JP2006238730A - Liver function-enhancing health food - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a liver function-enhancing health food effectively absorbed in the intestines, having high effects of ameliorating liver functions by the direct action of an active ingredient on the liver, and effective for the enhancement of the liver functions. <P>SOLUTION: The liver function-enhancing health food contains dry substance of turmeric extract, dry substance of shiitake mushroom extract, dry substance of freshwater clam, dry substance of oyster flesh extract, dry substance of dandelion, dry substance of yam extract, dry substance of woad extract, dry substance of chrysanthemum extract, dry substance of boxthorn extract, dry substance of Glehnia littoralis extract, dry substance of jujube extract, dry substance of cassia seed extract, and dry substance of Polygonatum falcatum extract and malted rice so that the malted rice ferments the extracts to produce the food. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a liver function-enhancing health food. In particular, the present invention relates to a liver function-enhancing health food that has a high intestinal absorption effect, an active ingredient that directly acts on the liver, has a high liver function improving action, and is effective in enhancing liver function.

  Shijimi, turmeric, agaricus, ginseng, oyster meat, and thistle are known as foods good for the liver. That is, shijimi is rich in minerals and contains a large amount of sulfur-containing amino acids such as methionine and cystine, and these sulfur-containing amino acids are said to have an action of activating liver function. It is also said that taurine binds bile acids and enhances detoxification. Turmeric is a ginger plant, also called turmeric, and its bright and spicy flavor is also used in curry powder. Turmeric has long been used as a traditional treatment for digestive and liver diseases in China and India. That is, curcumin contained in turmeric has an action of accelerating the decomposition of alcohol and an action of increasing the secretion of bile. Bile emulsifies fat, enhances functions such as pancreatic juice lipase, and has an action of assisting digestion and absorption. Then, the burden on the liver is reduced by promoting the secretion of bile. Agaricus is also known as Himematsutake in Japan and contains β-glucan and has attracted attention for its anti-cancer properties. Agaricus contains a large amount of γ-aminobutyric acid (gabba) and can also be expected to lower blood glucose levels and lower blood pressure. Nana ginseng is a plant belonging to the family Araceae and contains many saponins and flavonoids, and has been used mainly as a tonic since ancient times. In addition to saponins, organic germanium, flavonoids and sterols that induce interferon, as well as a variety of minerals, the inclusion of ketones and new saponins that are contained only in the seven ginsengs have been pointed out. For this reason, ginseng is often used as a herbal medicine, and it is said that in addition to the effects of hemorrhage due to trauma, hemostasis of internal hemorrhage, analgesia, etc., the blood is made smooth and the inflammation of the liver is suppressed. Like swordfish, oysters are rich in taurine, have liver function improving action, and are said to have amino acids that are compositionally ideal. Maria Thistle has long been used as a folk medicine in Europe. Maria thistle, also called milk thistle, is a chrysanthemum plant and its seeds have been widely used for diseases of the liver, gallbladder, spleen, digestive organs, and lack of breast milk. In particular, it is widely used as a therapeutic agent for liver disease. In particular, the action of silymarin, a component of Maria Thistle, has attracted attention. Glutathione is a coenzyme for glutathione peroxidase and a coenzyme that enhances alcohol-degrading enzymes. It is said that it is a necessary ingredient for people who drink a lot of alcohol. The mother yeast is rich in vitamins and minerals and contains many components necessary to activate the enzyme.

By the way, the foodstuff containing the said component is ingested well now in order to strengthen a liver function. However, they were simply powdered or in the form of extracts.
Some of them are known to ferment turmeric with lactic acid bacteria to improve bitterness peculiar to turmeric.

  Now, the effects of the above active ingredients on the liver function are being clarified. Under such circumstances, it has been found that even if a food containing a large amount of these is ingested, not all of them are effectively acting on the body.

  By the way, since ancient times, Japan has been enjoying an ideal diet with fermented foods such as miso, soy sauce, and natto, mainly cereals, vegetables and fish. And it is said that it is a diet where there are many raw foods, and many natural enzymes of vegetables and fruits and live enzymes of fermented foods are utilized.

