CN107982331B - External traditional Chinese medicine formula essential oil for treating hyperplasia of mammary glands - Google Patents
External traditional Chinese medicine formula essential oil for treating hyperplasia of mammary glands Download PDFInfo
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Abstract
The invention relates to an external traditional Chinese medicine essential oil for treating hyperplasia of mammary glands, which can effectively solve the problem of treatment medication of the hyperplasia of mammary glands and adopts the technical scheme that: the traditional Chinese medicine composition is prepared by uniformly mixing licorice essential oil, peach blossom essential oil, safflower essential oil, mint ice = (2.5-3.5): 1.8-2.2): 0.8-1.2.
Description
Technical Field
The invention relates to a medicament, in particular to a traditional Chinese medicine formula essential oil (also called peach red grass essential oil) for treating hyperplasia of mammary glands by external application.
Background
The hyperplasia of mammary glands refers to hyperplasia of mammary epithelium and fibrous tissue, degenerative changes of mammary tissue ducts and mammary lobules on structure and growth of progressive connective tissue, and the pathogenesis of the hyperplasia of mammary glands is mainly due to endocrine hormone imbalance. Hyperplasia of mammary glands is the most common breast disease in women, and the incidence rate accounts for the first place of breast diseases. The incidence of the disease has been increasing year by year in recent years, and the age has been getting lower. About 70-80% of women have different degrees of hyperplasia of mammary glands according to the survey, and the number of women is more than 25-45 years old.
The clinical manifestations are different characteristics in different age groups, and the main symptom of the breast distending pain is breast pain of unmarried women, married and unintuied women and breast-feeding women, which can affect both sides of the body at the same time, but one side is heavier. The distending pain of the mammary gland before menstruation is obvious, the pain is relieved and gradually stopped immediately after menstruation, the pain reappears before next menstruation, and the whole breast has diffuse nodular sensation and is accompanied with tenderness. The main symptoms of women after age 35 are breast lumps, mild breast pain and tenderness, and are independent of the menstrual cycle. When the breast is touched by hand, the breast can touch nodules with different sizes, oblate or irregular shapes and flexible textures, the boundaries are not clear, no adhesion exists between the breast and skin and deep tissues, and the breast can be pushed. After age 45, it often appears as a single or multiple loose cystic mass with clear borders, often accompanied by dull pain, distending pain or burning sensation. Postmenopausal women have atrophic breast glands and more prominent cystic lesions. The severity of breast pain is not related to the presence or absence and extent of nodules, and pain can be spread to the axilla and the shoulders and back. A few patients may be accompanied by nipple discharge. Because the etiology comes from endocrine dysfunction, except for symptoms in the aspect of breasts, the traditional Chinese medicine also can have symptoms of irregular menstruation, bad spleen qi, urgent love of vital energy, love of sweating and the like. Although various medicines for treating hyperplasia of mammary glands exist at present, the use of the medicines is not satisfactory for various reasons, so that improvement and innovation of the medicines for treating hyperplasia of mammary glands are imperative.
Disclosure of Invention
Aiming at the situation and overcoming the defects of the prior art, the invention aims to provide the traditional Chinese medicine formula essential oil for treating the hyperplasia of mammary glands by external use, which can effectively solve the problem of treatment medication of the hyperplasia of mammary glands.
The technical scheme of the invention is that the traditional Chinese medicine formula essential oil for treating hyperplasia of mammary glands by external use is prepared from the following components in parts by weight: glycyrrhrizae radix essential oil, flos persicae essential oil, Carthami flos essential oil, Mentholum (2.5-3.5): 1.8-2.2): 0.8-1.2, and mixing to obtain the final product:
the licorice essential oil is prepared by crushing licorice into coarse powder which is sieved by a sieve of 10-20 meshes, soaking the coarse powder in a mixed solvent of any one or more than two of ethanol, ethyl acetate or cyclohexane which is 0.5-1.5 times of the weight of medicinal materials for 2-4 min, taking the wet medicinal materials, and performing supercritical CO extraction2Fluid Extraction (SFE), wherein the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that licorice essential oil is obtained;
the peach blossom essential oil is prepared by crushing peach blossom into coarse powder which is sieved by a sieve of 10-20 meshes, soaking the coarse powder in a mixed solvent of any one or more than two of ethanol, ethyl acetate or cyclohexane which is 0.5-1.5 times of the weight of medicinal materials for 2-4 min, taking the wet medicinal materials, and performing supercritical CO extraction2Fluid Extraction (SFE), wherein the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction is carried out1.5-2.5 h to obtain peach blossom essential oil;
the safflower essential oil is prepared by crushing safflower, sieving with a 10-20 mesh sieve to obtain coarse powder, soaking in a mixed solvent of 0.5-1.5 times of ethanol, ethyl acetate or cyclohexane for 2-4 min, collecting the wet medicinal material, and performing supercritical CO extraction2Fluid Extraction (SFE), wherein the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the safflower essential oil is obtained.
