CN109170734A - Compound royal jelly product and preparation method thereof - Google Patents
Compound royal jelly product and preparation method thereof Download PDFInfo
- Publication number
- CN109170734A CN109170734A CN201811070638.7A CN201811070638A CN109170734A CN 109170734 A CN109170734 A CN 109170734A CN 201811070638 A CN201811070638 A CN 201811070638A CN 109170734 A CN109170734 A CN 109170734A
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- Prior art keywords
- parts
- royal jelly
- hours
- honey
- temperature
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Classifications
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention discloses a kind of compound royal jelly products, it is related to technical field of health care food, its key points of the technical solution are that being grouped as by the group of following parts by weight: 30~60 parts of royal jelly, 5~20 parts of Bee Pollen, 5~20 parts of honey, 1~20 part of propolis, 10~20 parts of mangosteen shell extracting solution, 15~30 parts of walnut powder, 1~10 part of grape seed extract, 5~10 parts of lemon juice, 5~10 parts of Chinese flowering quince juice, 2~8 parts of American Ginseng, 1.5~6 parts of maltodextrin；The mesh number of walnut powder is 90~110 mesh；The present invention solves the problems, such as that royal jelly products are difficult to improve human body oxidation resistance, using specially treated mangosteen shell extracting solution and walnut powder, can not only improve the immunity of human body, moreover it is possible to improve the oxidation resistant ability of human body.
Description
Technical field
The present invention relates to technical field of health care food, more specifically, it is related to a kind of compound royal jelly product and its system
Preparation Method.
Background technique
Fresh royal jelly, Bee Pollen and propolis all have good healthcare function, and royal jelly nutritive is abundant, have whole to human body
A immune system generates excellent influence, adjusts the effect of immune function；Bee Pollen is known as " nutrition library of concentration ", has benefit
Immune, beneficial blood vessel, beneficial anti-ageing, beneficial stomach and other effects；Propolis is rich in flavones isoreactivity substance, has very strong strengthen immunity,
Anti-aging and other effects.
In the prior art, it can refer to the Chinese invention patent application file that application publication number is CN101953947A, it is public
A kind of preparation method of composite propolis health care product, herbal raw material and its parts by weight in health care product are as follows: propolis 40- are opened
50 parts, 5-8 parts of ganoderma spore polysaccharide, 5-8 parts of Ganodenna Lucidum P.E, 5-8 parts of ginkgo biloba extract, 10-15 parts of tea polyphenols, royal jelly freeze
5-8 parts of dry powder, it is made of following steps: A. first prepares Chinese herbal medicine: pure propolis, ganoderma spore polysaccharide, Ganodenna Lucidum P.E, apricot mention
Object is taken, tea polyphenols, queen bee encourage freeze-dried powder；B. by above-mentioned A herbal raw material propolis, ginkgo biloba extract, tea polyphenols difference it is selected after
It dries and is prepared by above-mentioned parts by weight；C. the raw material of above-mentioned B is carried out being crushed to 200-600 mesh, is sieved；D. by above-mentioned C powder
Broken good raw material and the ganoderma spore polysaccharide prepared by above-mentioned parts by weight, royal jelly freeze-dried powder, are put into stirring at Ganodenna Lucidum P.E
Machine is sufficiently mixed；E. the irradiation of above-mentioned D mixture ultraviolet light is carried out disinfection；F. the mixture after above-mentioned E disinfection is conventional
Method is made particle, tablet or will enter capsule.
Though existing this composite propolis health care product nutritive value is high, nutrition is comprehensive, can be improved disease resistance, and enhancing is exempted from
Epidemic disease power, but human body oxidation resistance cannot be improved.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to provide a kind of compound royal jelly product, pass through
The substances such as mangosteen shell extracting solution and walnut powder are added, the immune function of human body can not only be improved, it is anti-also to can be improved human body
Oxidability.
To achieve the above object, the present invention provides the following technical scheme that a kind of compound royal jelly product, by following weight
The group of part is grouped as: 30~60 parts of royal jelly, 5~20 parts of Bee Pollen, 5~20 parts of honey, 1~20 part of propolis, mangosteen shell mention
Take 10~20 parts of liquid, 15~30 parts of walnut powder, 1~10 part of grape seed extract, 5~10 parts of lemon juice, 5~10 parts of Chinese flowering quince juice,
2~8 parts of American Ginseng, 1.5~6 parts of maltodextrin, 3-8 parts of silica；The mesh number of walnut powder is 90~110 mesh.
By using above-mentioned technical proposal, royal jelly can promote the power of regeneration of body wounded tissue, make aging, injured
Histocyte is substituted by neonatal cell, can be had adjustment effect to hyperlipidemia, hyperglycemia, can be reduced cholesterol in serum, also
Have the function of adjusting blood pressure, purification blood, enhancing blood vessel elasticity, prevention coronary sclerosis and atherosclerosis；Propolis
It is adjustable immunity, enhances premunition and vis medicatrix naturae, reduces the brittleness and permeability of blood vessel, increases drag yield, increases body fluid
Immune and cellular immune function；Bee Pollen can enhance the activity of immunocyte, improve the immune function of body, help to improve super
The activity of Superoxide dismutase, builds up health, the effect of anti-aging；The antioxidant effect of grape seed extract is vitamin E
With ascorbic 30-50 times；Walnut powder is subjected to pre-freeze, distillation and parsing, can guarantee the flavor of walnut powder, and guarantee core
The nutriment of peach powder is not lost, the extract that mangosteen shell is extracted with 60% ethanol solution at 70 DEG C, extract
Inoxidizability is very high, can scavenging activated oxygen, suppress or eliminate and slow down oxidation reaction, improve the anti-oxidant energy of human body
Power.
