JP2011004695A - Health food and health drink - Google Patents
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Abstract
Description
本発明は、γ−アミノ酪酸（γ-aminobutiric acid：ＧＡＢＡ）を含有する食品又は飲料において、特に血圧上昇抑制作用を有する食品及び飲料に関する。 The present invention relates to foods and beverages containing γ-aminobutiric acid (GABA), and particularly to foods and beverages having a blood pressure increase inhibitory effect.
メタボリックシンドロームとは、内臓脂肪の蓄積に加え、高血糖、高血圧、脂質代謝異常のうち二以上を合併して発生している状態を指し、近年においては、４０歳から７４歳の中高年男性の２人に１人、女性の５人に１人がメタボリックシンドロームの予備軍であるとされ、大きな社会的問題になっている。
一方、血糖値及び血圧値の上昇を抑制し、メタボリックシンドロームの予防、改善を図る効果を有する食品及び飲料が昨今流通している。
Metabolic syndrome refers to a condition that occurs due to a combination of hyperglycemia, hypertension, and abnormal lipid metabolism in addition to visceral fat accumulation, and in recent years, 2 of middle-aged and older men aged 40 to 74 years. One person and one in five women are considered to be reserves of the metabolic syndrome, which has become a major social problem.
On the other hand, foods and beverages that have an effect of suppressing an increase in blood glucose level and blood pressure level and preventing and improving metabolic syndrome are now in circulation.
上記食品及び飲料において、有効成分の一つとして、アミノ酸の一種であるγ-アミノ酪酸を含有しているものが知られている。
γ−アミノ酪酸（γ-aminobutiric acid）は、神経伝達物質として機能し、その略称である「ＧＡＢＡ（ギャバ）」と称されることが多い。
一般的にγ−アミノ酪酸は、グルタミン酸ナトリウムを、乳酸菌、酵母等によって発酵させることによって生産され、γ−アミノ酪酸を多く含有する食品としては、茶葉を窒素ガス環境下で一定期間保存することによって、茶葉に含有されるグルタミン酸をγ-アミノ酪酸に変化させた「ギャバロン茶」が知られており、上記ギャバロン茶に血圧上昇を抑制する作用がある旨の研究報告がなされている。
しかしながら、γ−アミノ酪酸の摂取量と血圧上昇抑制作用の発現との関連性については、現在までに明確な提示がされていない。
またギャバロン茶の茶葉には、約１５０mg／１００ｇ程度のγ−アミノ酪酸が含有されているが、茶葉を直接摂取するのではなく、浸出液である茶液を摂取こととなるため、浸出液に含有されるγ−アミノ酪酸の量は上記量よりも減少すると考えられ、一般的には５００〜６００ｍｌの浸出液の摂取が推奨されている。
従って、上記の量を毎日確実に摂取ことが困難であると共に、茶葉の煮出し作業等の手間を要していた。
In the foods and beverages, those containing γ-aminobutyric acid, which is a kind of amino acid, are known as one of active ingredients.
γ-aminobutiric acid functions as a neurotransmitter and is often referred to as its abbreviation “GABA”.
Generally, γ-aminobutyric acid is produced by fermenting sodium glutamate with lactic acid bacteria, yeast, etc., and as a food containing a lot of γ-aminobutyric acid, tea leaves are stored for a certain period in a nitrogen gas environment. In addition, “Gabalon tea” in which glutamic acid contained in tea leaves is changed to γ-aminobutyric acid is known, and a research report has been made that the above-mentioned Gabalon tea has an action of suppressing an increase in blood pressure.
However, no clear presentation has been made so far regarding the relationship between the intake of γ-aminobutyric acid and the expression of the blood pressure increase inhibitory effect.
The tea leaves of Gabalon tea contain about 150 mg / 100 g of γ-aminobutyric acid, but instead of directly ingesting the tea leaves, it is ingested with the tea liquid that is the exudate, so it is contained in the exudate. The amount of γ-aminobutyric acid is considered to be lower than the above amount, and generally 500 to 600 ml of infusion is recommended.
Accordingly, it is difficult to reliably take the above amount every day, and it has been time-consuming to boil tea leaves.