The invention has the advantages of rich raw materials, easy production and preparation, convenient use and good effect, can be effectively used for treating hyperplasia of mammary glands, is an innovation on medicaments for treating hyperplasia of mammary glands, exploits the medicinal value and the economic value of the liquorice, the peach blossom, the safflower and the mentholum, and has obvious economic and social benefits.
Detailed Description
The following examples are provided to explain the present invention in detail.
The invention may be embodied in the form of the following examples.
Example 1
In the specific implementation of the invention, the traditional Chinese medicine formula essential oil for treating hyperplasia of mammary glands through external use is prepared from the following components in parts by weight: mixing Glycyrrhrizae radix essential oil, flos persicae essential oil, Carthami flos essential oil, Mentholum, and Glycyrrhrizae radix essential oil, 3: 2: 1.
The licorice essential oil, the peach blossom essential oil and the safflower essential oil are the same as the invention content and are the same as the following.
Example 2
In the specific implementation of the invention, the traditional Chinese medicine formula essential oil for treating hyperplasia of mammary glands through external use is prepared from the following components in parts by weight: mixing Glycyrrhrizae radix essential oil, flos persicae essential oil, Carthami flos essential oil, Mentholum, and Glycyrrhrizae radix essential oil with herba Menthae ice powder at ratio of 2.6: 3.4: 1.9: 1.1.
Example 3
In the specific implementation of the invention, the traditional Chinese medicine formula essential oil for treating hyperplasia of mammary glands through external use is prepared from the following components in parts by weight: mixing Glycyrrhrizae radix essential oil, flos persicae essential oil, Carthami flos essential oil, Mentholum, and herba Menthae ice at ratio of 3.4: 2.6: 2.1: 0.9.
The components of the invention are organically matched and mutually supported, can be effectively used for treating hyperplasia of mammary glands, and obtains very satisfactory beneficial technical effects through tests, and the relevant test data are as follows:
first, the influence of the pink grass essential oil on the mammary gland hyperplasia mouse model
1. Experimental Material
1.1 pharmaceutical Agents
The invention is the essential oil (also known as the pink grass essential oil); estradiol benzoate injection produced by Hangzhou animal pharmaceutical factory; olive oil, produced by central european natural food gmbh.
1.2 Experimental animals
18-22g female mouse, KM, SPF, quality certification NO.37009200006989, provided by Experimental animals center, Shandong province.
2. Experimental methods
2.1 Molding and Experimental methods
20-22g of female mice are taken and normally bred, after the environment is adapted, 10 mice are randomly taken as a blank group without molding, another mouse is taken to make a mammary gland hyperplasia model, and the female benzoic acid glycol injection (0.5mg/kg) is diluted (1:9) by olive oil and is injected into the abdominal cavity for 1 time every other day until the experiment is finished. On the 4 th day of molding, 30 mice with red and swollen nipples were selected and randomly divided into 3 groups, which were a model group and a large and small dose of the essential oil of pink grass (the small dose group was a large dose of the essential oil of pink grass diluted with liquid paraffin). The large and small doses of the pink grass essence oil are respectively applied 1 time in the morning and at the evening every day, the dosage is about 0.03ml per place, and the model group is continuously applied with liquid paraffin for 30 days.
2.2 items tested
(1) And (3) detecting the weight of the mouse: after molding and drug drying, the body weight of each group of mice was weighed once a week.
(2) Detection of appearance of mouse udder: after the drug intervention, the diameter of the nipple of the second pair of breasts of each mouse was measured weekly using a vernier caliper, and the color and size of the breasts were observed.
(3) After the last administration, blood was collected from the orbit, left to stand for 30min, centrifuged at 4000 rpm-1 for 5min, and serum was collected and the level of E2, P in serum was measured by radioimmunoassay according to the kit instructions.
(4) And taking down the 2 nd pair of intact breasts, fixing the breasts by using 10 percent formaldehyde solution, conventionally flaking, HE dyeing, and observing and analyzing the conditions of the mammary tissues such as lobular acinus, ductal epithelial hyperplasia and the like under a microscope.
2.3 statistical methods
The experimental data were statistically processed with SPSS21.0 statistical software by ANOVA, and the data were obtained by
The results show that the comparison among groups adopts t test, and the P is less than 0.01 and less than 0.05.