  However, recent dietary habits are increasing in consumption of processed foods, heated foods, various food additives and drugs. Enzymes that are ingested from outside the body are deficient, burdening the pancreas, inadequate digestion and degradation, and increasing the burden on the liver. Furthermore, since it is an era when a lot of stress is felt, alcohol is often taken from the viewpoint of stress release, which increases the burden on the liver and increases the risk of liver damage.

  That is, even if you actively eat foods that are said to be good for the liver, such as shijimi, turmeric, agaricus, ginseng, oyster meat, maria thistle, etc., the effect is sufficient for the reasons mentioned above Has not been demonstrated.

  Therefore, the problem to be solved by the present invention is a liver function-enhancing health food that has a high intestinal absorption effect, an active ingredient directly acts on the liver, has a high liver function improving action, and is effective for enhancing liver function Is to provide.

  In order to solve the above-mentioned problems, research and development has been carried out with eagerness. As a result, we realize that it is important to make it possible to efficiently absorb active ingredients in foods that are said to be good for the liver such as shijimi, turmeric, agaricus, ginseng, oyster meat, and thistle. It came to.

  And as a result of further research to increase the absorbability of active ingredients, we came to the revelation that it would be important to reduce the molecular weight. However, it seems that it cannot be improved by simply reducing the molecular weight, and has reached the knowledge that it is important to reduce the molecular weight by any means.

  By the way, a product called fermented turmeric is provided. In this product, turmeric alone is reduced in molecular weight using enzyme preparations such as α-amylase (starch degrading enzyme), protease (proteolytic enzyme), lipase (lipolytic enzyme), and then lactic acid bacteria are used. It is fermented. This was an artificial decomposition, and lactic acid bacteria fermentation was carried out in a liquid medium, which was unsatisfactory as a product.

  On the other hand, in Japan, potatoes have been used for miso, soy sauce, natto, sake, etc., which have been known as traditional fermented foods since ancient times, and these traditional fermented foods are said to be good for the body. As is well known. And it contains many kinds of digestive (degrading) enzymes, such as α-amylase, β-amylase, glucoamylase, acidic protease, neutral protease, alkaline protease, lipase, etc. By the action of various enzymes, starch is broken down into sugar, protein is broken down into amino acids, and fat is broken down into fatty acids and glycerin. This step is the same as the digestion / degradation performed in the human digestive tract.

  Therefore, the present inventor, for example, even in turmeric, is superior to conventional fermented turmeric products if it is fermented and decomposed using koji that has been used in traditional fermented foods since ancient times in Japan. I came to imagine that something could be obtained.

  And the product obtained by trying it was found to be superior to the conventional fermented turmeric.

  Based on such knowledge, a liver function-enhancing health food characterized by including a food containing a component that enhances liver function and salmon has been proposed (Japanese Patent Application No. 2004-185931) by one of the present inventors. It came to be.

  However, as a result of pursuing further studies by the present inventor who is not satisfied with the proposed technique, the present inventors have reached a liver function-enhancing health food that exhibits even better features than those proposed above. is there.

Thus, the present invention has been achieved.
Turmeric extract dry matter, shiitake extract dry matter, shijimi extract dry matter, oyster meat extract dry matter, dandelion extract dry matter, potato extract dry matter, fried buckwheat extract dry matter, chrysanthemum flower extract dry matter And a dried wolfberry extract, a dried cassava extract, a dried jujube extract, a dried ketsumeishi extract, and a dried narco lily extract,
It is solved by a liver function-enhancing health food characterized by containing salmon.

In particular, dried turmeric extract, dried shiitake extract, dried shii extract, dried oyster meat extract, dried dandelion extract, dried yam extract, dried soba cabbage extract, and chrysanthemum flower extract A dried product, a dried wolfberry extract, a dried clover extract, a dried jujube extract, a dried extract of ketsumeishi, a dried extract of narco lily, and a strawberry,
It is solved by a liver function-enhancing health food characterized in that the extract is fermented with the koji.

  And in the above-mentioned invention, as the straw, one or more selected from the group of barley, rice bran, and rice is used as a substrate, and Aspergillus oryzae, Aspergillus niger, and Aspergillus soya are used as this substrate. Preferred is a composite koji containing two or more koji selected from the group of koji fermented by inoculating one or two or more koji molds selected from the group and a red koji fermented with the koji mold of the genus Monascus Can be cited.

