The execution standard GB/T22492 of soy peptide powder；Zinc lactate and compound
Vitamin standard is referring to " national food safety standard food enrichment uses standard GB14880-2012 " solid beverage
Addition range be added.Composite sweetener and essence standard are referring to " national food safety standard food additives use
Standard GB2760-2014 " the addition range of solid beverage is added.
It is GB/T 29602-2013 that solid beverage product, which executes standard,.
The every box total weight of the incretin peptide solid beverage being prepared in following embodiments and comparative example is 10g.
Embodiment 1
A kind of incretin peptide solid beverage, is to be prepared from the following materials: major ingredient: L-arabinose 4.0g and soy peptide powder
5.9g；Auxiliary material: zinc lactate 0.01g, composite sweetener 0.05g, black tea essence 0.02g, multi-vitamins 0.02g.
Above-mentioned incretin peptide method for preparing solid beverage thereof is as follows:
(1) middling speed mixes 20min after above-mentioned major ingredient being carried out sterile weighing；
(2) middling speed mixes 30min after above-mentioned auxiliary material being carried out sterile weighing；
(3) after major ingredient and auxiliary material middling speed being mixed 30min, sampling Detection physicochemical property and color；
(4) uniformly mixed sample is dispensed, obtains inner wrapping finished product, finished product is sampled detection net weight, micro- life
The indexs such as object, after qualified,Mounted box, coding, plastic packaging, 5 box of finished product (10 grams of every box).Finished product need to be kept in dark place.
Embodiment 2
A kind of incretin peptide solid beverage, is to be prepared from the following materials: major ingredient: L-arabinose 4.5g and soy peptide powder
5.4g；Auxiliary material: zinc lactate 0.004g, composite sweetener 0.04g, black tea essence 0.04g, multi-vitamins 0.015g.
Above-mentioned incretin peptide method for preparing solid beverage thereof is as follows:
(1) middling speed mixes 20min after above-mentioned major ingredient being carried out sterile weighing；
(2) middling speed mixes 30min after above-mentioned auxiliary material being carried out sterile weighing；
(3) after major ingredient and auxiliary material middling speed being mixed 30min, sampling Detection physicochemical property and color；
(4) uniformly mixed sample is dispensed, obtains inner wrapping finished product, finished product is sampled detection net weight, micro- life
The indexs such as object, after qualified, mounted box, coding, plastic packaging, 5 box of finished product.Finished product need to be kept in dark place.
Embodiment 3
A kind of incretin peptide solid beverage, is to be prepared from the following materials: major ingredient: L-arabinose 4.9g and soy peptide powder
5.0g；Auxiliary material: zinc lactate 0.004g, composite sweetener 0.038g, black tea essence 0.03g, multi-vitamins 0.01g.
Above-mentioned incretin peptide method for preparing solid beverage thereof is as follows:
(1) middling speed mixes 20min after above-mentioned major ingredient being carried out sterile weighing；
(2) middling speed mixes 30min after above-mentioned auxiliary material being carried out sterile weighing；
(3) after major ingredient and auxiliary material middling speed being mixed 30min, sampling Detection physicochemical property and color；
(4) uniformly mixed sample is dispensed, obtains inner wrapping finished product, finished product is sampled detection net weight, micro- life
The indexs such as object, after qualified, mounted box, coding, plastic packaging, 5 box of finished product.Finished product need to be kept in dark place.
Embodiment 4
A kind of incretin peptide solid beverage, is to be prepared from the following materials: major ingredient: L-arabinose 5.8g and soy peptide powder
4.1g；Auxiliary material: zinc lactate 0.0027g, composite sweetener 0.041g, ginseng extract 0.03g, multi-vitamins 0.01g.
Above-mentioned incretin peptide method for preparing solid beverage thereof is as follows:
(1) middling speed mixes 20min after major ingredient in above-mentioned qualified samples being carried out sterile weighing；
(2) middling speed mixes 30min after auxiliary material in above-mentioned qualified samples being carried out sterile weighing；
(3) after major ingredient and auxiliary material middling speed being mixed 30min, sampling Detection physicochemical property and color；
(4) uniformly mixed sample is dispensed, obtains inner wrapping finished product, finished product is sampled detection net weight, micro- life
The indexs such as object, after qualified, mounted box, coding, plastic packaging, 12 box of finished product.Finished product need to be kept in dark place.
Embodiment 5
A kind of incretin peptide solid beverage, is to be prepared from the following materials: major ingredient: L-arabinose 6.4g and soy peptide powder
3.5g；Auxiliary material: zinc lactate 0.0022g, composite sweetener 0.045g, black tea essence 0.032g, multi-vitamins 0.011g.
