CN109172732A - 一种抗hpv的中药组合物及其制备方法与应用 - Google Patents
一种抗hpv的中药组合物及其制备方法与应用 Download PDFInfo
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- CN109172732A CN109172732A CN201811328510.6A CN201811328510A CN109172732A CN 109172732 A CN109172732 A CN 109172732A CN 201811328510 A CN201811328510 A CN 201811328510A CN 109172732 A CN109172732 A CN 109172732A
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Abstract
本发明一种抗HPV的中药组合物及其制备方法与应用，所述的组合物包括淮山药、蒲公英、黄芪、生地、麦冬、金银花和苦参。本发明通过各中药原料的协同作用，具有明显的抗HPV病毒，增强机体免疫的作用，能够用于各种HPV病毒引起的皮肤病，主要是通过分解黑色素，直击病毒细胞，抑制病毒复制，迅速锁定并杀死病毒细胞；采用纯天然的中药原料，安全可控，对人体无副作用，通过增强人体的免疫力，有效的抑制和清除HPV病毒，还具有消炎的作用，防止HPV病毒的再次感染；本发明的制备方法简单，可以将各原料中的有效成分提取出来，提高治疗效果。
Description
技术领域
本发明属于医药技术领域，具体涉及一种抗HPV的中药组合物及其制备方法与应用。
背景技术
人乳头瘤病毒简称HPV，是一种属于人乳头多瘤空泡病毒，属小DNA病毒，人是其唯一宿主，宿主细胞是皮肤和黏膜上皮细胞，人乳头瘤病毒感染鳞状上皮，导致人体皮肤黏膜的鳞状上皮增殖，引起人类各种皮肤疣，表现为寻常疣、跖疣、扁平疣、肛周生殖器疣(又称尖锐湿疣)。
疣可通过直接或间接接触传染，肛周、生殖器疣大多数通过性接触传染。疣可发生在任何年龄，随着年龄的增长，发病率逐渐增高，到青壮年时期最高。疣的病程与机体免疫有重要关系，在免疫缺陷状态者，疣的发病率增高，但在相对健康人群长期不消退的机制目前尚未清楚，可能与局部或全身的免疫功能低下或产生免疫耐受有关。
现有技术中还没有十分有效的抗HPV的药物，治疗非常困难，大多采用内服的药物，起效慢并且治愈疗程长。
鉴于以上原因，特提出本发明。
发明内容
为了解决现有技术存在的以上问题，本发明提供了一种抗HPV的中药组合物及其制备方法与应用，本发明的抗HPV的中药组合物可以分解黑色素，直击病毒细胞，抑制病毒复制，迅速锁定并杀死病毒，可抗病毒，提高机体的免疫力，促进循环代谢。
为了实现上述目的，本发明采用如下技术方案：
一种抗HPV的中药组合物，所述的组合物包括淮山药、蒲公英、黄芪、生地、麦冬、金银花和苦参。
淮山药作为高营养食品含有大量蛋白质、糖类、B族维生素、维生素C、维生素E、葡萄糖、粗蛋白氨基酸、胆汁碱、尿囊素、及碘、钙、铁、磷等人体不可缺少的无机盐和微量元素等营养成分。山药块茎中富含多糖，可刺激和调节人类免疫系统，还含有尿囊素具有消炎和抑菌的作用，可以抑制HPV病毒。
蒲公英植物体中含有蒲公英醇、蒲公英素、胆碱、有机酸、菊糖等多种健康营养成分。性味甘，微苦，寒。归肝、胃经。有利尿、缓泻、退黄疸、利胆等功效。治热毒、痈肿、疮疡、内痈、目赤肿痛、湿热、黄疸、小便淋沥涩痛、疔疮肿毒，乳痈，瘰疬，牙痛，目赤，咽痛，肺痈，肠痈，湿热黄疸，热淋涩痛。
黄芪增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。但表实邪盛，气滞湿阻，食积停滞，