  In the present invention, it is also preferable to contain dietary fibers such as cellulose and pine fiber. The inclusion of Yamabushitake is also preferable. In order to reduce liver damage caused by alcohol, inclusion of glutathione that enhances alcohol-degrading enzyme is also preferred.

  The liver function-enhancing health food of the present invention is preferably in a powder form by low temperature drying so that the enzyme activity is not easily deactivated.

  The present invention includes a dried turmeric extract, a dried shiitake extract, a dried shiitake extract, a dried oyster extract, a dried dandelion extract, and a dried yam extract. , Hosoba Taisei (Pion Ane) extract dry product, Chrysanthemum flower extract dry product, Kuko (Zushi) extract dry product, Hamabou Fu (San Gan) extract dry product, Jujube (Daisen) extract dry product, Ketsumeishi (Keiko): Extracted dried product and Narukoyuri (yellow spirit) extracted dried product are included.

  By the way, the dried turmeric extract contains curcumin and essential oil components (flavonoids, camphor, asunon, shioner, etc.), has the function of promoting the detoxification function of the liver, removing biliary calculi, and diuresis. Has anti-cardiac, anti-bleeding, anti-bacterial, anti-tumor and blood cholesterol inhibitory effects.

  The dried shiitake extract has an effect of nourishing energy and enhancing immunity when tired, and also has an anti-cancer effect. Furthermore, the effect of reducing hepatitis B and C viruses is also expected.

  Shijimi (potato) extract dried product contains glycogen, succinic acid, minerals, vitamin B12, high quality protein (amino acid score 100), alanine, taurine, etc., strong liver action, promotion of metabolism by organic acids, Has haematopoietic action, activation of brain cells, improvement of hypertension, enhancement of liver detoxification.

  The dried oyster meat extract is rich in high-quality proteins and minerals, essential amino acids promote the secretion of bile, activate liver function, activate anemia prevention and metabolic function in the body, recover fatigue, weak constitution It is effective for improvement. It also has the effect of improving hypertension and enhancing the detoxification of the liver.

  The dried dandelion extract has a liver cleansing action and a bile promoting action. It also has anti-inflammatory, antipyretic, gastric, diuretic and lactating effects.

  The dried extract of yam (yakuyaku) has the effect of helping the gastrointestinal and liver functions.

  Fried soba taisai (bamboo radish) extract contains indican, β-sitosterol, etc., and has antibacterial action, antiviral action, fresh heat cool blood action, and detoxification action.

  The dried chrysanthemum flower extract has a clean fever detoxification effect, a liver function improvement effect, a light effect, and an antibacterial effect.

  The dried wolfberry extract contains betaine, zeaxanthin and the like, is good for the liver, has an action of promoting digestion and preventing liver fat.

  Hamabofu extract dry matter has a calming, expectorant and tonic effect.

  The dried extract of jujube (Otsuka) contains tolterpenes and saponins, and has antiallergic action, antipeptic ulcer action, antistress action, and blood coagulation inhibitory action.

  Ketsumeishi (Keiko) extract dried product has the effects of Kiyo-Kyome, Kyoufu-fever, and stool, and is said to be good for liver disease, kidney disease, indigestion, and chronic gastrointestinal disease.

  Narco lily (yellow spirit) extract dry matter has blood glucose level inhibitory action and antibacterial action.

  And the above-mentioned dried turmeric extract, dried shiitake extract, dried shiitake extract, dried oyster meat extract, dried dandelion extract, dried yam extract, Hosoba Taisei (Plate Ainone) extract dry matter, Chrysanthemum flower extract dry matter, Kuko (Zushi) extract dry matter, Hamaboufu extract, dried jujube (Daisen) extract dry matter, Ketsumeishi ( Keiko, extracted dried product, and Narco Yuri (yellow spirit) extracted dried product, using as a substrate one or more selected from the group of rice bran, especially barley, rice bran, and rice, Aspergillus oryzae, Two selected from the group of Aspergillus niger and Aspergillus soya inoculated and fermented with one or more Aspergillus oryzae fermented with Monascus The health food fermented with the composite koji containing the above koji has a high absorption effect in the intestine, the active ingredient acts directly on the liver, the liver function improving action is high, and the liver function effective in strengthening the liver function It was a fortified health food.

