CN109172728A - A kind of drug for treating the proliferation of mammary gland - Google Patents

A kind of drug for treating the proliferation of mammary gland Download PDF

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Publication number
CN109172728A
CN109172728A CN201811287851.3A CN201811287851A CN109172728A CN 109172728 A CN109172728 A CN 109172728A CN 201811287851 A CN201811287851 A CN 201811287851A CN 109172728 A CN109172728 A CN 109172728A
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parts
mammary gland
proliferation
drug
treating
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CN201811287851.3A
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田春生
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
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  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a kind of drugs for treating the proliferation of mammary gland, specially pharmaceutical compounding techniques field.The drug of the treatment proliferation of mammary gland includes following raw material: 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, 5-10 parts of the spina gleditsiae stem pith of the rice-paper plant, 5-10 parts of olibanum, 6-10 parts of myrrh.Such Chinese medicine has exclusion breast lump, dispersing stagnated hepatoqi, activating microcirculation and removing stasis medicinal, medicinal powder for relieving pain knot, clearing heat and detoxicating, purging intense heat, the multiple efficacies such as nourishing Yin and moistening dryness, apocenosis.There is preferable treatment proliferation of mammary gland effect, and prescription is simple, cheap, using effect is good, and it is hormone-free, it has no toxic side effect to body.