また、鹿角霊芝とは、マンネンタケ属に属する茸であり、鹿の角に似た形状を有し、傘が開かない点で一般的な霊芝と形状が異なる。
霊芝には元来より血圧上昇を抑制する効果を有する旨が報告されており、また含有成分であるβ−グルカンに抗腫瘍効果がある旨も報告されている。
しかし、γ−アミノ酪酸と同様、摂取量と有効性の発現との関連性を明示されておらず、またγ−アミノ酪酸との相乗効果についても具体的に報告されているものは無い。
Deer antler is a moth belonging to the genus Mannentake, has a shape resembling a deer antler, and is different in shape from a general reishi in that the umbrella does not open.
Ganoderma has been reported to have an effect of suppressing an increase in blood pressure from the beginning, and β-glucan as a contained component has also been reported to have an antitumor effect.
However, like γ-aminobutyric acid, the relationship between intake and expression of effectiveness is not clearly shown, and there is no specific report on the synergistic effect with γ-aminobutyric acid.
また、γ−アミノ酪酸、及びきのこ由来成分を有効成分とする生理活性組成物について、アスパラガスから抽出されたγ−アミノ酪酸と、ハナビラダケの粉末とを混合した組成物を餌に混入させ、上記餌をラットに摂取させることによって、一定の血圧降下作用を得ることが可能である旨が開示されている（特許文献１）。
しかしながら、上記特許文献１の発明に係る組成物は、薬剤若しくは、食品添加物として使用することを想定しており、推奨量を摂取する為には、上記組成物が添加された食品を、毎日一定量以上食する必要があるため、推奨量をコンスタントに摂取することは困難であった。
However, the composition according to the invention of Patent Document 1 is supposed to be used as a drug or food additive, and in order to ingest the recommended amount, the food to which the composition is added is daily. Since it is necessary to eat more than a certain amount, it was difficult to take the recommended amount constantly.
本発明の解決する課題は、通常の食事を取りながら、無理なく摂取可能であると共に、少量で高い血圧降下作用を得ることが可能な食品を提供することにある。 The problem to be solved by the present invention is to provide a food that can be taken without difficulty while eating a normal meal and that can obtain a high blood pressure lowering effect in a small amount.
上記課題を解決するために、請求項１の発明にかかる食品は、米糠を発酵栄養源として生産されるγ−アミノ酪酸と、鹿角霊芝抽出物とを含有することを特徴とする。 In order to solve the above-mentioned problems, a food according to the invention of claim 1 is characterized in that it contains γ-aminobutyric acid produced using rice bran as a fermented nutrient source, and kakukaku reishi extract.
本発明におけるγ−アミノ酪酸は、米糠に所定量のグルタミン酸ナトリウムを添加した培地に乳酸菌を添加し、上記米糠を唯一の栄養源として所定期間発酵させることで、上記グルタミン酸ナトリウムが変換されて得られるものである。
本方法によれば、非常に高い変換効率で、グルタミン酸ナトリウムがγ−アミノ酪酸に変換され、容易にγ−アミノ酪酸の高含有抽出液を得ることが可能である。
従って、少量の抽出液で多量のγ−アミノ酪酸を摂取することが可能である。
また、熱水抽出液として添加される鹿角霊芝には、高濃度のβ‐グルカンが含まれ、免疫力の活性化、血液循環の改善、及び抗酸化作用を有することから、γ−アミノ酪酸の血圧降下作用に相乗的に作用し、γ−アミノ酪酸の血圧降下作用を強める働きがある。
The γ-aminobutyric acid in the present invention is obtained by converting the sodium glutamate by adding lactic acid bacteria to a medium in which a predetermined amount of glutamic acid sodium is added to rice bran and fermenting the rice bran as a sole nutrient source for a predetermined period. Is.
According to this method, sodium glutamate is converted to γ-aminobutyric acid with a very high conversion efficiency, and an extract with a high content of γ-aminobutyric acid can be easily obtained.
Therefore, a large amount of γ-aminobutyric acid can be ingested with a small amount of the extract.
In addition, Kakuno Ganoderma added as a hot water extract contains a high concentration of β-glucan, which activates immunity, improves blood circulation, and has an antioxidant effect. It acts synergistically on the blood pressure lowering action of γ-aminobutyric acid and strengthens the blood pressure lowering action of γ-aminobutyric acid.
また、請求項２の発明に係る食品は、上記食品には、カシス濃縮液が含有されることを特徴とする。
従って、上記カシス濃縮液に含まれるポリフェノールによって、体内に発生する活性酸素が除去される。
The food according to the invention of claim 2 is characterized in that the food contains a cassis concentrate.