The liver function-enhancing health food according to the present invention includes a dried turmeric extract, a dried shiitake extract, a dried shiitake extract, a dried oyster extract, a dried dandelion extract, and yam (Yakuyaku) extract dry matter, Hosoba Taisei (Pion Ane) extract dry matter, Chrysanthemum flower extract dry matter, wolfberry (Zushi) extract dry matter, Hamabofu (Sansan) extract dry matter, and jujube (large) Ii) Contains an extract dry product, a Ketsumeishi (Keiko) extract dry product, a Naruko Yuri (yellow spirit) extract dry product, and an strawberry. As the extraction method, appropriate means are used. For example, an extraction method using water such as hot water or warm water, an extraction method using an organic solvent such as ethanol, or an extraction method using a mixture of the water and the organic solvent is appropriately employed. In addition, it contains dietary fiber. In addition, dietary fibers such as cellulose and pine fiber are also included. Also includes Yamabushitake. Moreover, yeast containing many active ingredients, such as glutathione which strengthens alcohol-degrading enzyme, is also included. As the straw, one or more selected from the group of barley, rice bran, and rice is used as a substrate, and this substrate is selected from the group of Aspergillus oryzae, Aspergillus niger, and Aspergillus soya A preferred example is a composite koji containing two or more types of koji selected from the group of koji fermented with one or more koji molds and fermented with Monascus koji molds.
Hereinafter, specific examples will be described.

[Example 1]
80 parts by weight of barley and 20 parts by weight of rice bran are mixed, the mixture is immersed in water and steamed for 1 to 1.5 hours, and this is used as a substrate. This is inoculated with seed pods (Aspergillus oryzae) and is kneaded over 48 to 72 hours. In addition, when making this koji, care should be taken so that no contamination of germs occurs.

  In addition, 100 parts by mass of rice is soaked in water and steamed for 1 to 1.5 hours to use as a substrate. This is inoculated with seed pods (Aspergillus soya) and kneaded for 48 to 72 hours. When making this koji, be careful not to mix any germs. The soot obtained in this way contains a large amount of active enzyme.

  The barley / rice bran koji and rice koji obtained as described above were mixed at a mass ratio of 2: 1 to obtain a composite koji.

  Next, 40 to 65 parts by mass, for example, 60 parts by mass of powdered reduced maltose starch syrup, 5 to 15 parts by mass, for example, 10 parts by mass of cellulose (dietary fiber), with respect to 100 parts by mass of the dried turmeric extract, 5 to 15 parts by weight, for example, 10 parts by weight of pine fiber (dietary fiber), 1 to 5 parts by weight, for example, 3 parts by weight of dried shiitake extract, and 1 to 5 parts by weight, for example, 3 parts by weight of vegetable oil (Lubricant), 1-5 parts by weight, for example 3 parts by weight of a squeezed (boiled) extract, 1-5 parts by weight, for example 3 parts by weight of gluta yeast, and 1-5 parts by weight, for example 3 1 part by weight of oyster meat extract dried product, 1-5 parts by weight, for example, 3 parts by weight Yamabushitake, 1-5 parts by weight, for example, 3 parts by weight of dandelion extract (1), 1-5 parts by weight, For example, 3 parts by mass of yam (yakuyaku) extract and 1-5 quality Parts, for example, 3 parts by weight of dried soba raisins (bamboo root extract), 1-5 parts by weight, for example, 3 parts by weight of chrysanthemum flower extract, 1-5 parts by weight, for example, 3 parts by weight of wolfberry (枸杞Child) Extracted dried product, 1 to 5 parts by weight, for example, 3 parts by weight of a dried extract of sunflower, 1 to 5 parts by weight, for example, 3 parts by weight of a jujube extract, and 1 -5 parts by mass, for example, 3 parts by mass of a dried extract of Ketsumeishi (Keiko), and 1-5 parts by mass, for example, 3 parts by mass of a dried narco lily (yellow spirit) were mixed.