The present invention is further arranged to: the extraction process of the mangosteen shell extracting solution are as follows: grind after drying mangosteen shell
At 80~90 targeted fine powders, mangosteen shell fine powder is subjected to vacuum freeze drying, cryogenic temperature is -20~-30 DEG C, cooling time
It is 1-3 hours, vacuum pressure 1.5-2.5MPa, the alcohol steep for being 60% using concentration, extraction time is 2~3 hours, material
Liquor ratio is 1:20, and Extracting temperature is 70 DEG C, obtains mangosteen shell extracting solution.
By using above-mentioned technical proposal, the extract that mangosteen shell is extracted with 60% ethanol solution at 70 DEG C,
The inoxidizability of extract is very high, can scavenging activated oxygen, suppress or eliminate and slow down oxidation reaction, improve human body
Oxidation resistance.
The present invention is further arranged to: the treatment process of the walnut powder is that walnut powder is poured into freeze-drying vessel, walnut powder
With a thickness of 2~3mm, it is put into freeze-drying in vacuum freeze drier, three steps of part are completed: pre-freeze, distillation and parsing, the pre-freeze
For pre-freeze 4 hours at -30~-28 DEG C, control vacuum pressure is 0.6~0.8MPa, keeps the temperature 2 hours；The distillation is with every
2 DEG C of hour heating, is to slowly warm up to -5 DEG C, keeps the temperature 2~3 hours, described to resolve to heat up per hour 5 DEG C, is to slowly warm up to
30 DEG C, and keep the temperature 1-2 hours.
By using above-mentioned technical proposal, walnut powder is subjected to pre-freeze, distillation and parsing, can guarantee the wind of walnut powder
Taste, and guarantee that the nutriment of walnut powder is not lost.
The present invention is further arranged to: the treatment process of the honey are as follows: is poured into honey maltodextrin, is stirred evenly, uses
It is 10~15% that water, which is adjusted to solid content,；It uses colloid mill homogeneous 3 times again, places defoaming, place into -30 DEG C of refrigerator
Freezing 0.5 hour, is again heated to 100 DEG C, and controlling vacuum degree is 50MPa, 2~3 hours dry, and it is thin to be ground into 80-100 purpose
Powder.
By using above-mentioned technical proposal, use maltodextrin as auxiliary material, and the parts by weight of maltodextrin are honey
The 30% of parts by weight, the honey after freezing is blocky in honeycomb, moisture content in honey can be made to be lower than 2%, and software performance is good
It is good, it is not easy the moisture absorption, is unlikely to deteriorate, main nutrient composition is preferably remained.
The present invention is further arranged to: the propolis is extracted by following methods: by propolis raw material -10~-20
It is freezed 4-10 hours at DEG C, then low-temperature grinding, 3~7 times of 60~95% ethyl alcohol is then added and extracts 10~20 hours, uses
Filtrate is collected in the sieve centrifugal filtration of 120 mesh.
By using above-mentioned technical proposal, propolis is extracted using ethyl alcohol, recovery rate is high, and Extracting temperature is low, prevents propolis
Middle active constituent is destroyed, and avoids the stability and the human absorptivity that influence propolis.
The present invention is further arranged to: the filtrate after freezing 2~10 hours, crosses 300 in the environment of -10~-20 DEG C
Purpose filter cloth centrifugal filtration 2~4 times is collected filtrate, and is concentrated under reduced pressure, and temperature is 35~45 DEG C, and vacuum degree is -0.07~-
0.09MPa is concentrated into relative density greater than 1.3.
By using above-mentioned technical proposal, filtrate is first freezed and is heated up afterwards, beeswax can be made to be melted into liquid, beeswax is through dense
It is removed after contracting, to obtain pure propolis, makes the antibacterial, anti-oxidant, strengthen immunity, hypoglycemic, reducing blood lipid work of propolis
With performing to maximum.
The present invention is further arranged to: the Bee Pollen crosses the sieve separation of 120 mesh, and color sorting removal of impurities removes bee corpse and sand
Stone impurity, then pollen is put into vacuum freeze drier, control drying temperature is lower than 30 DEG C, drying time 10~12 hours, will
Bee Pollen is ground into 80 targeted fine powders, then spare through ultraviolet disinfection.
By using above-mentioned technical proposal, Bee Pollen is handled in the way of vacuum freeze drying, can reduce drying mode
Influence to Vitamin C content in Bee Pollen, vacuum freeze drying can be avoided flavones in Bee Pollen and be decomposed or be oxidized, and
The drying temperature of vacuum freeze drying is low, low vacuum treatment, is conducive to the extraction of catalase in Bee Pollen, and guarantee peroxide
Change the activity of hydrogen enzyme.
The present invention is further arranged to: the extracting method of the grape seed extract are as follows: is chosen grape pip, is to extract with water
Agent, material-water ratio 1:9 are extracted three times at 60-70 DEG C, and 1.5 hours every time, combined extract both obtained grape seed extract.