生地具有清热生津，凉血，止血。用于热病伤阴，舌绛烦渴，发斑发疹，吐血，衄血，咽喉肿痛，抗菌消炎的作用。
麦冬主要含沿阶草苷、甾体皂苷、生物碱、谷甾醇、葡萄糖、氨基酸、维生素等，具有抗疲劳、清除自由基、提高细胞免疫功能以及降血糖的作用。另外，麦冬有镇静、催眠、抗心肌缺血、抗心律失常、抗肿瘤等作用。
金银花性甘寒气芳香，甘寒清热而不伤胃，芳香透达又可祛邪。金银花既能宣散风热，还善清解血毒，用于各种热性病，如身热、发疹、发斑、热毒疮痈、咽喉肿痛等症，均效果显著，消毒消炎，增强免疫力的作用。
苦参为豆科植物苦参的干燥根，春、秋二季采挖，除去根头和小支根，洗净，干燥，或趁鲜切片，干燥。其苦，寒。有清热燥湿，杀虫，利尿之功。用于热痢，便血，黄疸尿闭，赤白带下，阴肿阴痒，湿疹，湿疮，皮肤瘙痒，疥癣麻风，外治滴虫性阴道炎。
进一步的，按照重量份，所述的组合物包括淮山药20-30重量份、蒲公英16-22重量份、黄芪8-12重量份、生地14-18重量份、麦冬10-20重量份、金银花25-35重量份和苦参8-12重量份。
进一步的，按照重量份，所述的组合物包括淮山药25重量份、蒲公英19重量份、黄芪10重量份、生地16重量份、麦冬15重量份、金银花30重量份和苦参10重量份。
进一步的，中药组合物的剂型可以为外洗液、粉剂、片剂和胶囊。
本发明中各剂型根据药物中规定添加辅料制备而成，辅料均采用现有的原料进行添加，剂型的制备不在本发明的保护范围之内。
一种所述的抗HPV的中药组合物的制备方法，所述的制备方法包括如下步骤：
(1)按照各原料的重量分别称取备用；
(2)将称取的淮山药、麦冬和苦参加入乙醇进行低温萃取，过滤，得到提取液A和药渣A；
(3)然后将称取的蒲公英、黄芪、生地和金银花加入水进行低温萃取，过滤，得到提取液B和药渣B；
(4)将提取液A和提取液B混合浓缩成浸膏；
(5)将药渣A和药渣B烘干，粉碎，过筛，将浸膏和粉碎的药渣混合均匀，进行干燥，得到所述的中药组合物。
进一步的，步骤(2)中萃取温度为30-40℃，萃取至少两次。
进一步的，步骤(3)中萃取的温度为40-50℃，萃取至少三次。
本发明中采取低温萃取的目的是为了防止温度过高将其中的有效成分破坏，同时采用上述的温度范围，有效成分的提取率较高。
进一步的，步骤(5)中过130-140目筛处理。
进一步的，步骤(5)中干燥的温度为70-80℃。
其中，本发明人经过大量试验发现淮山药、麦冬和苦参在乙醇中可以将其中的抗病毒成分提取率高、治疗效果好，而蒲公英、黄芪、生地和金银花在水中即可以提取出来，
一种所述的抗HPV的中药组合物在治疗HPV病毒的药物中的应用。
与现有技术相比，本发明的有益效果如下：
(1)本发明通过各中药原料的协同作用，具有明显的抗病毒，增强机体免疫的作用，能够用于各种HPV病毒引起的皮肤病，主要是通过分解黑色素，直击病毒细胞，抑制病毒复制，迅速锁定并杀死病毒细胞；
(2)本发明采用纯天然的中药原料，安全可控，对人体无副作用，通过增强人体的免疫力，有效的抑制和清除HPV病毒，还具有消炎的作用，防止HPV病毒的再次感染；
(3)本发明的制备方法简单，可以将各原料中的有效成分提取出来，提高治疗效果。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将对本发明的技术方案进行详细的描述。显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式，都属于本发明所保护的范围。
实施例1
本实施例的一种抗HPV的中药组合物，所述的组合物包括淮山药20kg、蒲公英16kg、黄芪8kg、生地14kg、麦冬10kg、金银花25kg和苦参8kg。
