MX2018008447A - Modulacion de especies afucosilados en una composicion de anticuerpo monoclonal. - Google Patents

Modulacion de especies afucosilados en una composicion de anticuerpo monoclonal.

Info

Publication number
MX2018008447A
MX2018008447A MX2018008447A MX2018008447A MX2018008447A MX 2018008447 A MX2018008447 A MX 2018008447A MX 2018008447 A MX2018008447 A MX 2018008447A MX 2018008447 A MX2018008447 A MX 2018008447A MX 2018008447 A MX2018008447 A MX 2018008447A
Authority
MX
Mexico
Prior art keywords
species
level
monoclonal antibodies
culture
modulation
Prior art date
Application number
MX2018008447A
Other languages
English (en)
Spanish (es)
Inventor
Santoro Marc
John Jose Kevin
Madabhushi Sri
Gangloff Scott
Original Assignee
Oncobiologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57944513&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2018008447(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Oncobiologics Inc filed Critical Oncobiologics Inc
Publication of MX2018008447A publication Critical patent/MX2018008447A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
MX2018008447A 2016-01-06 2017-01-05 Modulacion de especies afucosilados en una composicion de anticuerpo monoclonal. MX2018008447A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662275384P 2016-01-06 2016-01-06
PCT/US2017/012349 WO2017120347A1 (en) 2016-01-06 2017-01-05 Modulation of afucosylated species in a monoclonal antibody composition

Publications (1)

Publication Number Publication Date
MX2018008447A true MX2018008447A (es) 2019-05-30

Family

ID=57944513

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018008447A MX2018008447A (es) 2016-01-06 2017-01-05 Modulacion de especies afucosilados en una composicion de anticuerpo monoclonal.

Country Status (8)

Country Link
US (1) US20190161543A1 (https=)
EP (1) EP3400241B1 (https=)
JP (1) JP6674028B2 (https=)
CN (1) CN109153716A (https=)
AU (1) AU2017206006B2 (https=)
CA (1) CA3010598A1 (https=)
MX (1) MX2018008447A (https=)
WO (1) WO2017120347A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3057616B1 (en) 2013-10-16 2020-03-11 Outlook Therapeutics, Inc. Buffer formulations for enhanced antibody stability
WO2016118707A1 (en) 2015-01-21 2016-07-28 Oncobiologics, Inc. Modulation of charge variants in a monoclonal antibody composition
CN109563161A (zh) 2016-02-03 2019-04-02 安口生物公司 用于提高抗体稳定性的缓冲制剂
US12325737B2 (en) * 2018-03-26 2025-06-10 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
HU231514B1 (hu) * 2018-11-07 2024-07-28 Richter Gedeon Nyrt. Sejttenyészetben előállított rekombináns glikoprotein glikozilációs mintázatának megváltoztatására szolgáló módszer
AU2019402923A1 (en) * 2018-12-19 2021-07-15 Seagen Inc. Controlled fucosylation of antibodies
WO2021066772A1 (en) * 2019-10-01 2021-04-08 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Cell culture medium for reducing fucosylation and basic variants in the production of antibodies
CN116964215A (zh) * 2021-02-12 2023-10-27 隆萨本德股份有限公司 用于调节抗体产物的无岩藻糖基化的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
US8227241B2 (en) 2004-03-12 2012-07-24 Unigene Laboratories, Inc. Bacterial host cell for the direct expression of peptides
CA2608579C (en) 2005-05-26 2019-09-10 Cytos Biotechnology Ag Scalable fermentation process
US7846724B2 (en) 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
WO2009135181A2 (en) * 2008-05-02 2009-11-05 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
US8409838B2 (en) 2009-06-02 2013-04-02 Regeneron Pharmaceuticals, Inc. Fucosylation-deficient cells
CA2763164A1 (en) 2009-06-05 2010-12-09 Momenta Pharmaceuticals, Inc. Methods of modulating fucosylation of glycoproteins
US20120258496A1 (en) 2010-09-27 2012-10-11 Boehringer Ingelheim International Gmbh Production of low fucose antibodies in h4-ii-e rat cells
WO2013114165A1 (en) * 2012-01-30 2013-08-08 Dr Reddy's Laboratories Limited Process of obtaining glycoprotein composition with increased afucosylation content
NO2760138T3 (https=) * 2012-10-01 2018-08-04
WO2015140700A1 (en) * 2014-03-19 2015-09-24 Dr. Reddy's Laboratories Limited Cell culture process
ES2875274T3 (es) * 2015-11-02 2021-11-10 Hoffmann La Roche Procedimientos de preparación de formas fucosiladas y afucosiladas de una proteína

Also Published As

Publication number Publication date
EP3400241A1 (en) 2018-11-14
AU2017206006A1 (en) 2018-07-19
JP2019500876A (ja) 2019-01-17
CN109153716A (zh) 2019-01-04
US20190161543A1 (en) 2019-05-30
WO2017120347A1 (en) 2017-07-13
JP6674028B2 (ja) 2020-04-01
CA3010598A1 (en) 2017-07-13
AU2017206006B2 (en) 2019-08-29
EP3400241B1 (en) 2020-07-22

Similar Documents

Publication Publication Date Title
MX2018008447A (es) Modulacion de especies afucosilados en una composicion de anticuerpo monoclonal.
MX2018008448A (es) Reducción de especies de alto peso molecular, especies con carga ácida, y fragmentos en una composición de anticuerpo monoclonal.
Li et al. The multifaceted regulation and functions of PKM2 in tumor progression
GEAP202315128A (en) Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof
SG10201903912XA (en) Delivery of biomolecules to immune cells
PH12017500918A1 (en) Antibodies against cd73 and uses thereof
MX2021008143A (es) Metodos para cosechar cultivos de celulas de mamifero.
MX2020004094A (es) Metodos para administrar inmunoterapia con receptores de antigeno quimerico.
MY200337A (en) Nucleic acid molecules encoding chimeric antigen receptors comprising a cd20 binding domain
GB2555728A (en) Cancer cell enrichment system
EP4303229A3 (en) Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
HK1243631A1 (zh) 用於提高过继细胞免疫疗法效力的组合物和方法
MX2021001859A (es) Medio de cultivo celular libre de suero.
EP4279136A3 (en) Methods for determining car-t cells dosing
MX2020013695A (es) Biorreactores de peque?o volumen con volumenes de trabajo sustancialmente constantes y sistemas y metodos relacionados.
MX366106B (es) Composiciones y metodos para producir glucoproteinas.
AU2016335217A8 (en) Antigen receptors and uses thereof
IL276910A (en) Fully fucose-free glycoforms of antibodies are produced in cell culture
MX2015011781A (es) Medio de cultivo celular y metodos de produccion de anticuerpos.
EA202190736A1 (ru) Способы и композиции для увеличения экспрессии белка и/или лечения расстройства, связанного с гаплонедостаточностью
MX2015010428A (es) Anticuerpos anti-her2 altamente galactosilados y sus usos.
IN2014MU01100A (https=)
MX2015017414A (es) Bacteria acetogenica.
AU2017254665A1 (en) Compositions and methods for enhanced gene expression of pklr
WO2020012244A3 (en) Treating ulcerative colitis with brazikumab