  100 parts by mass of this mixture is mixed with 20 parts by mass of the above-mentioned composite koji, and digestion / decomposition (fermentation) is performed in aseptic pure culture over 24 hours. Thereafter, in order to minimize the inactivation of the enzyme as much as possible, the koji mixed powder is dried at a low temperature, and this dried koji mixed powder is pulverized with a mill or the like. 20 parts by mass of a saccharide such as was added to obtain a liver function-enhancing health food according to the present invention.

[Example 2]
60 parts by mass of barley, 10 parts by mass of rice bran and 30 parts by mass of rice were mixed, the mixture was immersed in water and steamed for 1 to 1.5 hours, and this was used as a substrate.

  In addition, agaricus mycelium is subjected to liquid culture and self-digested to obtain fermented agaricus containing γ-aminobutyric acid (gaba) at a high concentration. And this was heat-concentrated, and it was set as the powder extraction extract by spray-drying then.

  And 50 parts by mass of powdered reduced maltose starch syrup, 12 parts by mass of cellulose (dietary fiber), 8 parts by mass of pine fiber (dietary fiber) and 4 parts by mass with respect to 100 parts by mass of the dried turmeric extract Dried shiitake extract, 3 parts by weight of vegetable oil (lubricant), 2.8 parts by weight of extract of dried shiitake (potato), 2.9 parts by weight of gluta yeast, and 3.2 parts by weight Parts of oyster meat extract dried product, 3.1 parts by weight of Yamabushitake, 3.2 parts by weight of dandelion extract, 3.1 parts by weight of dried potato (yaku) extract, 3 .2 parts by weight of dried soba raisins (bamboo root extract), 2.9 parts by weight of chrysanthemum flower extract, 2.8 parts by weight of dried wolfberry extract, and 3.1 parts by weight Hamabofu extract and 3.1 parts by weight of jujube extract Inoculate the mixture of 3.3 parts by weight of dried Ketsumeishi extract and 3.1 parts by weight of Narcoyuri (yellow spirit) extract with seed meal (Aspergillus soya) for 48 to 72 hours. To make iron. When making this koji, be careful not to mix any germs.

  In order to minimize enzyme inactivation as much as possible, the soot-mixed powder obtained in this way is dried at a low temperature, and this dry soot-mixed powder is pulverized with a mill or the like to obtain 80 parts by weight of this dry-salt-mixed powder. On the other hand, 20 parts by mass of a saccharide such as oligosaccharide was added to obtain a liver function-enhancing health food according to the present invention.

[Example 3]
80 parts by weight of barley and 20 parts by weight of rice bran are mixed, the mixture is immersed in water and steamed for 1 to 1.5 hours, and this is used as a substrate. This is inoculated with seed pods (Aspergillus oryzae) and is kneaded over 48 to 72 hours. In addition, when making this koji, care should be taken so that no contamination of germs occurs.

  In addition, 100 parts by mass of rice is soaked in water and steamed for 1 to 1.5 hours to use as a substrate. This is inoculated with seed pods (Aspergillus soya) and kneaded for 48 to 72 hours. When making this koji, be careful not to mix any germs. The soot obtained in this way contains a large amount of active enzyme.

  The barley / rice bran and rice bran obtained as described above were mixed at a mass ratio of 2: 1, dried at a low temperature, pulverized, and powdered with the active enzyme still high. Got.

  In addition, agaricus mycelium is subjected to liquid culture and self-digested to obtain fermented agaricus containing γ-aminobutyric acid (gaba) at a high concentration. And this was heat-concentrated, and it was set as the powder extraction extract by spray-drying then.