本实施例的中药组合物的制备方法，包括如下步骤：
(1)按照各原料的重量分别称取备用；
(2)将称取的淮山药、麦冬和苦参加入乙醇进行低温萃取，萃取温度为30℃，萃取两次，过滤，得到提取液A和药渣A；
(3)然后将称取的蒲公英、黄芪、生地和金银花加入水进行低温萃取，萃取温度为40℃，萃取三次，过滤，得到提取液B和药渣B；
(4)将提取液A和提取液B混合浓缩成浸膏；
(5)将药渣A和药渣B烘干，粉碎，过130目筛处理，将浸膏和粉碎的药渣混合均匀，在温度为70℃下进行干燥，得到所述的中药组合物。
将上述制备的组合物制成药学上可接受的外洗洗剂型。
实施例2
本实施例的一种抗HPV的中药组合物，所述的组合物包括淮山药25kg、蒲公英19kg、黄芪10kg、生地16kg、麦冬15kg、金银花30kg和苦参10kg。
本实施例的中药组合物的制备方法，包括如下步骤：
(1)按照各原料的重量分别称取备用；
(2)将称取的淮山药、麦冬和苦参加入乙醇进行低温萃取，萃取温度为35℃，萃取三次，过滤，得到提取液A和药渣A；
(3)然后将称取的蒲公英、黄芪、生地和金银花加入水进行低温萃取，萃取温度为45℃，萃取三次，过滤，得到提取液B和药渣B；
(4)将提取液A和提取液B混合浓缩成浸膏；
(5)将药渣A和药渣B烘干，粉碎，过135目筛处理，将浸膏和粉碎的药渣混合均匀，在温度为75℃下进行干燥，得到所述的中药组合物。
将上述制备的组合物制成药学上可接受的粉剂剂型。
实施例3
本实施例的一种抗HPV的中药组合物，所述的组合物包括淮山药30kg、蒲公英22kg、黄芪12kg、生地18kg、麦冬20kg、金银花35kg和苦参12kg。
本实施例的中药组合物的制备方法，包括如下步骤：
(1)按照各原料的重量分别称取备用；
(2)将称取的淮山药、麦冬和苦参加入乙醇进行低温萃取，萃取温度为40℃，萃取两次，过滤，得到提取液A和药渣A；
(3)然后将称取的蒲公英、黄芪、生地和金银花加入水进行低温萃取，萃取温度为50℃，萃取四次，过滤，得到提取液B和药渣B；
(4)将提取液A和提取液B混合浓缩成浸膏；
(5)将药渣A和药渣B烘干，粉碎，过140目筛处理，将浸膏和粉碎的药渣混合均匀，在温度为80℃下进行干燥，得到所述的中药组合物。
将上述制备的组合物制成药学上可接受的胶囊剂型。
实施例4
本实施例的一种抗HPV的中药组合物，所述的组合物包括淮山药22kg、蒲公英19kg、黄芪11kg、生地15kg、麦冬18kg、金银花28kg和苦参12kg。
本实施例的中药组合物的制备方法，包括如下步骤：
(1)按照各原料的重量分别称取备用；
(2)将称取的淮山药、麦冬和苦参加入乙醇进行低温萃取，萃取温度为32℃，萃取两次，过滤，得到提取液A和药渣A；
(3)然后将称取的蒲公英、黄芪、生地和金银花加入水进行低温萃取，萃取温度为48℃，萃取三次，过滤，得到提取液B和药渣B；
(4)将提取液A和提取液B混合浓缩成浸膏；
(5)将药渣A和药渣B烘干，粉碎，过133目筛处理，将浸膏和粉碎的药渣混合均匀，在温度为74℃下进行干燥，得到所述的中药组合物。
将上述制备的组合物制成药学上可接受的片剂剂型。
对比例1
本发明的组合物各原料配比与制备方法与实施例2相同，不同之处，在于所有的原料均在乙醇中提取；
对比例2
本发明的组合物各原料配比与制备方法与实施例2相同，不同之处，在于所有的原料均在水中提取；
试验例1
试验对象：分别选取感染宫颈HR-HPV病毒的患者300例，平均分成3组，每组100人。
试验方法：将实施例2和对比例1和2制备的中药组合物分别用于三组中，每天服用两次，一次3g，连续用药2个星期，检测患者HR-HPV转阴的情况，转阴率如表1所示。
表1