Therefore, the active oxygen generated in the body is removed by the polyphenol contained in the cassis concentrate.
また、請求項３の発明に係る食品は、米黒酢が含有されていることを特徴とする。
米黒酢に含まれる酢酸は、圧降下作用を有する旨が報告されている。
従って、上記γ−アミノ酪酸との相乗的に作用することによって、血圧降下作用を向上させる。
Moreover, the foodstuff which concerns on invention of Claim 3 contains rice black vinegar.
It has been reported that acetic acid contained in rice black vinegar has a pressure-lowering effect.
Therefore, the blood pressure lowering action is improved by acting synergistically with the γ-aminobutyric acid.
また、請求項４の発明に係る食品は、上記食品には、アカシヤ蜂蜜が含有されることを特徴とする。
蜂蜜は消化吸収が非常に良く、栄養素も豊富であると共に、摂取しても血糖値の急激な上昇が発生することがない。
Moreover, the food according to the invention of claim 4 is characterized in that the food contains acacia honey.
Honey is very good for digestion and absorption, is rich in nutrients, and does not cause a rapid increase in blood sugar even when ingested.
また、請求項５の発明に係る食品は、上記食品には、ガラクトオリゴ糖が含有されていることを特徴とする。
ガラクトオリゴ糖は母乳にも含まれ、腸内善玉菌を選択的に増加させる作用を有すると共に、免疫力の強化及び血中コレステロールの低下作用を有する。
The food according to the invention of claim 5 is characterized in that the food contains galactooligosaccharide.
Galactooligosaccharide is also contained in breast milk and has the effect of selectively increasing intestinal good bacteria and has the effect of enhancing immunity and lowering blood cholesterol.
また、請求項６の発明に係る食品は、飲料であることを特徴とする。 The food according to the invention of claim 6 is a beverage.
請求項１の発明に係る食品は、米糠を発酵栄養源として使用して生産されるγ−アミノ酪酸と、鹿角霊芝抽出物とを含有することから、高濃度のγ−アミノ酪酸を含有し、少量の摂取で多量のγ−アミノ酪酸を摂取可能である。
従って、通常の食事を取りつつ、無理なくγ−アミノ酪酸を摂取することが可能であると共に、鹿角霊芝抽出物との相乗効果によって、少量で高い血圧降下作用を得ることが可能な食品を提供することが可能となる。
The food according to the invention of claim 1 contains γ-aminobutyric acid produced by using rice bran as a fermented nutrient source and kakuno ganoderma extract, and therefore contains a high concentration of γ-aminobutyric acid. In a small amount, a large amount of γ-aminobutyric acid can be ingested.
Therefore, it is possible to take γ-aminobutyric acid without difficulty while taking a normal meal, and a food that can obtain a high blood pressure lowering effect in a small amount by synergistic effect with Kakuno Ganoderma extract. It becomes possible to provide.
また、請求項２の発明に係る食品は、カシス濃縮液が含有されることによって、請求項１の効果に加え、上記カシス濃縮液に含まれるポリフェノールによって、体内に発生する活性酸素が除去され、上記活性酸素に起因すると考えられる様々な疾患を予防しうると共に、抹消血管の血流の改善によって肩こり、冷え性に対しても有効な食品を提供することが可能となる。 In addition to the effect of claim 1, the food according to the invention of claim 2 contains the cassis concentrate, and the active oxygen generated in the body is removed by the polyphenol contained in the cassis concentrate, Various diseases considered to be caused by the active oxygen can be prevented, and by improving the blood flow of peripheral blood vessels, it is possible to provide a food effective for stiff shoulders and coldness.
また、請求項３の発明に係る食品は、米黒酢が含有されていることから、請求項１の効果に加え、黒酢の主要成分である酢酸の血圧降下作用とγ−アミノ酪酸の血圧降下作用とが相乗的に機能し、より少量の摂取で高い血圧降下作用を有する食品を提供することが可能となる。 Moreover, since the food which concerns on invention of Claim 3 contains rice black vinegar, in addition to the effect of Claim 1, the blood pressure lowering effect | action of the acetic acid which is a main component of black vinegar, and the blood pressure of (gamma) -aminobutyric acid It is possible to provide a food that functions synergistically with a lowering action and has a high blood pressure lowering action with a smaller amount of ingestion.