  Then, 40 parts by mass of powdered reduced maltose starch syrup, 10 parts by mass of cellulose (dietary fiber), 9 parts by mass of pine fiber (dietary fiber), and 3.3 parts by mass of 100 parts by mass of the dried turmeric extract. Parts by weight of dried shiitake extract, 2.8 parts by weight of vegetable oil (lubricant), 3.3 parts by weight of extract of dried potato (sulphur), 2.7 parts by weight of gluta yeast, 3.2 parts by weight of dried oyster meat extract, 3.5 parts by weight of Yamabushitake, 2.9 parts by weight of dandelion extract and 2.9 parts by weight of yam (yakuyaku) extract dried 3.1 parts by weight of a dried soba cabbage extract, 2.9 parts by weight of a chrysanthemum flower extract, 3.1 parts by weight of a dried wolfberry extract, 3 .2 parts by weight of dried extract of sunfish and 3 parts by weight of jujube extract 10 parts by weight of saccharides such as oligosaccharides are added to 100 parts by weight of a mixture of the product, 2.8 parts by weight of Ketsumeishi (Keiko) extracted dry product, and 3 parts by weight of Narukoyuri (yellow spirit) extracted dry product Thus, a liver function-enhancing health food according to the present invention was obtained.

[Characteristic]
The following tests were conducted on the liver function-enhancing health food obtained in Examples 1, 2, and 3 and the conventional commercially available fermented turmeric (comparative example).

  40 people over 40 years of age who continue drinking alcohol every day and who drink a lot are divided into 4 subjects A, B, C, and D, each with 10 subjects. A group B person drinks the liver function-enhancing health food of Example 2, and a group C person takes the liver function-enhancing health food of Example 3. A group D person was ingested with a commercially available fermented turmeric of a comparative example and observed the physical condition over one month.

  As a result, 60% of the subjects reported that the effect was effective / somewhat effective for Group A, 70% of the subjects reported that the effect was effective / somewhat effective for Group B, and 7% of the subjects for Group C. While there were reports of effective / slightly effective effects, only about 30% of the subjects had reports of effective / slightly effective effects for group D.

  From the result of this report, the excellentness of the liver function-enhancing health food of the present invention can be seen.

  In addition, 28 patients whose liver function values were diagnosed by the doctor as below standard were divided into 4 groups E, F, G, and H, each of 7 patients. 5 to 6 g of sexual health food is ingested every day, group F persons are ingested of 5 to 6 g of liver function-enhancing health food of Example 2 every day, and group G persons are ingested in liver of Example 3 Daily ingestion of 5-6 g of functional health food is received, and in Group H, 5-6 g of commercially available fermented turmeric as a comparative example is ingested daily, and liver function improvement effect (GOT, GPT, (γ-GTP, LDH, ZTT, A / G, total bilirubin, total protein, cholesterol and neutral fat) were examined.

As a result, for group A, there are reports of effectiveness / somewhat effective for 4 of the subjects, for group B, there are reports of effectiveness / somewhat effective for 5 of the subjects, and for group C There were reports of effectiveness / slightly effective for 54 of the subjects, and Group D had reports of effective / slightly effective for 2 of the subjects.
From this report result, it can be seen that the liver function-enhancing health food of the present invention is excellent.
Representative Katsumi Udaka

Claims (5)

Turmeric extract dry matter, shiitake extract dry matter, shijimi extract dry matter, oyster meat extract dry matter, dandelion extract dry matter, potato extract dry matter, fried buckwheat extract dry matter, chrysanthemum flower extract dry matter And a dried wolfberry extract, a dried cassava extract, a dried jujube extract, a dried ketsumeishi extract, and a dried narco lily extract,
A liver function-enhancing health food characterized by containing salmon. Turmeric extract dry matter, shiitake extract dry matter, shijimi extract dry matter, oyster meat extract dry matter, dandelion extract dry matter, potato extract dry matter, fried buckwheat extract dry matter, chrysanthemum flower extract dry matter And a dried wolfberry extract, a dried cassava extract, a dried jujube extract, a dried ketsumeshi extract, a dried narco lily extract, and a cocoon,
A liver function-enhancing health food, wherein the extract is fermented with the koji.   The liver function-enhancing health food according to claim 1 or 2, further comprising dietary fiber.   One kind selected from the group of Aspergillus oryzae, Aspergillus niger and Aspergillus soya Or a combination of two or more types of koji selected from the group of koji fermented with two or more types of koji molds and fermented with koji molds of the genus Monascus. Or the liver function-strengthening health food of Claim 2. The liver function-enhancing health food according to any one of claims 1 to 4, which is in a powder form by low-temperature drying.