CN109195666A - 美丽海绵内酯、其类似物及其用途 - Google Patents

美丽海绵内酯、其类似物及其用途 Download PDF

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Publication number
CN109195666A
CN109195666A CN201780032805.6A CN201780032805A CN109195666A CN 109195666 A CN109195666 A CN 109195666A CN 201780032805 A CN201780032805 A CN 201780032805A CN 109195666 A CN109195666 A CN 109195666A
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CN
China
Prior art keywords
compound
alkyl
formula
aryl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780032805.6A
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English (en)
Chinese (zh)
Inventor
阿伦·K·高希
卢克·A·卡塞克特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
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Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Priority to CN202410801829.5A priority Critical patent/CN118812488A/zh
Publication of CN109195666A publication Critical patent/CN109195666A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
CN201780032805.6A 2016-05-27 2017-05-26 美丽海绵内酯、其类似物及其用途 Pending CN109195666A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202410801829.5A CN118812488A (zh) 2016-05-27 2017-05-26 美丽海绵内酯、其类似物及其用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662342601P 2016-05-27 2016-05-27
US62/342,601 2016-05-27
PCT/US2017/034760 WO2017205791A1 (en) 2016-05-27 2017-05-26 Callyspongiolide, analogs thereof and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202410801829.5A Division CN118812488A (zh) 2016-05-27 2017-05-26 美丽海绵内酯、其类似物及其用途

Publications (1)

Publication Number Publication Date
CN109195666A true CN109195666A (zh) 2019-01-11

Family

ID=60411563

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780032805.6A Pending CN109195666A (zh) 2016-05-27 2017-05-26 美丽海绵内酯、其类似物及其用途
CN202410801829.5A Pending CN118812488A (zh) 2016-05-27 2017-05-26 美丽海绵内酯、其类似物及其用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202410801829.5A Pending CN118812488A (zh) 2016-05-27 2017-05-26 美丽海绵内酯、其类似物及其用途

Country Status (7)

Country Link
US (1) US10875836B2 (enExample)
EP (1) EP3463579B1 (enExample)
JP (3) JP7502846B2 (enExample)
KR (1) KR102481799B1 (enExample)
CN (2) CN109195666A (enExample)
CA (1) CA3025178A1 (enExample)
WO (1) WO2017205791A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10875836B2 (en) 2016-05-27 2020-12-29 Purdue Research Foundation Callyspongiolide, analogs thereof and uses thereof
CN115323011A (zh) * 2022-07-29 2022-11-11 上海皓元医药股份有限公司 一种艾日布林中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104177209A (zh) * 2014-08-05 2014-12-03 太原理工大学 一种芳基末端炔的制备方法
CN105777702A (zh) * 2016-03-31 2016-07-20 北京大学深圳研究生院 Callyspongiolide立体异构体的合成及抗癌应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017205791A1 (en) 2016-05-27 2017-11-30 Purdue Research Foundation Callyspongiolide, analogs thereof and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104177209A (zh) * 2014-08-05 2014-12-03 太原理工大学 一种芳基末端炔的制备方法
CN105777702A (zh) * 2016-03-31 2016-07-20 北京大学深圳研究生院 Callyspongiolide立体异构体的合成及抗癌应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CONG-DAT PHAM等: "Callyspongiolide, a Cytotoxic Macrolide from the Marine Sponge Callyspongia sp.", 《ORGANIC LETTERS》 *
JIE JACK LI: "《Name Reactions》", 31 December 2009 *
JINGJING ZHOU等: "Total Synthesis and Stereochemical Assignment of Callyspongiolide", 《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10875836B2 (en) 2016-05-27 2020-12-29 Purdue Research Foundation Callyspongiolide, analogs thereof and uses thereof
CN115323011A (zh) * 2022-07-29 2022-11-11 上海皓元医药股份有限公司 一种艾日布林中间体的制备方法
WO2024021261A1 (zh) * 2022-07-29 2024-02-01 上海皓元医药股份有限公司 一种艾日布林中间体的制备方法
CN115323011B (zh) * 2022-07-29 2025-08-29 上海皓元医药股份有限公司 一种艾日布林中间体的制备方法

Also Published As

Publication number Publication date
EP3463579B1 (en) 2025-07-16
JP2024164181A (ja) 2024-11-26
US20190218198A1 (en) 2019-07-18
JP7502846B2 (ja) 2024-06-19
CN118812488A (zh) 2024-10-22
KR102481799B1 (ko) 2022-12-26
US10875836B2 (en) 2020-12-29
WO2017205791A1 (en) 2017-11-30
JP2019517474A (ja) 2019-06-24
EP3463579A1 (en) 2019-04-10
JP7641933B2 (ja) 2025-03-07
CA3025178A1 (en) 2017-11-30
EP3463579A4 (en) 2019-11-27
JP2022120170A (ja) 2022-08-17
KR20190012194A (ko) 2019-02-08

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Application publication date: 20190111

RJ01 Rejection of invention patent application after publication