By using above-mentioned technical proposal, using water as extractant, starch, pectin and lymphatic temperament in grape pip etc. are water-soluble
Substance can be also extracted, and after 60 DEG C, be extracted at high temperature, the diffusion rate of extract can be improved, and then improve leaching
Speed-raising rate, upon extracting between be 1.5 hours, the effective component in aqueous solution reaches balance, even if extending the time again, recovery rate
It not will increase.
In view of the deficiencies of the prior art, the present invention intends to provide a kind of preparation side of compound royal jelly product
Method can not only improve the immune function of human body, also can be improved by adding the substances such as mangosteen shell extracting solution and walnut powder
Human body oxidation resistance.
To achieve the above object, the present invention provides the following technical scheme that a kind of preparation method of compound royal jelly product,
The following steps are included:
(1) royal jelly, Bee Pollen, lemon juice, Chinese flowering quince juice, mangosteen shell extracting solution and grape seed extract are stirred 30 minutes,
It is transferred to Fluidbedgranulatingdrier and continues to blow room temperature wind and carry out mixing 10 minutes, it is spare；
(2) honey is handled with maltodextrin, then by treated honey, honey and propolis is molten with the ethanol solution of 60-85%
Solution, stirs evenly, and with spare mixture wet granulation in Fluidbedgranulatingdrier in step (1), sprays to honey and propolis liquid
After leaching completely, start to warm up 1-4 hour dry, inlet air temperature is 40-60 DEG C, then by particle through pelletizing machine 14-20 mesh sieve,
Then it requires to carry out tabletting, i.e. 750mg/ piece according to product specification, pack, examine.
By using above-mentioned technical proposal, the walnut powder in conjunction with mangosteen shell extracting solution and Jing Guo vacuum freeze drying etc. is former
Material, develops the royal jelly products of strengthen immunity and oxidation resistance, in production process, mostly uses the work of vacuum freeze drying
Skill processing, after complete at a lower temperature compared with multioperation, low-temperature operation is very suitable to using royal jelly and Bee Pollen be raw material production
The technique of product, the active material that can be sufficiently reserved in royal jelly and Bee Pollen.
The present invention is further arranged to: the particle in the step (2) after whole grain puts into bipyramid convolution vacuum drier again
In, the silica for being 50:1 with royal jelly mass ratio is added, is uniformly mixed material.
By using above-mentioned technical proposal, silica is mixed with the particle after whole grain, can prevent particle aggregation from agglomerating,
Its laxity is kept, silica dioxide granule is subtle, loose porous, strong adsorption force, easy adsorption moisture, and the particle after making whole grain is kept
Graininess.
In conclusion the present invention has the advantages that compared with the prior art
(1) by the present invention in that royal jelly products are made with substances such as royal jelly, Bee Pollen and propolis, royal jelly can promote body
The power of regeneration of wounded tissue substitutes aging, injured histocyte by neonatal cell, can have to hyperlipidemia, hyperglycemia
There is adjustment effect, cholesterol in serum can be reduced, also has adjusting blood pressure, purification blood, enhancing blood vessel elasticity, prevention coronal dynamic
The effect of arteries and veins hardening and atherosclerosis；Propolis is adjustable immunity, enhances premunition and vis medicatrix naturae, reduces the brittleness of blood vessel
With permeability, increase drag yield, increases humoral immunity and cellular immune function；Bee Pollen can enhance the activity of immunocyte,
The immune function for improving body, helps to improve the activity of superoxide dismutase, builds up health, the effect of anti-aging；
(2) present invention adds grape seed extract in the feed, and the antioxidant effect of grape seed extract is vitamin E and Wei Sheng
30-50 times of plain C can effectively improve the oxidation resistance of human body；
(3) present invention can guarantee the flavor of walnut powder, and guarantee walnut by the way that walnut powder is carried out pre-freeze, distillation and parsing
The nutriment of powder is not lost, and at 70 DEG C, extract resists the extract that mangosteen shell is extracted with 60% ethanol solution
Oxygen activity is very high, can scavenging activated oxygen, suppress or eliminate and slow down oxidation reaction；
(4) present invention will mix the particle after whole grain with silica, can prevent particle aggregation from agglomerating, and keep it loose
Property, silica dioxide granule is subtle, loose porous, strong adsorption force, easy adsorption moisture, and the particle after making whole grain keeps graininess.
Specific embodiment
Embodiment 1: a kind of compound royal jelly product is grouped as by the group of following parts by weight: 30 parts of royal jelly, Bee Pollen 5
Part, 5 parts of honey, 1 part of propolis, 10 parts of mangosteen shell extracting solution, 15 parts of walnut powder, 1 part of grape seed extract, 5 parts of lemon juice, wood
5 parts of melon juice, 2 parts of American Ginseng, 1.5 parts of maltodextrin, 3 parts of silica；The mesh number of walnut powder is 90 mesh；The wherein place of walnut powder
Reason process is that walnut powder is poured into freeze-drying vessel, and walnut powder is put into vacuum freeze drier and is lyophilized with a thickness of 2mm, part three
Step is completed: pre-freeze, distillation and parsing, and the pre-freeze is pre-freeze 4 hours at -30 DEG C, and control vacuum pressure is 0.6MPa, is protected
Temperature 2 hours；To heat up per hour 2 DEG C, to be to slowly warm up to -5 DEG C, heat preservation 2 hours is described to resolve to per hour for the distillation
5 DEG C of heating is to slowly warm up to 30 DEG C, and keeps the temperature 1 hour.
The extraction process of mangosteen shell extracting solution are as follows: the extraction process of the mangosteen shell extracting solution are as follows: by mangosteen shell
80 targeted fine powders are worn into after drying, and mangosteen shell fine powder are subjected to vacuum freeze drying, cryogenic temperature is -20 DEG C, cooling time
It is 1 hour, vacuum pressure 1.5MPa, the alcohol steep for being 60% using concentration, extraction time is 2 hours, solid-liquid ratio 1:
20, Extracting temperature is 70 DEG C, obtains mangosteen shell extracting solution.
