CN109154603A - 用于治疗真菌感染的给药方案 - Google Patents

用于治疗真菌感染的给药方案 Download PDF

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Publication number
CN109154603A
CN109154603A CN201780030072.2A CN201780030072A CN109154603A CN 109154603 A CN109154603 A CN 109154603A CN 201780030072 A CN201780030072 A CN 201780030072A CN 109154603 A CN109154603 A CN 109154603A
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China
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dose
administered
salt
day
neutral form
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CN201780030072.2A
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English (en)
Chinese (zh)
Inventor
K.巴蒂扎尔
P.达鲁瓦拉
J.B.洛克
V.翁
T.桑迪森
D.赛伊
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Seachaid Pharmaceuticals LLC
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Seachaid Pharmaceuticals LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56961Plant cells or fungi

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780030072.2A 2016-03-16 2017-03-15 用于治疗真菌感染的给药方案 Pending CN109154603A (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201662309211P 2016-03-16 2016-03-16
US62/309211 2016-03-16
US201662350591P 2016-06-15 2016-06-15
US62/350591 2016-06-15
US201662415928P 2016-11-01 2016-11-01
US62/415928 2016-11-01
US201662418727P 2016-11-07 2016-11-07
US62/418727 2016-11-07
US201662419076P 2016-11-08 2016-11-08
US62/419076 2016-11-08
US201662436716P 2016-12-20 2016-12-20
US62/436716 2016-12-20
PCT/US2017/022551 WO2017161016A1 (en) 2016-03-16 2017-03-15 Dosing regimens for treatment of fungal infections

Publications (1)

Publication Number Publication Date
CN109154603A true CN109154603A (zh) 2019-01-04

Family

ID=59850952

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780030072.2A Pending CN109154603A (zh) 2016-03-16 2017-03-15 用于治疗真菌感染的给药方案

Country Status (8)

Country Link
US (2) US11712459B2 (https=)
EP (2) EP4268896A3 (https=)
JP (3) JP7224916B2 (https=)
CN (1) CN109154603A (https=)
CA (1) CA3017485A1 (https=)
ES (1) ES2955711T3 (https=)
MA (1) MA43825A (https=)
WO (1) WO2017161016A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2645074T3 (es) 2011-03-03 2017-12-04 Cidara Therapeutics, Inc. Agentes antifúngicos y sus usos
RU2639483C2 (ru) 2012-03-19 2017-12-21 Сидара Терапьютикс, Инк. Режимы дозирования для соединений класса эхинокандинов
CN108883152A (zh) 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
WO2017161016A1 (en) 2016-03-16 2017-09-21 Cidara Therapeutics, Inc. Dosing regimens for treatment of fungal infections
US11197909B2 (en) 2017-07-12 2021-12-14 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
CA3103619A1 (en) 2018-06-15 2019-12-19 Cidara Therapeutics, Inc. Synthesis of echinocandin antifungal agent
WO2020086931A1 (en) 2018-10-25 2020-04-30 Cidara Therapeutics, Inc. Polymorph of echinocandin antifungal agent
BR112021022876A2 (pt) * 2019-05-16 2022-04-12 Scynexis Inc Método para descolonizar candida auris de uma área anatômica de um sujeito

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1339959A (zh) * 1999-03-26 2002-03-13 前技术专业产品公司 抗菌义齿清洁组合物
CN1355699A (zh) * 1999-04-16 2002-06-26 藤泽药品工业株式会社 抗真菌组合物
CN101374502A (zh) * 2006-01-05 2009-02-25 药物技术公司 局部应用的药剂
CN103889221A (zh) * 2011-03-03 2014-06-25 西蔡德制药公司 抗真菌剂及其应用
US20150087583A1 (en) * 2012-03-19 2015-03-26 Cidara Therapeutics, Inc. Dosing regimens for echinocandin class compounds