TABLE 1 integral criteria for mammary gland hyperplasia lesions
3 results of the experiment
3.1 Effect of Tambopogon Erecta essential oil on weight of mice in mammary gland hyperplasia model
TABLE 2 influence of Tao hong grass essential oil on the body weight of mice with mammary gland hyperplasia
Note: comparison with model group of P <0.01, P <0.05
After the mice are injected with estradiol benzoate, the weight of the mice in the model group is increased obviously compared with that in the blank group (P is less than 0.05); compared with the model group, the large-dose group of the pink grass essential oil can obviously reduce the weight of the mice (P <0.01), and the large-dose group of the pink grass essential oil can obviously reduce the weight of the mice (P < 0.01).
4.2 Effect of Taglauca alternifolia essential oil on Nipple diameter and Nipple height of mammary gland hyperplasia model mouse
TABLE 3 influence of Taurus niveus essential oil on the papilla diameter of mouse mammary gland hyperplasia model
Note: comparison with model group
Compared with the blank group, the diameter and height of the nipple are obviously increased and increased after the model group is injected with the estradiol benzoate (P < 0.01). Compared with the model group, the large and small dose group of the pink grass essential oil can obviously reduce the diameter and height of the nipple of the model mouse (P < 0.01).
4.3 Effect of Tao hong grass essential oil on levels of estradiol and progesterone in serum of mice with mammary gland hyperplasia model
TABLE 4 treatment of mouse serum E with Taglauca alternifolia essential oil for mammary gland hyperplasia model2Influence of P level
Note: comparison with model group
The level of estradiol in serum was significantly increased in the model mice (P) compared to the blank group<0.01), marked reduction in progesterone levels (P)<0.01), which indicates that the model is successfully prepared; compared with the model group, the large and small dose groups of the pink grass essential oil can obviously reduce the serum E of the mammary gland hyperplasia mice2Level (P)<0.01), significantly increased serum P levels (P)<0.01)。
4.4 Effect of Taglauca alternifolia essential oil on mammary tissue morphology of mammary gland hyperplasia model mice
TABLE 5 Effect of Taglauca essential oil on mammary tissue of mammary hyperplasia model mice
Note: comparison with model group
Compared with the blank group, the mammary gland hyperplasia integral of the model group mice is obviously increased (P is less than 0.01), which indicates that the model is successfully prepared; compared with the model group, the large and small dose groups of the pink grass essential oil can obviously reduce the mammary gland hyperplasia integral of the mouse (P is less than 0.01).
Breast tissue morphology for each group: the blank group is stationary-stage mammary gland, and has no proliferative lesion, few acini, acinar epithelium in single-layer cuboids, no expansion of glandular cavity, no epithelial cell proliferation, no secretion of duct, and no lymphocyte infiltration phenomenon; the acini of the model group is obviously expanded, secretion in the acinus cavity is increased, epithelium is peeled off, and the obvious difference is obtained compared with that of the blank group; the large-dose tissue of the pink grass essential oil has slightly dilated acinus, less secretion, no obvious hyperplasia of fibrous connective tissue and occasional lymphocytes; the small-dose acinar cavity of the pink grass essential oil is slightly dilated, a little secretion exists in the cavity, the small-dose acinar cavity is obviously increased, hyperplasia is not obvious, the secretion exists, and the lymphocyte is occasionally seen.
The result shows that the inventive pink grass essential oil for external use has good therapeutic effect on mouse mammary gland hyperplasia model.
The invention obtains the same or similar results through repeated experiments, shows that the curative effect of the medicine is stable and reliable, and is further proved through clinical experiments.
Clinical observation of 58 cases of external application of pink grass essential oil for treating hyperplasia of mammary glands
1. General data: 58 cases are outpatients, patients without gestation period, and are married; the age is 26 years minimum and 44 years maximum, and is more than 28 years to 35 years old; the shortest disease course is 2 months, the longest disease course is 3 years, and more than 1-2 years are taken; 44 cases of bilateral hyperplasia of mammary glands and 8 cases of unilateral hyperplasia of mammary glands. It is distending pain in breast, and radiates to armpit without red swelling, and is mostly related to menstruation or emotion; most of the masses are in the form of oval nodules or cords, which are movable. Among them, 30 cases were treated, and 28 cases were controlled. The age and the disease condition of the two groups have no obvious difference.
2. Diagnostic criteria: there is pain or distending pain on one or both sides of the mammary gland, which worsens before each menstruation. Secondly, the mammary gland has cord-shaped and nodular lumps which are usually enlarged and hardened before menstruation and softened after menstruation. Excluding tumor and inflammatory lesion.
3. Treatment regimens
The treatment group is topically coated with 0.05mL/cm of the essential oil of herba Carpesii Cernui for treating hyperplasia of mammary glands2The external application is used for assisting local massage for 3 times every day. The treatment course is 14 days. The second treatment course is 14-28 days in the next menstrual cycle. 2, the evaluation result is finished after the treatment course.
