CN109153716A - 调节单克隆抗体组合物中的非岩藻糖基化物类 - Google Patents

调节单克隆抗体组合物中的非岩藻糖基化物类 Download PDF

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Publication number
CN109153716A
CN109153716A CN201780015362.XA CN201780015362A CN109153716A CN 109153716 A CN109153716 A CN 109153716A CN 201780015362 A CN201780015362 A CN 201780015362A CN 109153716 A CN109153716 A CN 109153716A
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CN
China
Prior art keywords
culture
day
monoclonal antibody
fucose
species
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780015362.XA
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English (en)
Chinese (zh)
Inventor
M.桑托罗
K.J.乔斯
S.马达布施
S.甘格洛夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Outlook Therapeutics Inc
Original Assignee
Oncobiologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57944513&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN109153716(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Oncobiologics Inc filed Critical Oncobiologics Inc
Publication of CN109153716A publication Critical patent/CN109153716A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN201780015362.XA 2016-01-06 2017-01-05 调节单克隆抗体组合物中的非岩藻糖基化物类 Pending CN109153716A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662275384P 2016-01-06 2016-01-06
US62/275384 2016-01-06
PCT/US2017/012349 WO2017120347A1 (en) 2016-01-06 2017-01-05 Modulation of afucosylated species in a monoclonal antibody composition

Publications (1)

Publication Number Publication Date
CN109153716A true CN109153716A (zh) 2019-01-04

Family

ID=57944513

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780015362.XA Pending CN109153716A (zh) 2016-01-06 2017-01-05 调节单克隆抗体组合物中的非岩藻糖基化物类

Country Status (8)

Country Link
US (1) US20190161543A1 (https=)
EP (1) EP3400241B1 (https=)
JP (1) JP6674028B2 (https=)
CN (1) CN109153716A (https=)
AU (1) AU2017206006B2 (https=)
CA (1) CA3010598A1 (https=)
MX (1) MX2018008447A (https=)
WO (1) WO2017120347A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3057616B1 (en) 2013-10-16 2020-03-11 Outlook Therapeutics, Inc. Buffer formulations for enhanced antibody stability
WO2016118707A1 (en) 2015-01-21 2016-07-28 Oncobiologics, Inc. Modulation of charge variants in a monoclonal antibody composition
CN109563161A (zh) 2016-02-03 2019-04-02 安口生物公司 用于提高抗体稳定性的缓冲制剂
US12325737B2 (en) * 2018-03-26 2025-06-10 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
HU231514B1 (hu) * 2018-11-07 2024-07-28 Richter Gedeon Nyrt. Sejttenyészetben előállított rekombináns glikoprotein glikozilációs mintázatának megváltoztatására szolgáló módszer
AU2019402923A1 (en) * 2018-12-19 2021-07-15 Seagen Inc. Controlled fucosylation of antibodies
WO2021066772A1 (en) * 2019-10-01 2021-04-08 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Cell culture medium for reducing fucosylation and basic variants in the production of antibodies
CN116964215A (zh) * 2021-02-12 2023-10-27 隆萨本德股份有限公司 用于调节抗体产物的无岩藻糖基化的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102076865A (zh) * 2008-05-02 2011-05-25 西雅图基因公司 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物
CN102459603A (zh) * 2009-06-02 2012-05-16 瑞泽恩制药公司 岩藻糖基化缺陷型细胞
WO2013114165A1 (en) * 2012-01-30 2013-08-08 Dr Reddy's Laboratories Limited Process of obtaining glycoprotein composition with increased afucosylation content
US20150259425A1 (en) * 2012-10-01 2015-09-17 Abbvie Biotherapeutics Inc. Compositions and methods for producing glycoproteins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
US8227241B2 (en) 2004-03-12 2012-07-24 Unigene Laboratories, Inc. Bacterial host cell for the direct expression of peptides
CA2608579C (en) 2005-05-26 2019-09-10 Cytos Biotechnology Ag Scalable fermentation process
US7846724B2 (en) 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
CA2763164A1 (en) 2009-06-05 2010-12-09 Momenta Pharmaceuticals, Inc. Methods of modulating fucosylation of glycoproteins
US20120258496A1 (en) 2010-09-27 2012-10-11 Boehringer Ingelheim International Gmbh Production of low fucose antibodies in h4-ii-e rat cells
WO2015140700A1 (en) * 2014-03-19 2015-09-24 Dr. Reddy's Laboratories Limited Cell culture process
ES2875274T3 (es) * 2015-11-02 2021-11-10 Hoffmann La Roche Procedimientos de preparación de formas fucosiladas y afucosiladas de una proteína

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102076865A (zh) * 2008-05-02 2011-05-25 西雅图基因公司 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物
CN102459603A (zh) * 2009-06-02 2012-05-16 瑞泽恩制药公司 岩藻糖基化缺陷型细胞
WO2013114165A1 (en) * 2012-01-30 2013-08-08 Dr Reddy's Laboratories Limited Process of obtaining glycoprotein composition with increased afucosylation content
US20150259425A1 (en) * 2012-10-01 2015-09-17 Abbvie Biotherapeutics Inc. Compositions and methods for producing glycoproteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YUTAKA KANDA，等: "Establishment of a GDP-mannose 4,6-dehydratase (GMD) knockout host cell line: A new strategy for generating completely non-fucosylated recombinant therapeutics", 《JOURNAL OF BIOTECHNOLOGY》 *

Also Published As

Publication number Publication date
EP3400241A1 (en) 2018-11-14
AU2017206006A1 (en) 2018-07-19
JP2019500876A (ja) 2019-01-17
US20190161543A1 (en) 2019-05-30
MX2018008447A (es) 2019-05-30
WO2017120347A1 (en) 2017-07-13
JP6674028B2 (ja) 2020-04-01
CA3010598A1 (en) 2017-07-13
AU2017206006B2 (en) 2019-08-29
EP3400241B1 (en) 2020-07-22

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SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: New jersey, USA

Applicant after: Prospective Therapy Co.

Address before: New jersey, USA

Applicant before: ONCOBIOLOGICS Inc.

CB02 Change of applicant information
RJ01 Rejection of invention patent application after publication

Application publication date: 20190104

RJ01 Rejection of invention patent application after publication