The treatment process of honey are as follows: the treatment process of the honey are as follows: maltodextrin is poured into honey, is stirred evenly, water is used
Being adjusted to solid content is 10%；It uses colloid mill homogeneous 3 times again, the revolving speed of first time colloid mill is 2000r/min, and the time is
8min, the revolving speed of second of colloid mill are 3000r/min, and homogeneous 5min, the revolving speed of third time colloid mill is 4000r/min, when
Between be 2min；Defoaming is placed, freezing 0.5 hour in -30 DEG C of refrigerator is placed into, is again heated to 100 DEG C, and control vacuum degree
It is 2 hours dry for 50MPa, it is ground into 80 targeted fine powders.
Propolis is extracted by following methods: propolis raw material being freezed 4 hours at -10 DEG C, then low-temperature grinding, then
3 times of 60% ethyl alcohol is added to extract 10 hours, with the sieve centrifugal filtration of 120 mesh, filtrate is collected, by filtrate at -10 DEG C
Under environment, after freezing 2 hours, filter cloth centrifugal filtration 2 times for crossing 300 mesh are collected filtrate, and are concentrated under reduced pressure, and temperature is 35 DEG C, very
Reciprocal of duty cycle is -0.07MPa, is concentrated into relative density greater than 1.3.
Bee Pollen crosses the sieve separation of 120 mesh, and color sorting removal of impurities removes bee corpse and sandstone impurity, then pollen is put into vacuum
Freeze drier, control drying temperature are lower than 30 DEG C, drying time 10 hours, Bee Pollen are ground into 80 targeted fine powders, then pass through
Ultraviolet disinfection is spare.
The extracting method of the grape seed extract are as follows: choose grape pip, using water as extractant, material-water ratio 1:9,60
It is extracted at DEG C three times, 1.5 hours every time, combined extract both obtains grape seed extract.
The preparation method of above-mentioned compound royal jelly product, comprising the following steps: (1) by royal jelly, Bee Pollen, lemon juice,
Chinese flowering quince juice, mangosteen shell extracting solution and grape seed extract stir 30 minutes, are transferred to Fluidbedgranulatingdrier and continue to blow room temperature wind
Mixing 10 minutes is carried out, it is spare；
(2) handle honey with maltodextrin, then by treated honey, by honey and propolis with 60% ethanol solution dissolution,
It stirs evenly, with spare mixture wet granulation in Fluidbedgranulatingdrier in step (1), has been sprayed to honey and propolis liquid
Quan Hou is started to warm up dry 1 hour, and inlet air temperature is 40 DEG C, then the particle by particle through 14 mesh sieve of pelletizing machine, after whole grain
It is put into bipyramid convolution vacuum drier again, the silica for being 50:1 with royal jelly mass ratio is added, is uniformly mixed material, so
It requires to carry out tabletting, i.e. 750mg/ piece according to product specification afterwards, tabletting is carried out ultrasonication 10 minutes, pack, examine.
Embodiment 2: a kind of compound royal jelly product, a kind of compound royal jelly product are grouped as by the group of following parts by weight:
30 parts of royal jelly, 5 parts of Bee Pollen, 5 parts of honey, 1 part of propolis, 10 parts of mangosteen shell extracting solution, 15 parts of walnut powder, grape pip extract
1 part of object, 5 parts of lemon juice, 5 parts of Chinese flowering quince juice, 2 parts of American Ginseng, 1.5 parts of maltodextrin, 3 parts of silica；The mesh number of walnut powder is
90 mesh.
Wherein the treatment process of walnut powder is walnut powder to be poured into freeze-drying vessel, walnut powder is put into vacuum with a thickness of 3mm
Freeze-drying in freeze drier, three steps of part are completed: pre-freeze, distillation and parsing, the pre-freeze are pre-freeze 4 hours at -28 DEG C,
Control vacuum pressure is 0.8MPa, keeps the temperature 2 hours；The distillation is to heat up per hour 2 DEG C, is to slowly warm up to -5 DEG C, heat preservation 3
Hour, it is described to resolve to heat up per hour 5 DEG C, 30 DEG C are to slowly warm up to, and keep the temperature 2 hours.
The extraction process of mangosteen shell extracting solution are as follows: the extraction process of the mangosteen shell extracting solution are as follows: by mangosteen shell
80 targeted fine powders are worn into after drying, and mangosteen shell fine powder are subjected to vacuum freeze drying, cryogenic temperature is -30 DEG C, cooling time
It is 3 hours, vacuum pressure 2.5MPa, the alcohol steep for being 60% using concentration, extraction time is 3 hours, solid-liquid ratio 1:
20, Extracting temperature is 70 DEG C, obtains mangosteen shell extracting solution.