Description

A kind of drug for treating the proliferation of mammary gland
Technical field
The present invention relates to a kind of drugs for treating the proliferation of mammary gland, specially pharmaceutical compounding techniques field.
Background technique
The proliferation of mammary gland is the most common women's diseases, and disease incidence accounts for the first place of mammary gland disease, has been mainly in the menstrual cycle Women, disease incidence is about between 40%~50%；Its basic pathology variation be mammary gland constituent hyperplasia, structure, Exception is shown in quantity and tissue morphology, is substantially mammary gland normal configuration caused by a kind of physiology hyperplasia and subinvolution Disorder；
The classical symptom of the proliferation of mammary gland is breast pain, lump in breast, nipple discharge, according to cyclomastopathy endocrine disturbance Pathogenesis；Western medicine cyclomastopathy is to adjust ovarian endocrine or block hormonal action target spot, blocks morbidity link, Alleviate symptom, therefore mostly uses the therapeutic scheme for inhibiting estrogen drugs.Its Western medicine has: 1. tamoxifen (tamoxifen) Class: being a kind of antiestrogen of nonsteroidal for estrogen receptor antagon, is widely used in treating the proliferation of mammary gland, is Current most effective therapeutic agent；Main mechanism is the estrogen receptor with estrogen competitive binding target cell, is directly sealed Estrogen receptor is closed, the effect of estrogen is blocked.Most of case breast pain can also recur after drug withdrawal, and side effect is dry Menstruation is disturbed, shows as menses reduction, menstruation is postponed or in advance, endometrial thickness is obvious, menoxenia；It takes for a long time, and has Dramatically increase the risk for suffering from carcinoma of endometrium；Furthermore Toremifene Citrate (fareston) has similar to tamoxifen Pharmacological action and adverse reaction.2. bromocriptine class Dopaminergic Agents: inhibit the secretion of tethelin prolactin(PRL, Without influencing other pituitrins, it can be used for treating by the excessively high caused various illnesss of prolactin(PRL, inhibit or reduce prolactinoma, Restore the normal secretions of lutropin, reduce the quantity and volume of galactocele or brief summary, it is uneven to mitigate progestogen/estrogen Breast pain caused by weighing apparatus；The side effect of this medicine is dizzy sleepy, GI irritation, prosopospasm, illusion, dyskinesia etc.. 3. hormone medicine: such as progesterone, testosterone propionate, danazol, such drug main function mechanism be using androgen or Progestational hormone fights the estrogen increased；To adjust the balance of intracorporal estrogen and progestogen level, mitigate pain, softens tubercle；But mesh It is preceding that oneself seldom applies such drug as the routine administration for treating this disease, because while hormone therapy initial performances are pretty good, but by The amount and application time of input hormone are difficult snugly to be suitble to the needs of this disease when treatment, often exceed the proper limits in righting a wrong it Disadvantage；Misapplication will certainly more aggravate this unbalance state.Therefore, relatively mild Chinese traditional treatment mode is got at present More to attract attention.
Summary of the invention
The purpose of the present invention is to provide a kind of drugs for treating the proliferation of mammary gland.
To achieve the above object, the invention provides the following technical scheme: a kind of drug for treating the proliferation of mammary gland includes following Raw material: 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, soap 5-10 parts of Medulla Trevesiae palmatae, 5-10 parts of olibanum, 6-10 parts of myrrh.
Further preferably, the drug of the treatment proliferation of mammary gland includes following raw material: 25 parts of dandelion, great Bei 12 parts, 12 parts of oyster, 18 parts of rhizoma anemarrhenae, 8 parts of Prunella vulgaris, 8 parts of the spina gleditsiae stem pith of the rice-paper plant, 8 parts of olibanum, 8 parts of myrrh.
A kind of drug that treating the proliferation of mammary gland the preparation method comprises the following steps: the raw material of the drug according to the treatment proliferation of mammary gland Proportion, dandelion, great Bei, oyster, rhizoma anemarrhenae, Prunella vulgaris, the spina gleditsiae stem pith of the rice-paper plant, olibanum, myrrh are mixed and are ground into 150-200 Purpose medicinal powder, medicinal powder is uniformly mixed, and obtains medicinal powder mixture；Medicinal powder mixture and dextrin are mixed according to the mass ratio of 1:1-2 After conjunction plus hydraulic pressure piece can be made into Chinese medicinal tablet.
Compared with prior art, beneficial effects of the present invention are as follows: such Chinese medicine has exclusion breast lump, soothing the liver Qi-regulating, activating microcirculation and removing stasis medicinal, medicinal powder for relieving pain knot, clearing heat and detoxicating, purging intense heat, the multiple efficacies such as nourishing Yin and moistening dryness, apocenosis.There is preferable treatment mammary gland Hyperplasia effect, and prescription is simple, cheap, using effect is good, and it is hormone-free, it has no toxic side effect to body.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction in the embodiment of the present invention, it is clear that institute The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, Every other embodiment obtained by those of ordinary skill in the art without making creative efforts, belongs to this hair The range of bright protection.
Embodiment 1:
A kind of drug that treating the proliferation of mammary gland the preparation method comprises the following steps: matching according to the raw material of the drug of the treatment proliferation of mammary gland Than by 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, the spina gleditsiae stem pith of the rice-paper plant 5-10 parts, 5-10 parts of olibanum, 6-10 parts of myrrh mix the medicinal powder for being ground into 150 mesh, medicinal powder is uniformly mixed, medicine is obtained Powder mixture；After medicinal powder mixture and dextrin are mixed according to the mass ratio of 1:1 plus hydraulic pressure piece can be made into Chinese medicinal tablet.
Embodiment 2:
A kind of drug that treating the proliferation of mammary gland the preparation method comprises the following steps: matching according to the raw material of the drug of the treatment proliferation of mammary gland Than by 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, the spina gleditsiae stem pith of the rice-paper plant 5-10 parts, 5-10 parts of olibanum, 6-10 parts of myrrh mix the medicinal powder for being ground into 200 mesh, medicinal powder is mixed Uniformly, medicinal powder mixture is obtained；Adding hydraulic pressure piece after medicinal powder mixture and dextrin are mixed according to the mass ratio of 1:2 is in can be made into Tablet.
Embodiment 3:
A kind of drug that treating the proliferation of mammary gland the preparation method comprises the following steps: matching according to the raw material of the drug of the treatment proliferation of mammary gland Than by 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, the spina gleditsiae stem pith of the rice-paper plant 5-10 parts, 5-10 parts of olibanum, 6-10 parts of myrrh mix the medicinal powder for being ground into 180 mesh, medicinal powder is uniformly mixed, medicine is obtained Powder mixture；After medicinal powder mixture and dextrin are mixed according to the mass ratio of 1:1.5 plus hydraulic pressure piece can be made into Chinese medicinal tablet.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (3)