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427660A (en) 1982-03-03 1984-01-24 Research Corporation Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections
US5166135A (en) 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
US6030944A (en) 1991-10-01 2000-02-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compounds
US5399552A (en) 1991-10-17 1995-03-21 Merck & Co, Inc Antibiotic peptides bearing aminoalkylthioether moieties
US5378804A (en) 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US6268338B1 (en) 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5948753A (en) 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
CA2161149A1 (en) 1993-05-04 1994-11-10 James M. Balkovec Cyclohexapeptidyl aminoalkyl ethers
US5541160A (en) 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5514651A (en) 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516756A (en) 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
WO1996022784A1 (en) 1995-01-26 1996-08-01 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5652213A (en) 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
AR006598A1 (es) 1996-04-19 1999-09-08 Merck Sharp & Dohme "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación"
USRE38984E1 (en) 1996-09-12 2006-02-14 Merck & Co., Inc. Antifungal combination therapy
DE69933046T2 (de) 1998-12-09 2007-09-13 Eli Lilly And Co., Indianapolis Reinigung von echinocandin cyclopeptiden
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
EP1582204B1 (en) 1999-03-03 2013-09-25 Eli Lilly & Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
WO2000051567A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Processes for making pharmaceutical oral ecb formulations and compositions
HU0104790D0 (en) 2001-11-08 2002-01-28 Human Rt Pharmaceutical combinations for topical application
US6991800B2 (en) 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
AU2003304398A1 (en) 2002-10-16 2005-02-25 Board Of Regents, The University Of Texas System Methods and compositions for increasing the efficacy of biologically-active ingredients
US6913759B2 (en) 2003-03-11 2005-07-05 Curatek Pharmaceuticals Holding, Inc. Gel composition and method for treatment of vaginal infections
DE602004010915T2 (de) 2003-07-22 2008-12-11 Theravance, Inc., South San Francisco Verwendung eines antimykotischen echinocandin-mittels in kombination mit einem antibakteriellen glycopeptid-mittel
JP5319281B2 (ja) 2005-07-26 2013-10-16 ユニバーシティ オブ メディシン アンド デンティストリー オブ ニュージャージー エキノカンジン系薬物に対する耐性の分析法並びに同分析法のためのオリゴヌクレオチド・セット及び試薬キット
WO2007113386A1 (en) 2006-03-31 2007-10-11 Karyon-Ctt Ltd Peptide conjugates
GB0702020D0 (en) 2007-02-02 2007-03-14 Novabiotics Ltd Peptides and their use
US20090238867A1 (en) 2007-12-13 2009-09-24 Scott Jenkins Nanoparticulate Anidulafungin Compositions and Methods for Making the Same
US20100009009A1 (en) 2008-07-10 2010-01-14 Micropure, Inc. Method and composition for prevention and treatment of oral fungal infections
GB0817121D0 (en) 2008-09-18 2008-10-29 Univ St Andrews Anti-fungal therapy
PT2400951T (pt) 2009-02-25 2018-11-26 Mayne Pharma Llc Composições de espuma tópica
CN102421790A (zh) 2009-05-07 2012-04-18 帝斯曼知识产权资产管理有限公司 制备环肽的方法
NO2470168T3 (https=) 2009-08-26 2018-06-30
EP2470190A4 (en) 2009-08-27 2013-07-17 Seachaid Pharmaceuticals Inc ECHINOCANDINDERIVATE
US9561285B2 (en) 2010-01-22 2017-02-07 Ascendis Pharma As Carrier-linked carbamate prodrug linkers
WO2013017691A1 (en) 2011-08-04 2013-02-07 Medizinische Universität Innsbruck Cahgt1p inhibitors for use in the treatment of candidiasis
US8829053B2 (en) 2011-12-07 2014-09-09 Rochal Industries Llp Biocidal compositions and methods of using the same
CN102766198A (zh) 2012-05-04 2012-11-07 中国人民解放军第二军医大学 一种糖肽类抗真菌化合物及其制备方法与应用
WO2014113693A1 (en) 2013-01-18 2014-07-24 University Of Utah Research Foundation Modified release osmotic pump for ph-responsive intravaginal drug delivery
WO2014124504A1 (en) 2013-02-13 2014-08-21 Katholieke Universiteit Leuven Ku Leuven Research & Development Compositions and methods for treating biofilms
EP2968381A4 (en) 2013-03-15 2016-11-30 Sidney Hecht Sugar-linker-drug conjugates
NZ713615A (en) 2013-05-01 2020-05-29 Neoculi Pty Ltd Methods for treating bacterial infections
US20160213742A1 (en) 2013-09-04 2016-07-28 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
WO2017049105A1 (en) 2015-09-16 2017-03-23 Cidara Therapeutics, Inc. Formulations for treating fungal infections
WO2017049102A1 (en) 2015-09-16 2017-03-23 Cidara Therapeutics, Inc. Methods for treating fungal infections
CN108883152A (zh) 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
WO2017161016A1 (en) 2016-03-16 2017-09-21 Cidara Therapeutics, Inc. Dosing regimens for treatment of fungal infections
WO2018085200A1 (en) 2016-11-01 2018-05-11 Cidara Therapeutics, Inc. Single dose methods for preventing and treating fungal infections
US20210002346A1 (en) 2016-11-29 2021-01-07 Cidara Therapeutics, Inc Methods for preventing fungal infections
CN110753698A (zh) 2017-01-31 2020-02-04 奇达拉治疗公司 用于治疗真菌感染的方法
WO2018187574A1 (en) 2017-04-05 2018-10-11 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
WO2018191692A1 (en) 2017-04-14 2018-10-18 Cidara Therapeutics, Inc. Methods for treating fungal infections
US11197909B2 (en) 2017-07-12 2021-12-14 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
WO2019027498A1 (en) 2017-08-03 2019-02-07 Cidara Therapeutics, Inc. METHOD FOR PREVENTING AND TREATING INTRA-ABDOMINAL CANDIDOSIS
CA3103619A1 (en) 2018-06-15 2019-12-19 Cidara Therapeutics, Inc. Synthesis of echinocandin antifungal agent