The treatment process of honey are as follows: the treatment process of the honey are as follows: maltodextrin is poured into honey, is stirred evenly, water is used
Being adjusted to solid content is 15%；It uses colloid mill homogeneous 3 times again, the revolving speed of first time colloid mill is 2000r/min, and the time is
8min, the revolving speed of second of colloid mill are 3000r/min, and homogeneous 5min, the revolving speed of third time colloid mill is 4000r/min, when
Between be 2min；Defoaming is placed, freezing 0.5 hour in -30 DEG C of refrigerator is placed into, is again heated to 100 DEG C, and control vacuum degree
It is 3 hours dry for 50MPa, it is ground into 80 targeted fine powders.
Propolis is extracted by following methods: propolis raw material being freezed 4 hours at -20 DEG C, then low-temperature grinding, then
7 times of 95% ethyl alcohol is added to extract 20 hours, with the sieve centrifugal filtration of 120 mesh, filtrate is collected, by filtrate at -20 DEG C
Under environment, after freezing 10 hours, filter cloth centrifugal filtration 4 times for crossing 300 mesh are collected filtrate, and are concentrated under reduced pressure, and temperature is 45 DEG C,
Vacuum degree is -0.09MPa, is concentrated into relative density greater than 1.3.
Bee Pollen crosses the sieve separation of 120 mesh, and color sorting removal of impurities removes bee corpse and sandstone impurity, then pollen is put into vacuum
Freeze drier, control drying temperature are lower than 30 DEG C, drying time 12 hours, Bee Pollen are ground into 80 targeted fine powders, then pass through
Ultraviolet disinfection is spare.
The extracting method of the grape seed extract are as follows: choose grape pip, using water as extractant, material-water ratio 1:9,70
It is extracted at DEG C three times, 1.5 hours every time, combined extract both obtains grape seed extract.
The preparation method of above-mentioned compound royal jelly product, comprising the following steps: (1) by royal jelly, Bee Pollen, lemon juice,
Chinese flowering quince juice, mangosteen shell extracting solution and grape seed extract stir 30 minutes, are transferred to Fluidbedgranulatingdrier and continue to blow room temperature wind
Mixing 10 minutes is carried out, it is spare；
(2) handle honey with maltodextrin, then by treated honey, by honey and propolis with 85% ethanol solution dissolution,
It stirs evenly, with spare mixture wet granulation in Fluidbedgranulatingdrier in step (1), has been sprayed to honey and propolis liquid
Quan Hou is started to warm up dry 4 hours, and inlet air temperature is 60 DEG C, then the particle by particle through 20 mesh sieve of pelletizing machine, after whole grain
It is put into bipyramid convolution vacuum drier again, the silica for being 50:1 with royal jelly mass ratio is added, is uniformly mixed material, so
It requires to carry out tabletting, i.e. 750mg/ piece according to product specification afterwards, tabletting is carried out ultrasonication 10 minutes, pack, examine.
Embodiment 3-8: a kind of compound royal jelly product, the difference from embodiment 1 is that, raw materials used and parts by weight are such as
Shown in table 1, feedstock processing and preparation method are same as Example 1.
Raw materials used and parts by weight in 1 embodiment 3-8 of table
Comparative example 1-6: a kind of compound royal jelly product, the difference from embodiment 1 is that, raw materials used and parts by weight such as table 2
Shown, same as Example 1 ("/" indicates in the comparative example without the substance, and corresponding preparation side for feedstock processing and preparation method
The substance is not added in method).
Raw materials used and parts by weight in 2 comparative example 1-6 of table
One, the strengthen immunity function zoopery of compound royal jelly product of the present invention
1.1, tested material: compound royal jelly product made from embodiment 1-8 and comparative example 1-6, every 750mg, adult recommend every
Its intake 2 times, 4 tablets once, presses adult 60kg batheroom scale, i.e. 0.1g/kg.bw, is configured to required concentration stomach-filling with distilled water.
1.2, experimental animal: purchased from cleaning grade BALB/c mouse 70 of western Poole-Bi Kai experimental animal Co., Ltd, male,
18-22g, quality certification number are SCXK (Shanghai) No. 2003-0002 number, each embodiment and each comparative example each 5.
1.3, dosage selects: test sets a dosage group, and with 10 times of human intaking amounts (1.0g/kg.bw), intragastric administration on mice volume is
0.2mg/10g.bw, stomach-filling liquid are prepared daily, 10 multiple dose group preparation methods: are taken 5.0g sample to be dissolved in distilled water, are settled to
100mL。
1.4, it test method: is examined by the strengthen immunity function of " health food is examined and assessment technique specification -2003 editions "
Proved recipe method carries out.
1.4.1, delayed allergy (DTH): with 10 multiple dose continuous gavage 30 days, with depilatory agent to the abdomen of mouse
Position carries out depilation processing, and lose hair or feathers area about 3cm × 3cm, then the DNFB solution that the concentration of 50ul is 1% is uniformly applied to
Sensitivity response is carried out at mouse web portion depilation；Observation detection mouse 5 days, then uniformly applied on mouse right ear two sides and spread 10ul's
DNFB solution carries out attack processing；After 5 days, then with DNFB solution 10ul uniformly it is applied to mouse right ear two sides；It is small to observe 24
When, mouse is put to death with cervical dislocation mode, and cut the left and right ear of mouse after death, then remove diameter with punch
The auricle of 6mm, weighing, weighing results are as shown in table 3.
