CN109172569A - 一种防治肺癌患者顺铂耐药性的生物碱化合物 - Google Patents
一种防治肺癌患者顺铂耐药性的生物碱化合物 Download PDFInfo
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- CN109172569A CN109172569A CN201811068087.0A CN201811068087A CN109172569A CN 109172569 A CN109172569 A CN 109172569A CN 201811068087 A CN201811068087 A CN 201811068087A CN 109172569 A CN109172569 A CN 109172569A
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- lung cancer
- resistant
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- platinum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
组别 | IC50值(μg/ml) | 组别 | IC50值(μg/ml) |
H460组 | 14.21±1.25 | TB-3给药组 | 20.06±1.19 |
H460/DDP组 | 52.85±1.63 | TB-4给药组 | 48.72±1.55 |
TA-1给药组 | 21.07±1.47 | TC-1给药组 | 7.61±0.93 |
TA-2给药组 | 23.42±1.38 | TD-1给药组 | 7.33±0.88 |
TB-1给药组 | 18.95±1.10 | TE-1给药组 | 15.62±1.27 |
TB-2给药组 | 17.18±1.08 | TE-2给药组 | 9.24±0.96 |
Claims (2)
Priority Applications (1)
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CN201811068087.0A CN109172569B (zh) | 2018-09-13 | 2018-09-13 | 一种防治肺癌患者顺铂耐药性的生物碱化合物 |
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CN201811068087.0A CN109172569B (zh) | 2018-09-13 | 2018-09-13 | 一种防治肺癌患者顺铂耐药性的生物碱化合物 |
Publications (2)
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CN109172569A true CN109172569A (zh) | 2019-01-11 |
CN109172569B CN109172569B (zh) | 2020-12-22 |
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CN201811068087.0A Active CN109172569B (zh) | 2018-09-13 | 2018-09-13 | 一种防治肺癌患者顺铂耐药性的生物碱化合物 |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102008475A (zh) * | 2010-09-09 | 2011-04-13 | 汕头大学医学院 | 喹诺里西啶生物碱在制备用于治疗肿瘤药物的应用 |
CN102952134A (zh) * | 2012-12-05 | 2013-03-06 | 上海药明康德新药开发有限公司 | 含二氟甲基的金雀花碱衍生物及制备方法和抗癌作用研究 |
CN103509021A (zh) * | 2012-06-21 | 2014-01-15 | 上海药明康德新药开发有限公司 | 金雀花碱衍生物及其制备方法和抗癌作用研究 |
CN104710422A (zh) * | 2013-12-13 | 2015-06-17 | 上海壹志医药科技有限公司 | 金雀花碱衍生物 |
CN106913571A (zh) * | 2017-04-19 | 2017-07-04 | 山西大学 | 一种用于治疗肿瘤的药物及其应用 |
-
2018
- 2018-09-13 CN CN201811068087.0A patent/CN109172569B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102008475A (zh) * | 2010-09-09 | 2011-04-13 | 汕头大学医学院 | 喹诺里西啶生物碱在制备用于治疗肿瘤药物的应用 |
CN103509021A (zh) * | 2012-06-21 | 2014-01-15 | 上海药明康德新药开发有限公司 | 金雀花碱衍生物及其制备方法和抗癌作用研究 |
CN102952134A (zh) * | 2012-12-05 | 2013-03-06 | 上海药明康德新药开发有限公司 | 含二氟甲基的金雀花碱衍生物及制备方法和抗癌作用研究 |
CN104710422A (zh) * | 2013-12-13 | 2015-06-17 | 上海壹志医药科技有限公司 | 金雀花碱衍生物 |
CN106913571A (zh) * | 2017-04-19 | 2017-07-04 | 山西大学 | 一种用于治疗肿瘤的药物及其应用 |
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CN109172569B (zh) | 2020-12-22 |
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