Above-mentioned incretin peptide method for preparing solid beverage thereof is as follows:
(1) middling speed mixes 20min after above-mentioned major ingredient being carried out sterile weighing；
(2) middling speed mixes 30min after above-mentioned auxiliary material being carried out sterile weighing；
(3) after major ingredient and auxiliary material middling speed being mixed 30min, sampling Detection physicochemical property and color；
(4) uniformly mixed sample is dispensed, obtains inner wrapping finished product, finished product is sampled detection net weight, micro- life
The indexs such as object, after qualified, mounted box, coding, plastic packaging, 5 box of finished product.Finished product need to be kept in dark place.
Embodiment 6
A kind of incretin peptide solid beverage, is to be prepared from the following materials: major ingredient: L-arabinose 6.9g and soy peptide powder
3.0g；Auxiliary material: zinc lactate 0.002g, composite sweetener 0.03g, black tea essence 0.04g, multi-vitamins 0.012g.
Above-mentioned incretin peptide method for preparing solid beverage thereof is as follows:
(1) middling speed mixes 20min after above-mentioned major ingredient being carried out sterile weighing；
(2) middling speed mixes 30min after above-mentioned auxiliary material being carried out sterile weighing；
(3) after major ingredient and auxiliary material middling speed being mixed 30min, sampling Detection physicochemical property and color；
(4) uniformly mixed sample is dispensed, obtains inner wrapping finished product, finished product is sampled detection net weight, micro- life
The indexs such as object, after qualified, mounted box, coding, plastic packaging, 5 box of finished product.Finished product need to be kept in dark place.
Comparative example 1
A kind of solid beverage containing L-arabinose, is to be prepared from the following materials: major ingredient: L-arabinose 9.9g；It is auxiliary
Material: zinc lactate 0.00265g, composite sweetener 0.041g, black tea essence 0.03g, multi-vitamins 0.01g.
Above-mentioned L-arabinose method for preparing solid beverage thereof is as follows:
(1) middling speed mixes 20min after above-mentioned major ingredient being carried out sterile weighing；
(2) middling speed mixes 30min after above-mentioned auxiliary material being carried out sterile weighing；
(3) after major ingredient and auxiliary material middling speed being mixed 30min, sampling Detection detects physicochemical property and color；
(4) uniformly mixed sample is dispensed, obtains inner wrapping finished product, finished product is sampled detection net weight, micro- life
The indexs such as object, after qualified, mounted box, coding, plastic packaging, 30 box of finished product.Finished product need to be kept in dark place.
Comparative example 2
One kind containing soybean peptide solid beverage, is to be prepared by the raw material of following parts by weight: major ingredient: soy peptide powder 9.9g；
Auxiliary material: zinc lactate 0.0027g, composite sweetener 0.041g, black tea essence 0.03g, multi-vitamins 0.01g.
Above-mentioned soybean peptide solid beverage the preparation method is as follows:
(1) middling speed mixes 20min after above-mentioned major ingredient being carried out sterile weighing；
(2) middling speed mixes 30min after above-mentioned auxiliary material being carried out sterile weighing；
(3) after major ingredient and auxiliary material middling speed being mixed 30min, sampling Detection detects physicochemical property and color；
(4) uniformly mixed sample is dispensed, obtains inner wrapping finished product, finished product is sampled detection net weight, micro- life
The indexs such as object, after qualified, mounted box, coding, plastic packaging, 30 box of finished product.Finished product need to be kept in dark place.
Effect test of the incretin peptide solid beverage of the present invention of embodiment 7 to the unstable diabetic population of postprandial blood sugar
Selected crowd: suffering from diabetes, and the unstable patient of postprandial blood sugar, and 18-55 years old, men and women was fifty-fifty, and totally 90.
Sample: test specimen is the incretin peptide solid beverage of the embodiment of the present invention 1；Control sample is simple L- Arabic
Sugared solid beverage and simple soybean peptide solid beverage；
Test method: test group and control group each 30.One box of incretin peptide solid beverage (10 grams) of the embodiment of the present invention 1
And one box of soybean peptide solid beverage (10 grams).Respectively use 150ml warm water (20~25 degree) stirring and dissolving.Test group and control group
It is drunk respectively at half an hour before the meal, daily so amount is taken 2 times.
Test result: test group is respectively compared with control group one and control group two, the hypoglycemic effect and smoothness of test group
Being significantly stronger than control group one and control group two, (patient takes control group one (containing simple L-arabinose solid beverage) and right
After two (containing simple soybean peptide solid beverages) of group, the flat temperature of postprandial blood sugar is respectively 70% and 60%.), and postprandial blood
The smoothness of sugar nearly reaches 100%.