Influence test result of the 3 compound royal jelly product of table to DNFB inducing mouse DTH
It can be seen that the compound royal jelly product of the invention for giving mouse various dose, embodiment and comparison by data in table 2
Example takes the weight differences of mouse in 1.0g/kg.bw, embodiment 1-8 and comparative example 1-6, and there are no significant, to the body of mouse
Increase no influence again.
1.4.2, serum hemolysin measures: with 10 multiple dose continuous gavage mouse 30 days, the sheep for preparing 2% (v/v) was red
Cell (SRBC) suspension, is injected intraperitoneally every mouse, every injection 0.2ml, and the eyeball of mouse is extractd after 4 days, and takes
Blood is placed in centrifuge tube, centrifuge tube is placed 1h, and be centrifuged 10min in 2000-3000r/min, is separated and collect serum, will
Serum dilutes 200 times, presses the strengthen immunity functional check method of " health food is examined and assessment technique specification -2003 editions ",
OD value when sample cell and SRBC half hemolysis is measured, the amount of hemolysin is indicated with half hemolytic value (HC50), test knot
Fruit is as shown in table 4.
1.4.3, NK cytoactive detection (determination of lactate dehydrogenase method): by the mouse in embodiment 1-8 and comparative example 1-6
Equal continuous gavage 30d, then puts to death mouse with cervical dislocation mode, the spleen of mouse is aseptically taken out, by mice spleen
It is dirty to be placed in the nutrient agar plate equipped with appropriate sterile Hanks liquid, the spleen in nutrient agar plate is ground, is made
Cell suspension, then cleaned 2 times with sterile Hanks liquid, then with the screen to filtrate cell suspension of 200 mesh, with the revolving speed of 1000r/min
Centrifugal treating 10min is added aqua sterilisa 20 seconds of 0.5ml later, after erythrocyte splitting, add 0.5ml Hanks liquid and
The Hanks liquid of 8ml, then it is centrifuged 10min with the revolving speed of 1000r/min, resuspension processing is carried out with 1ml complete medium later, is used
1% glacial acetic acid dilution after count, with platform expect blue dyeing counting viable count (should be 95% or more) adjustment cell concentration be 2 ×
107A/ml takes target cell and each 100ul of effector cell, is added in 96 well culture plates, in 37 DEG C, 5%CO2Culture 4 in incubator
Hour, culture plate is then handled into 5min under the conditions of 1500r/min, measures OD value (OD) at microplate reader 490nm, is surveyed
Test result is as shown in table 4.
1.4.4, antibody-producting cell detection (Jerne improves slide method): the mouse in embodiment 1-8 and comparative example 1-6
Equal continuous gavage 30d, the mouse spleen after taking SRBC 5 days immune, is placed on the nutrient agar plate for filling appropriate sterile Hanks liquid
In, spleen is gently ground, through 200 mesh net filtrations, cell suspension is made, 10min is centrifuged under the conditions of 1000r/min, then use
Hanks liquid cleans 2 times, and cell is suspended in 5mlRPMI-1640 culture solution, surface layer culture medium is dissolved by heating, with equivalent
The Hanks liquid mixing of pH7.2-7.4 and 2 times of concentration, and be respectively charged into test tube with the amount of 0.5ml, then add 50ul into test tube
The SRBC that concentration is 10%, 20ul splenocyte suspension (5 × 106A/ml), it mixes rapidly, the brushing agarose thin layer on slide,
Invisible spectro substance is poured on agarose thin layer, after agar solidification, slide level is buckled and is placed on horse, horse is put into
CO2It is incubated for 1.5h in incubator, then dilutes complement with the SA that mass ratio is 1:10, is added to after dilution in glass frame groove,
Continue to be incubated for 1.5h, count hemolysis plaque number, test result is as shown in table 4.
1.4.5, ConA inducing mouse Splenic vein hemodynamics test (mtt assay): in embodiment 1-8 and comparative example 1-6
The equal continuous gavage 30d of mouse, puts to death mouse with cervical dislocation mode, the spleen of mouse is taken out under sterile conditions, by spleen
It is placed in the nutrient agar plate for filling sterile Hanks liquid, is gently torn up spleen with tweezers, through 200 mesh net filtrations, be made
Cell suspension is washed 3 times with Hanks liquid, centrifugal treating 10min under conditions of 1000r/min, is then suspended complete with 1ml
In culture solution, living cell counting (should be 95% or more) after blue dyeing is expected with platform, cell concentration is adjusted to 3 × 106A/ml,
It is divided to two holes that 24 well culture plates are added every part of cell suspension, every hole content is 1ml, wherein 75ulConA liquid is added in a hole,
It being not added in another hole, placement is cultivated for 24 hours in the incubator, and 4 hours before culture terminates, each Kong Jun sucks supernatant 0.7ml, and
And the MTT of RPMI-1640 culture solution and 50ul of the 0.7ml without serum is added simultaneously, continue culture 4 hours.After culture,
The acid isopropyl alcohol of 1ml is added in each hole, is uniformly mixed, until purple crystal is completely dissolved, then is dispensed into the culture of 96 holes
In plate, OD value is measured with 570nm wavelength with microplate reader, test result is as shown in table 4.