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1339959A (zh) * 1999-03-26 2002-03-13 前技术专业产品公司 抗菌义齿清洁组合物
CN1355699A (zh) * 1999-04-16 2002-06-26 藤泽药品工业株式会社 抗真菌组合物
CN101374502A (zh) * 2006-01-05 2009-02-25 药物技术公司 局部应用的药剂
CN103889221A (zh) * 2011-03-03 2014-06-25 西蔡德制药公司 抗真菌剂及其应用
US20150087583A1 (en) * 2012-03-19 2015-03-26 Cidara Therapeutics, Inc. Dosing regimens for echinocandin class compounds
CN104507309A (zh) * 2012-03-19 2015-04-08 奇达拉治疗公司 用于棘白菌素类化合物的给药方案

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
OPTIONK. JAMES 等: "Biafungin(CD101), a Novel Echinocandin, Displays a Long Half-life in the Chimpanzee, Suggesting a Once-Weekly IV Dosing Option", 《ABSTR 54TH INTERSCI CONF ANTIMICROB AGENTS CHEMOTHER,ABSTR A-694》 *

Also Published As

Publication number Publication date
JP2019511496A (ja) 2019-04-25
EP3430400B1 (en) 2023-06-21
JP2023139211A (ja) 2023-10-03
US20190216885A1 (en) 2019-07-18
JP7224916B2 (ja) 2023-02-20
EP4268896A3 (en) 2024-01-03
US20240108684A1 (en) 2024-04-04
CA3017485A1 (en) 2017-09-21
EP3430400A1 (en) 2019-01-23
MA43825A (fr) 2021-04-07
WO2017161016A1 (en) 2017-09-21
EP3430400A4 (en) 2019-10-30
JP2022169599A (ja) 2022-11-09
US11712459B2 (en) 2023-08-01
ES2955711T3 (es) 2023-12-05
JP7322259B2 (ja) 2023-08-07
EP4268896A2 (en) 2023-11-01

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