また、請求項４の発明に係る食品は、アカシヤ蜂蜜が含有されることから、請求項１の効果に加え、栄養価が高く、また摂取によって血糖値の急激な上昇が発生しないため、高血糖の者であっても、安全に摂取可能な食品を提供することが可能となる。 Further, since the food according to the invention of claim 4 contains acacia honey, in addition to the effect of claim 1, it has a high nutritional value and does not cause a rapid increase in blood sugar level due to ingestion. It is possible to provide foods that can be safely consumed even by those who are.
また、請求項５の発明に係る食品は、ラクトオリゴ糖が含有されていることから、請求項１の効果に加え、腸内環境を整え、免疫力の向上させる共に、毛血中コレステロールの低下作用を期待できる食品を提供することが可能となる。 Moreover, since the food which concerns on invention of Claim 5 contains lacto-oligosaccharide, in addition to the effect of Claim 1, while improving intestinal environment and improving immunity, the action of lowering cholesterol in hair blood It is possible to provide foods that can be expected.
また請求項６の発明に係る食品は、飲料である為、老人や子供にも飲み易い。 In addition, since the food according to the invention of claim 6 is a beverage, it is easy for the elderly and children to drink.
本発明の実施する為の最適な形態を、図表を用いて説明する。
本実施例に係る食品は飲料であり、表１に示すように、米糠を発酵栄養源として使用して生産されるγ−アミノ酪酸を含有する抽出液１２５ｇと、鹿角霊芝抽出液２１２ｇと、カシス濃縮液４５ｇと、米黒酢６３ｇと、アカシヤ蜂蜜３００ｇを混合して形成され、夫々の重量比は全体１００に対し、γ−アミノ酪酸含有抽出液約１５．２％、鹿角霊芝抽出液約２５．９％、カシス濃縮液約５．５％、米黒酢約７．７％、アカシヤ蜂蜜３６．６％である。
また、表２に示すように夫々の原料の体積比は、全体１００に対し、γ−アミノ酪酸含有抽出液約１７．４％、鹿角霊芝抽出液約２９．４％、カシス濃縮液約５．８％、米黒酢８．８％、アカシヤ蜂蜜３０．８％である。
The food according to the present example is a beverage, and as shown in Table 1, 125 g of an extract containing γ-aminobutyric acid produced using rice bran as a fermented nutrient source, 212 g of Kakukaku Reishi extract, It is formed by mixing 45 g of cassis concentrate, 63 g of rice black vinegar, and 300 g of red pepper honey. Each weight ratio is about 15.2% γ-aminobutyric acid-containing extract with respect to 100 as a whole. About 25.9%, Cassis concentrate about 5.5%, Rice black vinegar about 7.7%, Acacia honey 36.6%.
In addition, as shown in Table 2, the volume ratio of each raw material was about 17.4% of the γ-aminobutyric acid-containing extract, about 29.4% deer antrum extract, and about 5 cassis concentrate with respect to the total 100. 8%, rice black vinegar 8.8%, red honey honey 30.8%.
以下に、図表を用いて本実施例に係る飲料を実験動物に摂取させた場合の効果検証実験について詳細を説明する。
（１）試料
試験用試料は、上記に示したように、γ−アミノ酪酸を含有する抽出液と、
鹿角霊芝抽出液と、カシス濃縮液と、米黒酢と、アカシヤ蜂蜜が上記表１及び表２に記載した割合で混合された溶液であり、詳細成分組成は表３に示すとおりである。
カシヤ蜂蜜を３０．８％と水を６９．２％の割合で混合した溶液を使用した。
（２）実験対象動物
実験対象となる動物には、高血圧自然発祥ラットＳＨＲ／Ｉｚｍ（１２週齢、
雄）用いた。
上記実験動物１２匹を、温度２４±２℃、湿度５０±１０％、１日１２時間（７：００〜１９：００）人工照明照射の飼育室環境下で１週間の予備飼育の後、血圧を測定して試料群（６匹）と試料群（６匹）の群間血圧がほぼ均一となるように群分けした。
飼育期間は８週間とし、試験開始日から試験終了日まで毎日１回、試料群には試料溶液。対照群には対象溶液を強制投与した。
試料の投与量はラット体重１ｋｇ当たり４ｍL（２５０ｇラットの場合１ｍL）とし、飼育期間中は、体重、摂食量を試験開始時、終了時、及び試験期間中１週間に１回測定した。
また、摂食量は、前日の給餌量と翌日の残餌量の差を一日当たりの摂食量とし、血圧は試験開始時と終了時、及び試験期間中は２週間に１回測定した。
なお、血圧の測定は小動物用非観血式血圧測定装置ＵＲ５０００（ウエダ製作所製）を使用し、テイルカフ法で行った。
Below, the effect verification experiment at the time of making the experimental animal ingest the drink which concerns on a present Example using a chart is demonstrated in detail.