Knot is tested in influence of the 4 compound royal jelly product of table to mice serum hemolysin, NK cell activity and hemolysis plaque number
Fruit
As can be seen from Table 4, take the serum hemolysis cellulose content of the mouse of compound royal jelly product made of embodiment 1-8 compared with
Height, and the intracorporal serum hemolysis cellulose content of mouse for taking compound royal jelly product made from comparative example 1-6 is lower；Take implementation
The NK cells in mice activity of compound royal jelly product made from example 1-8 is significantly higher than using compound queen bee made from comparative example 1-6
The NK cell activity of the mouse of milk products；Take the mouse hemolysis plaque digital display of compound royal jelly product made from embodiment 1-8
Write the hemolysis plaque number for being higher than and taking the mouse of compound royal jelly product made from comparative example 1-6；It takes made from embodiment 1-8
The mouse of compound royal jelly product adds the hole of ConA liquid to be significantly higher than with the hole absorbance serum hemolysis cellulose content that ConA liquid is not added
The mouse for taking compound royal jelly product made from comparative example 1-6 adds the hole of ConA liquid and the hole absorbance serum of ConA liquid is not added
Haemolysis cellulose content；Illustrate that compound royal jelly product produced by the present invention can promote mouse boosting cell hemolysis plaque and serum hemolysis
The formation of element enhances the competence for added value of splenic lymphocytes, improves the activity of NK cell, therefore compound as made from embodiment 1-8
Royal jelly has the function of strengthen immunity.
Two, the anti-oxidation function experiment of compound royal jelly product of the present invention
2.1, tested material: compound royal jelly product made from embodiment 1-8 and comparative example 1-6, every 750mg, adult recommend every
Its intake 2 times, 4 tablets once.
2.2, study subject: selection meets 70 people that anti-oxidant diagnosis requires, and the age at 45-65 years old, solicits subject's meaning
It sees below and is included in observation object, there is the one exclusion of following situations not to be included in observation.
(1) article related with tested function is taken in a short time, influences the judgement person to result, or took other in a short time
Health care product person；
(2) intentionally, the patient of liver,kidney,spleen and hematopoietic disorder；
(3) gestation or nursing women, to health food allergy sufferers；
(4) not by the edible given the test agent person of regulation.
2.3, test-meal method: 70 people of volunteer is selected according to above-mentioned standard, five one group of people are divided into 14 groups, eat respectively
With the compound royal jelly product as made from embodiment 1-8 and comparative example 1-6,2 times a day, 4 tablets once (750mg/ piece).
2.4, observation index: indices are detected respectively before the test and after test, Testing index includes following items:
2.4.1, lipid peroxide content measures: the variation of 2% hemolysate sample MDA and MDA decline percentage before and after detection test-meal
Rate, calculation formula are as follows: MDA declines percentage=(measured value after measured value-test before testing)/measured value × 100% before testing,
Testing result is as shown in table 5.
2.4.2, superoxide dismutase measures: the variation of the SOD of detection test front and back red blood cell extract and SOD increase percentage
Rate, calculation formula are as follows: SOD increases measured value × 100% before percentage=(measured value before measured value-test after test)/test,
Testing result is as shown in table 5.
2.4.3, glutathione peroxidase measures: the variation of detection test 2% hemolysate sample GSH-PX of front and back and GSH-
PX increases percentage, calculation formula are as follows: before GSH-PX increases percentage=(measured value before measured value-test after test)/test
Measured value × 100%, testing result are as shown in table 5.
Excessively every Testing index before and after compound royal jelly product made from table 5 test-meal embodiment 1-8 and comparative example 1-6
Testing result
2.4.4, blood parameters include: total serum protein (TP), albumin (ALB), glutamic-oxalacetic transaminease (AST), creatinine
(CRE), urea nitrogen (BUN), blood glucose (GLU), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), glutamic-pyruvic transaminase
(ALT), total cholesterol (CHO) test result is as shown in table 6.
Subject's blood safety index that table 6 takes compound royal jelly product made from embodiment 1-8 and comparative example 1-6 is surveyed
Test result
Continued 6
All subjects adhere to primary work during test, and diet is constant, recommend every group of crowd's dosage 2 times a day, 4 tablets once
(750mg/ piece) takes tested material, and continuous 3 months, compound bee made from embodiment 1-8 is taken it can be seen from data in table 5
The subject of royal jelly product is taking the decline of front and back lipid peroxide content, and rate of descent reaches 18-19%, and takes comparative example 1-
The subject of compound royal jelly product made from 8 is taking front and back, and lipid peroxide rate of descent is lower；Take embodiment 1-8 system
Compound royal jelly product subject to take front and back superoxide dismutase rate of rise higher, and take comparative example 1-8
The subject of compound royal jelly product obtained is taking front and back, and the rate of rise of superoxide dismutase is negative value；Take implementation
The subject of compound royal jelly product made from example 1-8 takes pair taking front and back, glutathione peroxidase rate of rise ratio
Compound royal jelly made from ratio 1-6 is high；It can be seen from data in table 6 before and after test-meal, eat multiple made from embodiment 1-8
The indices for closing the subject of royal jelly products in the normal range, illustrate compound royal jelly product pair produced by the present invention
The health of subject has no adverse effects, according to " health food is examined and assessment technique specification " (2003), it is possible to determine that by this hair
The compound royal jelly product of bright preparation has antioxidation to tested crowd.
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation
Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of compound royal jelly product, it is characterised in that: be grouped as by the group of following parts by weight: 30~60 parts of royal jelly, bee
5~20 parts of pollen, 5~20 parts of honey, 1~20 part of propolis, 10~20 parts of mangosteen shell extracting solution, 15~30 parts of walnut powder, Portugal
1~10 part of grape seed extract, 5~10 parts of lemon juice, 5~10 parts of Chinese flowering quince juice, 2~8 parts of American Ginseng, 1.5~6 parts of maltodextrin,
3-8 parts of silica；The mesh number of walnut powder is 90~110 mesh.