The control group is prepared from anti-inflammatory analgesic ointment, and is applied by health materials factory in Guangzhou city for 12h, and the application is removed for auxiliary local massage, and the treatment course is 14 d. The second course of treatment is carried out on the 14 th to 28 th days of the next menstrual cycle.
The curative effect standard is as follows: the standard of the second mammary gland disease conference of the traditional Chinese medicine general society is referred for judgment. Curing, namely the breast pain and the tumor disappear, and the treatment is stopped for 3 months without relapse; the effect is shown: the breast mass is reduced by more than 1/2, and the pain is obviously relieved; the method has the following advantages: breast mass reduction 1/3, pain relief; and (4) invalidation: after 3 courses of treatment, symptoms and signs are unchanged, or the pain is slightly relieved and then relapses.
4. Therapeutic results
The treatment group has 30 cases, 10 cases are cured, 15 cases with obvious effect, 3 cases with effect and 2 cases with no effect, the cure rate is 33.3 percent, and the total effective rate is 93.3 percent.
In a control group, 28 cases have obvious effect, 19 cases have effective effect and 8 cases have ineffective effect, the cure rate is 0 percent, and the total effective rate is 71.4 percent.
In the experiments, no toxic or side effect or adverse reaction is found, and the medicine is safe to use and stable and reliable in curative effect.
The data clearly show that the invention has rich raw materials, easy production and preparation, convenient use and good treatment effect on the hyperplasia of mammary glands, the effective rate is up to more than 93 percent through clinical application, the good effect is unexpected, the invention not only solves the medication problem of treating the hyperplasia of mammary glands, but also exploits the medicinal value and the economic value of the liquorice, the peach blossom, the safflower and the mentholum, and is the innovation of the medicine for treating the hyperplasia of mammary glands, and the economic and social benefits are obvious.
Claims (5)
1. The externally-applied traditional Chinese medicine essential oil for treating hyperplasia of mammary glands is characterized by comprising the following components in parts by weight: glycyrrhrizae radix essential oil, flos Persicae essential oil, Carthami flos essential oil, Mentholum = (2.5-3.5): 1.8-2.2): 0.8-1.2, and mixing to obtain the final product, wherein:
the licorice essential oil is prepared by crushing licorice into coarse powder which is sieved by a sieve of 10-20 meshes, soaking the coarse powder in a mixed solvent of any one or more than two of ethanol, ethyl acetate or cyclohexane which is 0.5-1.5 times of the weight of medicinal materials for 2-4 min, taking the wet medicinal materials, and performing supercritical CO extraction2Fluid extraction is carried out, wherein the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the licorice essential oil is obtained;
the peach blossom essential oil is prepared by crushing peach blossom into coarse powder which is sieved by a sieve of 10-20 meshes, soaking the coarse powder in a mixed solvent of any one or more than two of ethanol, ethyl acetate or cyclohexane which is 0.5-1.5 times of the weight of medicinal materials for 2-4 min, taking the wet medicinal materials, and performing supercritical CO extraction2Extracting with a fluid at the extraction temperature of 42-50 ℃, the extraction pressure of 20-25 MPa, the separation temperature of 50-60 ℃, the separation pressure of 4.5-5.5 MPa, and the extraction time of 1.5-2.5 h to obtain the peach blossom essential oil;
the safflower essential oil is prepared by crushing safflower, sieving with a 10-20 mesh sieve to obtain coarse powder, soaking in a mixed solvent of 0.5-1.5 times of ethanol, ethyl acetate or cyclohexane for 2-4 min, collecting the wet medicinal material, and performing supercritical CO extraction2Fluid extraction is carried out, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the safflower essential oil is obtained.
2. The essential oil of the external traditional Chinese medicine formula for treating the hyperplasia of mammary glands according to claim 1, which is prepared from the following components in percentage by weight: and mixing Glycyrrhrizae radix essential oil, flos persicae essential oil, Carthami flos essential oil, Mentholum = 3: 2: 1.
3. The essential oil of the external traditional Chinese medicine formula for treating the hyperplasia of mammary glands according to claim 1, which is prepared from the following components in percentage by weight: and mixing Glycyrrhrizae radix essential oil, flos persicae essential oil, Carthami flos essential oil, Mentholum = 2.6: 3.4: 1.9: 1.1.
4. The essential oil of the external traditional Chinese medicine formula for treating the hyperplasia of mammary glands according to claim 1, which is prepared from the following components in percentage by weight: mixing Glycyrrhrizae radix essential oil, flos persicae essential oil, Carthami flos essential oil, Mentholum = 3.4: 2.6: 2.1: 0.9.
5. Use of the essential oil of a traditional Chinese medicine formulation according to any one of claims 1 or 2 to 4 in the preparation of a medicament for treating hyperplasia of mammary glands.
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