It discusses: the work that incretin peptide solid beverage of the present invention passes through the small intestine alpha-glucosidase in mucous membrane of small intestine inhibition human body
Property, to play the role of inhibiting diabetes patient zooming containing blood glucose after confectionery, show significant hypoglycemic effect；
Soybean peptide is the effective component of alpha-glucosidase restrainer, can hinder alleviate alpha-glucosidase effect, delay starch,
The digestion of the carbohydrates such as sucrose, oligosaccharide, to achieve the purpose that mitigate blood glucose rise.Due to the mechanism of action and body of soybean peptide
Excreting insulin is unrelated, is not influenced by insulin, therefore plays good booster action to the control of blood glucose；Meanwhile soybean
Peptide can provide good protein for diabetes patient, be human body supplying energy instead of carbohydrate, reduce original protein in vivo
Decomposition, improve basic metabolism, accelerate sugar decomposition, reach hypoglycemic effect；The two collaboration inhibits the activity of alpha-glucosidase, suppression
Blood glucose quickly increases after diabetes patient processed contains confectionery, to reach hypoglycemic effect.
Application of the incretin peptide solid beverage of the present invention of embodiment 8 to the unstable diabetes patient of postprandial blood sugar
Lee, male have beaten 5 years short-acting insulins, but postprandial two hours blood glucose is higher recently, and next before the meal and always low
Blood glucose takes incretin peptide solid beverage of the present invention (preparation of embodiment 1), twice daily, a box, 150ml before lunch, dinner
Warm water Instant Drinks.After a week, blood glucose peak can be made to shift, it is steady to maintain postprandial blood sugar.
8 product of the present invention incretin peptide solid beverage stability test (one) of embodiment
1 product of embodiment: incretin peptide solid beverage
Condition of storage: 25 DEG C of temperature room temperature, relative humidity RH is 65%
Purpose: detection business Storage period
Conclusion: from aforementioned stable test result it is found that at 25 DEG C of room temperature, relative humidity RH be 65% condition of storage
Under, the taste of product of the present invention incretin peptide solid beverage storage front and back, color, overall organoleptic, moisture, ash content, protein content, peptide
The indexs such as content, PH (10%), total plate count, coliform, mould/saccharomycete all remain unchanged substantially, to obtain this hair
The good conclusion of bright product incretin peptide solid beverage storage stability.
Product of the present invention incretin peptide solid beverage stability test (two)
1 product of embodiment: incretin peptide solid beverage
Condition of storage: 45 DEG C of temperature room temperature, relative humidity RH is 65%
Purpose: detection business Storage period
Conclusion: from aforementioned stable test result it is found that at 45 DEG C of room temperature, relative humidity RH be 65% condition of storage
Under, the taste of product of the present invention incretin peptide solid beverage storage front and back, color, overall organoleptic, moisture, ash content, protein content, peptide
The indexs such as content, PH (10%), total plate count, coliform, mould/saccharomycete all remain unchanged substantially, to obtain this hair
The good conclusion of bright product incretin peptide solid beverage storage stability.
Claims (9)
1. a kind of incretin peptide solid beverage, which is characterized in that the incretin peptide solid beverage is made of the major ingredient of following mass parts:
L-arabinose 40-69 and soy peptide powder 30-59.
2. a kind of incretin peptide solid beverage according to claim 1, which is characterized in that the incretin peptide solid beverage also by
The auxiliary material of following mass parts forms: zinc lactate 0.02-0.04, composite sweetener 0.3-0.5, essence 0.2-0.4 and the life of compound dimension
Plain 0.08-0.12.
3. a kind of incretin peptide solid beverage, which is characterized in that the incretin peptide solid beverage is made of the raw material of following mass parts:
Major ingredient: L-arabinose 58 and soy peptide powder 41；Auxiliary material: zinc lactate 0.0265, black tea essence 0.3, is answered at composite sweetener 0.41
Close vitamin 0.1.
4. a kind of incretin peptide solid beverage according to claim 1 or 3, which is characterized in that the soybean of the soy peptide powder
Peptide content in terms of butt >=80%, wherein molecular weight distribution≤10000Dalton of >=90% soybean peptide.
5. a kind of incretin peptide solid beverage according to claim 2 or 3, which is characterized in that the composite sweetener is selected from
One of acesulfame potassium, Sucralose, Aspartame, stevioside or neotame are a variety of.
6. a kind of incretin peptide solid beverage according to claim 2 or 3, which is characterized in that it is fragrant that the essence is selected from green tea
One of essence, black tea essence, balsam pear powder or ginseng extract are a variety of.
7. a kind of incretin peptide solid beverage according to claim 2 or 3, which is characterized in that the multi-vitamins are selected from
Vitamin C, vitamin B1, vitamin B6Or one of folic acid or a variety of.
8. incretin peptide solid beverage as claimed in claim 1,2 or 3 is in the health food for preparing preventing/treating diabetes
Using.
9. application according to claim 4, which is characterized in that the application is to prepare preventing/treating to postprandial blood sugar
Application in the health food of unstable diabetes.
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| CN110326788A (en) * | 2019-08-17 | 2019-10-15 | 哈尔滨工业大学 | A kind of bitter buckwheat d-chiro-inositol compound hypoglycemic tabletting and preparation method thereof |
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