(1) A sample test sample, as shown above, an extract containing γ-aminobutyric acid,
Kazukaku Reishi extract, cassis concentrate, rice black vinegar, and red honey honey are mixed in the proportions described in Tables 1 and 2 above, and the detailed composition is as shown in Table 3.
(2) Experimental animals The animals to be tested include spontaneously hypertensive rats SHR / Izm (12 weeks old,
Male).
Twelve experimental animals described above were preliminarily raised for 1 week in a breeding room environment of artificial lighting irradiation at a temperature of 24 ± 2 ° C., a humidity of 50 ± 10%, 12 hours a day (7: 0 to 19:00), and blood pressure Were measured and the sample groups (6 animals) and the sample groups (6 animals) were divided into groups so that the blood pressure between the groups was almost uniform.
The breeding period is 8 weeks, and once a day from the test start date to the test end date, sample solution for the sample group. The control solution was forcibly administered the target solution.
The dose of the sample was 4 mL / kg rat body weight (1 mL in the case of 250 g rat), and the body weight and food intake were measured at the start and end of the test and once a week during the test period.
In addition, the amount of food intake was defined as the amount of food intake per day, which was the difference between the amount of food supplied on the previous day and the amount of remaining food on the following day, and blood pressure was measured at the start and end of the test and once every two weeks during the test period.
The blood pressure was measured by a tail cuff method using a small animal non-invasive blood pressure measuring device UR5000 (manufactured by Ueda Seisakusho).
表３に示すように、試験溶液には２．５２ｍｇ／ｍｌのγ−アミノ酪酸が含有されていたが、対照溶液のγ−アミノ酪酸は検出限界以下であった。
上記ラットには１日１回体重１ｋｇ当たり４ｍｌの溶液を経口投与することから、試料群のラット異は１０．１ｍｇ／ｋｇ 体重/日のγ−アミノ酪酸を摂取したこととなる。
As shown in Table 3, the test solution contained 2.52 mg / ml of γ-aminobutyric acid, but the control solution had γ-aminobutyric acid below the detection limit.
Since the above rats are orally administered with 4 ml of solution per kg of body weight once a day, the rats in the sample group were ingested 10.1 mg / kg body weight / day of γ-aminobutyric acid.
図１に示すように試験期間中において、ラットの体重の増減については、試料群と対照群との間に際は認められなかったが、摂食量については、図２に示すように６週目において試料群と対照群との間に統計的な有意差が認められた。 As shown in FIG. 1, during the test period, no increase or decrease in the body weight of the rat was observed between the sample group and the control group, but the food intake was 6 weeks as shown in FIG. A statistically significant difference was observed between the sample group and the control group.
また、図３に示すように、試験期間中において、対照群に対して試料群は３週目から低値を示し、試験開始７週目の血圧は対照群の２３４±５．１ｍｍＨｇに対し試料群は２１８±２．８ｍｍＨｇであり、有意な低値を示した。 In addition, as shown in FIG. 3, during the test period, the sample group showed a low value from the 3rd week with respect to the control group, and the blood pressure at the 7th week of the start of the test was a sample with respect to 234 ± 5.1 mmHg of the control group. The group was 218 ± 2.8 mmHg and showed a significant low value.
また、表４及び表５に示すように、内臓組織の重量及び血液生化学値については両群に有意な差は認められなかった。
以上の結果を考察すると、試験期間中ラットの体重は一度も減少することなく少しずつ増加した。これに対し摂食量は試験開始後両群とも２〜４ｇ程度減少している。投与溶液の熱量を計算すると、試料群で６．０ｋｃａｌ／ｋｇ体重／日、対照群で８．９ｋｃａｌ／ｋｇ体重／日となる。
給餌飼料の熱量は３５９．２ｋｃａｌ／１００ｇであるため、飼料摂食量の減少分２〜３ｇはほぼこのようと溶液由来のエネルギーと一致する、
従って、ラットの摂食量の減少は投与溶液の成分に起因するものではなく、投与されている溶液から活動に必要なエネルギーの一部を摂取していることによるものと考えられる。
上記に加え、飼育中のラットの外見的異常が発生せず、且つ上記表４及び５に示すように、内臓重量、血液生化学値に両群間で差異が生じていないことから、ラットに投与した試料溶液の安全性は高いと考えられる。
Considering the above results, the body weight of the rat increased little by little during the test period. In contrast, the amount of food intake decreased by about 2 to 4 g in both groups after the start of the test. The calorie of the administration solution is calculated to be 6.0 kcal / kg body weight / day in the sample group and 8.9 kcal / kg body weight / day in the control group.