1. a kind of drug for treating the proliferation of mammary gland, it is characterised in that: the drug of the treatment proliferation of mammary gland includes following weight Part raw material: 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, spina gleditsiae are logical 5-10 parts careless, 5-10 parts of olibanum, 6-10 parts of myrrh.
2. a kind of drug for treating the proliferation of mammary gland according to claim 1, it is characterised in that: the treatment proliferation of mammary gland Drug include following raw material: 25 parts of dandelion, 12 parts of great Bei, 12 parts of oyster, 18 parts of rhizoma anemarrhenae, 8 parts of Prunella vulgaris, spina gleditsiae 8 parts of the stem pith of the rice-paper plant, 8 parts of olibanum, 8 parts of myrrh.
3. a kind of preparation method for the drug for treating the proliferation of mammary gland, it is characterised in that: specific the preparation method comprises the following steps: according to treatment mammary gland The raw material of the drug of hyperplasia matches, by dandelion, great Bei, oyster, rhizoma anemarrhenae, Prunella vulgaris, the spina gleditsiae stem pith of the rice-paper plant, olibanum, myrrh The medicinal powder for being ground into 150-200 mesh is mixed, medicinal powder is uniformly mixed, obtains medicinal powder mixture；By medicinal powder mixture and After dextrin is mixed according to the mass ratio of 1:1-2 plus hydraulic pressure piece can be made into Chinese medicinal tablet.
CN201811287851.3A 2018-10-31 2018-10-31 A kind of drug for treating the proliferation of mammary gland Pending CN109172728A (en)

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CN201811287851.3A CN109172728A (en) 2018-10-31 2018-10-31 A kind of drug for treating the proliferation of mammary gland

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CN201811287851.3A CN109172728A (en) 2018-10-31 2018-10-31 A kind of drug for treating the proliferation of mammary gland

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1692933A (en) * 2005-04-15 2005-11-09 扬子江药业集团有限公司 Compound traditional Chinese medicine for treating proliferation of mammary gland, and its prepn. method
CN101912587A (en) * 2010-07-17 2010-12-15 苗丽华 Medicament for treating cyclomastopathy
CN102988543A (en) * 2012-11-21 2013-03-27 郑州瑞龙制药股份有限公司 Traditional Chinese medicine for treating hyperplasia of mammary glands and preparation method of traditional Chinese medicine
CN107019780A (en) * 2017-02-04 2017-08-08 洛阳士雄聚元医疗集团股份有限公司 A kind of Chinese medicine composition for treating the proliferation of mammary gland

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1692933A (en) * 2005-04-15 2005-11-09 扬子江药业集团有限公司 Compound traditional Chinese medicine for treating proliferation of mammary gland, and its prepn. method
CN101912587A (en) * 2010-07-17 2010-12-15 苗丽华 Medicament for treating cyclomastopathy
CN102988543A (en) * 2012-11-21 2013-03-27 郑州瑞龙制药股份有限公司 Traditional Chinese medicine for treating hyperplasia of mammary glands and preparation method of traditional Chinese medicine
CN107019780A (en) * 2017-02-04 2017-08-08 洛阳士雄聚元医疗集团股份有限公司 A kind of Chinese medicine composition for treating the proliferation of mammary gland

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
史柯: "消瘰丸临床应用观察", 《河南中医》 *
唐昊等: "叶腾辉主任治疗妇科疾病经验举隅", 《云南中医中药杂志》 *

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Application publication date: 20190111