从表1可以看出，对比例1和2的转阴率均低于实施例2，这是因为采用本发明的提取方法，各原料中的有效成分提取率高，起到了较好的抗HPV病毒的作用。
本发明人也对其他实施例做了上述试验，由于篇幅有限，不再一一列出。
以上所述，仅为本发明的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，可轻易想到变化或替换，都应涵盖在本发明的保护范围之内。因此，本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种抗HPV的中药组合物，其特征在于，所述的组合物包括淮山药、蒲公英、黄芪、生地、麦冬、金银花和苦参。
2.根据权利要求1所述的抗HPV的中药组合物，其特征在于，按照重量份，所述的组合物包括淮山药20-30重量份、蒲公英16-22重量份、黄芪8-12重量份、生地14-18重量份、麦冬10-20重量份、金银花25-35重量份和苦参8-12重量份。
3.根据权利要求2所述的抗HPV的中药组合物，其特征在于，按照重量份，所述的组合物包括淮山药25重量份、蒲公英19重量份、黄芪10重量份、生地16重量份、麦冬15重量份、金银花30重量份和苦参10重量份。
4.根据权利要求1-3任意一项所述的抗HPV的中药组合物，其特征在于，所述的中药组合物的剂型可以为外洗液、粉剂、片剂和胶囊。
5.一种权利要求1-4任意一项所述的抗HPV的中药组合物的制备方法，其特征在于，所述的制备方法包括如下步骤：
(1)按照各原料的重量分别称取备用；
(2)将称取的淮山药、麦冬和苦参加入乙醇进行低温萃取，过滤，得到提取液A和药渣A；
(3)然后将称取的蒲公英、黄芪、生地和金银花加入水进行低温萃取，过滤，得到提取液B和药渣B；
(4)将提取液A和提取液B混合浓缩成浸膏；
(5)将药渣A和药渣B烘干，粉碎，过筛，将浸膏和粉碎的药渣混合均匀，进行干燥，得到所述的中药组合物。
6.根据权利要求5所述的抗HPV的中药组合物的制备方法，其特征在于，步骤(2)中萃取温度为30-40℃，萃取至少两次。
7.根据权利要求5所述的抗HPV的中药组合物的制备方法，其特征在于，步骤(3)中萃取的温度为40-50℃，萃取至少三次。
8.根据权利要求5所述的抗HPV的中药组合物的制备方法，其特征在于，步骤(5)中过130-140目筛处理。
9.根据权利要求5所述的抗HPV的中药组合物的制备方法，其特征在于，步骤(5)中干燥的温度为70-80℃。
10.一种权利要求1-3任意一项所述的抗HPV的中药组合物在治疗HPV病毒的药物中的应用。
Priority Applications (1)
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| CN1206606A (zh) * | 1997-07-25 | 1999-02-03 | 初新东 | 一种外用中药及其制备方法 |
| CN105727211A (zh) * | 2016-04-29 | 2016-07-06 | 山东省立医院 | 一种治疗人乳头瘤病毒感染的中药栓剂及其制备方法 |
| CN108186718A (zh) * | 2018-03-13 | 2018-06-22 | 余晓晴 | 一种预防及抑制hpv病毒的妇科喷剂 |
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| CN115137791B (zh) * | 2022-08-09 | 2023-04-28 | 杭州师范大学 | 治疗气虚湿热型hpv感染的中药组合物及其制备方法 |
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