Since the amount of heat of the feed is 359.2 kcal / 100 g, the decrease in the amount of feed consumed is 2-3 g, which almost coincides with the energy derived from the solution.
Therefore, the decrease in the amount of food intake of the rat is not due to the components of the administration solution, but is considered to be due to taking part of the energy necessary for activity from the solution being administered.
In addition to the above, no abnormal appearance occurred in the rats being bred, and as shown in Tables 4 and 5 above, there was no difference between the two groups in visceral weight and blood biochemistry. It is considered that the administered sample solution is highly safe.
また、試料群のラットの血圧値は、上記に示すような有意な低値を示したことから、本試料溶液には含有されるγ−アミノ酪酸は血圧上昇抑制作用を発現するのに十分な量であるといえる。
更に、試験溶液に含まれている鹿角霊芝抽出液、及び黒酢中の酢酸も上述のように血圧上昇抑制作用が報告されていることから、γ−アミノ酪酸に加えこれらの成分が相加的あるいは相乗的に作用して血圧の上昇が抑制された可能性が高い。
In addition, since the blood pressure value of the rats in the sample group showed a significantly low value as shown above, γ-aminobutyric acid contained in this sample solution was sufficient to exhibit an antihypertensive effect. It can be said that it is a quantity.
In addition, the Kakuno Ganoderma lucidum extract contained in the test solution and acetic acid in black vinegar have been reported to suppress blood pressure elevation as described above, so these components were added in addition to γ-aminobutyric acid. There is a high possibility that the increase in blood pressure was suppressed by acting on the subject or synergistically.
また、本試料溶液のヒトに対する効果については、日本食品化学工学会誌５１（２）７９−８６（２００４年）において、梶本らによって報告されているように、軽症高血圧及び正常高値血圧のヒトボランティアを用いた研究において、１２．３ｍｇのγ−アミノ酪酸を含む発酵乳飲料を一日一本、４週間以上摂取させると血圧が有意に低下するとある。
本試料溶液の一日の推奨摂取量は３０ｍｌであり、本量中には、表３より７５．６ｍｇのγ−アミノ酪酸が含有されている。
上記量は、上記報告にて血圧低下作用が認められた際のγ−アミノ酪酸の一日の摂取量を大きく越えていることから、本実験によってラットに発現した血圧上昇抑制作用は、ヒトでも同様に発現しうると考えられる。
As for the effects of this sample solution on humans, as reported by Enomoto et al. In Japanese Journal of Food Chemical Engineering 51 (2) 79-86 (2004), human volunteers with mild hypertension and normal high blood pressure In the study used, blood pressure may be significantly reduced if a fermented milk drink containing 12.3 mg of γ-aminobutyric acid is ingested once a day for 4 weeks or more.
The recommended daily intake of this sample solution is 30 ml, and 75.6 mg of γ-aminobutyric acid is contained in this amount from Table 3.
Since the above amount greatly exceeds the daily intake of γ-aminobutyric acid when the blood pressure lowering effect was observed in the above report, the blood pressure increase suppressing effect expressed in the rat by this experiment is It is thought that it can be expressed similarly.
また、上記の３０ｍｌという摂取量は、一日の飲食量に比して非常に少量であることから、通常の食事には全く影響を与えることなく、無理なく摂取可能であると共に、少量で高い血圧降下作用を得ることが可能である。 In addition, the intake amount of 30 ml is very small compared to the daily amount of food and drink, so that it can be taken reasonably without affecting the normal meal at all, and it is high in a small amount. It is possible to obtain a blood pressure lowering effect.
本発明は、γ−アミノ酪酸を含有する食品又は飲料において、特に血圧上昇抑制作用を有する食品及び飲料に適用可能である。 The present invention is applicable to foods and beverages containing γ-aminobutyric acid, and particularly to foods and beverages that have a blood pressure increase-inhibiting action.
Claims (6)
The food according to claim 1, wherein the food is a beverage.
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