AU2017206006B2 - Modulation of afucosylated species in a monoclonal antibody composition - Google Patents

Modulation of afucosylated species in a monoclonal antibody composition Download PDF

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Publication number
AU2017206006B2
AU2017206006B2 AU2017206006A AU2017206006A AU2017206006B2 AU 2017206006 B2 AU2017206006 B2 AU 2017206006B2 AU 2017206006 A AU2017206006 A AU 2017206006A AU 2017206006 A AU2017206006 A AU 2017206006A AU 2017206006 B2 AU2017206006 B2 AU 2017206006B2
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Australia
Prior art keywords
culture
monoclonal antibody
species
fucose
feed
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AU2017206006A
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English (en)
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AU2017206006A1 (en
Inventor
Scott Gangloff
Kevin John JOSE
Sri MADABHUSHI
Marc Santoro
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Outlook Therapeutics Inc
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Outlook Therapeutics Inc
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Application filed by Outlook Therapeutics Inc filed Critical Outlook Therapeutics Inc
Publication of AU2017206006A1 publication Critical patent/AU2017206006A1/en
Assigned to OUTLOOK THERAPEUTICS, INC. reassignment OUTLOOK THERAPEUTICS, INC. Amend patent request/document other than specification (104) Assignors: ONCOBIOLOGICS, INC.
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AU2017206006A 2016-01-06 2017-01-05 Modulation of afucosylated species in a monoclonal antibody composition Active AU2017206006B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662275384P 2016-01-06 2016-01-06
US62/275,384 2016-01-06
PCT/US2017/012349 WO2017120347A1 (en) 2016-01-06 2017-01-05 Modulation of afucosylated species in a monoclonal antibody composition

Publications (2)

Publication Number Publication Date
AU2017206006A1 AU2017206006A1 (en) 2018-07-19
AU2017206006B2 true AU2017206006B2 (en) 2019-08-29

Family

ID=57944513

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017206006A Active AU2017206006B2 (en) 2016-01-06 2017-01-05 Modulation of afucosylated species in a monoclonal antibody composition

Country Status (8)

Country Link
US (1) US20190161543A1 (https=)
EP (1) EP3400241B1 (https=)
JP (1) JP6674028B2 (https=)
CN (1) CN109153716A (https=)
AU (1) AU2017206006B2 (https=)
CA (1) CA3010598A1 (https=)
MX (1) MX2018008447A (https=)
WO (1) WO2017120347A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3057616B1 (en) 2013-10-16 2020-03-11 Outlook Therapeutics, Inc. Buffer formulations for enhanced antibody stability
WO2016118707A1 (en) 2015-01-21 2016-07-28 Oncobiologics, Inc. Modulation of charge variants in a monoclonal antibody composition
CN109563161A (zh) 2016-02-03 2019-04-02 安口生物公司 用于提高抗体稳定性的缓冲制剂
US12325737B2 (en) * 2018-03-26 2025-06-10 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
HU231514B1 (hu) * 2018-11-07 2024-07-28 Richter Gedeon Nyrt. Sejttenyészetben előállított rekombináns glikoprotein glikozilációs mintázatának megváltoztatására szolgáló módszer
AU2019402923A1 (en) * 2018-12-19 2021-07-15 Seagen Inc. Controlled fucosylation of antibodies
WO2021066772A1 (en) * 2019-10-01 2021-04-08 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Cell culture medium for reducing fucosylation and basic variants in the production of antibodies
CN116964215A (zh) * 2021-02-12 2023-10-27 隆萨本德股份有限公司 用于调节抗体产物的无岩藻糖基化的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010141855A1 (en) * 2009-06-05 2010-12-09 Momenta Pharmaceuticals, Inc. Methods of modulating fucosylation of glycoproteins
WO2014055370A1 (en) * 2012-10-01 2014-04-10 Abbvie Biotherapeutics Inc. Compostions and methods for producing glycoproteins

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
US8227241B2 (en) 2004-03-12 2012-07-24 Unigene Laboratories, Inc. Bacterial host cell for the direct expression of peptides
CA2608579C (en) 2005-05-26 2019-09-10 Cytos Biotechnology Ag Scalable fermentation process
US7846724B2 (en) 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
WO2009135181A2 (en) * 2008-05-02 2009-11-05 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
US8409838B2 (en) 2009-06-02 2013-04-02 Regeneron Pharmaceuticals, Inc. Fucosylation-deficient cells
US20120258496A1 (en) 2010-09-27 2012-10-11 Boehringer Ingelheim International Gmbh Production of low fucose antibodies in h4-ii-e rat cells
WO2013114165A1 (en) * 2012-01-30 2013-08-08 Dr Reddy's Laboratories Limited Process of obtaining glycoprotein composition with increased afucosylation content
WO2015140700A1 (en) * 2014-03-19 2015-09-24 Dr. Reddy's Laboratories Limited Cell culture process
ES2875274T3 (es) * 2015-11-02 2021-11-10 Hoffmann La Roche Procedimientos de preparación de formas fucosiladas y afucosiladas de una proteína

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010141855A1 (en) * 2009-06-05 2010-12-09 Momenta Pharmaceuticals, Inc. Methods of modulating fucosylation of glycoproteins
WO2014055370A1 (en) * 2012-10-01 2014-04-10 Abbvie Biotherapeutics Inc. Compostions and methods for producing glycoproteins

Also Published As

Publication number Publication date
EP3400241A1 (en) 2018-11-14
AU2017206006A1 (en) 2018-07-19
JP2019500876A (ja) 2019-01-17
CN109153716A (zh) 2019-01-04
US20190161543A1 (en) 2019-05-30
MX2018008447A (es) 2019-05-30
WO2017120347A1 (en) 2017-07-13
JP6674028B2 (ja) 2020-04-01
CA3010598A1 (en) 2017-07-13
EP3400241B1 (en) 2020-07-22

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Owner name: OUTLOOK THERAPEUTICS, INC.

Free format text: FORMER NAME(S): ONCOBIOLOGICS, INC.

FGA Letters patent sealed or granted (standard patent)