2. compound royal jelly product according to claim 1, it is characterised in that: the extraction of the mangosteen shell extracting solution
Journey are as follows: wear into 80~90 targeted fine powders after drying mangosteen shell, mangosteen shell fine powder is subjected to vacuum freeze drying, freezing temperature
Degree is -20~-30 DEG C, and cooling time is 1-3 hours, vacuum pressure 1.5-2.5MPa, is soaked using the ethyl alcohol that concentration is 60%
It mentions, extraction time is 2~3 hours, solid-liquid ratio 1:20, and Extracting temperature is 70 DEG C, obtains mangosteen shell extracting solution.
3. compound royal jelly product according to claim 1, it is characterised in that: the treatment process of the walnut powder is to incite somebody to action
Walnut powder pours into freeze-drying vessel, and walnut powder is put into freeze-drying in vacuum freeze drier with a thickness of 2~3mm, complete in three steps
At pre-freeze, distillation and parsing, the pre-freeze is pre-freeze 4 hours at -30~-28 DEG C, control vacuum pressure is 0.6~
0.8MPa keeps the temperature 2 hours；The distillation keeps the temperature 2~3 hours, the solution to heat up per hour 2 DEG C, to be to slowly warm up to -5 DEG C
Analysis is to be to slowly warm up to 30 DEG C, and keep the temperature 1-2 hours to heat up per hour 5 DEG C.
4. compound royal jelly product according to claim 1, it is characterised in that: the treatment process of the honey are as follows: by wheat
Bud dextrin pours into honey, stirs evenly, and water use regulation to solid content is 10~15%；It uses colloid mill homogeneous 3 times again, placement disappears
Bubble places into freezing 0.5 hour in -30 DEG C of refrigerator, is again heated to 100 DEG C, and controlling vacuum degree is 50MPa, dry 2~
3 hours, it is ground into 80-100 targeted fine powder.
5. compound royal jelly product according to claim 1, it is characterised in that: the propolis be by following methods extract and
At: propolis raw material is freezed 4-10 hours, then low-temperature grinding at -10~-20 DEG C, the 60~95% of 3~7 times are then added
Ethyl alcohol extracts 10~20 hours, with the sieve centrifugal filtration of 120 mesh, collects filtrate.
6. compound royal jelly product according to claim 4, it is characterised in that: environment of the filtrate at -10~-20 DEG C
Under, it after freezing 2~10 hours, crosses filter cloth centrifugal filtration for 2~4 times of 300 mesh, collects filtrate, and be concentrated under reduced pressure, temperature is 35~
45 DEG C, vacuum degree is -0.07~-0.09MPa, is concentrated into relative density greater than 1.3.
7. compound royal jelly product according to claim 1, it is characterised in that: the Bee Pollen crosses the sieve point of 120 mesh
From color sorting removal of impurities removes bee corpse and sandstone impurity, then pollen is put into vacuum freeze drier, and control drying temperature is lower than 30
DEG C, drying time 10~12 hours, Bee Pollen is ground into 80 targeted fine powders, then spare through ultraviolet disinfection.
8. compound royal jelly product according to claim 1, it is characterised in that: the extracting method of the grape seed extract
Are as follows: grape pip is chosen, using water as extractant, material-water ratio 1:9 is extracted three times at 60-70 DEG C, and 1.5 hours every time, merging mentioned
Liquid is taken both to obtain grape seed extract.
9. a kind of preparation method such as the described in any item compound royal jelly products of claim 1-8, it is characterised in that: including with
Lower step: (1) royal jelly, Bee Pollen, lemon juice, Chinese flowering quince juice, mangosteen shell extracting solution and grape seed extract is stirred 30 point
Clock, is transferred to Fluidbedgranulatingdrier and continues to blow room temperature wind and carry out mixing 10 minutes, spare；
(2) honey is handled with maltodextrin, then by treated honey, honey and propolis is molten with the ethanol solution of 60-85%
Solution, stirs evenly, and with spare mixture wet granulation in Fluidbedgranulatingdrier in step (1), sprays to honey and propolis liquid
After leaching completely, start to warm up 1-4 hour dry, inlet air temperature is 40-60 DEG C, then by particle through pelletizing machine 14-20 mesh sieve,
Then it requires to carry out tabletting, i.e. 750mg/ piece according to product specification, pack, examine.
10. the preparation method of compound royal jelly product according to claim 9, it is characterised in that: whole in the step (2)
Particle after grain is put into again in bipyramid convolution vacuum drier, and the silica for being 50:1 with royal jelly mass ratio, mixing is added
Homogeneous material.
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Cited By (3)
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| CN110214943A (en) * | 2019-07-03 | 2019-09-10 | 齐鲁工业大学 | A kind of full nutrition special medicine purposes formula food and preparation method thereof based on Bee Pollen quinoa |
| CN110959831A (en) * | 2019-10-31 | 2020-04-07 | 绵阳市田蜜佳人蜂业有限公司 | Composite honey product and preparation method thereof |
| KR20210156541A (en) * | 2020-06-18 | 2021-12-27 | 대한민국(농촌진흥청장) | Granule royal jelly composition and method for thereof |
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